LOCUS       NM_153236               1214 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens GTPase, IMAP family member 7 (GIMAP7), mRNA.
ACCESSION   NM_153236
VERSION     NM_153236.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1214)
  AUTHORS   Xu,A., Fan,Y., Liu,S., Sheng,L., Sun,Y. and Yang,H.
  TITLE     GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa
            cells in polycystic ovary syndrome by inhibiting sonic hedgehog
            signalling pathway
  JOURNAL   J Ovarian Res 15 (1), 141 (2022)
   PUBMED   36581994
  REMARK    GeneRIF: GIMAP7 induces oxidative stress and apoptosis of ovarian
            granulosa cells in polycystic ovary syndrome by inhibiting sonic
            hedgehog signalling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1214)
  AUTHORS   Usman,M., Ilyas,A., Hashim,Z. and Zarina,S.
  TITLE     Identification of GIMAP7 and Rabl3 as Putative Biomarkers for Oral
            Squamous Cell Carcinoma Through Comparative Proteomic Approach
  JOURNAL   Pathol Oncol Res 26 (3), 1817-1822 (2020)
   PUBMED   31748878
  REMARK    GeneRIF: Identification of GIMAP7 and Rabl3 as Putative Biomarkers
            for Oral Squamous Cell Carcinoma Through Comparative Proteomic
            Approach.
REFERENCE   3  (bases 1 to 1214)
  AUTHORS   Schwefel,D., Arasu,B.S., Marino,S.F., Lamprecht,B., Kochert,K.,
            Rosenbaum,E., Eichhorst,J., Wiesner,B., Behlke,J., Rocks,O.,
            Mathas,S. and Daumke,O.
  TITLE     Structural insights into the mechanism of GTPase activation in the
            GIMAP family
  JOURNAL   Structure 21 (4), 550-559 (2013)
   PUBMED   23454188
  REMARK    GeneRIF: The crystal structure of GTP-bound GIMAP7 shows a
            homodimer assembled via the G domains, with the helical extensions
            protruding in opposite directions.
REFERENCE   4  (bases 1 to 1214)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1214)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   6  (bases 1 to 1214)
  AUTHORS   Cambot,M., Aresta,S., Kahn-Perles,B., de Gunzburg,J. and Romeo,P.H.
  TITLE     Human immune associated nucleotide 1: a member of a new guanosine
            triphosphatase family expressed in resting T and B cells
  JOURNAL   Blood 99 (9), 3293-3301 (2002)
   PUBMED   11964296
REFERENCE   7  (bases 1 to 1214)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX440511.2, BC027613.1 and
            AA854865.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153236.3.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027613.1, SRR5189664.58287.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313543.5/ ENSP00000315474.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BX440511.2         43-46
            5-1194              BC027613.1         9-1198
            1195-1214           AA854865.1         14-33               c
FEATURES             Location/Qualifiers
     source          1..1214
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1214
                     /gene="GIMAP7"
                     /gene_synonym="hIAN7; IAN7"
                     /note="GTPase, IMAP family member 7"
                     /db_xref="GeneID:168537"
                     /db_xref="HGNC:HGNC:22404"
                     /db_xref="MIM:616961"
     exon            1..74
                     /gene="GIMAP7"
                     /gene_synonym="hIAN7; IAN7"
                     /inference="alignment:Splign:2.1.0"
     exon            75..1214
                     /gene="GIMAP7"
                     /gene_synonym="hIAN7; IAN7"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..1018
                     /gene="GIMAP7"
                     /gene_synonym="hIAN7; IAN7"
                     /note="immune associated nucleotide; IAN-7;
                     immunity-associated nucleotide 7 protein;
                     immune-associated nucleotide-binding protein 7"
                     /codon_start=1
                     /product="GTPase IMAP family member 7"
                     /protein_id="NP_694968.1"
                     /db_xref="CCDS:CCDS5903.1"
                     /db_xref="GeneID:168537"
                     /db_xref="HGNC:HGNC:22404"
                     /db_xref="MIM:616961"
                     /translation="MAESEDRSLRIVLVGKTGSGKSATANTILGEEIFDSRIAAQAVT
                     KNCQKASREWQGRDLLVVDTPGLFDTKESLDTTCKEISRCIISSCPGPHAIVLVLLLG
                     RYTEEEQKTVALIKAVFGKSAMKHMVILFTRKEELEGQSFHDFIADADVGLKSIVKEC
                     GNRCCAFSNSKKTSKAEKESQVQELVELIEKMVQCNEGAYFSDDIYKDTEERLKQREE
                     VLRKIYTDQLNEEIKLVEEDKHKSEEEKEKEIKLLKLKYDEKIKNIREEAERNIFKDV
                     FNRIWKMLSEIWHRFLSKCKFYSS"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP7"
                     /gene_synonym="hIAN7; IAN7"
                     /note="hexamer: AATAAA"
     polyA_site      1214
                     /gene="GIMAP7"
                     /gene_synonym="hIAN7; IAN7"
                     /note="major polyA site"
ORIGIN      
        1 acagtaaaag caaaagcaac agctcaagca gcctccttgg agaaaacctg aaaattcaac
       61 ttgttcaaga gaaggtcttg tacgtgccta agttctagag cctcctgacg tgagcatggc
      121 tgagagtgag gaccgctccc tgaggatcgt tctggtaggg aaaactggaa gtgggaaaag
      181 tgcaacagcg aacaccatcc ttggagagga aatctttgat tctagaattg ctgcccaagc
      241 tgttaccaag aactgtcaaa aagcatcccg ggaatggcag gggagagacc ttcttgttgt
      301 agacactcca gggctctttg acaccaagga gagcctggac accacctgca aggaaatcag
      361 ccgctgcatc atctcctcct gcccagggcc ccatgctatt gtcctagttc tgctgctggg
      421 ccgctacaca gaggaggagc agaaaaccgt tgcattgatc aaggctgtct ttgggaagtc
      481 agccatgaag cacatggtca tcttgttcac tcgcaaagaa gagttggagg gccagagctt
      541 ccatgacttc atagcagatg cggatgtggg cctaaaaagc atcgtcaagg agtgcgggaa
      601 ccgctgctgt gcctttagca acagcaagaa aaccagtaag gcagagaagg aaagtcaagt
      661 gcaggagttg gtggagctga tagagaaaat ggtgcagtgc aacgaagggg cttacttttc
      721 tgatgacata tacaaggaca cagaggaaag gctgaaacaa cgggaagagg ttttgaggaa
      781 aatctacact gaccaattaa atgaagaaat taaactagta gaagaggata agcataaatc
      841 agaggaagaa aaggagaaag aaattaaatt actaaaatta aaatatgatg aaaaaataaa
      901 aaatataagg gaagaagctg agagaaatat atttaaagat gtttttaata ggatttggaa
      961 gatgctttca gaaatatggc ataggttttt gtcgaaatgt aagttttatt cttcctaatt
     1021 tactgtgatt tgttaatgga tgaattgtat tttgcaaaga tagttagaga aatacctcct
     1081 tccccttagc tttattaagg tatcattgat aaataaaaat aaaatatgtt taatgtatat
     1141 aatgtgattt ttaaatatat atatatatat acacacattg tgaaataatg aaataaaggt
     1201 aattaacaca tcta
//
