LOCUS       NM_024711               3440 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens GTPase, IMAP family member 6 (GIMAP6), transcript
            variant 1, mRNA.
ACCESSION   NM_024711
VERSION     NM_024711.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3440)
  AUTHORS   Chen,X., Li,Z., Wang,X., Zhou,J., Wei,Q., Chen,K. and Jiang,R.
  TITLE     Investigation and verification of GIMAP6 as a robust biomarker for
            prognosis and tumor immunity in lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 149 (13), 11041-11055 (2023)
   PUBMED   37338641
  REMARK    GeneRIF: Investigation and verification of GIMAP6 as a robust
            biomarker for prognosis and tumor immunity in lung adenocarcinoma.
REFERENCE   2  (bases 1 to 3440)
  AUTHORS   Yao,Y., Du Jiang,P., Chao,B.N., Cagdas,D., Kubo,S.,
            Balasubramaniyam,A., Zhang,Y., Shadur,B., NaserEddin,A.,
            Folio,L.R., Schwarz,B., Bohrnsen,E., Zheng,L., Lynberg,M.,
            Gottlieb,S., Leney-Greene,M.A., Park,A.Y., Tezcan,I., Akdogan,A.,
            Gocmen,R., Onder,S., Rosenberg,A., Soilleux,E.J., Johnson,E.,
            Jackson,P.K., Demeter,J., Chauvin,S.D., Paul,F., Selbach,M.,
            Bulut,H., Clatworthy,M.R., Tuong,Z.K., Zhang,H., Stewart,B.J.,
            Bosio,C.M., Stepensky,P., Clare,S., Ganesan,S., Pascall,J.C.,
            Daumke,O., Butcher,G.W., McMichael,A.J., Simon,A.K. and
            Lenardo,M.J.
  TITLE     GIMAP6 regulates autophagy, immune competence, and inflammation in
            mice and humans
  JOURNAL   J Exp Med 219 (6) (2022)
   PUBMED   35551368
  REMARK    GeneRIF: GIMAP6 regulates autophagy, immune competence, and
            inflammation in mice and humans.
REFERENCE   3  (bases 1 to 3440)
  AUTHORS   Shadur,B., Asherie,N., Kfir-Erenfeld,S., Dubnikov,T.,
            NaserEddin,A., Schejter,Y.D., Elpeleg,O., Mor-Shaked,H. and
            Stepensky,P.
  TITLE     A human case of GIMAP6 deficiency: a novel primary immune
            deficiency
  JOURNAL   Eur J Hum Genet 29 (4), 657-662 (2021)
   PUBMED   33328581
  REMARK    GeneRIF: A human case of GIMAP6 deficiency: a novel primary immune
            deficiency.
REFERENCE   4  (bases 1 to 3440)
  AUTHORS   Ho,C.H. and Tsai,S.F.
  TITLE     Functional and biochemical characterization of a T cell-associated
            anti-apoptotic protein, GIMAP6
  JOURNAL   J Biol Chem 292 (22), 9305-9319 (2017)
   PUBMED   28381553
  REMARK    GeneRIF: GIMAP6 plays a role in modulating immune function and that
            it does this by controlling cell death and the activation of T
            cells.
REFERENCE   5  (bases 1 to 3440)
  AUTHORS   Huang,Z., Zhang,W., Gao,C., Ji,B., Chi,X., Zheng,W. and Wang,H.L.
  TITLE     Dysregulation of GTPase IMAP family members in hepatocellular
            cancer
  JOURNAL   Mol Med Rep 14 (5), 4119-4123 (2016)
   PUBMED   27667392
  REMARK    GeneRIF: These data,demonstrating the downregulation of the mRNA
            and protein expression levels of GIMAP5 and GIMAP6 in the tumor
            tissues and blood of patients with Hepatocellular carcinoma (HCC) ,
            suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis
            of HCC, and indicate their possible use as diagnostic markers for
            HCC.
REFERENCE   6  (bases 1 to 3440)
  AUTHORS   Schwefel,D., Arasu,B.S., Marino,S.F., Lamprecht,B., Kochert,K.,
            Rosenbaum,E., Eichhorst,J., Wiesner,B., Behlke,J., Rocks,O.,
            Mathas,S. and Daumke,O.
  TITLE     Structural insights into the mechanism of GTPase activation in the
            GIMAP family
  JOURNAL   Structure 21 (4), 550-559 (2013)
   PUBMED   23454188
REFERENCE   7  (bases 1 to 3440)
  AUTHORS   Shiao,Y.M., Chang,Y.H., Liu,Y.M., Li,J.C., Su,J.S., Liu,K.J.,
            Liu,Y.F., Lin,M.W. and Tsai,S.F.
  TITLE     Dysregulation of GIMAP genes in non-small cell lung cancer
  JOURNAL   Lung Cancer 62 (3), 287-294 (2008)
   PUBMED   18462827
REFERENCE   8  (bases 1 to 3440)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   9  (bases 1 to 3440)
  AUTHORS   Cambot,M., Aresta,S., Kahn-Perles,B., de Gunzburg,J. and Romeo,P.H.
  TITLE     Human immune associated nucleotide 1: a member of a new guanosine
            triphosphatase family expressed in resting T and B cells
  JOURNAL   Blood 99 (9), 3293-3301 (2002)
   PUBMED   11964296
REFERENCE   10 (bases 1 to 3440)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR749355.1 and BC060760.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024711.5.
            
            Summary: This gene encodes a member of the GTPases of
            immunity-associated proteins (GIMAP) family. GIMAP proteins contain
            GTP-binding and coiled-coil motifs, and may play roles in the
            regulation of cell survival. Decreased expression of this gene may
            play a role in non-small cell lung cancer. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene, which is found in a cluster with seven additional
            GIMAP genes on the long arm of chromosome 7. [provided by RefSeq,
            Sep 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749355.1, SRR1660805.244915.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328902.9/ ENSP00000330374.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1364              CR749355.1         1-1364
            1365-3440           BC060760.1         1290-3365
FEATURES             Location/Qualifiers
     source          1..3440
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..3440
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /note="GTPase, IMAP family member 6"
                     /db_xref="GeneID:474344"
                     /db_xref="HGNC:HGNC:21918"
                     /db_xref="MIM:616960"
     exon            1..217
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1096
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     immune associated nucleotide 6; immune associated
                     nucleotide 2; immune-associated nucleotide-binding protein
                     6"
                     /codon_start=1
                     /product="GTPase IMAP family member 6 isoform 1"
                     /protein_id="NP_078987.3"
                     /db_xref="CCDS:CCDS34778.1"
                     /db_xref="GeneID:474344"
                     /db_xref="HGNC:HGNC:21918"
                     /db_xref="MIM:616960"
                     /translation="MEEEEYEQIPQENPPEELSQDPVLELSGGLREKEQKTPRRLRLI
                     LMGKTGSGKSATGNSILGRDVFESKLSTRPVTKTSQRRSREWAGKELEVIDTPNILSP
                     QVSPEVADAICQAIVLSAPGPHAVLLVTQLGRFTDEDQQVVRRLQEVFGVGVLGHTIL
                     VFTRKEDLAGGSLEDYVRETNNQALAWLDVTLARRHCGFNNRAQGEEQEAQLRELMEK
                     VEAIMWENEGDYYSNKAYQYTQQNFRLKELQERQVSQGQGSEDVPGEESWLEGLSQIQ
                     KESEEAHRCLLGKADL"
     exon            218..302
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /inference="alignment:Splign:2.1.0"
     exon            303..3440
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3413..3418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /note="hexamer: ATTAAA"
     polyA_site      3440
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /note="major polyA site"
ORIGIN      
        1 acttcctgtt cctccatctc cagcggacac tgctctttca agggcaggtc tccagcccag
       61 ctctctgaaa acattttgct gaaaatataa gcaaacatcg gccttgtcct ccttgtgttc
      121 atacactgtg gaagcttttc tctgcctcct ccgtgagagt gcgtggccgg gagaccagaa
      181 acgtggtcct ttctcttgcc tgtgagctgg tgcagagatg gaggaagaag aatatgaaca
      241 aattccccag gagaatcccc cagaagagct gtcccaggat cctgtgctgg agctgtcagg
      301 aggtctaagg gagaaagaac agaagacccc aaggagactg aggctcattc tcatggggaa
      361 aacagggagt gggaagagtg caacaggaaa cagcatcctc ggcagggacg tcttcgagtc
      421 taaactcagc accagacccg tgaccaagac ctcccagaga cggagccgag agtgggctgg
      481 gaaggagctt gaggtgattg acacacccaa cattctgtcc ccccaggtct cgccagaggt
      541 ggcagacgct atctgccaag ccatcgtctt atccgcccca gggccccacg ccgtgctcct
      601 ggtgacacaa ctgggccggt tcacggatga ggatcagcag gtggtcaggc gcctgcagga
      661 ggtctttgga gtgggggttc tgggtcacac catcctggtg ttcacccgga aggaagacct
      721 ggctggcggc tccctggaag actatgtgcg agagaccaac aaccaggccc ttgcctggct
      781 ggatgtgacc cttgcacggc gccattgcgg cttcaacaac agggcacagg gggaggagca
      841 ggaggcccaa ctgcgagagc tcatggagaa agttgaagcc attatgtggg aaaacgaagg
      901 agattattac agcaacaagg cttaccaata tacccagcaa aactttcggc tgaaagaact
      961 acaggaaagg caagtaagcc agggccaagg ctctgaggac gtgcctggtg aggagtcttg
     1021 gctggaagga ctgtcccaga tccagaagga atctgaggaa gcccacagat gcctgctggg
     1081 gaaggctgac ctttgagcct gtgctggact tgagccaagg acaccatcag cctttgcacc
     1141 cccctgtgtc cagccctctg tttctctttc catcccatgg agtgcttccc agtctccagg
     1201 tcatgacgtc tggtgtagga agaggggcat ggggcttgag gacagggtcc agcatgccca
     1261 gatcacattc cagttccttc attccttctt ccagaacatc tgggtcctcc ctcctctgtg
     1321 ccccaacagc acgctgtctt cctattggac cttctatctc attgcattgc ctttcatgag
     1381 ttacttgtct atactctgat agaaccaaag tttcttgagg gcaggcctgt atcttttact
     1441 tctgtgtaac ttccacagct tttgactgca ttggagtcat gcagtcacgt ttggtgcggc
     1501 aactccatgc aagctgttga ccagatgact tctcatctct ccccacacca tgatggttta
     1561 aggtgcctgt tgtgtctggt ggctggaaca tggcagtggt gctgagacat ggggagggtt
     1621 ggagactggg tggggagggt tggagactgg gctgggagga gagcaagcag gaacagggat
     1681 ggaggcagga ggagcagccc ttttattcac tcttgagctg taacaaacaa gccccgttgg
     1741 aacttcctag tgggaatgat gggagaagtt tggggcaggg tatccaagaa gtcagactgt
     1801 ggtcaagtag gtggtccctt gccctggcta cagaacatgg aagcccctag ggatgcaagt
     1861 ggacttgggc agaggaggtc acaccacccc accaaggtag acttagatta gagatgactt
     1921 gcatctgtta cttccccttt ttccatgggt ttcatggccc ctcatgatat ttgccttctg
     1981 ctcctagaag gcacagacta ctttcaacct gcctcgccct tcactgccac ccctcccttc
     2041 tcccttgata atgggagcat gtggatgggg tgtctgcgtg tgcaaacggg ttccctagca
     2101 aagtatttgt gggggtccaa tgcaaggagg cagggaagaa agggggcctg caaaggaagc
     2161 agtagagtga cttaaacatc ttgcgaggca gcctgcctgg tttatgggag aactctgaag
     2221 cccatgatgt tttcctggaa ggctgttcct acagacgggg tttataagta ctgatactgg
     2281 acaggatgag aagggagtag gatgtcatcc tgtctcaggc ctcggatagg aagctgcctg
     2341 ccagcaagag gagactgatg tgccccgggt gcaccccacc tcctttgagg tccaagatgc
     2401 tcctggggag ttgaccgaca tttgggaaga taataggagg cattggggaa actgctcccc
     2461 aatatattcc tcttttcctt tcttcaagct gcgtagcagg gggcctttag ctagtttctc
     2521 ccgagagggg cgggaagtac agctggtgga gacagtgctg ggagatgatc agaaatctca
     2581 gggcacagcc tcaggtctac ctggacactc atccactgtt ggagatgctc aacagctaga
     2641 cacagatgct cacagccgac ctgtggcctc ttgctctgaa gccatccccc atcttcccta
     2701 gacacagcag acatctgaga aagcttcagc atttctcttg ctaacagatt cagaaaagtg
     2761 tctcaaagca gagcacagag ttatttggtg tttgctgaag acagcctttg tgccacaatc
     2821 acttattaaa taagcgatca atttcccatt gaactgaaca tgcaacattt atcatacatt
     2881 cagttctcat tcacactcct taagatttgg tcagaatttt tatttctgtt catgtcttct
     2941 acttttctac tcctgtatga ataaaatatt gatttgatta cagtggcttt gactataatg
     3001 tgggagccaa tttttgcctc agtcttcatt tttatattta ccttgttatt ctcaggcatt
     3061 tttttcttct atgtgagagt taaaatcatt ctgtaatttc cccccaaaat catattggta
     3121 ttctagttgg caatgtctta catttatgtt aagtttgagg gaattggtag ttcaagtata
     3181 agttaattaa ggccatttta tttctaagtg aacagacttg aaactccaga gctactgaag
     3241 taaaagttag aatcatttgc attttcattc agataggaga taattttgta aattttgatg
     3301 ctattatttt aactctatta gcttaagtaa tgtcataata gaaaacacaa gcatttgacc
     3361 aaatgagatc cattcagcga ctaactggca aggcactcaa aacatgtcat tcattaaatg
     3421 ttgtttttat ttacctcaaa
//
