LOCUS       NP_078987                292 aa            linear   PRI 28-APR-2025
DEFINITION  GTPase IMAP family member 6 isoform 1 [Homo sapiens].
ACCESSION   NP_078987
VERSION     NP_078987.3
DBSOURCE    REFSEQ: accession NM_024711.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 292)
  AUTHORS   Chen,X., Li,Z., Wang,X., Zhou,J., Wei,Q., Chen,K. and Jiang,R.
  TITLE     Investigation and verification of GIMAP6 as a robust biomarker for
            prognosis and tumor immunity in lung adenocarcinoma
  JOURNAL   J Cancer Res Clin Oncol 149 (13), 11041-11055 (2023)
   PUBMED   37338641
  REMARK    GeneRIF: Investigation and verification of GIMAP6 as a robust
            biomarker for prognosis and tumor immunity in lung adenocarcinoma.
REFERENCE   2  (residues 1 to 292)
  AUTHORS   Yao,Y., Du Jiang,P., Chao,B.N., Cagdas,D., Kubo,S.,
            Balasubramaniyam,A., Zhang,Y., Shadur,B., NaserEddin,A.,
            Folio,L.R., Schwarz,B., Bohrnsen,E., Zheng,L., Lynberg,M.,
            Gottlieb,S., Leney-Greene,M.A., Park,A.Y., Tezcan,I., Akdogan,A.,
            Gocmen,R., Onder,S., Rosenberg,A., Soilleux,E.J., Johnson,E.,
            Jackson,P.K., Demeter,J., Chauvin,S.D., Paul,F., Selbach,M.,
            Bulut,H., Clatworthy,M.R., Tuong,Z.K., Zhang,H., Stewart,B.J.,
            Bosio,C.M., Stepensky,P., Clare,S., Ganesan,S., Pascall,J.C.,
            Daumke,O., Butcher,G.W., McMichael,A.J., Simon,A.K. and
            Lenardo,M.J.
  TITLE     GIMAP6 regulates autophagy, immune competence, and inflammation in
            mice and humans
  JOURNAL   J Exp Med 219 (6) (2022)
   PUBMED   35551368
  REMARK    GeneRIF: GIMAP6 regulates autophagy, immune competence, and
            inflammation in mice and humans.
REFERENCE   3  (residues 1 to 292)
  AUTHORS   Shadur,B., Asherie,N., Kfir-Erenfeld,S., Dubnikov,T.,
            NaserEddin,A., Schejter,Y.D., Elpeleg,O., Mor-Shaked,H. and
            Stepensky,P.
  TITLE     A human case of GIMAP6 deficiency: a novel primary immune
            deficiency
  JOURNAL   Eur J Hum Genet 29 (4), 657-662 (2021)
   PUBMED   33328581
  REMARK    GeneRIF: A human case of GIMAP6 deficiency: a novel primary immune
            deficiency.
REFERENCE   4  (residues 1 to 292)
  AUTHORS   Ho,C.H. and Tsai,S.F.
  TITLE     Functional and biochemical characterization of a T cell-associated
            anti-apoptotic protein, GIMAP6
  JOURNAL   J Biol Chem 292 (22), 9305-9319 (2017)
   PUBMED   28381553
  REMARK    GeneRIF: GIMAP6 plays a role in modulating immune function and that
            it does this by controlling cell death and the activation of T
            cells.
REFERENCE   5  (residues 1 to 292)
  AUTHORS   Huang,Z., Zhang,W., Gao,C., Ji,B., Chi,X., Zheng,W. and Wang,H.L.
  TITLE     Dysregulation of GTPase IMAP family members in hepatocellular
            cancer
  JOURNAL   Mol Med Rep 14 (5), 4119-4123 (2016)
   PUBMED   27667392
  REMARK    GeneRIF: These data,demonstrating the downregulation of the mRNA
            and protein expression levels of GIMAP5 and GIMAP6 in the tumor
            tissues and blood of patients with Hepatocellular carcinoma (HCC) ,
            suggested the involvement of GIMAP5 and GIMAP6 in the pathogenesis
            of HCC, and indicate their possible use as diagnostic markers for
            HCC.
REFERENCE   6  (residues 1 to 292)
  AUTHORS   Schwefel,D., Arasu,B.S., Marino,S.F., Lamprecht,B., Kochert,K.,
            Rosenbaum,E., Eichhorst,J., Wiesner,B., Behlke,J., Rocks,O.,
            Mathas,S. and Daumke,O.
  TITLE     Structural insights into the mechanism of GTPase activation in the
            GIMAP family
  JOURNAL   Structure 21 (4), 550-559 (2013)
   PUBMED   23454188
REFERENCE   7  (residues 1 to 292)
  AUTHORS   Shiao,Y.M., Chang,Y.H., Liu,Y.M., Li,J.C., Su,J.S., Liu,K.J.,
            Liu,Y.F., Lin,M.W. and Tsai,S.F.
  TITLE     Dysregulation of GIMAP genes in non-small cell lung cancer
  JOURNAL   Lung Cancer 62 (3), 287-294 (2008)
   PUBMED   18462827
REFERENCE   8  (residues 1 to 292)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   9  (residues 1 to 292)
  AUTHORS   Cambot,M., Aresta,S., Kahn-Perles,B., de Gunzburg,J. and Romeo,P.H.
  TITLE     Human immune associated nucleotide 1: a member of a new guanosine
            triphosphatase family expressed in resting T and B cells
  JOURNAL   Blood 99 (9), 3293-3301 (2002)
   PUBMED   11964296
REFERENCE   10 (residues 1 to 292)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CR749355.1 and BC060760.1.
            
            On Nov 29, 2004 this sequence version replaced NP_078987.2.
            
            Summary: This gene encodes a member of the GTPases of
            immunity-associated proteins (GIMAP) family. GIMAP proteins contain
            GTP-binding and coiled-coil motifs, and may play roles in the
            regulation of cell survival. Decreased expression of this gene may
            play a role in non-small cell lung cancer. Alternatively spliced
            transcript variants encoding multiple isoforms have been observed
            for this gene, which is found in a cluster with seven additional
            GIMAP genes on the long arm of chromosome 7. [provided by RefSeq,
            Sep 2011].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749355.1, SRR1660805.244915.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328902.9/ ENSP00000330374.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..292
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     Protein         1..292
                     /product="GTPase IMAP family member 6 isoform 1"
                     /note="immune associated nucleotide 6; immune associated
                     nucleotide 2; immune-associated nucleotide-binding protein
                     6"
                     /calculated_mol_wt=32818
     Region          1..39
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P9H5.1)"
     Region          41..241
                     /region_name="AIG1"
                     /note="AvrRpt2-Induced Gene 1 (AIG1); cd01852"
                     /db_xref="CDD:206651"
     Site            47..54
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206651"
     Site            order(50..55,68,164,166,201..202)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206651"
     Site            75..82
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206651"
     Site            76
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206651"
     Site            95..98
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206651"
     Site            order(97..99,108..125)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206651"
     Site            163..166
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206651"
     Site            193..195
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206651"
     Region          250..275
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P9H5.1)"
     CDS             1..292
                     /gene="GIMAP6"
                     /gene_synonym="IAN-2; IAN-6; IAN2; IAN6"
                     /coded_by="NM_024711.6:218..1096"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS34778.1"
                     /db_xref="GeneID:474344"
                     /db_xref="HGNC:HGNC:21918"
                     /db_xref="MIM:616960"
ORIGIN      
        1 meeeeyeqip qenppeelsq dpvlelsggl rekeqktprr lrlilmgktg sgksatgnsi
       61 lgrdvfeskl strpvtktsq rrsrewagke levidtpnil spqvspevad aicqaivlsa
      121 pgphavllvt qlgrftdedq qvvrrlqevf gvgvlghtil vftrkedlag gsledyvret
      181 nnqalawldv tlarrhcgfn nraqgeeqea qlrelmekve aimwenegdy ysnkayqytq
      241 qnfrlkelqe rqvsqgqgse dvpgeeswle glsqiqkese eahrcllgka dl
//
