LOCUS       NM_018384               1804 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens GTPase, IMAP family member 5 (GIMAP5), mRNA.
ACCESSION   NM_018384
VERSION     NM_018384.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1804)
  AUTHORS   Dai,P., Ruan,P., Mao,Y., Tang,Z., Qiu,X., Bajinka,O. and Tan,Y.
  TITLE     Gimap5 promoted RSV degradation through interaction with M6PR
  JOURNAL   J Med Virol 95 (1), e28390 (2023)
   PUBMED   36484389
  REMARK    GeneRIF: Gimap5 promoted RSV degradation through interaction with
            M6PR.
REFERENCE   2  (bases 1 to 1804)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1804)
  AUTHORS   Patterson,A.R., Endale,M., Lampe,K., Aksoylar,H.I., Flagg,A.,
            Woodgett,J.R., Hildeman,D., Jordan,M.B., Singh,H., Kucuk,Z.,
            Bleesing,J. and Hoebe,K.
  TITLE     Gimap5-dependent inactivation of GSK3beta is required for CD4+ T
            cell homeostasis and prevention of immune pathology
  JOURNAL   Nat Commun 9 (1), 430 (2018)
   PUBMED   29382851
  REMARK    GeneRIF: GIMAP5 loss-of-function mutation results in T cell
            deficiencies.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1804)
  AUTHORS   Huang,Z., Zhang,W., Gao,C., Ji,B., Chi,X., Zheng,W. and Wang,H.L.
  TITLE     Dysregulation of GTPase IMAP family members in hepatocellular
            cancer
  JOURNAL   Mol Med Rep 14 (5), 4119-4123 (2016)
   PUBMED   27667392
  REMARK    GeneRIF: These data,demonstrating the downregulation of the mRNA
            and protein expression levels of GIMAP5 and GIMAP6 in the tumor
            tissues and blood of patients with HCC, suggested the involvement
            of GIMAP5 and GIMAP6 in the pathogenesis of HCC, and indicate their
            possible use as diagnostic markers for HCC.
REFERENCE   5  (bases 1 to 1804)
  AUTHORS   Endale,M., Aksoylar,H.I. and Hoebe,K.
  TITLE     Central role of gimap5 in maintaining peripheral tolerance and T
            cell homeostasis in the gut
  JOURNAL   Mediators Inflamm 2015, 436017 (2015)
   PUBMED   25944983
  REMARK    GeneRIF: gimap5 has a role in maintaining peripheral tolerance and
            T cell homeostasis in the gut [review]
            Review article
REFERENCE   6  (bases 1 to 1804)
  AUTHORS   Zenz,T., Roessner,A., Thomas,A., Frohling,S., Dohner,H.,
            Calabretta,B. and Daheron,L.
  TITLE     hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member
            of the Ian family that is overexpressed in B-cell lymphoid
            malignancies
  JOURNAL   Genes Immun 5 (2), 109-116 (2004)
   PUBMED   14724691
REFERENCE   7  (bases 1 to 1804)
  AUTHORS   Sandal,T., Aumo,L., Hedin,L., Gjertsen,B.T. and Doskeland,S.O.
  TITLE     Irod/Ian5: an inhibitor of gamma-radiation- and okadaic
            acid-induced apoptosis
  JOURNAL   Mol Biol Cell 14 (8), 3292-3304 (2003)
   PUBMED   12925764
REFERENCE   8  (bases 1 to 1804)
  AUTHORS   Cambot,M., Aresta,S., Kahn-Perles,B., de Gunzburg,J. and Romeo,P.H.
  TITLE     Human immune associated nucleotide 1: a member of a new guanosine
            triphosphatase family expressed in resting T and B cells
  JOURNAL   Blood 99 (9), 3293-3301 (2002)
   PUBMED   11964296
REFERENCE   9  (bases 1 to 1804)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
REFERENCE   10 (bases 1 to 1804)
  AUTHORS   Daheron,L., Zenz,T., Siracusa,L.D., Brenner,C. and Calabretta,B.
  TITLE     Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an
            outer membrane mitochondrial protein with GTP-binding activity
  JOURNAL   Nucleic Acids Res 29 (6), 1308-1316 (2001)
   PUBMED   11238997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006479.2 and CA431916.1.
            
            On Aug 11, 2020 this sequence version replaced NM_018384.4.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. This gene encodes an
            antiapoptotic protein that functions in T-cell survival.
            Polymorphisms in this gene are associated with systemic lupus
            erythematosus. Read-through transcription exists between this gene
            and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1)
            gene. [provided by RefSeq, Dec 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002158.1, SRR18074968.1990779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358647.5/ ENSP00000351473.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-291               AC006479.2         104225-104515       c
            292-340             AC006479.2         101006-101054       c
            341-1712            AC006479.2         98379-99750         c
            1713-1804           CA431916.1         22-113              c
FEATURES             Location/Qualifiers
     source          1..1804
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1804
                     /gene="GIMAP5"
                     /gene_synonym="HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3;
                     IROD; NCPH2"
                     /note="GTPase, IMAP family member 5"
                     /db_xref="GeneID:55340"
                     /db_xref="HGNC:HGNC:18005"
                     /db_xref="MIM:608086"
     exon            1..291
                     /gene="GIMAP5"
                     /gene_synonym="HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3;
                     IROD; NCPH2"
                     /inference="alignment:Splign:2.1.0"
     exon            292..340
                     /gene="GIMAP5"
                     /gene_synonym="HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3;
                     IROD; NCPH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             298..1221
                     /gene="GIMAP5"
                     /gene_synonym="HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3;
                     IROD; NCPH2"
                     /note="immunity associated protein 3; inhibitor of
                     radiation- and OA-induced apoptosis, Irod/Ian5;
                     immunity-associated nucleotide 5 protein; immune
                     associated nucleotide 4 like 1; immune-associated
                     nucleotide-binding protein 5"
                     /codon_start=1
                     /product="GTPase IMAP family member 5"
                     /protein_id="NP_060854.2"
                     /db_xref="CCDS:CCDS5907.1"
                     /db_xref="GeneID:55340"
                     /db_xref="HGNC:HGNC:18005"
                     /db_xref="MIM:608086"
                     /translation="MGGFQRGKYGTMAEGRSEDNLSATPPALRIILVGKTGCGKSATG
                     NSILGQPVFESKLRAQSVTRTCQVKTGTWNGRKVLVVDTPSIFESQADTQELYKNIGD
                     CYLLSAPGPHVLLLVIQLGRFTAQDTVAIRKVKEVFGTGAMRHVVILFTHKEDLGGQA
                     LDDYVANTDNCSLKDLVRECERRYCAFNNWGSVEEQRQQQAELLAVIERLGREREGSF
                     HSNDLFLDAQLLQRTGAGACQEDYRQYQAKVEWQVEKHKQELRENESNWAYKALLRVK
                     HLMLLHYEIFVFLLLCSILFFIIFLFIFHYI"
     exon            341..1804
                     /gene="GIMAP5"
                     /gene_synonym="HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3;
                     IROD; NCPH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP5"
                     /gene_synonym="HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3;
                     IROD; NCPH2"
                     /note="hexamer: AATAAA"
     polyA_site      1804
                     /gene="GIMAP5"
                     /gene_synonym="HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3;
                     IROD; NCPH2"
                     /note="major polyA site"
ORIGIN      
        1 aatcagtttc cagccaacac cagggtgtcc tagtccgcag aggtgtgggg gacacactcc
       61 ataatctcta cttttctttt tgtgcagctg agtcatggag ctttcagccc cagcacatgg
      121 ctcctcctta actgcgtctg ctcaacctcc ctcagccctg tgaacagcat ccccgcacac
      181 agacgcagag caggactctc tctgctgcca cttcaccttc ctgagagagg accagcggcc
      241 agagcctcag tgactgccac cctggaggac agggcacaac aaccgtttct ggagagaatg
      301 ggaggattcc agaggggcaa atatggaact atggctgaag gtagatcaga agataacttg
      361 tctgcaacac caccggcatt gaggattatc ctagtgggca aaacaggctg cgggaaaagt
      421 gccacaggga acagcatcct tggccagccc gtgtttgagt ccaagctgag ggcccagtca
      481 gtgaccagga cgtgccaggt gaaaacagga acatggaacg ggaggaaagt cctggtggtt
      541 gacacgccct ccatctttga gtcacaggcc gatacccaag agctgtacaa gaacatcggg
      601 gactgctacc tgctctctgc cccggggccc cacgtcctgc ttctggtgat ccagctgggg
      661 cgtttcactg ctcaggacac agtggccatc aggaaggtga aagaggtctt tgggacaggg
      721 gccatgagac atgtggtcat cctcttcacc cacaaagagg acttaggggg ccaggccctg
      781 gatgactatg tagcaaacac ggacaactgc agcctgaaag acctggtgcg ggagtgtgag
      841 agaaggtact gtgccttcaa caactggggc tctgtggagg agcagaggca gcagcaggca
      901 gagctcctgg ctgtgattga gaggctgggg agggagcgag agggctcctt ccacagcaat
      961 gacctcttct tggatgccca gctgctccaa agaactggag ctggggcctg ccaggaagac
     1021 tacaggcagt accaggccaa agtggaatgg caggtggaga agcacaagca agagctgagg
     1081 gagaacgaga gtaactgggc atacaaggcg ctcctcagag tcaaacactt gatgcttttg
     1141 cattatgaga tttttgtttt tctattgttg tgcagcatac tttttttcat tatttttctg
     1201 ttcatctttc attacattta aatctctgga ccctggagca cttctaatgt atcaccccat
     1261 ggagtcattg ttctaataat caccaattca gactcagatc ctcgtggtct atggagcatg
     1321 ctgcttgctg tctgtgcagc tcccatttcc ccttcttcct gatagacttg gagctgtgtg
     1381 cctccactcc aaggctgcct gcctgctgta aacactattc cactctgtct gccaacaact
     1441 gcttcaggaa tgggcctgag atcccatgca ggtccctgag aagtgagtaa aagtccgcag
     1501 aggtggggat ggaagatctc tccttagata gaacctgtct tcctccctgg cattgtgggg
     1561 tctgggcgtg acactgggac tctcagcagc tttgtgctgc caacctgaga ttgaaggcag
     1621 tgcctcagag cagcacagag agttggggcc ccctgagccc tgagccacca gccctgcagc
     1681 ctgccctatc tccgcatttc cagttgtatt agccaataga tttcctactt atttaagcta
     1741 tttgagctcc gggtctcttc tacctgcatt ctaaaacatt caaagtaata aaaatttctc
     1801 caca
//
