LOCUS       NM_018326               1945 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens GTPase, IMAP family member 4 (GIMAP4), transcript
            variant 1, mRNA.
ACCESSION   NM_018326
VERSION     NM_018326.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1945)
  AUTHORS   Chen,S., Tian,D., Petersen,L., Cao,S., Quinn,Z., Kan,J., Zheng,M.,
            Mao,W. and Wan,Y.
  TITLE     Prognostic Value of GIMAP4 and Its Role in Promoting Immune Cell
            Infiltration into Tumor Microenvironment of Lung Adenocarcinoma
  JOURNAL   Biomed Res Int 2022, 7440189 (2022)
   PUBMED   36246963
  REMARK    GeneRIF: Prognostic Value of GIMAP4 and Its Role in Promoting
            Immune Cell Infiltration into Tumor Microenvironment of Lung
            Adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1945)
  AUTHORS   Heinonen,M.T., Kanduri,K., Lahdesmaki,H.J., Lahesmaa,R. and
            Henttinen,T.A.
  TITLE     Tubulin- and actin-associating GIMAP4 is required for IFN-gamma
            secretion during Th cell differentiation
  JOURNAL   Immunol Cell Biol 93 (2), 158-166 (2015)
   PUBMED   25287446
  REMARK    GeneRIF: GIMAP4 regulates secretion of cytokines in early
            differentiating human CD4(+) T helper lymphocytes and in particular
            the secretion of interferon-gamma also affecting its downstream
            targets.
REFERENCE   3  (bases 1 to 1945)
  AUTHORS   Lee,Y.J., Horie,Y., Wallace,G.R., Choi,Y.S., Park,J.A., Choi,J.Y.,
            Song,R., Kang,Y.M., Kang,S.W., Baek,H.J., Kitaichi,N., Meguro,A.,
            Mizuki,N., Namba,K., Ishida,S., Kim,J., Niemczyk,E., Lee,E.Y.,
            Song,Y.W., Ohno,S. and Lee,E.B.
  TITLE     Genome-wide association study identifies GIMAP as a novel
            susceptibility locus for Behcet's disease
  JOURNAL   Ann Rheum Dis 72 (9), 1510-1516 (2013)
   PUBMED   23041938
  REMARK    GeneRIF: Genome-wide association study identifies GIMAP as a novel
            susceptibility locus for Behcet's disease
REFERENCE   4  (bases 1 to 1945)
  AUTHORS   Schwefel,D., Arasu,B.S., Marino,S.F., Lamprecht,B., Kochert,K.,
            Rosenbaum,E., Eichhorst,J., Wiesner,B., Behlke,J., Rocks,O.,
            Mathas,S. and Daumke,O.
  TITLE     Structural insights into the mechanism of GTPase activation in the
            GIMAP family
  JOURNAL   Structure 21 (4), 550-559 (2013)
   PUBMED   23454188
REFERENCE   5  (bases 1 to 1945)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 1945)
  AUTHORS   Nitta,T., Nasreen,M., Seike,T., Goji,A., Ohigashi,I., Miyazaki,T.,
            Ohta,T., Kanno,M. and Takahama,Y.
  TITLE     IAN family critically regulates survival and development of T
            lymphocytes
  JOURNAL   PLoS Biol 4 (4), e103 (2006)
   PUBMED   16509771
REFERENCE   7  (bases 1 to 1945)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   8  (bases 1 to 1945)
  AUTHORS   Cambot,M., Aresta,S., Kahn-Perles,B., de Gunzburg,J. and Romeo,P.H.
  TITLE     Human immune associated nucleotide 1: a member of a new guanosine
            triphosphatase family expressed in resting T and B cells
  JOURNAL   Blood 99 (9), 3293-3301 (2002)
   PUBMED   11964296
  REMARK    GeneRIF: molecular and genetic properties; expression in resting T-
            and B-cells and decreased expression during lymphocyte activation
REFERENCE   9  (bases 1 to 1945)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
REFERENCE   10 (bases 1 to 1945)
  AUTHORS   Dominguez,O., Ashhab,Y., Sabater,L., Belloso,E., Caro,P. and
            Pujol-Borrell,R.
  TITLE     Cloning of ARE-containing genes by AU-motif-directed display
  JOURNAL   Genomics 54 (2), 278-286 (1998)
   PUBMED   9828130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX476689.1 and AF117333.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018326.2.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. The encoded protein of this gene
            may be negatively regulated by T-cell acute lymphocytic leukemia 1
            (TAL1). In humans, the IAN subfamily genes are located in a cluster
            at 7q36.1. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.179469.1,
                                           SRR1660805.164383.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000255945.4/ ENSP00000255945.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BX476689.1         22-33
            13-1945             AF117333.1         1-1933
FEATURES             Location/Qualifiers
     source          1..1945
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1945
                     /gene="GIMAP4"
                     /gene_synonym="IAN-1; IAN1; IMAP4; MSTP062"
                     /note="GTPase, IMAP family member 4"
                     /db_xref="GeneID:55303"
                     /db_xref="HGNC:HGNC:21872"
                     /db_xref="MIM:608087"
     exon            1..48
                     /gene="GIMAP4"
                     /gene_synonym="IAN-1; IAN1; IMAP4; MSTP062"
                     /inference="alignment:Splign:2.1.0"
     exon            49..120
                     /gene="GIMAP4"
                     /gene_synonym="IAN-1; IAN1; IMAP4; MSTP062"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1052
                     /gene="GIMAP4"
                     /gene_synonym="IAN-1; IAN1; IMAP4; MSTP062"
                     /note="isoform 1 is encoded by transcript variant 1;
                     immunity associated protein 4; human immune associated
                     nucleotide 1; immune-associated nucleotide-binding protein
                     1; immunity-associated nucleotide 1 protein"
                     /codon_start=1
                     /product="GTPase IMAP family member 4 isoform 1"
                     /protein_id="NP_060796.1"
                     /db_xref="CCDS:CCDS5904.1"
                     /db_xref="GeneID:55303"
                     /db_xref="HGNC:HGNC:21872"
                     /db_xref="MIM:608087"
                     /translation="MAAQYGSMSFNPSTPGASYGPGRQEPRNSQLRIVLVGKTGAGKS
                     ATGNSILGRKVFHSGTAAKSITKKCEKRSSSWKETELVVVDTPGIFDTEVPNAETSKE
                     IIRCILLTSPGPHALLLVVPLGRYTEEEHKATEKILKMFGERARSFMILIFTRKDDLG
                     DTNLHDYLREAPEDIQDLMDIFGDRYCALNNKATGAEQEAQRAQLLGLIQRVVRENKE
                     GCYTNRMYQRAEEEIQKQTQAMQELHRVELEREKARIREEYEEKIRKLEDKVEQEKRK
                     KQMEKKLAEQEAHYAVRQQRARTEVESKDGILELIMTALQIASFILLRLFAED"
     exon            121..1945
                     /gene="GIMAP4"
                     /gene_synonym="IAN-1; IAN1; IMAP4; MSTP062"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP4"
                     /gene_synonym="IAN-1; IAN1; IMAP4; MSTP062"
                     /note="hexamer: AATAAA"
     polyA_site      1945
                     /gene="GIMAP4"
                     /gene_synonym="IAN-1; IAN1; IMAP4; MSTP062"
                     /note="major polyA site"
ORIGIN      
        1 agtattgtgt gcaaaatcag agaggggtgc aagatcctga tttttcagga gttcaagcga
       61 caatggcagc ccaatacggc agtatgagct tcaaccccag cacaccaggg gccagttatg
      121 ggcctggaag gcaagagccc agaaattccc aattgagaat tgtgttagtg ggtaaaaccg
      181 gagcaggaaa aagtgcaaca ggaaacagca tccttggccg gaaagtgttt cattctggca
      241 ctgcagcaaa atccattacc aagaagtgtg agaaacgcag cagctcatgg aaggaaacag
      301 aacttgtcgt agttgacaca ccaggcattt tcgacacaga ggtgcccaat gctgaaacgt
      361 ccaaggagat tattcgctgc attcttctga cctccccagg gcctcatgct ctgcttctgg
      421 tggttccact gggccgttac actgaggaag agcacaaagc cacagagaag atcctgaaaa
      481 tgtttggaga gagggctaga agtttcatga ttctcatatt cacccggaaa gatgacttag
      541 gtgacaccaa tttgcatgac tacttaaggg aagctccaga agacattcaa gacttgatgg
      601 acattttcgg tgaccgctac tgtgcgttaa acaacaaggc aacaggcgct gagcaggagg
      661 cccagagggc acagttgctg ggcctgatcc agcgcgtggt gagggagaac aaggaaggct
      721 gctacactaa taggatgtac caaagggcgg aggaggagat ccagaagcaa acacaagcaa
      781 tgcaagaact ccacagagtg gagctggaga gagagaaagc gcggataaga gaggagtatg
      841 aagagaaaat cagaaagctg gaagataaag tggagcagga aaagagaaag aagcaaatgg
      901 agaagaaact agcagaacag gaggctcact atgctgtaag gcagcaaagg gcaagaacgg
      961 aagtggagag taaggatggg atacttgaat taatcatgac agcgttacag attgcttcct
     1021 ttattttgtt acgtctgttc gcggaagatt aaacttaatg aaaatctgtt tgtattttct
     1081 gcatattctc tggcaacctt gccccatact tacttattta gcatagtcga gtgctctagt
     1141 ttctgtctct caggcactcg taactaagga ccaccattgg ccattggtag atgtttgatt
     1201 gacttaacaa gagagggaca aattttcaat ttgtgaaact ccaaagcaga aagtattggt
     1261 gcttgctacc ttgtgaattc ttccttagac atgcagagaa aatgtatgca agagaccaaa
     1321 aagatggctc caagctatgt catgttacct gtaataaaat cttttcttct agattctttc
     1381 tatgttggca gataatctcc ccttgtagct tccactcact tattcttgca ttcagagtca
     1441 caatgatcat cttacccatg tggtttttga gaaagaaaga tcaattcttt gtttgcagta
     1501 ggtaatctta gagatggaga tgattgtaga attattccta gatgagtgtc aatttattta
     1561 attccattgt catataagga gtcaaattgt ttcttatcat ttgttcattg aagaacagag
     1621 acctgtctgg aaaatcgatc tctacaaatt caattaaata atgatcccca aatgctgaaa
     1681 aagtgaaata cagcaattca acagataata gagcaatgtt tagtatattc agctgtatct
     1741 gtagaaactc tttgacgaac ctcaatttaa ccaatttgat gaatacccag ttctcttctt
     1801 ttctagagaa agatagttgc aacctcacct ccctcactca acactttgaa tacttattgt
     1861 ttggcaggtc atccacacac ttctgccccc actgcattga attttttgct tatgttgttt
     1921 ataataaaac ttttcaatta tctca
//
