LOCUS       NM_015660               1443 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens GTPase, IMAP family member 2 (GIMAP2), mRNA.
ACCESSION   NM_015660
VERSION     NM_015660.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   Schwefel,D., Arasu,B.S., Marino,S.F., Lamprecht,B., Kochert,K.,
            Rosenbaum,E., Eichhorst,J., Wiesner,B., Behlke,J., Rocks,O.,
            Mathas,S. and Daumke,O.
  TITLE     Structural insights into the mechanism of GTPase activation in the
            GIMAP family
  JOURNAL   Structure 21 (4), 550-559 (2013)
   PUBMED   23454188
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Siedlinski,M., Cho,M.H., Bakke,P., Gulsvik,A., Lomas,D.A.,
            Anderson,W., Kong,X., Rennard,S.I., Beaty,T.H., Hokanson,J.E.,
            Crapo,J.D. and Silverman,E.K.
  CONSRTM   COPDGene Investigators; ECLIPSE Investigators
  TITLE     Genome-wide association study of smoking behaviours in patients
            with COPD
  JOURNAL   Thorax 66 (10), 894-902 (2011)
   PUBMED   21685187
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Schwefel,D., Frohlich,C., Eichhorst,J., Wiesner,B., Behlke,J.,
            Aravind,L. and Daumke,O.
  TITLE     Structural basis of oligomerization in septin-like GTPase of
            immunity-associated protein 2 (GIMAP2)
  JOURNAL   Proc Natl Acad Sci U S A 107 (47), 20299-20304 (2010)
   PUBMED   21059949
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   Schwefel,D., Frohlich,C. and Daumke,O.
  TITLE     Purification, crystallization and preliminary X-ray analysis of
            human GIMAP2
  JOURNAL   Acta Crystallogr Sect F Struct Biol Cryst Commun 66 (Pt 6), 725-729
            (2010)
   PUBMED   20516611
  REMARK    GeneRIF: GDP-bound GIMAP2(21-260) and GDP-bound GIMAP2(1-234)
            crystallized in space group P2(1)2(1)2(1) and the crystals
            diffracted X-rays to 2.9 and 1.7 A resolution, respectively.
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG687383.1 and BC032345.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015660.2.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.375681.1,
                                           SRR1163655.551100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000223293.10/ ENSP00000223293.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BG687383.1         2-25
            25-1443             BC032345.1         1-1419
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..1443
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /note="GTPase, IMAP family member 2"
                     /db_xref="GeneID:26157"
                     /db_xref="HGNC:HGNC:21789"
                     /db_xref="MIM:608085"
     exon            1..80
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            81..116
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1102
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /note="immunity associated protein 2; immune-associated
                     nucleotide-binding protein 12"
                     /codon_start=1
                     /product="GTPase IMAP family member 2"
                     /protein_id="NP_056475.1"
                     /db_xref="CCDS:CCDS5905.1"
                     /db_xref="GeneID:26157"
                     /db_xref="HGNC:HGNC:21789"
                     /db_xref="MIM:608085"
                     /translation="MDQNEHSHWGPHAKGQCASRSELRIILVGKTGTGKSAAGNSILR
                     KQAFESKLGSQTLTKTCSKSQGSWGNREIVIIDTPDMFSWKDHCEALYKEVQRCYLLS
                     APGPHVLLLVTQLGRYTSQDQQAAQRVKEIFGEDAMGHTIVLFTHKEDLNGGSLMDYM
                     HDSDNKALSKLVAACGGRICAFNNRAEGSNQDDQVKELMDCIEDLLMEKNGDHYTNGL
                     YSLIQRSKCGPVGSDERVKEFKQSLIKYMETQRSYTALAEANCLKGALIKTQLCVLFC
                     IQLFLRLIILWLCILHSMCNLFCCLLFSMCNLFCSLLFIIPKKLMIFLRTVIRLERKT
                     PRL"
     exon            117..1443
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1416..1421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /note="hexamer: AATAAA"
     regulatory      1427..1432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /note="hexamer: ATTACA"
     polyA_site      1436
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /note="major polyA site"
     polyA_site      1443
                     /gene="GIMAP2"
                     /gene_synonym="HIMAP2; IAN12; IMAP2"
                     /note="major polyA site"
ORIGIN      
        1 ctttcttttt ctcttggagc tgagctataa gacaacagga ctgaacaggg agccaactgt
       61 ttctttgaac agtaaatcag gaacaccaat ggaccaaaat gaacacagtc actggggacc
      121 acatgcaaag ggccaatgtg ccagcagatc tgagctgaga atcatcctgg tgggcaaaac
      181 aggaactggc aaaagtgctg cagggaacag catcctcagg aagcaagcat ttgaatcgaa
      241 gctgggttcc cagaccttga ctaagacttg cagcaaaagt cagggaagct ggggaaatag
      301 agagattgtc attattgaca caccagatat gttttcttgg aaggaccact gtgaagctct
      361 gtacaaagag gtgcagaggt gctacttgct gtctgcacca ggaccccatg tgctgctcct
      421 ggtgactcag ctgggccgct atacctcaca ggaccagcag gctgcacaga gggtgaagga
      481 gatctttgga gaggatgcca tgggacacac aattgtcctc tttacccaca aggaagacct
      541 caatggtggc tccctgatgg attacatgca cgactcagat aacaaagccc taagcaagct
      601 ggtggcagca tgtggtgggc gaatctgtgc ctttaataac cgtgctgaag ggagcaatca
      661 ggatgaccaa gtgaaggaac taatggactg tattgaggat ctgttgatgg agaaaaatgg
      721 tgatcactat accaatgggt tgtacagcct aatacagagg tctaaatgtg gacctgtggg
      781 atcagatgaa agagtaaagg aattcaaaca gagccttata aagtacatgg aaactcaaag
      841 aagttacaca gccttggctg aagcaaactg cctaaaagga gccttaatca aaacacaact
      901 gtgtgtttta ttttgtattc agttgtttct cagattgata attctgtggc tttgcatact
      961 gcacagcatg tgcaatttgt tttgttgctt actctttagt atgtgcaatt tattctgcag
     1021 tttgctgttt attataccca aaaagttaat gatatttttg agaacagtta ttagactaga
     1081 acgcaagact cctaggttat agttacagat cccagttatt atttactcac tatcatttag
     1141 tgggtgaatc acagtaattt ccctgtaaaa tgtggtacct gaagtcatat ttgagattct
     1201 atgaaatgtt taaatctgaa catcactcca attattaatg aaccaaatca tacgataagt
     1261 tactgtttgc attgaaatat aatatcaaag ccttttgaaa tctgtaaaca taaaattcct
     1321 ctcattttca aatatctaaa gccagtttta tgttcctaaa atctcatttt cttctttcta
     1381 gtactactat ttctactgaa tataatgaaa atggcaataa aataatatta cataaactgt
     1441 aaa
//
