LOCUS       NM_130759               4364 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens GTPase, IMAP family member 1 (GIMAP1), mRNA.
ACCESSION   NM_130759
VERSION     NM_130759.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4364)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 4364)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4364)
  AUTHORS   Ran,S., Liu,Y.J., Zhang,L., Pei,Y., Yang,T.L., Hai,R., Han,Y.Y.,
            Lin,Y., Tian,Q. and Deng,H.W.
  TITLE     Genome-wide association study identified copy number variants
            important for appendicular lean mass
  JOURNAL   PLoS One 9 (3), e89776 (2014)
   PUBMED   24626161
  REMARK    GeneRIF: GIMAP1 and SERHL variants may be important for
            appendicular lean mass
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4364)
  AUTHORS   Saunders,A., Webb,L.M., Janas,M.L., Hutchings,A., Pascall,J.,
            Carter,C., Pugh,N., Morgan,G., Turner,M. and Butcher,G.W.
  TITLE     Putative GTPase GIMAP1 is critical for the development of mature B
            and T lymphocytes
  JOURNAL   Blood 115 (16), 3249-3257 (2010)
   PUBMED   20194894
  REMARK    GeneRIF: Shows a critical role for the related mouse gene in mature
            lymphocyte development and survival.
REFERENCE   5  (bases 1 to 4364)
  AUTHORS   Filen,J.J., Filen,S., Moulder,R., Tuomela,S., Ahlfors,H., West,A.,
            Kouvonen,P., Kantola,S., Bjorkman,M., Katajamaa,M., Rasool,O.,
            Nyman,T.A. and Lahesmaa,R.
  TITLE     Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be
            differentially regulated during human T helper cell differentiation
  JOURNAL   Mol Cell Proteomics 8 (1), 32-44 (2009)
   PUBMED   18701445
  REMARK    GeneRIF: GIMAP1 and GIMAP4 genes are up-regulated by IL-12 and
            other Th1 differentiation-inducing cytokines in cells induced to
            differentiate toward Th1 lineage and down-regulated by IL-4 in
            cells induced to Th2.
REFERENCE   6  (bases 1 to 4364)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   7  (bases 1 to 4364)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
  REMARK    GeneRIF: The himap1 gene belongs to a gene family clustered on
            chromosome 7q32-36 within a region highly syntenic to the mouse
            imap38 locus on chromosome 6B.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA817535.1, BC040736.1,
            AC006479.2 and AW029312.1.
            
            On Nov 22, 2018 this sequence version replaced NM_130759.3.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. This gene is thought to be
            involved in the differentiation of T helper (Th) cells of the Th1
            lineage, and the related mouse gene has been shown to be critical
            for the development of mature B and T lymphocytes. Read-through
            transcription exists between this gene and the downstream GIMAP5
            (GTPase, IMAP family member 5) gene. [provided by RefSeq, Dec
            2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK315127.1, SRR3476690.166481.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307194.6/ ENSP00000302833.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DA817535.1         57-72
            17-1245             BC040736.1         1-1229
            1246-4276           AC006479.2         117737-120767       c
            4277-4360           AW029312.1         15-98               c
            4361-4364           AC006479.2         117649-117652       c
FEATURES             Location/Qualifiers
     source          1..4364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4364
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /note="GTPase, IMAP family member 1"
                     /db_xref="GeneID:170575"
                     /db_xref="HGNC:HGNC:23237"
                     /db_xref="MIM:608084"
     exon            1..78
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /inference="alignment:Splign:2.1.0"
     exon            79..127
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1005
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /note="immunity associated protein 1; immune-associated
                     nucleotide-binding protein 2"
                     /codon_start=1
                     /product="GTPase IMAP family member 1"
                     /protein_id="NP_570115.1"
                     /db_xref="CCDS:CCDS5906.1"
                     /db_xref="GeneID:170575"
                     /db_xref="HGNC:HGNC:23237"
                     /db_xref="MIM:608084"
                     /translation="MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATG
                     NSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERG
                     HCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGG
                     SLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGA
                     HYSNEVYELAQVLRWAGPEERLRRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRL
                     GLALLLGGALLFWVLLHRRWSEAVAEVGPD"
     exon            128..4364
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /note="hexamer: AATAAA"
     polyA_site      1245
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /note="major polyA site"
     regulatory      3218..3223
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /note="hexamer: ATTAAA"
     polyA_site      3250
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
     regulatory      4335..4340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
                     /note="hexamer: AATAAA"
     polyA_site      4364
                     /gene="GIMAP1"
                     /gene_synonym="HIMAP1; IAN2; IMAP1; IMAP38"
ORIGIN      
        1 cttctgcact cacagccgaa gggaaagcag caggttgggg cttcttgtgg ccaacttcag
       61 agcctgtcac caggaaaggt aagcatggga ggaaggaaga tggcgacaga tgaagaaaat
      121 gtctatggtt tagaagagaa cgctcagtcc cggcaggagt ccacgcggag gctcatcctt
      181 gttgggagaa caggggccgg gaagagcgcc actgggaaca gcatcctggg ccagagacgg
      241 ttcttctcca ggctgggggc cacgtctgtg accagggcct gcaccacggg cagccgcagg
      301 tgggacaagt gccacgtgga agtcgtggac actccggaca ttttcagctc ccaagtgtcc
      361 aagacagatc ctggctgtga ggagagaggt cactgctacc tgctctcggc ccccggaccc
      421 cacgcgctgc tcctggtgac ccagttgggt cggttcaccg cccaggacca gcaggcggtg
      481 aggcaggtga gggacatgtt cggggaggac gtcctaaaat ggatggtcat cgtcttcacc
      541 aggaaggagg acctggccgg gggctccctg cacgattacg tgagcaacac agagaaccgg
      601 gccttgcgcg agctggtggc cgagtgcggg ggccgggtct gtgcctttga taaccgggcc
      661 accggccggg agcaggaagc ccaggtggag cagctgctgg ggatggtcga gggcttggtg
      721 ctggagcaca agggcgccca ttactccaac gaggtgtatg agctggcgca ggtgctgcgc
      781 tgggcaggcc ctgaggagcg gctccggcgg gtggcggagc gcgtggcagc cagggtgcag
      841 aggaggccat ggggcgcctg gctgtcggcc cggctgtgga agtggctgaa gtcccccagg
      901 agctggaggc tgggcctggc cctgctgctg gggggcgcgc tcctgttctg ggtgctgctc
      961 cacaggcggt ggtcggaggc cgttgcggag gtcgggcctg actgacagcg caggtcctaa
     1021 aactgaaggc aacttggtta agggaggctg aattcttgga gctgaaggga aaacttcatt
     1081 ccaacggaag gaatcctgta gtttcaggca tagttttaat gacacagaaa actttgctgc
     1141 atcacctttg caactttgcc aaagctcaga gttcactttt taagttttta actcatttta
     1201 aatgatgtgt atgcagagtt ttaaaataaa ttcgtctaac aataacttcc tttggtagtt
     1261 ttggtagtct aatgtcaagt agcttgtagt ggggacaaac gcatggcaca gggaaaacaa
     1321 gtgccattat tttcgagctt tttaaaaaat ttagactgcc cctccttgat aattttctag
     1381 ttcttataca tgggtagata ggttcctttg tgatccttgt agacttttag catcaataaa
     1441 agaaatgtgg gggttacaca cgtgaatgtt acttctgaga catcagttta tagtacaatg
     1501 atttactacc aaaaagatga atgtaactgt actgttacaa agtggaaaat aacagtttcc
     1561 acttttctag aacatattat ggttcatggc attccaaaat gaagtaaggg ccgggcgagg
     1621 tggctcacgc ctgtaatccc aacactttgg gaggtcgagg caggtggatc acctgaggtc
     1681 aggagttcga gaccagcctg accaacatgg cgaaacccca tctctactaa aaatacaaaa
     1741 attagccagg cgtgatagca ctcgcctgta atcccagcca ttcaggaggc tgaggcggga
     1801 gaatcacttg atgcagtgag ccgagatcgt gccactgcac tccaggctgg gtgacaaagc
     1861 aagaatctgt ctcaaaaaaa aaaaaagaaa agaaaagaaa aagaaaaaga gtaggatatt
     1921 gggaaaataa catataatat cttctatatg gttattcata tttttatcac acacacacac
     1981 acacacacac acacacacag tctgtatctc gagctcctct ctggttatgg agaagaggca
     2041 gagcaccagg tgcataggct gagactgcag acacctgagc atcctatgct gtgaggcgaa
     2101 agcatccggt tttttcggga tgggcctgtc caggaaggtt ctcgaatgcc acgtgattag
     2161 aaaatttgcc gctgactggt tgtgcgaatc aaacaatagg atttccttat ttctatttct
     2221 gagcataatg agaacccttt aagggaactc attgtcttta aatcagccag cctctagtga
     2281 ggtcatggag acatgggaag caggtattca cattagctct attcaagagg aagaggagga
     2341 gggagtgtgc gcaggcgccc tagggtcttc cccagcacac gttgggaaga aggggtctgc
     2401 aagcatgcgc acaattgcca gctcaggcta aggactgcag gaggttccag gtgggttgcg
     2461 ggcttcgggc aggctatggt gaggggtcct gagggccttg gtgaccgctg cagggagttg
     2521 gactttttga agcgtggctc aagaaaaacc catgtttaat tcctgccttt cgcttcctca
     2581 gcagcctttc tgggcccagg caggggcctc gagccaggga aggatccttt gatgaccaga
     2641 ggggacagca gggagggcac agcgtggtcg tccacggtca cttgcgcacg agccagtgct
     2701 gctgctggtg ttagacaaca acttttatca aagtggttta atgtacagca gcaacaaagc
     2761 tgctttgtgg agcagggctc ccaataggca gtgtgcccag agtagcagct cggaagcagt
     2821 actgcaatca catttatacc cactttcaac tatatgcaaa tttaggggtg gattatgcca
     2881 aaatttctag aaaaaaggtc gtaacttcca ggtcgtggga ttgttgctat ggaaaggagc
     2941 caaaacttcc agctgttgcc ttagcaatgg taacctgacg tggcactggt gagtgtgttt
     3001 tatggagaga ctctttcacc tcttcccttt cagcttgtct tcagtgtggt ctggagccca
     3061 atccccacct ccagagtcta gtcctgcctc ctacctcagt aataaaaagt agtagtatat
     3121 ggttaattgt caaatacatt tgcaaagtgt aatcaaagat acattaccaa tctgaatctc
     3181 aaaatgtgct atcatctttg aatttgaata atgtattatt aaagaagtta cagttttcct
     3241 ttacattcaa taacatttct ttagtggttt tctttttcag atactttgat tatgatcttt
     3301 tttttttcat ctttgtatcc ccgttataca acccagtgcc tggcatagaa agtgggatca
     3361 acaaatgttt ggaaaatgaa ttgtaaagtt gactttcctg taccttttta atattagatt
     3421 tctagctacc agacttttga ccattttcta aattttctac catagataac agaaaattct
     3481 ttcgcgcaag catgtcattg tattaatgat attctcctgc cctaaggaaa tttacttccc
     3541 ttcaagcaca gggtccccca aattactgta tttccacccc tttcagctta ttttatcctt
     3601 ttctcctgct acagaacagt tggcattcac cattcccttc ggtaaagtct ttttttaggc
     3661 tgtggcttaa aggttgcttt ttcccccata gctcaaggtt aggccttgtg acctcactta
     3721 tgtaatttga gtgatttgat agcacaaatc aattttatac ttaaattaca gcataaaaca
     3781 gcactgcctc ctgttggaaa aacttgcttg ctaattttaa ccagacacag taaaaatact
     3841 gtccaatacc tcaaaaattg tgtaaatata tatccatttc aattgtcccc cttcctctcc
     3901 tctcctttta tctcttggaa gataaaaatg tatgggtcct gtgctgataa tgtttctgtt
     3961 catatttcta tgccctggta cctggatcag cttttgttct acacaaaaag acttgtatct
     4021 ggcttatttc tgaaagctag tgttggccat gatgaacttt tagagcaaaa gatttcaggc
     4081 agagtacatt cttacatatt cttacacaat caatattcag ttccagcccg cacagtagcc
     4141 ctagcaaatg ccagtgctcc ttccagagat tcacctatgg attcagtacc ccagaagaga
     4201 atttctgtaa attcttgggg aagctatagc tagactatgg ctcaacactc atttttcccc
     4261 catgattctt aatctaacag tggcaatgtt ggcctcttct taggcaacta gattcggttc
     4321 ttgcttattc tgccaataaa atactttatt gagatgctta caaa
//
