LOCUS       NM_001199577            2203 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens GIMAP1-GIMAP5 readthrough (GIMAP1-GIMAP5), transcript
            variant 1, mRNA.
ACCESSION   NM_001199577
VERSION     NM_001199577.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2203)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2203)
  AUTHORS   Krucken J, Schroetel RM, Muller IU, Saidani N, Marinovski P, Benten
            WP, Stamm O and Wunderlich F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   3  (bases 1 to 2203)
  AUTHORS   Stamm O, Krucken J, Schmitt-Wrede HP, Benten WP and Wunderlich F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006479.2 and FY213136.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001199577.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring GIMAP1 (GTPase, IMAP family
            member 1) and GIMAP5 (GTPase, IMAP family member 5) genes on
            chromosome 7. Alternative splicing results in multiple readthrough
            transcript variants, one of which encodes a fusion protein that
            shares sequence identity with each individual gene product.
            [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FY213136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 55340, 170575
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AC006479.2         125266-125320       c
            56-605              FY213136.1         1-550
            606-667             AC006479.2         104248-104309       c
            668-702             FY213136.1         613-647
            703-706             AC006479.2         101039-101042       c
            707-750             FY213136.1         652-695
            751-2203            AC006479.2         98287-99739         c
FEATURES             Location/Qualifiers
     source          1..2203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2203
                     /gene="GIMAP1-GIMAP5"
                     /note="GIMAP1-GIMAP5 readthrough"
                     /db_xref="GeneID:100527949"
                     /db_xref="HGNC:HGNC:51257"
     exon            1..78
                     /gene="GIMAP1-GIMAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            79..127
                     /gene="GIMAP1-GIMAP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1620
                     /gene="GIMAP1-GIMAP5"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="GIMAP1-GIMAP5 protein isoform a"
                     /protein_id="NP_001186506.1"
                     /db_xref="GeneID:100527949"
                     /db_xref="HGNC:HGNC:51257"
                     /translation="MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATG
                     NSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERG
                     HCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQLSHGAFSPSTWLLLNCVCSTSLSPVN
                     SIPAHRRRAGLSLLPLHLPERGPAARASVTATLEDRAQQPFLERMGGFQRGKYGTMAE
                     GRSEDNLSATPPALRIILVGKTGCGKSATGNSILGQPVFESKLRAQSVTRTCQVKTGT
                     WNGRKVLVVDTPSIFESQADTQELYKNIGDCYLLSAPGPHVLLLVIQLGRFTAQDTVA
                     IRKVKEVFGTGAMRHVVILFTHKEDLGGQALDDYVANTDNCSLKDLVRECERRYCAFN
                     NWGSVEEQRQQQAELLAVIERLGREREGSFHSNDLFLDAQLLQRTGAGACQEDYRQYQ
                     AKVEWQVEKHKQELRENESNWAYKALLRVKHLMLLHYEIFVFLLLCSILFFIIFLFIF
                     HYI"
     exon            128..486
                     /gene="GIMAP1-GIMAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            487..690
                     /gene="GIMAP1-GIMAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            691..739
                     /gene="GIMAP1-GIMAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            740..2203
                     /gene="GIMAP1-GIMAP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2186..2191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIMAP1-GIMAP5"
                     /note="hexamer: AATAAA"
     polyA_site      2203
                     /gene="GIMAP1-GIMAP5"
                     /note="major polyA site"
ORIGIN      
        1 cttctgcact cacagccgaa gggaaagcag caggttgggg cttcttgtgg ccaacttcag
       61 agcctgtcac caggaaaggt aagcatggga ggaaggaaga tggcgacaga tgaagaaaat
      121 gtctatggtt tagaagagaa cgctcagtcc cggcaggagt ccacgcggag gctcatcctt
      181 gttgggagaa caggggccgg gaagagcgcc actgggaaca gcatcctggg ccagagacgg
      241 ttcttctcca ggctgggggc cacgtctgtg accagggcct gcaccacggg cagccgcagg
      301 tgggacaagt gccacgtgga agtcgtggac actccggaca ttttcagctc ccaagtgtcc
      361 aagacagatc ctggctgtga ggagagaggt cactgctacc tgctctcggc ccccggaccc
      421 cacgcgctgc tcctggtgac ccagttgggt cggttcaccg cccaggacca gcaggcggtg
      481 aggcagctga gtcatggagc tttcagcccc agcacatggc tcctccttaa ctgcgtctgc
      541 tcaacctccc tcagccctgt gaacagcatc cccgcacaca gacgcagagc aggactctct
      601 ctgctgccac ttcaccttcc tgagagagga ccagcggcca gagcctcagt gactgccacc
      661 ctggaggaca gggcacaaca accgtttctg gagagaatgg gaggattcca gaggggcaaa
      721 tatggaacta tggctgaagg tagatcagaa gataacttgt ctgcaacacc accggcattg
      781 aggattatcc tagtgggcaa aacaggctgc gggaaaagtg ccacagggaa cagcatcctt
      841 ggccagcccg tgtttgagtc caagctgagg gcccagtcag tgaccaggac gtgccaggtg
      901 aaaacaggaa catggaacgg gaggaaagtc ctggtggttg acacgccctc catctttgag
      961 tcacaggccg atacccaaga gctgtacaag aacatcgggg actgctacct gctctctgcc
     1021 ccggggcccc acgtcctgct tctggtgatc cagctggggc gtttcactgc tcaggacaca
     1081 gtggccatca ggaaggtgaa agaggtcttt gggacagggg ccatgagaca tgtggtcatc
     1141 ctcttcaccc acaaagagga cttagggggc caggccctgg atgactatgt agcaaacacg
     1201 gacaactgca gcctgaaaga cctggtgcgg gagtgtgaga gaaggtactg tgccttcaac
     1261 aactggggct ctgtggagga gcagaggcag cagcaggcag agctcctggc tgtgattgag
     1321 aggctgggga gggagcgaga gggctccttc cacagcaatg acctcttctt ggatgcccag
     1381 ctgctccaaa gaactggagc tggggcctgc caggaagact acaggcagta ccaggccaaa
     1441 gtggaatggc aggtggagaa gcacaagcaa gagctgaggg agaacgagag taactgggca
     1501 tacaaggcgc tcctcagagt caaacacttg atgcttttgc attatgagat ttttgttttt
     1561 ctattgttgt gcagcatact ttttttcatt atttttctgt tcatctttca ttacatttaa
     1621 atctctggac cctggagcac ttctaatgta tcaccccatg gagtcattgt tctaataatc
     1681 accaattcag actcagatcc tcgtggtcta tggagcatgc tgcttgctgt ctgtgcagct
     1741 cccatttccc cttcttcctg atagacttgg agctgtgtgc ctccactcca aggctgcctg
     1801 cctgctgtaa acactattcc actctgtctg ccaacaactg cttcaggaat gggcctgaga
     1861 tcccatgcag gtccctgaga agtgagtaaa agtccgcaga ggtggggatg gaagatctct
     1921 ccttagatag aacctgtctt cctccctggc attgtggggt ctgggcgtga cactgggact
     1981 ctcagcagct ttgtgctgcc aacctgagat tgaaggcagt gcctcagagc agcacagaga
     2041 gttggggccc cctgagccct gagccaccag ccctgcagcc tgccctatct ccgcatttcc
     2101 agttgtatta gccaatagat ttcctactta tttaagctat ttgagctccg ggtctcttct
     2161 acctgcattc taaaacattc aaagtaataa aaatttctcc aca
//
