LOCUS       NM_001375765            6559 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens GRB10 interacting GYF protein 1 (GIGYF1), transcript
            variant 7, mRNA.
ACCESSION   NM_001375765 XM_005250532
VERSION     NM_001375765.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6559)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6559)
  AUTHORS   Lee,C.Y., Hubrich,D., Varga,J.K., Schafer,C., Welzel,M.,
            Schumbera,E., Djokic,M., Strom,J.M., Schonfeld,J., Geist,J.L.,
            Polat,F., Gibson,T.J., Keller Valsecchi,C.I., Kumar,M.,
            Schueler-Furman,O. and Luck,K.
  TITLE     Systematic discovery of protein interaction interfaces using
            AlphaFold and experimental validation
  JOURNAL   Mol Syst Biol 20 (2), 75-97 (2024)
   PUBMED   38225382
REFERENCE   3  (bases 1 to 6559)
  AUTHORS   Ding,Z., Huang,G., Wang,T., Duan,W., Li,H., Wang,Y., Jia,H.,
            Yang,Z., Wang,K., Chu,X., Kurtz-Nelson,E.C., Ahlers,K., Earl,R.K.,
            Han,Y., Feliciano,P., Chung,W.K., Eichler,E.E., Jiang,M. and
            Xiong,B.
  TITLE     Genetic Ablation of GIGYF1, Associated With Autism, Causes
            Behavioral and Neurodevelopmental Defects in Zebrafish and Mice
  JOURNAL   Biol Psychiatry 94 (10), 769-779 (2023)
   PUBMED   36924980
  REMARK    GeneRIF: Genetic Ablation of GIGYF1, Associated With Autism, Causes
            Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
REFERENCE   4  (bases 1 to 6559)
  AUTHORS   Zhu,L., Yao,Z., Luo,Q., Liu,Y., Zhao,W., Shao,C., Shao,S. and
            Cui,F.
  TITLE     Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and
            Promotes Apoptosis and Autophagy of Gastric Cancer Cells
  JOURNAL   Int J Med Sci 20 (8), 1038-1045 (2023)
   PUBMED   37484805
  REMARK    GeneRIF: Low Expression of GIGYF1 Inhibits Metastasis,
            Proliferation, and Promotes Apoptosis and Autophagy of Gastric
            Cancer Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6559)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6559)
  AUTHORS   Peter,D., Weber,R., Sandmeir,F., Wohlbold,L., Helms,S.,
            Bawankar,P., Valkov,E., Igreja,C. and Izaurralde,E.
  TITLE     GIGYF1/2 proteins use auxiliary sequences to selectively bind to
            4EHP and repress target mRNA expression
  JOURNAL   Genes Dev 31 (11), 1147-1161 (2017)
   PUBMED   28698298
REFERENCE   7  (bases 1 to 6559)
  AUTHORS   Ajiro,M., Nishidate,T., Katagiri,T. and Nakamura,Y.
  TITLE     Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary
            carcinogenesis
  JOURNAL   Int J Oncol 37 (5), 1085-1093 (2010)
   PUBMED   20878056
REFERENCE   8  (bases 1 to 6559)
  AUTHORS   Kofler,M.M. and Freund,C.
  TITLE     The GYF domain
  JOURNAL   FEBS J 273 (2), 245-256 (2006)
   PUBMED   16403013
  REMARK    Review article
REFERENCE   9  (bases 1 to 6559)
  AUTHORS   Giovannone,B., Lee,E., Laviola,L., Giorgino,F., Cleveland,K.A. and
            Smith,R.J.
  TITLE     Two novel proteins that are linked to insulin-like growth factor
            (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
  JOURNAL   J Biol Chem 278 (34), 31564-31573 (2003)
   PUBMED   12771153
REFERENCE   10 (bases 1 to 6559)
  AUTHORS   Wilson,M.D., Riemer,C., Martindale,D.W., Schnupf,P., Boright,A.P.,
            Cheung,T.L., Hardy,D.M., Schwartz,S., Scherer,S.W., Tsui,L.C.,
            Miller,W. and Koop,B.F.
  TITLE     Comparative analysis of the gene-dense ACHE/TFR2 region on human
            chromosome 7q22 with the orthologous region on mouse chromosome 5
  JOURNAL   Nucleic Acids Res 29 (6), 1352-1365 (2001)
   PUBMED   11239002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC009488.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 1, 2019 this sequence version replaced XM_005250532.2.
            
            Summary: This gene encodes a member of the gyf family of adaptor
            proteins. The encoded protein contains a gyf protein interaction
            domain. It binds growth factor receptor bound 10, another adaptor
            protein that binds activated insulin-like growth factor 1 and
            insulin receptors and regulates receptor signaling. [provided by
            RefSeq, Apr 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.23100.1,
                                           SRR14038197.1453978.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000678049.1/ ENSP00000503354.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC009488.5         34920-35060         c
            142-1105            AC009488.5         29402-30365         c
            1106-1170           AC009488.5         29261-29325         c
            1171-1274           AC009488.5         29014-29117         c
            1275-1404           AC009488.5         28791-28920         c
            1405-1500           AC009488.5         28598-28693         c
            1501-1612           AC009488.5         28315-28426         c
            1613-1721           AC009488.5         28108-28216         c
            1722-1762           AC009488.5         27816-27856         c
            1763-1933           AC009488.5         27459-27629         c
            1934-2187           AC009488.5         26990-27243         c
            2188-2293           AC009488.5         26784-26889         c
            2294-2431           AC009488.5         26154-26291         c
            2432-2529           AC009488.5         25859-25956         c
            2530-2701           AC009488.5         25533-25704         c
            2702-2868           AC009488.5         25260-25426         c
            2869-2969           AC009488.5         25047-25147         c
            2970-3107           AC009488.5         24830-24967         c
            3108-3208           AC009488.5         24628-24728         c
            3209-3291           AC009488.5         24360-24442         c
            3292-3432           AC009488.5         24114-24254         c
            3433-3651           AC009488.5         23822-24040         c
            3652-3839           AC009488.5         23400-23587         c
            3840-4000           AC009488.5         23132-23292         c
            4001-4164           AC009488.5         22882-23045         c
            4165-4294           AC009488.5         22674-22803         c
            4295-6559           AC009488.5         20317-22581         c
FEATURES             Location/Qualifiers
     source          1..6559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..6559
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /note="GRB10 interacting GYF protein 1"
                     /db_xref="GeneID:64599"
                     /db_xref="HGNC:HGNC:9126"
                     /db_xref="MIM:612064"
     exon            1..141
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..1105
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1170
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1274
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1240..4347
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /note="isoform b is encoded by transcript variant 7;
                     postmeiotic segregation increased 2-like 12; PERQ amino
                     acid-rich with GYF domain-containing protein 1"
                     /codon_start=1
                     /product="GRB10-interacting GYF protein 1 isoform b"
                     /protein_id="NP_001362694.1"
                     /db_xref="CCDS:CCDS34708.1"
                     /db_xref="GeneID:64599"
                     /db_xref="HGNC:HGNC:9126"
                     /db_xref="MIM:612064"
                     /translation="MAAETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGRE
                     EMLALYVKENKVPEELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRL
                     MGKGAGPPLAGTSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDD
                     RGERRFEKSARRDGARCGFEEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAG
                     PRRDGDRWRSASPDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLR
                     RCRAPEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGL
                     EEEEEPSEGLEEEGPEAGGKELTPLPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKE
                     PPAAEDDIRGIQLSPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFT
                     AAMQTQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSL
                     LVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQL
                     QHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRG
                     GDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQ
                     HKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLK
                     LLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQ
                     APNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLG
                     LKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLS
                     ATGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQ
                     QQQEAWLSSASLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGSSGEIE
                     SVDDY"
     exon            1275..1404
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1500
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1612
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1721
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1762
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1933
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..2187
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2293
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2294..2431
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2529
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2701
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2868
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2869..2969
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            2970..3107
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3108..3208
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3209..3291
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3292..3432
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3433..3651
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..3839
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            3840..4000
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4001..4164
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4165..4294
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     exon            4295..6559
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6535..6540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /note="hexamer: AATAAA"
     polyA_site      6559
                     /gene="GIGYF1"
                     /gene_synonym="GYF1; PERQ1"
                     /note="major polyA site"
ORIGIN      
        1 gctacaaaca caaacacaga ggagcggccg ccgcgggagc gccagcgccc cctcccccgc
       61 tgctagccgc cgtcgccgtc cccggccccc gcccgccgcg cgccgcccac gccccgggac
      121 cggaccctcg cgccgcccgc gactgtggcg tcctggagtt gatgggagct gcagcaccaa
      181 gccgggccag cctccctccc agccagtgac aacaccgcag cacctggacc ccgcccaccc
      241 gcttgagtcc tctgcctggg gccccaggga tgcgcctcct cctgaaagtc ccctccatcc
      301 tcccttagag gaacaggctg ccgccgcgcc cccatcagcc tccattgccc tgaccttatt
      361 tccacctgat ggtgccagag gctgcttccc agctggtatc ctgagatcct cgttcccttg
      421 gtggcttggt tgtttaagcc tccattattg attgggggcg gtggtctggg tgtgattcct
      481 gtgggggaaa ccagcccgag gtgccttggc tcaggcttgc ctgcctggag tccttgtcgt
      541 gtacccgtct gtggccctag agtcacctcc tgctcctttt cactgggttt ctccccagac
      601 caagcccctg gatttgagct tctgagcagc caactgattt ttttcatgag ggaaagaatt
      661 ttgctcctag atttatttct aatccttttc tccgtaactg accttttctc tgtaagctat
      721 ttgtggctct agtgggtttt tgtttgcttg cttgtttttg ttttatcttt gccctgaacg
      781 tccatcctgg cctcggctgc ctccctcccc gagttcttca ctacacctcc tgtctcagcc
      841 tcccagagag ggtggcgagg gtgctgatgc ccagagacac catccggcga atggacctct
      901 cctgtcatgc ggggcagggc agggctgccg gcagagccat gtcctgaacc ctccctcctc
      961 ccccctgctc tccttaaggg tctttcccag atgtgaaggt ccctcccagg ctctactgag
     1021 gtcagaccaa ttcccagtgg cttgggtacc ctcgttcact ccagcaccag cccctgccct
     1081 ccttcttccc gggccaggct gccaggtctt tcaccgtctg gactcatctc tgggtaactc
     1141 atggtgtgag tggccacgtg gctggctcag gtgtttggac agtgaacgcc aggtcccctc
     1201 ctccccaccc ccggcctctc aaacacgccc agccccacga tggcagcaga gacactcaac
     1261 tttgggcctg agtggctcag ggccctgtcc gggggcggca gcgtggcctc cccacccccg
     1321 tcccctgcca tgcccaaata caagctggct gactaccgtt atgggcgaga ggaaatgctg
     1381 gctctctacg tcaaggagaa caaggtcccg gaagagctgc aggacaagga gttcgccgcg
     1441 gtgctgcagg acgagccact gcagcccctg gctctggagc cgctgactga ggaggaacag
     1501 agaaacttct ccctgtcagt gaacagcgtg gctgtgctga ggctgatggg gaaaggggct
     1561 ggcccccccc tggctggcac ctcccgaggc aggggcagca cgcggagccg aggccgcggc
     1621 cgtggtgaca gctgctttta ccaaagaagc atcgaagaag gcgatggggc ctttggacga
     1681 agcccccggg aaatccagcg cagccagagc tgggatgaca gaggcgagag gcggtttgag
     1741 aagtcagcaa ggcgggatgg agcacgatgt ggctttgagg agggaggggc tggcccaagg
     1801 aaggagcacg cccgctcaga cagcgagaac tggcgctccc tacgggagga acaggaggag
     1861 gaggaggagg gcagctggag gctcggagca gggccccggc gagacggcga ccgctggcgc
     1921 tccgccagcc ctgatggtgg tccccgctct gctggctggc gggaacatgg ggaacggcgg
     1981 cgcaagtttg aatttgattt gcgaggggat cgaggagggt gtggtgaaga ggaggggcgg
     2041 ggagggggag gcagctctca cctgcggcgg tgccgagcgc ctgaaggctt tgaggaggac
     2101 aaggatgggc tcccagagtg gtgcctggac gatgaggatg aagaaatggg cacctttgat
     2161 gcctctgggg ccttcttgcc tctcaagaag ggccccaagg agcccattcc tgaggagcag
     2221 gagctggact tccaagggtt ggaggaggag gaggaacctt ccgaagggct agaggaggaa
     2281 gggcctgagg caggtgggaa agagctgacc ccactgcctc ctcaggagga gaagtccagc
     2341 tccccatccc cactgcccac cctgggccca ctctggggga caaacgggga tggggacgaa
     2401 actgcagaga aagagccccc agcggccgaa gatgatattc gggggatcca gctgagtccc
     2461 ggggtgggct cctctgctgg cccacccgga gatctggagg atgatgaagg cttgaagcac
     2521 ctgcagcagg aggcggagaa gctggtggcc tccctgcagg acagctcctt ggaggaggag
     2581 cagttcacgg ctgccatgca gacccagggc ctgcgccact ctgcagccgc cactgccctc
     2641 ccgctcagcc atggggctgc ccggaagtgg ttctacaagg acccacaggg cgagatccaa
     2701 ggccccttca cgacacagga gatggcagag tggttccagg ccggctactt ttccatgtca
     2761 ctgctggtga agcggggctg cgatgagggc ttccagccgc tgggcgaggt gatcaagatg
     2821 tggggccgcg tgccctttgc cccagggccc tcacctcccc cactgctggg aaacatggac
     2881 caggagcggc tgaagaagca acaggagctg gccgcggcgg ccttgtacca gcagctgcag
     2941 caccagcagt ttctccagct ggtcagcagc cgccagctcc cacagtgcgc gctccgagaa
     3001 aaggcagctc tgggggacct gacaccgcca ccaccgccgc cgccacagca gcagcagcag
     3061 cagctcacgg cattcctgca gcagctccag gcgctcaaac cccccagagg cggggaccag
     3121 aacctgctcc cgacgatgag ccggtccttg tcggtgccag attcgggccg cctctgggac
     3181 gtacatacct cagcctcatc acagtcaggt ggtgaggcca gtctttggga cataccaatt
     3241 aactcttcga ctcagggtcc aattctagaa caactccagc tgcaacataa attccaggag
     3301 cgcagagaag tggagctcag ggcgaagcgg gaggaagagg aacgcaagcg tcgagaggag
     3361 aagcgccgcc agcagcagca ggaggagcag aagcggcggc aggaggagga agagctgttt
     3421 cggcgcaagc acgtgcggca gcaggagcta ttgctgaagt tgctacagca gcagcaggcg
     3481 gtccctgtgc cccccgcacc cagctccccg cccccactct gggctggcct ggccaagcag
     3541 gggctgtcca tgaagacgct cctggagttg cagctggagg gcgagcggca gctgcacaaa
     3601 cagcccccac ctcgggagcc agctcgggcc caggccccca accaccgagt gcagcttggg
     3661 ggcctgggca ctgcccccct gaaccagtgg gtgtctgagg ctgggccact gtggggcggg
     3721 ccagacaaga gtgggggcgg cagcagcggc ctggggctct gggaggacac ccccaagagc
     3781 ggcgggagcc tggtccgtgg cctcggcctg aagaacagcc ggagcagccc atctctcagt
     3841 gactcataca gccacctatc gggtcggccc attcgcaaaa agacggagga agaagagaag
     3901 ctgctgaagc tgctgcaggg cattcccagg ccccaggacg gcttcaccca gtggtgcgag
     3961 cagatgctgc acacgctgag cgccacgggc agcctggacg tgcccatggc tgtagcgatc
     4021 ctcaaggagg tggaatcccc ctatgatgtc cacgattata tccgttcctg cctgggggac
     4081 acgctggaag ccaaagaatt tgccaaacaa ttcctggagc ggagggccaa gcagaaagcc
     4141 agccagcagc ggcagcagca gcaggaggca tggctgagca gcgcctcgct gcagacggcc
     4201 ttccaggcca accacagcac caaactcggc cccggggagg gcagcaaggc caagaggcgg
     4261 gcactgatgc tgcactcaga ccccagcatc ctggggtact ccctgcacgg atcttctggt
     4321 gagatcgaga gcgtggatga ctactgacca gcccggaccc ccagcccctg ggctgtaggc
     4381 cagggcagcc acagcggcgt ggaccgaggg tcccagcctg caggctcccc gcagagagca
     4441 caggaagagg caggggcggg gtccccagca cttgttacaa acacacgatg caccttaact
     4501 cacccaccac gaggcacttt acagactggg ggagggggtt tttcttttta tttttttttt
     4561 taattttaaa cgactgaaga aaacattagg agaggcaaaa atattgttaa aaactagact
     4621 ctaaacaccc cttcctgctg tgaggatagt gggtgtgaca atggaaggtc cacagaggtt
     4681 tttgtttttt ggtttttttt ttttttttaa gaaaaaaaga tgaaaaatga aaaaaaaaat
     4741 ggttaggagg ctgaaagaaa aaacacactg ttattttggg gcagtgggga cacaggcccc
     4801 gtggacctgt cctgcctggc ccccaaggcc atacttaccc cccagaaggc gggccatggg
     4861 gtaactggaa gctgggggcc agcagtttgc acaggaggcc tgtctgagcc ccacccgcca
     4921 gacctgttgt gagcagctcc tgtcactgag gctggctgag gtgtccgggg tggggccaaa
     4981 gtagcccctt ggcttcgctg ctttggggga cagttgcaca aattggacga gtggccccag
     5041 ctctctggct gccatcttgt gctggccgag tagacgggag gggccaagcc gtgccaacct
     5101 ctctggctgg cagggtgggg cagcaggact ctggttctgg tgaggggcgt ctcccactgc
     5161 tgccattttg ggggacaccc tgggtttgaa cctgaaagcc ccagctctct gccttgccac
     5221 gtgaatgtat tctttgggcc acaagccccc gcctcacccc tgcctgagct gcctcacccc
     5281 tgtgagcggc gggggtggat gattgctcca gaggctgcag agagaaggct gagctgtttc
     5341 tccagtgaag ggggcaggag gaggggcctc aaaggcaagg agtgggtggc tttgggctta
     5401 gggttgcagt agaggggctg ccgcccgggg ccccaacctg tagccagctc gtaagatgtg
     5461 gaccacccag ctctgcacct gacccttccg ctgaccaaat gggagaggag caggtggcct
     5521 tccgggtctg atatgatgcg ctttttaccg ttgggtaagg ttggggtgaa gagaagtgtg
     5581 cggctcctgg gtcagaggag gctgcccctt ctattgctca cccacttctt attcccggtc
     5641 ccctacttgg gttcgtctcc gcccattttg ggttttgtaa cagttttgtc ttttgggttt
     5701 ctcatccagc tcctcccatt gacctcattg ctcagagtgc agtattaggg caaggcttcg
     5761 ccactgcctc cctccatgaa tgtatttctc cctcctgccc tggggacatg gggagtggcc
     5821 cgtttctttc cccatctagt cccagaaaga tggtgtttgg ttttctgttg ttggattttt
     5881 tttttttttt tttttttttt gcaccaaagt ggcaactagg tcagtgttgg gggatcaagc
     5941 tggcctcggg gtggggggcc cccacctgcc tctccctggt tcccacagtg ttagcgtccc
     6001 tgaaaagaca atattctctc taaagcaata aggggtgacg ggccgggggg agtgtttgct
     6061 gctgctggcc cccagctccc cttccctctt gccaggtgtg ggggagactc ctgttgtgac
     6121 tgaatgtaac ccccccaccc ctgccgcagc caatgcaggg gaagggggac actcttcctg
     6181 tctcttctcc ccagctaaag agactttgga cttagggggc ccatgagcct ggagaggcct
     6241 taaccctgtg aggaagtata gggggagccc tctcccaccc ccatcccctt ctgagagtgg
     6301 tcaatgttta caagcccctg agcccccctg cccagggact cagaccctgt tgctgtcctt
     6361 ccccggcccc ggtcttcctg ggccctcgct gctcccctgc ccttcctggg gttggggtgg
     6421 gtgcaggggt caccgtgttc cctgtctgcc ttgtacccac agtctccccg ccccctctcc
     6481 accctgtgtg acttccctct cttttacctg ctcctgtaaa tactcccttc tcccaataaa
     6541 acttggtgtg tgttctccc
//
