LOCUS       NM_017896               4369 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens GID complex subunit 8 homolog (GID8), mRNA.
ACCESSION   NM_017896 XM_005260220
VERSION     NM_017896.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4369)
  AUTHORS   Han,Y., Pu,Y., Liu,X., Liu,Z., Chen,Y., Tang,L., Zhou,J., Song,Q.
            and Ji,Q.
  TITLE     YTHDF1 regulates GID8-mediated glutamine metabolism to promote
            colorectal cancer progression in m6A-dependent manner
  JOURNAL   Cancer Lett 601, 217186 (2024)
   PUBMED   39151722
  REMARK    GeneRIF: YTHDF1 regulates GID8-mediated glutamine metabolism to
            promote colorectal cancer progression in m6A-dependent manner.
REFERENCE   2  (bases 1 to 4369)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4369)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4369)
  AUTHORS   Xiong,J., Feng,Z., Li,Z., Zhong,T., Yang,Z., Tu,Y., Xiao,T., Jie,Z.
            and Cao,Y.
  TITLE     Overexpression of TWA1 predicts poor prognosis in patients with
            gastric cancer
  JOURNAL   Pathol Res Pract 215 (11), 152594 (2019)
   PUBMED   31591053
  REMARK    GeneRIF: findings revealed that TWA1 plays an important role in the
            development of gastric cancer
REFERENCE   5  (bases 1 to 4369)
  AUTHORS   Lampert,F., Stafa,D., Goga,A., Soste,M.V., Gilberto,S., Olieric,N.,
            Picotti,P., Stoffel,M. and Peter,M.
  TITLE     The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell
            proliferation and targets the transcription factor Hbp1 for
            degradation
  JOURNAL   Elife 7, e35528 (2018)
   PUBMED   29911972
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4369)
  AUTHORS   Francis,O., Han,F. and Adams,J.C.
  TITLE     Molecular phylogeny of a RING E3 ubiquitin ligase, conserved in
            eukaryotic cells and dominated by homologous components, the
            muskelin/RanBPM/CTLH complex
  JOURNAL   PLoS One 8 (10), e75217 (2013)
   PUBMED   24143168
  REMARK    Erratum:[PLoS One. 2013 Nov 8;8(11). doi:
            10.1371/annotation/1e464689-3c86-4399-b229-1e00d65593a5.. PMID:
            29161723]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4369)
  AUTHORS   Svendsen,J.M., Smogorzewska,A., Sowa,M.E., O'Connell,B.C.,
            Gygi,S.P., Elledge,S.J. and Harper,J.W.
  TITLE     Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and
            is required for DNA repair
  JOURNAL   Cell 138 (1), 63-77 (2009)
   PUBMED   19596235
REFERENCE   8  (bases 1 to 4369)
  AUTHORS   Kobayashi,N., Yang,J., Ueda,A., Suzuki,T., Tomaru,K., Takeno,M.,
            Okuda,K. and Ishigatsubo,Y.
  TITLE     RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat
            proteins ARMC8alpha and ARMC8beta are components of the CTLH
            complex
  JOURNAL   Gene 396 (2), 236-247 (2007)
   PUBMED   17467196
REFERENCE   9  (bases 1 to 4369)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 4369)
  AUTHORS   Umeda,M., Nishitani,H. and Nishimoto,T.
  TITLE     A novel nuclear protein, Twa1, and Muskelin comprise a complex with
            RanBPM
  JOURNAL   Gene 303, 47-54 (2003)
   PUBMED   12559565
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD676269.1, AK000609.1, BC032120.2, BQ931571.1, BQ935273.1,
            AK025775.1 and BC031819.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017896.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.251224.1,
                                           SRR1803611.275507.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266069.5/ ENSP00000266069.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                CD676269.1         91-114
            25-1435             AK000609.1         19-1429
            1436-1526           BC032120.2         1464-1554
            1527-1813           BQ931571.1         62-348
            1814-2023           BQ935273.1         506-715
            2024-2163           BQ931571.1         559-698
            2164-3743           AK025775.1         115-1694
            3744-4369           BC031819.1         1422-2047
FEATURES             Location/Qualifiers
     source          1..4369
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..4369
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /note="GID complex subunit 8 homolog"
                     /db_xref="GeneID:54994"
                     /db_xref="HGNC:HGNC:15857"
                     /db_xref="MIM:611625"
     exon            1..107
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /inference="alignment:Splign:2.1.0"
     exon            108..237
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..806
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /note="protein C20orf11; two hybrid associated protein No.
                     1 with RanBPM; two hybrid-associated protein 1 with
                     RanBPM"
                     /codon_start=1
                     /product="glucose-induced degradation protein 8 homolog"
                     /protein_id="NP_060366.1"
                     /db_xref="CCDS:CCDS13510.1"
                     /db_xref="GeneID:54994"
                     /db_xref="HGNC:HGNC:15857"
                     /db_xref="MIM:611625"
                     /translation="MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKE
                     AAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYF
                     HLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPF
                     GDLLHTMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTD
                     LSKGVIEEPK"
     exon            238..434
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..632
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..4369
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1502..1507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /note="hexamer: AATAAA"
     polyA_site      1526
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /note="major polyA site"
     regulatory      4342..4347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /note="hexamer: AGTAAA"
     polyA_site      4369
                     /gene="GID8"
                     /gene_synonym="C20orf11; TWA1"
                     /note="major polyA site"
ORIGIN      
        1 ctccttctac tcgggcgccc cggcggccgc cacctctccc cagcccagga gaggctgcgg
       61 agccgcagcc gcccagaccg cgcagcgcgg gaggcaggtt ccgcacgaaa taaatcagaa
      121 tgagttatgc agaaaaaccc gatgaaatca cgaaagatga gtggatggaa aagctcaata
      181 acttgcatgt ccagagagca gacatgaacc gcctcatcat gaactacctg gtcacagagg
      241 gctttaagga agcagcggag aagtttcgaa tggaatctgg aatcgaacct agtgtggatc
      301 tggaaacact tgatgaacga atcaagatcc gggagatgat actgaaaggt cagattcagg
      361 aggccatcgc cttgatcaac agcctccacc cagagctctt ggacacaaac cggtatcttt
      421 acttccattt gcagcaacag catttgatcg agctgatccg ccagcgggag acagaggcgg
      481 cgctggagtt tgcacagact cagctggcgg agcagggcga ggagagccga gagtgcctca
      541 cagagatgga gcgtaccctg gcactgctgg cctttgacag tcccgaggag tcgcccttcg
      601 gagacctcct ccacaccatg cagaggcaga aggtgtggag tgaagttaac caagctgtgc
      661 tagattatga aaatcgcgag tcaacaccca aactggcaaa attactgaaa ctactacttt
      721 gggctcagaa cgagctggac cagaagaaag taaaatatcc caaaatgaca gacctcagca
      781 agggtgtgat tgaggagccc aagtagcgcc tgcgcttgcg tggtggatcc aacaccagcc
      841 ctgcgtcgtg ggacttgcct cagatcagcc tgcgactgca agattcttac tgcagtagag
      901 aactcttttt ctcccttgta cttttttttg acctggcatc tttttatagg gaaaaatggc
      961 ctttgtaggc agtggaaaac ttgcaaggaa agctgccgtc tctttggcag tctgatgcag
     1021 agcctgcact ctggcactcg ctgaagaatc tggaaggttg cggtttgctc ttccagtgtt
     1081 cgggggcctc tggctgctga aggattcggt ctaccacgga gggctgtgct gttaggctgc
     1141 atcccactca aaatacagga aaagcacgaa tcatgattct gctttctgtt agcttaggca
     1201 gacattgggc cttcacctac aagtttttcc ttacccctgt ggtttttgtg tttttttttt
     1261 tttctttttc cataggaaag aatatataaa tttgtaaatc ctaattcaaa gatggctcat
     1321 gtgtgagggc attgagtttg atttgttttc cctttggtct gggttgtgtg gcttttgggg
     1381 gatgcgtgtg agggggctat gtgtttttta attttttaaa tatatatttt ggtgctgtgt
     1441 gtggtaagag acttgttcct agtggatcaa tgaaccatct cttctgggca gttttgttga
     1501 aaataaaggt ttctctttga tttcaagaat gaccaaaatg gcctctaaaa gatgttaatc
     1561 atctcaaatg accttttgtc tttggggcgt tcttccccct gtgatagcgg cagtggcttt
     1621 ttctggtacc tgcagctgga aaggccactt ggccctgtgc tgagtgagcg gccttcatta
     1681 gagcgaggca gcccttggcc ggtggggacg cagagcccca gcaggtggtg cacgactgtt
     1741 ggcggaagga acgcgtgttc atcctcagtg atctgccctc cagcatctcg gcagcatctc
     1801 atcctccatc gtcagctggc tctgccgatg tcctgcttct gttcactcac agaactgtcc
     1861 cctgctccgt ggtgggcagg agggaagtgg tgcagggctg cgtgcattgc ctgcgagtcg
     1921 ggacagttga tgggcacatg gccttgtagc tctgggcaca gatgtgtttg gattcattgc
     1981 agcggaccac cgggcactgt tgaccccact gagcagtgct aagtgttggt ttagtggatg
     2041 ttcgtggaat tgctgaccca tccaagggcg tcctttggag ccagtggagc ctgccggcgc
     2101 atctgagggg cagaatgctg ctagcacttg aatctgggat ctcgccttat tctcaagtag
     2161 caaggcatct cgacaagcat ggtctaggtc tggtggccag cttgccagta cctgagccgg
     2221 tcgggtcatc tgcctctgag ggaccgtcct caccgagctc ctgcatccct tgagtgttga
     2281 tcaggaggcg tccacagcat tgttctcgcc tctgaatgat gcttctttct gtgttggagc
     2341 ctggcgaagt tgtgttttca agccctctac ttctctttcc agtgggtagg agcttttggc
     2401 agtgtttact ttacctagat ggcttatata atccagtaag agatgcaaag ataaaattgc
     2461 tgcggttgtt acagaagcat ggcggcctcc agactgaccc attggttgcc ctttagattt
     2521 tgtaaggatg cggtgctggg gaggtggtgc ttccctaccc cctagaaatg ctgccttcca
     2581 actaccactc tcccagatgt gacccttgcg attatttcct ctgaggtttg aggatgaaga
     2641 taagttggag ggaaagagag taactaatag gggatgaaat atagcagaag ctagaagaaa
     2701 gcggtgaggt gagagagatg catctgcacg ttttcttcaa cagcaccagg tgattcagca
     2761 tattcctaat tacctttcac tattcgtgta tataagatcg tttacttgca taatatatca
     2821 tcaatttgac atattcttaa aactagaggg tgtgagaagc acagcaatag gaagtctctc
     2881 cacaaactag gggaacacaa atggggtcat tcacgtgcct ggactgtcac tatgtggctg
     2941 tcacgtgaag tgctggtgtt gatttccatt tcagccagtg ggtagctgat aagccagtgc
     3001 cagcatccag catgagcaga tgtcggggag actgggaagt ctccagcgtt actgctctcc
     3061 ttcccttcat gataagccag tgccagcatc cagcgtgagc agacgtcggg gagactggga
     3121 agtctccgat gttactgcct gccttccttt cgtgtgaggg gctgcacttg cttttcttgt
     3181 gatctgttag tggacgaggt cttccaagga agtgctttgc acactttctt tgctcctttt
     3241 tacagtcttt gtctttgcag caagcaaatg aaattaagcc actttgggat aatgaacatt
     3301 cagtataatt ctactttgtc tcattttgga tctcactgtt gtctttataa aaatggcaca
     3361 ttttacaaag tagtttattc ttattatact ttctgctgga gagtgccttg aaataaaatg
     3421 tgagagtatt ctggtactct gtgttccaga tgcatgaaat tgggtgagga ataaccccta
     3481 gtctggaatc tttgtgaagc atagggttat tgcaaggcaa atgggaacta acacatcttg
     3541 ccatttgaat cagggtctcc agtttctaga aaaggcagac actggttggg accaaagtct
     3601 ccatggcaca tgactgaaga ctggtggtcg tgtgtgtgcg gagtccacgg aagcctcggg
     3661 gaggtggagc tgctccttcc attccgtcag gacgtgatct gaaaacatgt agagaagatg
     3721 agttgaggac agcttttcta aggcaatgtg atgtctttgc tttcttattt ctctttctct
     3781 gcgttgttag ttttgaagag tggaggagct aggggctcca gaaagaatct tacacatgtg
     3841 ttgaagacat tgatgtcata gggagcgggg agctgcattc ccttctgggc tgttactgct
     3901 aaatctcagt atgaacagac caggcggaaa gcttggtggc caagcagtct gtgtgcttcc
     3961 ccgctgatgg agaacgttgc gttgttcaca atagggcctc atgggtgtag ccgcatggca
     4021 gacccatggc tggcgcagct gcctgttgcc gtctgtcttc agtaactgct gctctgttaa
     4081 ctgttctatt ctgatactac gcgtgttgtt ttttacaaca ggtatgtttt tgtttcagaa
     4141 atatgtattg cttttctcat attttttgca aattgtattg tcaacatggg tcatttaaag
     4201 tcctgtatga accataacct gctgtggtac ctttgtacat gtttgattct gtattcttta
     4261 ttccagtgtg gcatatgtgc ccctctgtat cttttgagaa gtgcggaata ggttgcttct
     4321 accacctgtt cttaatgtaa cagtaaaagt tttcacattt ttctcagaa
//
