LOCUS       NM_032484               2408 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens GH3 domain containing (GHDC), transcript variant 1,
            mRNA.
ACCESSION   NM_032484 NM_001136048
VERSION     NM_032484.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2408)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   2  (bases 1 to 2408)
  AUTHORS   Cui,Y., Li,M., Walton,K.D., Sun,K., Hanover,J.A., Furth,P.A. and
            Hennighausen,L.
  TITLE     The Stat3/5 locus encodes novel endoplasmic reticulum and
            helicase-like proteins that are preferentially expressed in normal
            and neoplastic mammary tissue
  JOURNAL   Genomics 78 (3), 129-134 (2001)
   PUBMED   11735219
REFERENCE   3  (bases 1 to 2408)
  AUTHORS   Miyoshi,K., Cui,Y., Riedlinger,G., Robinson,P., Lehoczky,J.,
            Zon,L., Oka,T., Dewar,K. and Hennighausen,L.
  TITLE     Structure of the mouse Stat 3/5 locus: evolution from Drosophila to
            zebrafish to mouse
  JOURNAL   Genomics 71 (2), 150-155 (2001)
   PUBMED   11161808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB084267.1 and BC022784.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032484.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022784.1, SRR3476690.553016.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000587427.6/ ENSP00000467585.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DB084267.1         129-155
            28-2408             BC022784.1         1-2381
FEATURES             Location/Qualifiers
     source          1..2408
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2408
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /note="GH3 domain containing"
                     /db_xref="GeneID:84514"
                     /db_xref="HGNC:HGNC:24438"
                     /db_xref="MIM:608587"
     exon            1..102
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..186
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            187..464
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1792
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; homolog of mouse LGP1; GH3 domain-containing
                     protein"
                     /codon_start=1
                     /product="GH3 domain-containing protein isoform 1
                     precursor"
                     /protein_id="NP_115873.1"
                     /db_xref="CCDS:CCDS11422.1"
                     /db_xref="GeneID:84514"
                     /db_xref="HGNC:HGNC:24438"
                     /db_xref="MIM:608587"
                     /translation="MLLWPLLLLLLLLPTLALLRQQRSQDARLSWLAGLQHRVAWGAL
                     VWAATWQRRRLEQSTLHVHQSQQQALRWCLQGAQRPHCSLRRSTDISTFRNHLPLTKA
                     SQTQQEDSGEQPLPPTSNQDLGEASLQATLLGLAALNKAYPEVLAQGRTARVTLTSPW
                     PRPLPWPGNTLGQVGTPGTKDPRALLLDALRSPGLRALEAGTAVELLDVFLGLETDGE
                     ELAGAIAAGNPGAPLRERAAELREALEQGPRGLALRLWPKLQVVVTLDAGGQAEAVAA
                     LGALWCQGLAFFSPAYAASGGVLGLNLQPEQPHGLYLLPPGAPFIELLPVKEGTQEEA
                     ASTLLLAEAQQGKEYELVLTDRASLTRCRLGDVVRVVGAYNQCPVVRFICRLDQTLSV
                     RGEDIGEDLFSEALGRAVGQWAGAKLLDHGCVESSILDSSAGSAPHYEVFVALRGLRN
                     LSEENRDKLDHCLQEASPRYKSLRFWGSVGPARVHLVGQGAFRALRAALAACPSSPFP
                     PAMPRVLRHRHLAQCLQERVVS"
     exon            465..586
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..1088
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1281
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1353
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1487
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1573
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..2408
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2388..2393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /note="hexamer: AATAAA"
     polyA_site      2408
                     /gene="GHDC"
                     /gene_synonym="D11LGP1; LGP1"
                     /note="major polyA site"
ORIGIN      
        1 aaagccatcg ctccttcttt ctggccggat gtgtgctgag acccagagtc acccaggggt
       61 ctccgtcacg tgccaggagt aggcagaagt gggctgtgac agatcaggaa acagagctca
      121 gtgcagccca ctaaattgct cagggcccta cagctaacaa gcggcagagg caggatctgc
      181 actcaggagc tgcttggaga tgctgctgtg gccactgctg ctgctgctgc tgctgctgcc
      241 aacattggcc ctgctcaggc agcagcggtc ccaggatgcc aggctgtcct ggcttgctgg
      301 cctccagcac cgagtggcat ggggggccct ggtctgggca gccacctggc agcggcggag
      361 gctggagcag agcacgctcc atgtgcacca gagccagcag caggccctga ggtggtgtct
      421 acagggagcc cagcgccccc actgttccct cagaaggagc acagacataa gcaccttccg
      481 gaatcatctc cctctgacca aggccagcca gacccagcag gaagacagtg gagagcagcc
      541 actgcccccg acctcaaacc aggaccttgg ggaggcctct ctgcaggcca ccttgctggg
      601 tctggcagcc ctaaacaagg cctacccaga agtgctggct cagggacgca ctgcccgtgt
      661 gacgcttaca tccccttggc cccgacccct gccttggcct gggaataccc tgggccaggt
      721 gggcacccct ggaaccaagg accctagggc cctgctgctg gacgcactga ggtccccagg
      781 gctgagggca ctggaggctg ggacggctgt cgaacttctg gatgttttct tgggcctgga
      841 gactgatggt gaagagctag ctggggcgat agctgccggg aaccctggag cgcctctccg
      901 tgaacgggca gctgagctcc gggaggccct agagcagggg ccacggggac tggcccttcg
      961 gctctggcca aagctgcagg tggtggtgac tctggatgca ggaggccagg ccgaggctgt
     1021 ggctgccctc ggggccttgt ggtgccaagg actagccttc ttctctcctg cttatgctgc
     1081 ctcgggaggg gtgctgggcc taaacctaca gccagagcag ccccatgggc tctaccttct
     1141 gccccctggg gcccccttta tcgagctgct cccagtcaag gaaggcaccc aggaggaagc
     1201 tgcctccacc ctccttttgg ccgaggccca gcagggcaag gagtatgagc tggtgctgac
     1261 ggaccgcgcc agcctcacca ggtgccgcct gggtgatgtg gtgcgagtgg ttggtgccta
     1321 caatcagtgt ccagtcgtca ggttcatctg caggctggac cagaccctga gtgtgcgagg
     1381 ggaagatatt ggtgaagacc tgttctctga ggccctgggc cgggcagtgg ggcagtgggc
     1441 gggggccaag ctgctggacc atggctgtgt ggagagcagc attctggatt cctctgcggg
     1501 ctctgctccc cactacgagg tgtttgtggc gctgaggggg ctgaggaatc tgtcagagga
     1561 aaatcgagac aagctggacc actgccttca ggaagcctct ccccgctaca agtccctgcg
     1621 gttctggggc agcgtgggcc ctgccagagt ccacctggtg gggcagggag ccttccgagc
     1681 actccgggca gccctcgctg cctgcccctc ctcccccttc ccccctgcga tgccccgggt
     1741 ccttcggcac aggcacctgg cccagtgtct gcaggagagg gtggtgtcct gagtcaagtc
     1801 ctgccccacc gcccagctcc ccccagaggc cacctcgccc ctccctctgg gacctctccg
     1861 gatggggagt ccttggccag ggtctctgac tctgtgtcac ctgacatttg cccatgagag
     1921 ccgctgggcc ttagagaggc cttggcccag ctgaccggtt ctgaagtatg ggcctccggg
     1981 gttagcagat gccagcagtg cctgcccgtg tccccatgtc ccggcatgaa ggacactgct
     2041 agagagttac catgcacacc gatggtttcc tgtatcacag cccaaagagg ttctctggtg
     2101 gccacagctg tgtgctcagt cagtgcactg ggcaagctag aagtgttggg gggttaatgt
     2161 ccccaggagc agcaaccctg agtcaataag gagcaggacc tcagcttcat tgtccttgag
     2221 caggacaatt ctgaagtgta ttctacataa actctcagag gatgcccagc aggatggagt
     2281 cccagttgcc cgcagcagta acccactcat tcatgtactt cctgcggggg ctctcccttc
     2341 cctctcttcc ccactccccc gccttgggct tcctgggatg gctcccaaat aaacctcttg
     2401 cacccaga
//
