LOCUS       NM_001355479             968 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase light chain family member 3
            (GGTLC3), mRNA.
ACCESSION   NM_001355479
VERSION     NM_001355479.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 968)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   2  (bases 1 to 968)
  AUTHORS   Courtay,C., Heisterkamp,N., Siest,G. and Groffen,J.
  TITLE     Expression of multiple gamma-glutamyltransferase genes in man
  JOURNAL   Biochem J 297 (Pt 3) (Pt 3), 503-508 (1994)
   PUBMED   7906515
REFERENCE   3  (bases 1 to 968)
  AUTHORS   Rajpert-De Meyts,E., Heisterkamp,N. and Groffen,J.
  TITLE     Cloning and nucleotide sequence of human gamma-glutamyl
            transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 85 (23), 8840-8844 (1988)
   PUBMED   2904146
COMMENT     INFERRED REFSEQ: This record is predicted by genome sequence
            analysis and is not yet supported by experimental evidence. The
            reference sequence was derived from AC023490.5.
            
            Summary: Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a
            membrane-bound extracellular enzyme that cleaves gamma-glutamyl
            peptide bonds in glutathione and other peptides and transfers the
            gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the
            GGT1 precursor polypeptide produces a heavy chain and a light chain
            that associate with each other to form the functional enzyme. Light
            chain-only GGTs, such as GGTLC3, contain a region corresponding to
            the GGT1 light chain, but they lack the membrane-anchoring heavy
            chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied
            by OMIM, Oct 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1968189, SAMEA1968832
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000619998.1/ ENSP00000477856.1
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC023490.5         34550-34648         c
            100-309             AC023490.5         34209-34418         c
            310-437             AC023490.5         33849-33976         c
            438-550             AC023490.5         33634-33746         c
            551-664             AC023490.5         33439-33552         c
            665-968             AC023490.5         32831-33134         c
FEATURES             Location/Qualifiers
     source          1..968
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.21"
     gene            1..968
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /note="gamma-glutamyltransferase light chain family member
                     3"
                     /db_xref="GeneID:728226"
                     /db_xref="HGNC:HGNC:33426"
                     /db_xref="MIM:612340"
     exon            1..99
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /inference="alignment:Splign:2.1.0"
     exon            100..309
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..811
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /note="putative gamma-glutamyltransferase light chain 3"
                     /codon_start=1
                     /product="putative glutathione hydrolase light chain 3"
                     /protein_id="NP_001342408.1"
                     /db_xref="CCDS:CCDS86996.1"
                     /db_xref="GeneID:728226"
                     /db_xref="HGNC:HGNC:33426"
                     /db_xref="MIM:612340"
                     /translation="MTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVA
                     EDGSAVSATSTINLYFGSKVCSPVSGILFNNEWTTSALPAFTNEFGAPPSPANFIQPG
                     KQPLLSMCPTIMVGQDGQVRMVVGAAGGTQITTDTALAIIYNLWFGYDVKRAVEEPRL
                     HNKLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRK
                     GGEPAGY"
     exon            310..437
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /inference="alignment:Splign:2.1.0"
     exon            438..550
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /inference="alignment:Splign:2.1.0"
     exon            551..664
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /inference="alignment:Splign:2.1.0"
     exon            665..968
                     /gene="GGTLC3"
                     /gene_synonym="GGT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attgaatgcg gcaagggtct ggaggctgag gaccaggcag acagacattc agagttgctg
       61 gaacgcgaca gagacaggga gtcagactgg tcatgcaagg ccagctctgg ggtctcagca
      121 ggtggtccgc aacatgacct ctgagttctt cgctgcccag ctccggtccc agatctctga
      181 ccacaccact cacccgatct cctactacaa gcccgagttc tacacgccgg atgacggggg
      241 cactgctcac ctgtctgtcg tcgcagagga cggcagtgct gtgtccgcca ccagcaccat
      301 caacctctac tttggctcca aggtctgctc cccggtcagt gggatcctgt tcaataatga
      361 atggacgact tcagctctcc cagcattcac caatgagttt ggggcacccc cctcacctgc
      421 caatttcatc cagccaggga agcagccgct cttgtccatg tgcccgacga tcatggtggg
      481 ccaggacggc caggtccgga tggtggtggg agctgctggg ggcacgcaga tcaccacaga
      541 cactgcactg gccatcatct acaacctctg gttcggctat gacgtgaaga gggccgtgga
      601 ggagccccgg ctgcacaaca agcttctgcc caacgtcacg acagtggaga gaaacattga
      661 ccaggcagtg actgcagccc tggagacccg gcaccatcac acccagatcg catccacctt
      721 catcgctgtg gtgcaagcca tcgtccgcac ggctggtggc tgggcagctg cctcggactc
      781 caggaaaggc ggggaacctg ctggctactg attgctccag gcagacaagg ctgacaagca
      841 atccagggac aagatactca ccaggatgag gaagaggact ttgggggacg ggcttcccct
      901 gtgagcagca gagcagcata ataaatgagg ccactgtgcc aggctccagg tggcctccct
      961 ggcctgtc
//
