LOCUS       NM_199127                943 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase light chain 2 (GGTLC2),
            transcript variant 1, mRNA.
ACCESSION   NM_199127
VERSION     NM_199127.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 943)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 943)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   3  (bases 1 to 943)
  AUTHORS   Kawasaki,K., Minoshima,S., Nakato,E., Shibuya,K., Shintani,A.,
            Schmeits,J.L., Wang,J. and Shimizu,N.
  TITLE     One-megabase sequence analysis of the human immunoglobulin lambda
            gene locus
  JOURNAL   Genome Res 7 (3), 250-261 (1997)
   PUBMED   9074928
REFERENCE   4  (bases 1 to 943)
  AUTHORS   Leh,H., Courtay,C., Gerardin,P., Wellman,M., Siest,G. and
            Visvikis,A.
  TITLE     Cloning and expression of a novel type (III) of human
            gamma-glutamyltransferase truncated mRNA
  JOURNAL   FEBS Lett 394 (3), 258-262 (1996)
   PUBMED   8830654
REFERENCE   5  (bases 1 to 943)
  AUTHORS   Wetmore,L.A., Gerard,C. and Drazen,J.M.
  TITLE     Human lung expresses unique gamma-glutamyl transpeptidase
            transcripts
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7461-7465 (1993)
   PUBMED   7689219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244250.3.
            
            On Jan 14, 2021 this sequence version replaced NM_199127.2.
            
            Summary: This gene encodes a protein related to enzymes that
            cleaves gamma-glutamyl peptide bonds in glutathione and other
            peptides. Unlike similar proteins, the encoded protein contains
            only the light chain portion and may not have catalytic activity.
            Alternative splicing results in multiple transcript variants. There
            are several related family members and related pseudogene for this
            gene situated in the same region of chromosome 22. [provided by
            RefSeq, Sep 2013].
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC069534.1, EL736203.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968968, SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000448514.3/
                                                ENSP00000415676.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC244250.3         95351-95445
            96-305              AC244250.3         97049-97258
            306-433             AC244250.3         97491-97618
            434-489             AC244250.3         97720-97775
            490-639             AC244250.3         97878-98027
            640-943             AC244250.3         98332-98635
FEATURES             Location/Qualifiers
     source          1..943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..943
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /note="gamma-glutamyltransferase light chain 2"
                     /db_xref="GeneID:91227"
                     /db_xref="HGNC:HGNC:18596"
                     /db_xref="MIM:612339"
     exon            1..95
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            96..305
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..786
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma-glutamyltransferase-like 4;
                     gamma-glutamyltransferase-like protein 4; glutathione
                     hydrolase light chain 2"
                     /codon_start=1
                     /product="glutathione hydrolase light chain 2 isoform 1"
                     /protein_id="NP_954578.2"
                     /db_xref="CCDS:CCDS13802.2"
                     /db_xref="GeneID:91227"
                     /db_xref="HGNC:HGNC:18596"
                     /db_xref="MIM:612339"
                     /translation="MTSEFFAAQLRAQISDDTTHPISYYKPEFYTPVDGGTAHLSVVA
                     EDGSAVSATSTINLYFGSKVRSPVSEILFNDEMDDFSSPNITNEFGVPPSPANFIQPG
                     KQPLSSMCPTIMVGQDGQPPSHADHTPMPQAIIYNLWFGYDVKRAVEEPRLHNQLLPN
                     VTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
                     "
     exon            306..433
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            434..489
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..639
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            640..943
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgagct taacggatta ataagcgcag ccaggtaccc gcgcgaggca cttgctggca
       61 atggcgggag gcggacgtgg ggggtcatgc aataggccag ctctggggtc tcggcaggtg
      121 gtccacaaca tgacctctga gttcttcgct gcccagctcc gggcccagat ctctgacgac
      181 accactcacc cgatctccta ctacaagccc gagttctaca cgccggttga tgggggcact
      241 gctcacctgt ctgtcgtcgc agaggacggc agtgctgtgt ccgccaccag caccatcaac
      301 ctctactttg gctccaaggt ccgctccccg gtcagcgaga tcctgttcaa tgatgaaatg
      361 gatgacttca gctctcccaa catcaccaac gagtttgggg tgcccccctc acctgccaat
      421 ttcatccagc cagggaagca gccgctctcg tcaatgtgcc cgacgatcat ggtgggccag
      481 gacggccagc ccccaagcca tgctgatcac actcccatgc cccaggccat catctacaac
      541 ctctggttcg gctatgacgt gaagcgggcc gtggaggagc cccggctgca caaccagctt
      601 ctgcccaacg tcacgacagt ggagagaaac attgaccagg cagtgactgc agccctggag
      661 acccggcacc atcacaccca gatcgcgtcc accttcatcg ctgtggtgca agccatcgtc
      721 cgcacggctg gtggctgggc agctgcctcg gactccagga aaggcgggga gcctgccggc
      781 tactgagtgc tccaggagga caaggctgac aagcaatcca gggacaagat actcaccagg
      841 accaggaagg ggactctggg ggactggctt cccctgtgag cagcagagca gcacaataaa
      901 tgaggccact gtgccaggct ccaggtggcc tccctgccct gtc
//
