LOCUS       NM_001391911            1023 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase light chain 2 (GGTLC2),
            transcript variant 5, mRNA.
ACCESSION   NM_001391911 XM_005261817
VERSION     NM_001391911.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1023)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1023)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   3  (bases 1 to 1023)
  AUTHORS   Kawasaki,K., Minoshima,S., Nakato,E., Shibuya,K., Shintani,A.,
            Schmeits,J.L., Wang,J. and Shimizu,N.
  TITLE     One-megabase sequence analysis of the human immunoglobulin lambda
            gene locus
  JOURNAL   Genome Res 7 (3), 250-261 (1997)
   PUBMED   9074928
REFERENCE   4  (bases 1 to 1023)
  AUTHORS   Leh,H., Courtay,C., Gerardin,P., Wellman,M., Siest,G. and
            Visvikis,A.
  TITLE     Cloning and expression of a novel type (III) of human
            gamma-glutamyltransferase truncated mRNA
  JOURNAL   FEBS Lett 394 (3), 258-262 (1996)
   PUBMED   8830654
REFERENCE   5  (bases 1 to 1023)
  AUTHORS   Wetmore,L.A., Gerard,C. and Drazen,J.M.
  TITLE     Human lung expresses unique gamma-glutamyl transpeptidase
            transcripts
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7461-7465 (1993)
   PUBMED   7689219
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC244250.3.
            
            On Jan 14, 2021 this sequence version replaced XM_005261817.3.
            
            Summary: This gene encodes a protein related to enzymes that
            cleaves gamma-glutamyl peptide bonds in glutathione and other
            peptides. Unlike similar proteins, the encoded protein contains
            only the light chain portion and may not have catalytic activity.
            Alternative splicing results in multiple transcript variants. There
            are several related family members and related pseudogene for this
            gene situated in the same region of chromosome 22. [provided by
            RefSeq, Sep 2013].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.149786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC244250.3         95351-95445
            96-283              AC244250.3         97071-97258
            284-411             AC244250.3         97491-97618
            412-719             AC244250.3         97720-98027
            720-1023            AC244250.3         98332-98635
FEATURES             Location/Qualifiers
     source          1..1023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.22"
     gene            1..1023
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /note="gamma-glutamyltransferase light chain 2"
                     /db_xref="GeneID:91227"
                     /db_xref="HGNC:HGNC:18596"
                     /db_xref="MIM:612339"
     exon            1..95
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            96..283
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..866
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /note="isoform 3 is encoded by transcript variant 5;
                     gamma-glutamyltransferase-like 4;
                     gamma-glutamyltransferase-like protein 4; glutathione
                     hydrolase light chain 2"
                     /codon_start=1
                     /product="glutathione hydrolase light chain 2 isoform 3"
                     /protein_id="NP_001378840.1"
                     /db_xref="CCDS:CCDS93129.1"
                     /db_xref="GeneID:91227"
                     /db_xref="HGNC:HGNC:18596"
                     /db_xref="MIM:612339"
                     /translation="MTSEFFAAQLRAQISDDTTHPISYYKPEFYTPVDGGTAHLSVVA
                     EDGSAVSATSTINLYFGSKVRSPVSEILFNDEMDDFSSPNITNEFGVPPSPANFIQPG
                     KQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALICVTPFLPGRAHPAQPPSHAD
                     HTPMPQAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQ
                     IASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY"
     exon            284..411
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            412..719
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
     exon            720..1023
                     /gene="GGTLC2"
                     /gene_synonym="GGTL4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgagct taacggatta ataagcgcag ccaggtaccc gcgcgaggca cttgctggca
       61 atggcgggag gcggacgtgg ggggtcatgc aataggtggt ccacaacatg acctctgagt
      121 tcttcgctgc ccagctccgg gcccagatct ctgacgacac cactcacccg atctcctact
      181 acaagcccga gttctacacg ccggttgatg ggggcactgc tcacctgtct gtcgtcgcag
      241 aggacggcag tgctgtgtcc gccaccagca ccatcaacct ctactttggc tccaaggtcc
      301 gctccccggt cagcgagatc ctgttcaatg atgaaatgga tgacttcagc tctcccaaca
      361 tcaccaacga gtttggggtg cccccctcac ctgccaattt catccagcca gggaagcagc
      421 cgctctcgtc aatgtgcccg acgatcatgg tgggccagga cggccaggtc cggatggtgg
      481 tgggagctgc tgggggcaca cagatcacca cagccactgc actgatatgt gtcacccctt
      541 ttctccctgg ccgtgcccac cctgcacagc ccccaagcca tgctgatcac actcccatgc
      601 cccaggccat catctacaac ctctggttcg gctatgacgt gaagcgggcc gtggaggagc
      661 cccggctgca caaccagctt ctgcccaacg tcacgacagt ggagagaaac attgaccagg
      721 cagtgactgc agccctggag acccggcacc atcacaccca gatcgcgtcc accttcatcg
      781 ctgtggtgca agccatcgtc cgcacggctg gtggctgggc agctgcctcg gactccagga
      841 aaggcgggga gcctgccggc tactgagtgc tccaggagga caaggctgac aagcaatcca
      901 gggacaagat actcaccagg accaggaagg ggactctggg ggactggctt cccctgtgag
      961 cagcagagca gcacaataaa tgaggccact gtgccaggct ccaggtggcc tccctgccct
     1021 gtc
//
