LOCUS       NM_178311               1046 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase light chain 1 (GGTLC1),
            transcript variant A, mRNA.
ACCESSION   NM_178311
VERSION     NM_178311.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1046)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1046)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   3  (bases 1 to 1046)
  AUTHORS   Kerns,S.L., Ostrer,H., Stock,R., Li,W., Moore,J., Pearlman,A.,
            Campbell,C., Shao,Y., Stone,N., Kusnetz,L. and Rosenstein,B.S.
  TITLE     Genome-wide association study to identify single nucleotide
            polymorphisms (SNPs) associated with the development of erectile
            dysfunction in African-American men after radiotherapy for prostate
            cancer
  JOURNAL   Int J Radiat Oncol Biol Phys 78 (5), 1292-1300 (2010)
   PUBMED   20932654
REFERENCE   4  (bases 1 to 1046)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   5  (bases 1 to 1046)
  AUTHORS   Wetmore,L.A., Gerard,C. and Drazen,J.M.
  TITLE     Human lung expresses unique gamma-glutamyl transpeptidase
            transcripts
  JOURNAL   Proc Natl Acad Sci U S A 90 (16), 7461-7465 (1993)
   PUBMED   7689219
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC040904.1 and AL133466.22.
            
            On May 17, 2019 this sequence version replaced NM_178311.2.
            
            Summary: This gene encodes a member of the gamma-glutamyl
            transpeptidase (GGT) family, which are important in the metabolism
            of glutathione. The most ubiquitously expressed human GGT gene,
            GGT1, encodes a single transmembrane polypeptide that is
            post-translationally processed to form a heavy and a light chain.
            In contrast, the product of this gene only contains homology to the
            light chain region, and lacks a transmembrane domain. Multiple
            alternatively spliced variants, encoding the same protein, have
            been identified. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (A) represents the longer
            transcript. Both variants A and B encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040904.1, SRR5189667.388502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335694.4/ ENSP00000337587.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               BC040904.1         1-131
            132-132             AL133466.22        33387-33387         c
            133-1046            BC040904.1         133-1046
FEATURES             Location/Qualifiers
     source          1..1046
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..1046
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /note="gamma-glutamyltransferase light chain 1"
                     /db_xref="GeneID:92086"
                     /db_xref="HGNC:HGNC:16437"
                     /db_xref="MIM:612338"
     exon            1..171
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..381
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..883
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /EC_number="2.3.2.2"
                     /note="gamma-glutamyltransferase-like activity 4;
                     gamma-glutamyltransferase-like activity 3; gamma-glutamyl
                     transpeptidase; gamma-glutamyltransferase-like protein 6"
                     /codon_start=1
                     /product="glutathione hydrolase light chain 1"
                     /protein_id="NP_842563.1"
                     /db_xref="CCDS:CCDS13163.1"
                     /db_xref="GeneID:92086"
                     /db_xref="HGNC:HGNC:16437"
                     /db_xref="MIM:612338"
                     /translation="MTSEFFSAQLRAQISDDTTHPISYYKPEFYMPDDGGTAHLSVVA
                     EDGSAVSATSTINLYFGSKVRSPVSGILLNNEMDDFSSTSITNEFGVPPSPANFIQPG
                     KQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITMATALAIIYNLWFGYDVKWAVEEPRL
                     HNQLLPNVTTVERNIDQEVTAALETRHHHTQITSTFIAVVQAIVRMAGGWAAASDSRK
                     GGEPAGY"
     exon            382..509
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /inference="alignment:Splign:2.1.0"
     exon            510..622
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /inference="alignment:Splign:2.1.0"
     exon            623..736
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /inference="alignment:Splign:2.1.0"
     exon            737..1046
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /note="hexamer: AATAAA"
     polyA_site      1025
                     /gene="GGTLC1"
                     /gene_synonym="dJ831C21.1; dJ831C21.2; GGTL6; GGTLA3;
                     GGTLA4"
                     /note="major polyA site"
ORIGIN      
        1 ctcgagagct gggctctgcg tcctcgtcca gccgccaact cggccaaagg cgaagccagc
       61 agtttcttct gctgccgggc aacgcgcctt ttaaacctga gggagtgggc gcgtgagcac
      121 ttaatggcgc cggtgacaga gtgagcttaa cggattaata agcgcagcca ggccagctct
      181 ggggtctcgg caggtggtcc gcgacatgac ctccgagttc ttctctgccc agctccgggc
      241 ccagatctct gacgacacca ctcacccgat ctcctactac aagcccgagt tctacatgcc
      301 ggatgacggg ggcactgctc acctgtctgt ggtcgcagag gacggcagtg ctgtgtccgc
      361 caccagcacc atcaacctct actttggctc caaggtgcgc tccccagtca gcgggatcct
      421 gctcaataat gaaatggatg acttcagctc taccagcatc accaacgagt ttggggtacc
      481 cccctcacct gccaatttca tccagccagg gaagcagccg ctctcgtcca tgtgcccgac
      541 gatcatggtg ggccaggacg gccaggtccg gatggtggtg ggagctgccg ggggcacgca
      601 gatcaccatg gccactgcac tggccatcat ctacaacctc tggttcggct atgacgtgaa
      661 gtgggccgtg gaggagcccc ggctgcacaa ccagcttctg cccaacgtca cgacagtgga
      721 gagaaacatt gaccaggaag tgactgcagc cctggagacc cggcaccatc acacccagat
      781 cacgtccacc ttcattgctg tggtgcaagc catcgtccgc atggctggtg gctgggcagc
      841 tgcctcggac tccaggaaag gtggggaacc tgctggctac tgattgctcc aggcggacaa
      901 ggctgacaag caatccagga acaaaatact caccaggacg aggaagagga ctttggggga
      961 caggcttctc ctgtgagcag cagagcagca caataaatga ggccactgtg ccaggctcca
     1021 ggtggcctcc ctggcctgtc tcccca
//
