LOCUS       NM_178026               2638 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase 7 (GGT7), transcript variant
            1, mRNA.
ACCESSION   NM_178026 NM_052830
VERSION     NM_178026.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2638)
  AUTHORS   Wang,X., Zhang,L., Chan,F.K.L., Ji,J., Yu,J. and Liang,J.Q.
  TITLE     Gamma-glutamyltransferase 7 suppresses gastric cancer by
            cooperating with RAB7 to induce mitophagy
  JOURNAL   Oncogene 41 (26), 3485-3497 (2022)
   PUBMED   35662282
  REMARK    GeneRIF: Gamma-glutamyltransferase 7 suppresses gastric cancer by
            cooperating with RAB7 to induce mitophagy.
REFERENCE   2  (bases 1 to 2638)
  AUTHORS   Samgina,T.A. and Lazarenko,V.A.
  TITLE     [The role of polymorphic variants rs11546155 and rs6119534 of the
            GGT7 gene and risk factors in the development of acute
            pancreatitis]
  JOURNAL   Vopr Pitan 91 (2), 43-50 (2022)
   PUBMED   35596634
  REMARK    GeneRIF: [The role of polymorphic variants rs11546155 and rs6119534
            of the GGT7 gene and risk factors in the development of acute
            pancreatitis].
REFERENCE   3  (bases 1 to 2638)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2638)
  AUTHORS   Tan,C., Zhang,H., Yu,D., Hu,Y., Wang,P., Wang,D., Fa,J., Ran,H.,
            Zhang,X., Chen,Y., Qin,W., Fang,C., Ke,T., Dong,N., Cai,J., He,Q.,
            Huo,S., Wang,J., Ren,X., Tu,X., Lin,X., Wang,Q. and Xu,C.
  TITLE     A genome-wide association study identifies novel association
            between genetic variants in GGT7 and LINC00944 and hypertension
  JOURNAL   Clin Transl Med 11 (5), e388 (2021)
   PUBMED   34047475
  REMARK    GeneRIF: A genome-wide association study identifies novel
            association between genetic variants in GGT7 and LINC00944 and
            hypertension.
REFERENCE   5  (bases 1 to 2638)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2638)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   7  (bases 1 to 2638)
  AUTHORS   Bui,T.T., Nitta,R.T., Kahn,S.A., Razavi,S.M., Agarwal,M., Aujla,P.,
            Gholamin,S., Recht,L. and Li,G.
  TITLE     gamma-Glutamyl transferase 7 is a novel regulator of glioblastoma
            growth
  JOURNAL   BMC Cancer 15, 225 (2015)
   PUBMED   25884624
  REMARK    GeneRIF: Our study demonstrates that GGT7 is a novel player in GBM
            growth and that GGT7 can play a critical role in tumorigenesis by
            regulating anti-oxidative damage.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2638)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   9  (bases 1 to 2638)
  AUTHORS   He,X., Di,Y., Li,J., Xie,Y., Tang,Y., Zhang,F., Wei,L., Zhang,Y.,
            Qin,W., Huo,K., Li,Y., Wan,D. and Gu,J.
  TITLE     Molecular cloning and characterization of CT120, a novel
            membrane-associated gene involved in amino acid transport and
            glutathione metabolism
  JOURNAL   Biochem Biophys Res Commun 297 (3), 528-536 (2002)
   PUBMED   12270127
  REMARK    GeneRIF: GGTL3 protein interacts with CT120, a plasma
            membrane-associated protein possibly involved in lung
            carcinogenesis.
REFERENCE   10 (bases 1 to 2638)
  AUTHORS   Figlewicz,D.A., Delattre,O., Guellaen,G., Krizus,A., Thomas,G.,
            Zucman,J. and Rouleau,G.A.
  TITLE     Mapping of human gamma-glutamyl transpeptidase genes on chromosome
            22 and other human autosomes
  JOURNAL   Genomics 17 (2), 299-305 (1993)
   PUBMED   8104871
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033745.1, BX401449.2,
            DA117929.1 and AL049709.18.
            
            On Nov 23, 2018 this sequence version replaced NM_178026.2.
            
            Summary: This gene is a member of a gene family that encodes
            enzymes involved in both the metabolism of glutathione and in the
            transpeptidation of amino acids. Changes in the activity of
            gamma-glutamyltransferase may signal preneoplastic or toxic
            conditions in the liver or kidney. The protein encoded by this gene
            consists of a heavy and a light chain, and it can interact with
            CT120, a plasma membrane-associated protein that is possibly
            involved in lung carcinogenesis. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.106605.1,
                                           SRR3476690.883202.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336431.10/ ENSP00000338964.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-751               BC033745.1         3-753
            752-784             BX401449.2         761-793
            785-1818            BC033745.1         787-1820
            1819-2233           DA117929.1         61-475
            2234-2638           AL049709.18        50823-51227         c
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     gene            1..2638
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /note="gamma-glutamyltransferase 7"
                     /db_xref="GeneID:2686"
                     /db_xref="HGNC:HGNC:4259"
                     /db_xref="MIM:612342"
     exon            1..210
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..2030
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gamma-glutamyltransferase-like 3;
                     gamma-glutamyltranspeptidase-like 3;
                     gamma-glutamyltransferase 4;
                     gamma-glutamyltransferase-like 5; GGT 7;
                     gamma-glutamyltranspeptidase 7; glutathione hydrolase 7"
                     /codon_start=1
                     /product="glutathione hydrolase 7 isoform 1"
                     /protein_id="NP_821158.2"
                     /db_xref="CCDS:CCDS13242.2"
                     /db_xref="GeneID:2686"
                     /db_xref="HGNC:HGNC:4259"
                     /db_xref="MIM:612342"
                     /translation="MAAENEASQESALGAYSPVDYMSITSFPRLPEDEPAPAAPLRGR
                     KDEDAFLGDPDTDPDSFLKSARLQRLPSSSSEMGSQDGSPLRETRKDPFSAAAAECSC
                     RQDGLTVIVTACLTFATGVTVALVMQIYFGDPQIFQQGAVVTDAARCTSLGIEVLSKQ
                     GSSVDAAVAAALCLGIVAPHSSGLGGGGVMLVHDIRRNESHLIDFRESAPGALREETL
                     QRSWETKPGLLVGVPGMVKGLHEAHQLYGRLPWSQVLAFAAAVAQDGFNVTHDLARAL
                     AEQLPPNMSERFRETFLPSGRPPLPGSLLHRPDLAEVLDVLGTSGPAAFYAGGNLTLE
                     MVAEAQHAGGVITEEDFSNYSALVEKPVCGVYRGHLVLSPPPPHTGPALISALNILEG
                     FNLTSLVSREQALHWVAETLKIALALASRLGDPVYDSTITESMDDMLSKVEAAYLRGH
                     INDSQAAPAPLLPVYELDGAPTAAQVLIMGPDDFIVAMVSSLNQPFGSGLITPSGILL
                     NSQMLDFSWPNRTANHSAPSLENSVQPGKRPLSFLLPTVVRPAEGLCGTYLALGANGA
                     ARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDLQSNLLQVDSEFTEEEIEFLEARGH
                     HVEKVDVLSWVHGSRRTNNFIIAVKDPRSPDAAGATIL"
     exon            211..446
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            447..598
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            599..716
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            717..784
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            785..858
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1055
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1143
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1271
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1360
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1510
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1628
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1766
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1866
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2638
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /note="hexamer: AAGAAA"
     polyA_site      2638
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /note="major polyA site"
ORIGIN      
        1 acttccggca ggcgctgcgc tgctgggggg cgcgggcgag gatggcggcg gagaacgagg
       61 ccagccagga gagcgccctg ggcgcctact cgccagtgga ctacatgagc atcaccagct
      121 tcccgcggct gcccgaggac gagccggcgc ccgcggcccc gctgaggggc cgcaaggacg
      181 aggacgcctt tctgggagac cccgacaccg acccggactc cttcctgaag tctgcacggc
      241 tgcagcggct gccatcgtcg tcgtcggaga tgggcagcca agacgggtcg ccgctacgcg
      301 agacgcgcaa agacccgttc tccgccgcag cggccgagtg ctcctgccgc caggatgggc
      361 tcacggtcat cgtcacggcc tgtctcacct tcgctaccgg tgtcaccgtg gcgctggtca
      421 tgcagatcta cttcggggac ccccagatct tccagcaggg tgccgtggtg accgatgctg
      481 cccgctgcac ttcactgggc atcgaggtgc tcagtaaaca gggatcttct gtggacgcag
      541 cggtggcagc agccttgtgt ttgggtatcg tggctccaca cagttctggc ctgggcggtg
      601 ggggcgtgat gctggtacat gacatccgac gaaatgagag ccacctaatt gatttccggg
      661 agtccgcacc aggggccctc agggaagaga ccctgcaaag atcctgggag accaagcctg
      721 ggctcttggt gggggttccc ggaatggtga aggggctaca tgaagctcac cagctctatg
      781 gcaggctgcc atggtcccaa gtcctggcct ttgcagcagc tgtggcccaa gatggcttca
      841 acgtgactca tgatctagcc cgtgccctgg ctgaacagct gccacccaac atgtccgagc
      901 gcttccggga gacgttcctg ccatcgggcc gcccgccact acctggctcg ttgctgcatc
      961 ggcccgacct ggctgaggtg ctggatgtac ttggcacctc cggcccggct gccttctacg
     1021 caggtggcaa cctcacactg gagatggtgg ccgaggctca gcacgcaggg ggtgtcataa
     1081 ccgaagagga cttcagcaat tacagcgccc ttgtggagaa gcctgtgtgt ggcgtgtaca
     1141 gaggccacct ggttcttagt cccccacctc cgcacacggg ccctgccctc atcagtgctc
     1201 tcaacatcct ggagggcttc aatctcacca gcctggtatc ccgagaacag gctcttcact
     1261 gggtggcaga gaccctgaag attgcattag ccctggccag cagactggga gatcccgtct
     1321 atgattctac catcactgag agcatggatg acatgctcag caaggtggag gccgcctacc
     1381 tccggggcca tatcaatgac tcccaggcag cccctgcccc actcctgcct gtctatgaac
     1441 tagacggagc tcccacggct gcccaggtgc tgatcatggg acctgatgac ttcattgtgg
     1501 ccatggttag ctccctgaac cagccctttg gcagcggcct tatcaccccc tcggggatcc
     1561 tgctcaacag ccagatgctg gacttctcct ggcccaaccg gacagctaac cactctgcac
     1621 ccagcctgga gaattcagtg cagccaggga agcggccact ctctttcctg ctgcccacag
     1681 tggtccgacc cgcggagggg ctctgtggaa cctacctcgc tctgggggcc aatggagctg
     1741 cgcggggcct cagcggcctg acacaggttc tgctgaatgt cctgaccttg aaccggaacc
     1801 tgagtgacag cctggcccgc ggccgcctac acccggacct gcagtccaac ctcctgcagg
     1861 tggacagtga gttcacagag gaagagattg agttcctgga agccaggggt caccacgtgg
     1921 agaaagtaga tgtcttatcc tgggtccatg gcagccgaag gaccaacaac ttcatcatcg
     1981 ctgttaagga ccctcggagc ccagatgcag ctggagccac catcctgtag agcagcgggg
     2041 tggggcgggg tctctgctcc cccactttgc atgttcccag agtccctcct tctcccaggt
     2101 ttggtctcag ggggacccca gggatgcccc agatcagggg ccagagggga tgcttagcaa
     2161 acccaatccc agagtaactg gaaaattctc catcaggagg cctgtggtgg tggtggtggt
     2221 ggtggtggtg gtggtggtgg tggtgagtgt cagcatctac agtacagcca ggcaggcagg
     2281 accttgagga atcagactat ctgtctgtgt gtcacctctc ctccttcagc catgctggcc
     2341 ccgagcttag ggatgtgctt gcaaaccctt ctcaagggtc tcacaacccc aacatcttca
     2401 gactggcctg acctgggcct tgtcttccag ttcctttctc ccattcccag cctcatttct
     2461 taaatgacta ggaatttttt aatggaccat catagggagg gggtgctcct cttttcccac
     2521 caggttgagg tgggggcctt gcatcggggg tccccagggt atggggtagg ggtgggggtg
     2581 ggcaccagct caggggcttc catttgcaaa gggaaattaa agaaagaatg ttgcttaa
//
