LOCUS       NP_821158                662 aa            linear   PRI 28-APR-2025
DEFINITION  glutathione hydrolase 7 isoform 1 [Homo sapiens].
ACCESSION   NP_821158 NP_439895
VERSION     NP_821158.2
DBSOURCE    REFSEQ: accession NM_178026.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 662)
  AUTHORS   Wang,X., Zhang,L., Chan,F.K.L., Ji,J., Yu,J. and Liang,J.Q.
  TITLE     Gamma-glutamyltransferase 7 suppresses gastric cancer by
            cooperating with RAB7 to induce mitophagy
  JOURNAL   Oncogene 41 (26), 3485-3497 (2022)
   PUBMED   35662282
  REMARK    GeneRIF: Gamma-glutamyltransferase 7 suppresses gastric cancer by
            cooperating with RAB7 to induce mitophagy.
REFERENCE   2  (residues 1 to 662)
  AUTHORS   Samgina,T.A. and Lazarenko,V.A.
  TITLE     [The role of polymorphic variants rs11546155 and rs6119534 of the
            GGT7 gene and risk factors in the development of acute
            pancreatitis]
  JOURNAL   Vopr Pitan 91 (2), 43-50 (2022)
   PUBMED   35596634
  REMARK    GeneRIF: [The role of polymorphic variants rs11546155 and rs6119534
            of the GGT7 gene and risk factors in the development of acute
            pancreatitis].
REFERENCE   3  (residues 1 to 662)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (residues 1 to 662)
  AUTHORS   Tan,C., Zhang,H., Yu,D., Hu,Y., Wang,P., Wang,D., Fa,J., Ran,H.,
            Zhang,X., Chen,Y., Qin,W., Fang,C., Ke,T., Dong,N., Cai,J., He,Q.,
            Huo,S., Wang,J., Ren,X., Tu,X., Lin,X., Wang,Q. and Xu,C.
  TITLE     A genome-wide association study identifies novel association
            between genetic variants in GGT7 and LINC00944 and hypertension
  JOURNAL   Clin Transl Med 11 (5), e388 (2021)
   PUBMED   34047475
  REMARK    GeneRIF: A genome-wide association study identifies novel
            association between genetic variants in GGT7 and LINC00944 and
            hypertension.
REFERENCE   5  (residues 1 to 662)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 662)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   7  (residues 1 to 662)
  AUTHORS   Bui,T.T., Nitta,R.T., Kahn,S.A., Razavi,S.M., Agarwal,M., Aujla,P.,
            Gholamin,S., Recht,L. and Li,G.
  TITLE     gamma-Glutamyl transferase 7 is a novel regulator of glioblastoma
            growth
  JOURNAL   BMC Cancer 15, 225 (2015)
   PUBMED   25884624
  REMARK    GeneRIF: Our study demonstrates that GGT7 is a novel player in GBM
            growth and that GGT7 can play a critical role in tumorigenesis by
            regulating anti-oxidative damage.
            Publication Status: Online-Only
REFERENCE   8  (residues 1 to 662)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   9  (residues 1 to 662)
  AUTHORS   He,X., Di,Y., Li,J., Xie,Y., Tang,Y., Zhang,F., Wei,L., Zhang,Y.,
            Qin,W., Huo,K., Li,Y., Wan,D. and Gu,J.
  TITLE     Molecular cloning and characterization of CT120, a novel
            membrane-associated gene involved in amino acid transport and
            glutathione metabolism
  JOURNAL   Biochem Biophys Res Commun 297 (3), 528-536 (2002)
   PUBMED   12270127
  REMARK    GeneRIF: GGTL3 protein interacts with CT120, a plasma
            membrane-associated protein possibly involved in lung
            carcinogenesis.
REFERENCE   10 (residues 1 to 662)
  AUTHORS   Figlewicz,D.A., Delattre,O., Guellaen,G., Krizus,A., Thomas,G.,
            Zucman,J. and Rouleau,G.A.
  TITLE     Mapping of human gamma-glutamyl transpeptidase genes on chromosome
            22 and other human autosomes
  JOURNAL   Genomics 17 (2), 299-305 (1993)
   PUBMED   8104871
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC033745.1, BX401449.2,
            DA117929.1 and AL049709.18.
            
            On or before Jun 15, 2006 this sequence version replaced
            NP_439895.2, NP_821158.1.
            
            Summary: This gene is a member of a gene family that encodes
            enzymes involved in both the metabolism of glutathione and in the
            transpeptidation of amino acids. Changes in the activity of
            gamma-glutamyltransferase may signal preneoplastic or toxic
            conditions in the liver or kidney. The protein encoded by this gene
            consists of a heavy and a light chain, and it can interact with
            CT120, a plasma membrane-associated protein that is possibly
            involved in lung carcinogenesis. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.106605.1,
                                           SRR3476690.883202.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336431.10/ ENSP00000338964.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..662
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.22"
     Protein         1..662
                     /product="glutathione hydrolase 7 isoform 1"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /note="gamma-glutamyltransferase-like 3;
                     gamma-glutamyltranspeptidase-like 3;
                     gamma-glutamyltransferase 4;
                     gamma-glutamyltransferase-like 5; GGT 7;
                     gamma-glutamyltranspeptidase 7; glutathione hydrolase 7"
                     /calculated_mol_wt=70336
     mat_peptide     1..472
                     /product="Glutathione hydrolase 7 heavy chain.
                     /evidence=ECO:0000250. /id=PRO_0000011066"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJ14.2)"
                     /calculated_mol_wt=50055
     Site            17
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99MZ4; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Region          26..90
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            72
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            79
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JP7; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            83
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q99JP7; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            107..127
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Region          154..654
                     /region_name="G_glu_transpept"
                     /note="Gamma-glutamyltranspeptidase; pfam01019"
                     /db_xref="CDD:425991"
     Site            198
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            267
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            283
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            330
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            353
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            394
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            452
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     mat_peptide     473..662
                     /product="Glutathione hydrolase 7 light chain.
                     /evidence=ECO:0000250. /id=PRO_0000011067"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9UJ14.2)"
                     /calculated_mol_wt=20430
     Site            519
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            523
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     Site            586
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9UJ14.2)"
     CDS             1..662
                     /gene="GGT7"
                     /gene_synonym="D20S101; GGT4; GGTL3; GGTL5"
                     /coded_by="NM_178026.3:42..2030"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS13242.2"
                     /db_xref="GeneID:2686"
                     /db_xref="HGNC:HGNC:4259"
                     /db_xref="MIM:612342"
ORIGIN      
        1 maaeneasqe salgayspvd ymsitsfprl pedepapaap lrgrkdedaf lgdpdtdpds
       61 flksarlqrl pssssemgsq dgsplretrk dpfsaaaaec scrqdgltvi vtacltfatg
      121 vtvalvmqiy fgdpqifqqg avvtdaarct slgievlskq gssvdaavaa alclgivaph
      181 ssglggggvm lvhdirrnes hlidfresap galreetlqr swetkpgllv gvpgmvkglh
      241 eahqlygrlp wsqvlafaaa vaqdgfnvth dlaralaeql ppnmserfre tflpsgrppl
      301 pgsllhrpdl aevldvlgts gpaafyaggn ltlemvaeaq haggviteed fsnysalvek
      361 pvcgvyrghl vlspppphtg palisalnil egfnltslvs reqalhwvae tlkialalas
      421 rlgdpvydst itesmddmls kveaaylrgh indsqaapap llpvyeldga ptaaqvlimg
      481 pddfivamvs slnqpfgsgl itpsgillns qmldfswpnr tanhsapsle nsvqpgkrpl
      541 sfllptvvrp aeglcgtyla lgangaargl sgltqvllnv ltlnrnlsds largrlhpdl
      601 qsnllqvdse fteeeiefle arghhvekvd vlswvhgsrr tnnfiiavkd prspdaagat
      661 il
//
