LOCUS       NM_153338               2530 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase 6 (GGT6), transcript variant
            2, mRNA.
ACCESSION   NM_153338
VERSION     NM_153338.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2530)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2530)
  AUTHORS   Saxena,R., Plenge,R.M., Bjonnes,A.C., Dashti,H.S., Okada,Y., Gad El
            Haq,W., Hammoudeh,M., Al Emadi,S., Masri,B.K., Halabi,H.,
            Badsha,H., Uthman,I.W., Margolin,L., Gupta,N., Mahfoud,Z.R.,
            Kapiri,M., Dargham,S.R., Aranki,G., Kazkaz,L.A. and Arayssi,T.
  TITLE     A Multinational Arab Genome-Wide Association Study Identifies New
            Genetic Associations for Rheumatoid Arthritis
  JOURNAL   Arthritis Rheumatol 69 (5), 976-985 (2017)
   PUBMED   28118524
  REMARK    GeneRIF: Variants of GGT6 were associated with rheumatoid arthritis
            in an Arab population.
REFERENCE   3  (bases 1 to 2530)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC345075.1, AK074646.1, BC063111.1, AK296645.1, BM720407.1 and
            AI284219.1.
            
            On Jun 2, 2019 this sequence version replaced NM_153338.3.
            
            Summary: GGT6 belongs to the gamma-glutamyltransferase (GGT; EC
            2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme
            that cleaves gamma-glutamyl peptide bonds in glutathione and other
            peptides and transfers the gamma-glutamyl moiety to acceptors. GGT
            is also key to glutathione homeostasis because it provides
            substrates for glutathione synthesis (Heisterkamp et al., 2008
            [PubMed 18357469]).[supplied by OMIM, Oct 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the 5' coding region, compared to variant 3. It encodes
            isoform b, which is shorter than isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.768231.1, AK074646.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                DC345075.1         20-96
            78-173              AK074646.1         82-177
            174-196             BC063111.1         163-185
            197-1003            AK074646.1         201-1007
            1004-1836           AK296645.1         1118-1950
            1837-2145           BC063111.1         1922-2230
            2146-2485           BM720407.1         30-369
            2486-2530           AI284219.1         8-52                c
FEATURES             Location/Qualifiers
     source          1..2530
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2530
                     /gene="GGT6"
                     /note="gamma-glutamyltransferase 6"
                     /db_xref="GeneID:124975"
                     /db_xref="HGNC:HGNC:26891"
                     /db_xref="MIM:612341"
     exon            1..196
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1442
                     /gene="GGT6"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /note="isoform b is encoded by transcript variant 2;
                     gamma-glutamyltranspeptidase 6; gamma-glutamyltransferase
                     6 homolog; glutathione hydrolase 6"
                     /codon_start=1
                     /product="glutathione hydrolase 6 isoform b"
                     /protein_id="NP_699169.2"
                     /db_xref="CCDS:CCDS11047.1"
                     /db_xref="GeneID:124975"
                     /db_xref="HGNC:HGNC:26891"
                     /db_xref="MIM:612341"
                     /translation="MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPRRHQD
                     SSRNKAGGLPGTWARVVAALLLLAVGCSLAVRQLQNQGRSTGSLGSVAPPPGGHSHGP
                     GVYHHGAIISPAGAMFWGLFHDSSSGNSTALTSGPAQTLAPGLGLPAALPTLHLLHAR
                     FGRLPWPRLLVGPTTLAQEGFLVDTPLARALVARGTEGLCPLLCHADGTPLGAGARAT
                     NPQLAAVLRSAALAPTSDLAGDALLSLLAGDLGVEVPSAVPRPTLEPAEQLPVPQGIL
                     FTTPSPSAGPELLALLEAALRSGAPIPDPCPPFLQTAVSPESSALAAVDSSGSVLLLT
                     SSLNCSFGSAHLSPSTGVLLSNLVAKSTTSAWACPLILRGSLDDTEADVLGLVASGTP
                     DVARAMTHTLLRHLAARPPTQAQHQHQGQQEPTEHPSTCGQGTLLQVAAHTEHAHVSS
                     VPHACCPFQGF"
     exon            197..399
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     exon            400..2530
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2503..2508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGT6"
                     /note="hexamer: AATAAA"
     polyA_site      2530
                     /gene="GGT6"
                     /note="major polyA site"
ORIGIN      
        1 gagacacagc cggaaaggct ggcaggcagg agggctgggg cgagcactgg ggggccatgg
       61 agcgggcaga agagcccgtg gtctatcaga agctgctgcc ctgggagcca agcttggagt
      121 cggaggagga agtggaggag gaggagacat cagaggcgct ggttctaaac ccccggaggc
      181 accaggactc ttccaggaac aaggctggcg ggctgcccgg aacctgggcc cgtgtagtgg
      241 cagccctgct gctgctggct gttggctgct ccctggctgt gaggcagctc cagaatcagg
      301 gcaggtcgac aggaagcttg ggctctgtgg cccctccacc cggcggacac tcccacggcc
      361 ctggcgtata ccaccacggt gccatcatca gccctgcagg tgccatgttt tggggcctct
      421 tccacgatag ctcctcaggc aattccacgg ccctgacatc aggcccagca cagaccctgg
      481 cccccggcct ggggctgccc gcggctctgc ccaccctgca cctgctgcat gcacgcttcg
      541 gccgcctgcc ctggccacgc ctgctagtgg gccccaccac gctggctcag gagggcttcc
      601 tggtggacac acccctggca agggctctgg tggctcgggg cacagaaggc ctctgtccac
      661 tactttgcca tgctgatggg acacccctgg gcgctggggc ccgagccacc aacccacaac
      721 tggcagctgt gcttcgcagc gcagccctcg ctcccacctc agaccttgct ggggatgctc
      781 tactgagtct actggcggga gacctggggg tggaggtgcc ctcggctgtg cccaggccca
      841 ctttggaacc agcagagcag ctacctgtgc cccagggcat cctgttcacc acccccagtc
      901 cctcagctgg cccagaactg ctggcactgt tggaggcagc cctgcgctcc ggggcgccca
      961 tccctgaccc ctgcccaccg ttcctgcaga ctgctgtgag ccccgagagc agtgccctgg
     1021 ccgccgtgga cagcagcggc tctgtgctcc ttctcacctc ctcgctcaac tgctcctttg
     1081 gctctgcaca cctgtcccca agcactgggg ttctgctcag caacctggtg gccaagtcta
     1141 ccactagtgc ctgggcctgc cccctcatcc tccgtggcag cctggatgac acagaggctg
     1201 atgtgttggg gcttgtggct tcagggaccc ctgatgtggc cagggccatg actcacaccc
     1261 tactcaggca tctggcagca aggcccccta cccaggccca gcaccagcat cagggtcagc
     1321 aagaaccaac agagcatccc agcacttgtg gccaagggac cctgctccag gtggcagccc
     1381 acacagagca cgcccatgtc tccagtgtcc cccatgcctg ctgccccttc caggggttct
     1441 aacaggatgg gggtgggtct ggcagaaggc agagttatct gaagcatggg ggcaggagca
     1501 gagcagacac agcagcaatg gagtgtgcac ccgcagggtg tggtgcctca cacctgtaat
     1561 ctcagcactt tgggtggtca aggcaggaag atacctcgag gccaggagtt tgaaactagc
     1621 ctagacaaca aagcaagatc tcatctgtac taaaaattta aaaatttgcc aggggcggtg
     1681 gcacatgcct gttgtcccag ctgcttggga ggctgaggca ggaagctcgc ttgagctcag
     1741 gagttcaagg ctgcagagag ctaggatcac accactgcac tccagcctgg acaacagagt
     1801 gagaacctgt ctttaaaata ataataataa taataaaaaa atagctgggt gcggtggctc
     1861 atgcctgtaa tcccagcact ttgggaggcc aaggcaggtg gatcacctga ggctaggagt
     1921 tcgagaccag cttgggcaac atggcgaaac cccgtctcta ctaaaaatac aaaaaattag
     1981 ctgggcatgg tggcgggcac ctgtaatccc agctacttgg gaggctgagg caggagaatc
     2041 acttgaaccc gagaggtgga ggttgcagtg aaccaagatc gcaccattgc aaccccacct
     2101 gggcaacaag agggaaaccc tgtctaaaaa aaaaaaaaaa aaaaaggatt tattatgtgc
     2161 tcactgctgg ctcaggcccc aacctctggc cttttaagtt acctagactt gagttctggc
     2221 atccagagct aacaatcatt cttcagatca cccacaccgg atggaatctc tagctatttt
     2281 atcagctaag aaaatcaggg taataacgaa aaagcagtag ggcctggggc tagcactgag
     2341 ttcagatcca gctttcagga ggacagtgga aagagtgcag agcctctgcc taggccctgg
     2401 gccccacgaa gcaggacagg cagagcccag ggtactgttg gcatctctgt ccttcccttc
     2461 aggacacccc ttacctatct gcctcaacca gactgggtac aaaataaaga tcaagtctcc
     2521 cggaaaccaa
//
