LOCUS       NM_001288702            2644 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase 6 (GGT6), transcript variant
            3, mRNA.
ACCESSION   NM_001288702 XM_005256453
VERSION     NM_001288702.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Saxena,R., Plenge,R.M., Bjonnes,A.C., Dashti,H.S., Okada,Y., Gad El
            Haq,W., Hammoudeh,M., Al Emadi,S., Masri,B.K., Halabi,H.,
            Badsha,H., Uthman,I.W., Margolin,L., Gupta,N., Mahfoud,Z.R.,
            Kapiri,M., Dargham,S.R., Aranki,G., Kazkaz,L.A. and Arayssi,T.
  TITLE     A Multinational Arab Genome-Wide Association Study Identifies New
            Genetic Associations for Rheumatoid Arthritis
  JOURNAL   Arthritis Rheumatol 69 (5), 976-985 (2017)
   PUBMED   28118524
  REMARK    GeneRIF: Variants of GGT6 were associated with rheumatoid arthritis
            in an Arab population.
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC345075.1, AK296645.1, BP276563.1, BC063111.1, BM720407.1 and
            AI284219.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001288702.1.
            
            Summary: GGT6 belongs to the gamma-glutamyltransferase (GGT; EC
            2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme
            that cleaves gamma-glutamyl peptide bonds in glutathione and other
            peptides and transfers the gamma-glutamyl moiety to acceptors. GGT
            is also key to glutathione homeostasis because it provides
            substrates for glutathione synthesis (Heisterkamp et al., 2008
            [PubMed 18357469]).[supplied by OMIM, Oct 2008].
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (c).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK296645.1, SRR7346977.953933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381550.8/ ENSP00000370962.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DC345075.1         20-20
            2-228               AK296645.1         2-228
            229-399             BP276563.1         228-398
            400-1950            AK296645.1         400-1950
            1951-2259           BC063111.1         1922-2230
            2260-2599           BM720407.1         30-369
            2600-2644           AI284219.1         8-52                c
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2644
                     /gene="GGT6"
                     /note="gamma-glutamyltransferase 6"
                     /db_xref="GeneID:124975"
                     /db_xref="HGNC:HGNC:26891"
                     /db_xref="MIM:612341"
     exon            1..196
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1556
                     /gene="GGT6"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /note="isoform c is encoded by transcript variant 3;
                     gamma-glutamyltranspeptidase 6; gamma-glutamyltransferase
                     6 homolog; glutathione hydrolase 6"
                     /codon_start=1
                     /product="glutathione hydrolase 6 isoform c"
                     /protein_id="NP_001275631.1"
                     /db_xref="CCDS:CCDS73942.1"
                     /db_xref="GeneID:124975"
                     /db_xref="HGNC:HGNC:26891"
                     /db_xref="MIM:612341"
                     /translation="MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPRRHQD
                     SSRNKAGGLPGTWARVVAALLLLAVGCSLAVRQLQNQGRSTGSLGSVAPPPGGHSHGP
                     GVYHHGAIISPAATCSHLGRELLVAGGNVVDAGVGAALCLAVVHPHATGLGAMFWGLF
                     HDSSSGNSTALTSGPAQTLAPGLGLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEG
                     FLVDTPLARALVARGTEGLCPLLCHADGTPLGAGARATNPQLAAVLRSAALAPTSDLA
                     GDALLSLLAGDLGVEVPSAVPRPTLEPAEQLPVPQGILFTTPSPSAGPELLALLEAAL
                     RSGAPIPDPCPPFLQTAVSPESSALAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLL
                     SNLVAKSTTSAWACPLILRGSLDDTEADVLGLVASGTPDVARAMTHTLLRHLAARPPT
                     QAQHQHQGQQEPTEHPSTCGQGTLLQVAAHTEHAHVSSVPHACCPFQGF"
     exon            197..399
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     exon            400..513
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     exon            514..2644
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2617..2622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGT6"
                     /note="hexamer: AATAAA"
     polyA_site      2644
                     /gene="GGT6"
                     /note="major polyA site"
ORIGIN      
        1 gagacacagc cggaaaggct ggcaggcagg agggctgggg cgagcactgg ggggccatgg
       61 agcgggcaga agagcccgtg gtctatcaga agctgctgcc ctgggagcca agcttggagt
      121 cggaggagga agtggaggag gaggagacat cagaggcgct ggttctaaac ccccggaggc
      181 accaggactc ttccaggaac aaggctggcg ggctgcccgg aacctgggcc cgtgtagtgg
      241 cagccctgct gctgctggct gttggctgct ccctggctgt gaggcagctc cagaatcagg
      301 gcaggtcgac aggaagcttg ggctctgtgg cccctccacc cggcggacac tcccacggcc
      361 ctggcgtata ccaccacggt gccatcatca gccctgcagc cacatgctcc cacctaggcc
      421 gagagctgct tgttgccggg ggcaacgtcg tggatgctgg agttggagct gcattgtgcc
      481 tggcagtggt gcatcctcat gccacggggc taggtgccat gttttggggc ctcttccacg
      541 atagctcctc aggcaattcc acggccctga catcaggccc agcacagacc ctggcccccg
      601 gcctggggct gcccgcggct ctgcccaccc tgcacctgct gcatgcacgc ttcggccgcc
      661 tgccctggcc acgcctgcta gtgggcccca ccacgctggc tcaggagggc ttcctggtgg
      721 acacacccct ggcaagggct ctggtggctc ggggcacaga aggcctctgt ccactacttt
      781 gccatgctga tgggacaccc ctgggcgctg gggcccgagc caccaaccca caactggcag
      841 ctgtgcttcg cagcgcagcc ctcgctccca cctcagacct tgctggggat gctctactga
      901 gtctactggc gggagacctg ggggtggagg tgccctcggc tgtgcccagg cccactttgg
      961 aaccagcaga gcagctacct gtgccccagg gcatcctgtt caccaccccc agtccctcag
     1021 ctggcccaga actgctggca ctgttggagg cagccctgcg ctccggggcg cccatccctg
     1081 acccctgccc accgttcctg cagactgctg tgagccccga gagcagtgcc ctggccgccg
     1141 tggacagcag cggctctgtg ctccttctca cctcctcgct caactgctcc tttggctctg
     1201 cacacctgtc cccaagcact ggggttctgc tcagcaacct ggtggccaag tctaccacta
     1261 gtgcctgggc ctgccccctc atcctccgtg gcagcctgga tgacacagag gctgatgtgt
     1321 tggggcttgt ggcttcaggg acccctgatg tggccagggc catgactcac accctactca
     1381 ggcatctggc agcaaggccc cctacccagg cccagcacca gcatcagggt cagcaagaac
     1441 caacagagca tcccagcact tgtggccaag ggaccctgct ccaggtggca gcccacacag
     1501 agcacgccca tgtctccagt gtcccccatg cctgctgccc cttccagggg ttctaacagg
     1561 atgggggtgg gtctggcaga aggcagagtt atctgaagca tgggggcagg agcagagcag
     1621 acacagcagc aatggagtgt gcacccgcag ggtgtggtgc ctcacacctg taatctcagc
     1681 actttgggtg gtcaaggcag gaagatacct cgaggccagg agtttgaaac tagcctagac
     1741 aacaaagcaa gatctcatct gtactaaaaa tttaaaaatt tgccaggggc ggtggcacat
     1801 gcctgttgtc ccagctgctt gggaggctga ggcaggaagc tcgcttgagc tcaggagttc
     1861 aaggctgcag agagctagga tcacaccact gcactccagc ctggacaaca gagtgagaac
     1921 ctgtctttaa aataataata ataataataa aaaaatagct gggtgcggtg gctcatgcct
     1981 gtaatcccag cactttggga ggccaaggca ggtggatcac ctgaggctag gagttcgaga
     2041 ccagcttggg caacatggcg aaaccccgtc tctactaaaa atacaaaaaa ttagctgggc
     2101 atggtggcgg gcacctgtaa tcccagctac ttgggaggct gaggcaggag aatcacttga
     2161 acccgagagg tggaggttgc agtgaaccaa gatcgcacca ttgcaacccc acctgggcaa
     2221 caagagggaa accctgtcta aaaaaaaaaa aaaaaaaaag gatttattat gtgctcactg
     2281 ctggctcagg ccccaacctc tggcctttta agttacctag acttgagttc tggcatccag
     2341 agctaacaat cattcttcag atcacccaca ccggatggaa tctctagcta ttttatcagc
     2401 taagaaaatc agggtaataa cgaaaaagca gtagggcctg gggctagcac tgagttcaga
     2461 tccagctttc aggaggacag tggaaagagt gcagagcctc tgcctaggcc ctgggcccca
     2521 cgaagcagga caggcagagc ccagggtact gttggcatct ctgtccttcc cttcaggaca
     2581 ccccttacct atctgcctca accagactgg gtacaaaata aagatcaagt ctcccggaaa
     2641 ccaa
//
