LOCUS       NM_001122890            2626 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase 6 (GGT6), transcript variant
            1, mRNA.
ACCESSION   NM_001122890
VERSION     NM_001122890.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2626)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2626)
  AUTHORS   Saxena,R., Plenge,R.M., Bjonnes,A.C., Dashti,H.S., Okada,Y., Gad El
            Haq,W., Hammoudeh,M., Al Emadi,S., Masri,B.K., Halabi,H.,
            Badsha,H., Uthman,I.W., Margolin,L., Gupta,N., Mahfoud,Z.R.,
            Kapiri,M., Dargham,S.R., Aranki,G., Kazkaz,L.A. and Arayssi,T.
  TITLE     A Multinational Arab Genome-Wide Association Study Identifies New
            Genetic Associations for Rheumatoid Arthritis
  JOURNAL   Arthritis Rheumatol 69 (5), 976-985 (2017)
   PUBMED   28118524
  REMARK    GeneRIF: Variants of GGT6 were associated with rheumatoid arthritis
            in an Arab population.
REFERENCE   3  (bases 1 to 2626)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC345075.1, BC063111.1, AK129501.1, BM720407.1 and AI284219.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001122890.2.
            
            Summary: GGT6 belongs to the gamma-glutamyltransferase (GGT; EC
            2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme
            that cleaves gamma-glutamyl peptide bonds in glutathione and other
            peptides and transfers the gamma-glutamyl moiety to acceptors. GGT
            is also key to glutathione homeostasis because it provides
            substrates for glutathione synthesis (Heisterkamp et al., 2008
            [PubMed 18357469]).[supplied by OMIM, Oct 2008].
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 3. It
            encodes isoform a, which is shorter than isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063111.1, AK300648.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DC345075.1         20-34
            16-228              BC063111.1         5-217
            229-229             AK129501.1         217-217
            230-2241            BC063111.1         219-2230
            2242-2581           BM720407.1         30-369
            2582-2626           AI284219.1         8-52                c
FEATURES             Location/Qualifiers
     source          1..2626
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2626
                     /gene="GGT6"
                     /note="gamma-glutamyltransferase 6"
                     /db_xref="GeneID:124975"
                     /db_xref="HGNC:HGNC:26891"
                     /db_xref="MIM:612341"
     exon            1..196
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..1538
                     /gene="GGT6"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /note="isoform a is encoded by transcript variant 1;
                     gamma-glutamyltranspeptidase 6; gamma-glutamyltransferase
                     6 homolog; glutathione hydrolase 6"
                     /codon_start=1
                     /product="glutathione hydrolase 6 isoform a"
                     /protein_id="NP_001116362.1"
                     /db_xref="CCDS:CCDS45582.1"
                     /db_xref="GeneID:124975"
                     /db_xref="HGNC:HGNC:26891"
                     /db_xref="MIM:612341"
                     /translation="MERAEEPVVYQKLLPWEPSLESEEEVEEEETSEALVLNPRRHQD
                     SSRNKAGGLPGTWARVVAALLLLAVGCSLAVRQLQNQGRSTGSLGSVAPPPGGHSHGP
                     GVYHHGAIISPAGRELLVAGGNVVDAGVGAALCLAVVHPHATGLGAMFWGLFHDSSSG
                     NSTALTSGPAQTLAPGLGLPAALPTLHLLHARFGRLPWPRLLVGPTTLAQEGFLVDTP
                     LARALVARGTEGLCPLLCHADGTPLGAGARATNPQLAAVLRSAALAPTSDLAGDALLS
                     LLAGDLGVEVPSAVPRPTLEPAEQLPVPQGILFTTPSPSAGPELLALLEAALRSGAPI
                     PDPCPPFLQTAVSPESSALAAVDSSGSVLLLTSSLNCSFGSAHLSPSTGVLLSNLVAK
                     STTSAWACPLILRGSLDDTEADVLGLVASGTPDVARAMTHTLLRHLAARPPTQAQHQH
                     QGQQEPTEHPSTCGQGTLLQVAAHTEHAHVSSVPHACCPFQGF"
     exon            197..399
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     exon            400..495
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     exon            496..2626
                     /gene="GGT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2599..2604
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGT6"
                     /note="hexamer: AATAAA"
     polyA_site      2626
                     /gene="GGT6"
                     /note="major polyA site"
ORIGIN      
        1 gagacacagc cggaaaggct ggcaggcagg agggctgggg cgagcactgg ggggccatgg
       61 agcgggcaga agagcccgtg gtctatcaga agctgctgcc ctgggagcca agcttggagt
      121 cggaggagga agtggaggag gaggagacat cagaggcgct ggttctaaac ccccggaggc
      181 accaggactc ttccaggaac aaggctggcg ggctgcccgg aacctgggcc cgtgtagtgg
      241 cagccctgct gctgctggct gttggctgct ccctggctgt gaggcagctc cagaatcagg
      301 gcaggtcgac aggaagcttg ggctctgtgg cccctccacc cggcggacac tcccacggcc
      361 ctggcgtata ccaccacggt gccatcatca gccctgcagg ccgagagctg cttgttgccg
      421 ggggcaacgt cgtggatgct ggagttggag ctgcattgtg cctggcagtg gtgcatcctc
      481 atgccacggg gctaggtgcc atgttttggg gcctcttcca cgatagctcc tcaggcaatt
      541 ccacggccct gacatcaggc ccagcacaga ccctggcccc cggcctgggg ctgcccgcgg
      601 ctctgcccac cctgcacctg ctgcatgcac gcttcggccg cctgccctgg ccacgcctgc
      661 tagtgggccc caccacgctg gctcaggagg gcttcctggt ggacacaccc ctggcaaggg
      721 ctctggtggc tcggggcaca gaaggcctct gtccactact ttgccatgct gatgggacac
      781 ccctgggcgc tggggcccga gccaccaacc cacaactggc agctgtgctt cgcagcgcag
      841 ccctcgctcc cacctcagac cttgctgggg atgctctact gagtctactg gcgggagacc
      901 tgggggtgga ggtgccctcg gctgtgccca ggcccacttt ggaaccagca gagcagctac
      961 ctgtgcccca gggcatcctg ttcaccaccc ccagtccctc agctggccca gaactgctgg
     1021 cactgttgga ggcagccctg cgctccgggg cgcccatccc tgacccctgc ccaccgttcc
     1081 tgcagactgc tgtgagcccc gagagcagtg ccctggccgc cgtggacagc agcggctctg
     1141 tgctccttct cacctcctcg ctcaactgct cctttggctc tgcacacctg tccccaagca
     1201 ctggggttct gctcagcaac ctggtggcca agtctaccac tagtgcctgg gcctgccccc
     1261 tcatcctccg tggcagcctg gatgacacag aggctgatgt gttggggctt gtggcttcag
     1321 ggacccctga tgtggccagg gccatgactc acaccctact caggcatctg gcagcaaggc
     1381 cccctaccca ggcccagcac cagcatcagg gtcagcaaga accaacagag catcccagca
     1441 cttgtggcca agggaccctg ctccaggtgg cagcccacac agagcacgcc catgtctcca
     1501 gtgtccccca tgcctgctgc cccttccagg ggttctaaca ggatgggggt gggtctggca
     1561 gaaggcagag ttatctgaag catgggggca ggagcagagc agacacagca gcaatggagt
     1621 gtgcacccgc agggtgtggt gcctcacacc tgtaatctca gcactttggg tggtcaaggc
     1681 aggaagatac ctcgaggcca ggagtttgaa actagcctag acaacaaagc aagatctcat
     1741 ctgtactaaa aatttaaaaa tttgccaggg gcggtggcac atgcctgttg tcccagctgc
     1801 ttgggaggct gaggcaggaa gctcgcttga gctcaggagt tcaaggctgc agagagctag
     1861 gatcacacca ctgcactcca gcctggacaa cagagtgaga acctgtcttt aaaataataa
     1921 taataataat aaaaaaatag ctgggtgcgg tggctcatgc ctgtaatccc agcactttgg
     1981 gaggccaagg caggtggatc acctgaggct aggagttcga gaccagcttg ggcaacatgg
     2041 cgaaaccccg tctctactaa aaatacaaaa aattagctgg gcatggtggc gggcacctgt
     2101 aatcccagct acttgggagg ctgaggcagg agaatcactt gaacccgaga ggtggaggtt
     2161 gcagtgaacc aagatcgcac cattgcaacc ccacctgggc aacaagaggg aaaccctgtc
     2221 taaaaaaaaa aaaaaaaaaa aggatttatt atgtgctcac tgctggctca ggccccaacc
     2281 tctggccttt taagttacct agacttgagt tctggcatcc agagctaaca atcattcttc
     2341 agatcaccca caccggatgg aatctctagc tattttatca gctaagaaaa tcagggtaat
     2401 aacgaaaaag cagtagggcc tggggctagc actgagttca gatccagctt tcaggaggac
     2461 agtggaaaga gtgcagagcc tctgcctagg ccctgggccc cacgaagcag gacaggcaga
     2521 gcccagggta ctgttggcat ctctgtcctt cccttcagga caccccttac ctatctgcct
     2581 caaccagact gggtacaaaa taaagatcaa gtctcccgga aaccaa
//
