LOCUS       NM_004121               2428 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase 5 (GGT5), transcript variant
            2, mRNA.
ACCESSION   NM_004121
VERSION     NM_004121.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2428)
  AUTHORS   Zhao,W., Liang,Z., Yao,Y., Ge,Y., An,G., Duan,L. and Yao,J.
  TITLE     GGT5: a potential immunotherapy response inhibitor in gastric
            cancer by modulating GSH metabolism and sustaining memory CD8+ T
            cell infiltration
  JOURNAL   Cancer Immunol Immunother 73 (7), 131 (2024)
   PUBMED   38748299
  REMARK    GeneRIF: GGT5: a potential immunotherapy response inhibitor in
            gastric cancer by modulating GSH metabolism and sustaining memory
            CD8+ T cell infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2428)
  AUTHORS   Luo,Z., Chen,Y., Chen,B., Zhao,Z., Wu,R. and Ren,J.
  TITLE     GGT5 facilitates migration and invasion through the induction of
            epithelial-mesenchymal transformation in gastric cancer
  JOURNAL   BMC Med Genomics 17 (1), 82 (2024)
   PUBMED   38581025
  REMARK    GeneRIF: GGT5 facilitates migration and invasion through the
            induction of epithelial-mesenchymal transformation in gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2428)
  AUTHORS   Gallman,A.E., Wolfreys,F.D., Nguyen,D.N., Sandy,M., Xu,Y., An,J.,
            Li,Z., Marson,A., Lu,E. and Cyster,J.G.
  TITLE     Abcc1 and Ggt5 support lymphocyte guidance through export and
            catabolism of S-geranylgeranyl-l-glutathione
  JOURNAL   Sci Immunol 6 (60) (2021)
   PUBMED   34088745
  REMARK    GeneRIF: Abcc1 and Ggt5 support lymphocyte guidance through export
            and catabolism of S-geranylgeranyl-l-glutathione.
REFERENCE   4  (bases 1 to 2428)
  AUTHORS   Wei,J.R., Dong,J. and Li,L.
  TITLE     Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5
            promotes tumor growth and drug resistance in lung adenocarcinoma
  JOURNAL   Aging (Albany NY) 12 (13), 13220-13233 (2020)
   PUBMED   32640421
  REMARK    GeneRIF: Cancer-associated fibroblasts-derived
            gamma-glutamyltransferase 5 promotes tumor growth and drug
            resistance in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 2428)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   6  (bases 1 to 2428)
  AUTHORS   Enoiu,M., Aberkane,H., Salazar,J.F., Leroy,P., Groffen,J., Siest,G.
            and Wellman,M.
  TITLE     Evidence for the pro-oxidant effect of
            gamma-glutamyltranspeptidase-related enzyme
  JOURNAL   Free Radic Biol Med 29 (9), 825-833 (2000)
   PUBMED   11063908
REFERENCE   7  (bases 1 to 2428)
  AUTHORS   Edelmann,L., Pandita,R.K. and Morrow,B.E.
  TITLE     Low-copy repeats mediate the common 3-Mb deletion in patients with
            velo-cardio-facial syndrome
  JOURNAL   Am J Hum Genet 64 (4), 1076-1086 (1999)
   PUBMED   10090893
REFERENCE   8  (bases 1 to 2428)
  AUTHORS   Potdar,P.D., Andrews,K.L., Nettesheim,P. and Ostrowski,L.E.
  TITLE     Expression and regulation of gamma-glutamyl transpeptidase-related
            enzyme in tracheal cells
  JOURNAL   Am J Physiol 273 (5), L1082-L1089 (1997)
   PUBMED   9374738
REFERENCE   9  (bases 1 to 2428)
  AUTHORS   Morris,C., Courtay,C., Geurts van Kessel,A., ten Hoeve,J.,
            Heisterkamp,N. and Groffen,J.
  TITLE     Localization of a gamma-glutamyl-transferase-related gene family on
            chromosome 22
  JOURNAL   Hum Genet 91 (1), 31-36 (1993)
   PUBMED   8095916
REFERENCE   10 (bases 1 to 2428)
  AUTHORS   Heisterkamp,N., Rajpert-De Meyts,E., Uribe,L., Forman,H.J. and
            Groffen,J.
  TITLE     Identification of a human gamma-glutamyl cleaving enzyme related
            to, but distinct from, gamma-glutamyl transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6303-6307 (1991)
   PUBMED   1676842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000354.1 and AP000353.2.
            
            On Aug 10, 2020 this sequence version replaced NM_004121.4.
            
            Summary: This gene is a member of the gamma-glutamyl transpeptidase
            gene family, and some reports indicate that it is capable of
            cleaving the gamma-glutamyl moiety of glutathione. The protein
            encoded by this gene is synthesized as a single,
            catalytically-inactive polypeptide, that is processed
            post-transcriptionally to form a heavy and light subunit, with the
            catalytic activity contained within the small subunit. The encoded
            enzyme is able to convert leukotriene C4 to leukotriene D4, but
            appears to have distinct substrate specificity compared to
            gamma-glutamyl transpeptidase. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is one amino acid shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011362.1, SRR18074969.160042.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327365.10/ ENSP00000330080.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-530               AP000354.1         23082-23611         c
            531-661             AP000354.1         12403-12533         c
            662-757             AP000354.1         12027-12122         c
            758-953             AP000354.1         11352-11547         c
            954-1111            AP000354.1         10580-10737         c
            1112-1258           AP000354.1         9913-10059          c
            1259-1395           AP000354.1         5160-5296           c
            1396-1586           AP000354.1         4605-4795           c
            1587-1693           AP000354.1         4075-4181           c
            1694-1860           AP000353.2         123537-123703       c
            1861-1971           AP000353.2         123288-123398       c
            1972-2428           AP000353.2         117952-118408       c
FEATURES             Location/Qualifiers
     source          1..2428
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..2428
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /note="gamma-glutamyltransferase 5"
                     /db_xref="GeneID:2687"
                     /db_xref="HGNC:HGNC:4260"
                     /db_xref="MIM:137168"
     exon            1..530
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..2118
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="isoform 2 is encoded by transcript variant 2;
                     gamma-glutamyltransferase-like activity 1; gamma-glutamyl
                     transpeptidase-related protein;
                     gamma-glutamyltranspeptidase 5; gamma-glutamyl cleaving
                     enzyme; gamma-glutamyl transpeptidase-related enzyme;
                     leukotriene-C4 hydrolase; glutathione hydrolase 5
                     proenzyme"
                     /codon_start=1
                     /product="glutathione hydrolase 5 proenzyme isoform 2"
                     /protein_id="NP_004112.2"
                     /db_xref="CCDS:CCDS13825.1"
                     /db_xref="GeneID:2687"
                     /db_xref="HGNC:HGNC:4260"
                     /db_xref="MIM:137168"
                     /translation="MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHA
                     AVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTG
                     KVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWA
                     QLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWP
                     ALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLG
                     DYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRW
                     RLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVS
                     VLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPVSGDR
                     VGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLW
                     LGFDLRAAIAAPILHVNSKGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQ
                     EGACVYAVSDLRKSGEAAGY"
     exon            531..661
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            662..757
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..953
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1111
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1112..1258
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1395
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1586
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1693
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1860
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1971
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2428
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2410..2415
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /note="hexamer: ATTAAA"
     polyA_site      2428
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /note="major polyA site"
ORIGIN      
        1 ggccactccg tagtgtgcac ttggtgaggg cagcagctcg ccacagctgc cagccatctg
       61 tccattcacc catctgtcca tctggcagcc cgctgttcag acctgtctgt ctgtccgccc
      121 atctgtaagc ccatctctgt cccattgtct atctgaccat ctttctctta ctgtcctctt
      181 tgtctagcta tctggcctat ctgtcgatcc atcttcgtgt ctgtcttcag cccccacctg
      241 tttgtccatc tgtccaatta cctgtgactc tgtgcatctt cttgtccatt catctgccca
      301 cccatccgtc cctccgtctg cccaccagcc gcccctctcc tcctgggctg cagagccatg
      361 gcccggggct acggggccac ggtcagccta gtcctgctgg gtctggggct ggcgctggct
      421 gtcattgtgc tggctgtggt cctctctcga caccaggccc catgtggccc ccaggccttt
      481 gcccacgctg ctgttgccgc cgactccaag gtctgctcgg atattggacg agccatcctc
      541 cagcagcagg gctcacccgt ggatgccacc atcgcggctc tggtctgcac cagcgtcgtc
      601 aaccctcaga gcatgggcct gggcggaggg gtcatcttca ccatctacaa tgtgacaaca
      661 gggaaggtgg aggtcatcaa tgcccgggag acggtgccgg ccagccacgc cccgagcctg
      721 ctggaccagt gtgcacaggc tctgccactg ggcacagggg cccagtggat cggggtgccc
      781 ggggagctcc gtggctatgc cgaggcccac cgccgccatg gccgcctgcc ctgggcgcag
      841 ctgttccagc ccaccatcgc gctgctccga ggggggcatg tggtggcccc tgtcctcagc
      901 cgtttcctgc acaacagcat cctgcggcct tccttgcagg cgtcaaccct gcgccagctc
      961 ttcttcaacg ggacagaacc cctgaggcct caggacccac tcccatggcc tgcactggcc
     1021 accaccctgg agaccgtggc cacagagggc gtggaggtct tctacacggg gaggctgggc
     1081 cagatgctgg tggaggacat tgccaaggaa gggagccagc tgacgctgca ggacctggcc
     1141 aagttccagc ccgaggtggt ggatgccctg gaggtgcccc tgggggacta taccctgtac
     1201 tcaccaccgc cgcctgcagg gggtgccatt ctcagcttta tcctcaacgt gctaagaggg
     1261 ttcaacttct caacagagtc tatggccagg cctgaaggga gggtgaacgt gtaccaccac
     1321 cttgtagaga cgctcaagtt tgccaagggg cagaggtgga ggctggggga ccctcgaagc
     1381 cacccgaagc tccagaatgc ctcccgggac ctgctggggg agaccctggc ccagctcatc
     1441 cgccaacaga tcgatggccg gggggaccac cagctcagcc actacagctt ggccgaggcc
     1501 tggggccacg ggacaggcac gtcccatgtg tctgtgctgg gggaggatgg cagcgccgtg
     1561 gctgccacca gcaccatcaa cacacccttt ggagcgatgg tgtattcacc acggacaggc
     1621 atcatcctca acaacgagct cctggactta tgcgagcgat gcccccgggg ttccggcacc
     1681 accccctcac ctgtgagtgg agacagggtg ggtggagctc ccggaaggtg ctggccccca
     1741 gttccaggcg agcgttcccc atcctccatg gtgccctcca tcttgatcaa caaagcccag
     1801 gggtcgaagc tagtgattgg cggggctggc ggggagctca tcatctctgc tgtggcccag
     1861 gccatcatga gcaagctgtg gcttggcttt gacctgagag cggccattgc agcccccatc
     1921 ctgcatgtca acagcaaggg ctgtgtggag tacgagccca acttcagcca ggaggtgcag
     1981 aggggactcc aagaccgtgg ccagaaccag acccagaggc ccttcttcct gaacgtggtc
     2041 caggctgtgt cccaggaggg ggcctgtgtg tacgccgtct cggacctgag gaagagtggg
     2101 gaggccgcag gctactaaga cactgctctg cccagagctg aagtctggcc ccaccatgag
     2161 tcctgtgtcc aggccggaca tggctggggg accaactact ctggcaggat ctggacccct
     2221 ggcaggggag tccagctgag agtggaagag gtggcgggga ccagctgggc agatgagagg
     2281 ctgagcctca tccctaaccc cctttcccag agcccctggt ggtcctgaac cggcccctct
     2341 atccctccgc aggcctcttg cctggggcca ctctcccacc ctctcgatct gtatatcctc
     2401 cagtccaaga ttaaagaggc ggactgtg
//
