LOCUS       NP_004112                586 aa            linear   PRI 30-APR-2025
DEFINITION  glutathione hydrolase 5 proenzyme isoform 2 [Homo sapiens].
ACCESSION   NP_004112
VERSION     NP_004112.2
DBSOURCE    REFSEQ: accession NM_004121.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 586)
  AUTHORS   Zhao,W., Liang,Z., Yao,Y., Ge,Y., An,G., Duan,L. and Yao,J.
  TITLE     GGT5: a potential immunotherapy response inhibitor in gastric
            cancer by modulating GSH metabolism and sustaining memory CD8+ T
            cell infiltration
  JOURNAL   Cancer Immunol Immunother 73 (7), 131 (2024)
   PUBMED   38748299
  REMARK    GeneRIF: GGT5: a potential immunotherapy response inhibitor in
            gastric cancer by modulating GSH metabolism and sustaining memory
            CD8+ T cell infiltration.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 586)
  AUTHORS   Luo,Z., Chen,Y., Chen,B., Zhao,Z., Wu,R. and Ren,J.
  TITLE     GGT5 facilitates migration and invasion through the induction of
            epithelial-mesenchymal transformation in gastric cancer
  JOURNAL   BMC Med Genomics 17 (1), 82 (2024)
   PUBMED   38581025
  REMARK    GeneRIF: GGT5 facilitates migration and invasion through the
            induction of epithelial-mesenchymal transformation in gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 586)
  AUTHORS   Gallman,A.E., Wolfreys,F.D., Nguyen,D.N., Sandy,M., Xu,Y., An,J.,
            Li,Z., Marson,A., Lu,E. and Cyster,J.G.
  TITLE     Abcc1 and Ggt5 support lymphocyte guidance through export and
            catabolism of S-geranylgeranyl-l-glutathione
  JOURNAL   Sci Immunol 6 (60) (2021)
   PUBMED   34088745
  REMARK    GeneRIF: Abcc1 and Ggt5 support lymphocyte guidance through export
            and catabolism of S-geranylgeranyl-l-glutathione.
REFERENCE   4  (residues 1 to 586)
  AUTHORS   Wei,J.R., Dong,J. and Li,L.
  TITLE     Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5
            promotes tumor growth and drug resistance in lung adenocarcinoma
  JOURNAL   Aging (Albany NY) 12 (13), 13220-13233 (2020)
   PUBMED   32640421
  REMARK    GeneRIF: Cancer-associated fibroblasts-derived
            gamma-glutamyltransferase 5 promotes tumor growth and drug
            resistance in lung adenocarcinoma.
REFERENCE   5  (residues 1 to 586)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   6  (residues 1 to 586)
  AUTHORS   Enoiu,M., Aberkane,H., Salazar,J.F., Leroy,P., Groffen,J., Siest,G.
            and Wellman,M.
  TITLE     Evidence for the pro-oxidant effect of
            gamma-glutamyltranspeptidase-related enzyme
  JOURNAL   Free Radic Biol Med 29 (9), 825-833 (2000)
   PUBMED   11063908
REFERENCE   7  (residues 1 to 586)
  AUTHORS   Edelmann,L., Pandita,R.K. and Morrow,B.E.
  TITLE     Low-copy repeats mediate the common 3-Mb deletion in patients with
            velo-cardio-facial syndrome
  JOURNAL   Am J Hum Genet 64 (4), 1076-1086 (1999)
   PUBMED   10090893
REFERENCE   8  (residues 1 to 586)
  AUTHORS   Potdar,P.D., Andrews,K.L., Nettesheim,P. and Ostrowski,L.E.
  TITLE     Expression and regulation of gamma-glutamyl transpeptidase-related
            enzyme in tracheal cells
  JOURNAL   Am J Physiol 273 (5), L1082-L1089 (1997)
   PUBMED   9374738
REFERENCE   9  (residues 1 to 586)
  AUTHORS   Morris,C., Courtay,C., Geurts van Kessel,A., ten Hoeve,J.,
            Heisterkamp,N. and Groffen,J.
  TITLE     Localization of a gamma-glutamyl-transferase-related gene family on
            chromosome 22
  JOURNAL   Hum Genet 91 (1), 31-36 (1993)
   PUBMED   8095916
REFERENCE   10 (residues 1 to 586)
  AUTHORS   Heisterkamp,N., Rajpert-De Meyts,E., Uribe,L., Forman,H.J. and
            Groffen,J.
  TITLE     Identification of a human gamma-glutamyl cleaving enzyme related
            to, but distinct from, gamma-glutamyl transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6303-6307 (1991)
   PUBMED   1676842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000354.1 and AP000353.2.
            
            On Jul 24, 2007 this sequence version replaced NP_004112.1.
            
            Summary: This gene is a member of the gamma-glutamyl transpeptidase
            gene family, and some reports indicate that it is capable of
            cleaving the gamma-glutamyl moiety of glutathione. The protein
            encoded by this gene is synthesized as a single,
            catalytically-inactive polypeptide, that is processed
            post-transcriptionally to form a heavy and light subunit, with the
            catalytic activity contained within the small subunit. The encoded
            enzyme is able to convert leukotriene C4 to leukotriene D4, but
            appears to have distinct substrate specificity compared to
            gamma-glutamyl transpeptidase. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is one amino acid shorter than isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011362.1, SRR18074969.160042.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327365.10/ ENSP00000330080.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..586
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     Protein         1..586
                     /product="glutathione hydrolase 5 proenzyme isoform 2"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="gamma-glutamyltransferase-like activity 1;
                     gamma-glutamyl transpeptidase-related protein;
                     gamma-glutamyltranspeptidase 5; gamma-glutamyl cleaving
                     enzyme; gamma-glutamyl transpeptidase-related enzyme;
                     leukotriene-C4 hydrolase; glutathione hydrolase 5
                     proenzyme"
                     /calculated_mol_wt=62130
     mat_peptide     1..387
                     /product="Glutathione hydrolase 5 heavy chain.
                     /evidence=ECO:0000250|UniProtKB:P19440.
                     /id=PRO_0000011072"
                     /note="propagated from UniProtKB/Swiss-Prot (P36269.2)"
                     /calculated_mol_wt=41483
     Site            9..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P36269.2)"
     Region          58..581
                     /region_name="G_glu_transpept"
                     /note="Gamma-glutamyltranspeptidase; pfam01019"
                     /db_xref="CDD:425991"
     Site            98
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36269.2)"
     Site            204
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36269.2)"
     Site            303
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36269.2)"
     Site            347
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36269.2)"
     mat_peptide     388..586
                     /product="Glutathione hydrolase 5 light chain.
                     /evidence=ECO:0000250|UniProtKB:P19440.
                     /id=PRO_0000011073"
                     /note="propagated from UniProtKB/Swiss-Prot (P36269.2)"
                     /calculated_mol_wt=20797
     Site            535
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P36269.2)"
     Site            550
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218; propagated from
                     UniProtKB/Swiss-Prot (P36269.2)"
     CDS             1..586
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /coded_by="NM_004121.5:358..2118"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS13825.1"
                     /db_xref="GeneID:2687"
                     /db_xref="HGNC:HGNC:4260"
                     /db_xref="MIM:137168"
ORIGIN      
        1 margygatvs lvllglglal avivlavvls rhqapcgpqa fahaavaads kvcsdigrai
       61 lqqqgspvda tiaalvctsv vnpqsmglgg gviftiynvt tgkvevinar etvpashaps
      121 lldqcaqalp lgtgaqwigv pgelrgyaea hrrhgrlpwa qlfqptiall rgghvvapvl
      181 srflhnsilr pslqastlrq lffngteplr pqdplpwpal attletvate gvevfytgrl
      241 gqmlvediak egsqltlqdl akfqpevvda levplgdytl ysppppagga ilsfilnvlr
      301 gfnfstesma rpegrvnvyh hlvetlkfak gqrwrlgdpr shpklqnasr dllgetlaql
      361 irqqidgrgd hqlshyslae awghgtgtsh vsvlgedgsa vaatstintp fgamvysprt
      421 giilnnelld lcercprgsg ttpspvsgdr vggapgrcwp pvpgerspss mvpsilinka
      481 qgsklvigga ggeliisava qaimsklwlg fdlraaiaap ilhvnskgcv eyepnfsqev
      541 qrglqdrgqn qtqrpfflnv vqavsqegac vyavsdlrks geaagy
//
