LOCUS       NM_001302465            2283 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens gamma-glutamyltransferase 5 (GGT5), transcript variant
            5, mRNA.
ACCESSION   NM_001302465
VERSION     NM_001302465.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2283)
  AUTHORS   Zhao,W., Liang,Z., Yao,Y., Ge,Y., An,G., Duan,L. and Yao,J.
  TITLE     GGT5: a potential immunotherapy response inhibitor in gastric
            cancer by modulating GSH metabolism and sustaining memory CD8+ T
            cell infiltration
  JOURNAL   Cancer Immunol Immunother 73 (7), 131 (2024)
   PUBMED   38748299
  REMARK    GeneRIF: GGT5: a potential immunotherapy response inhibitor in
            gastric cancer by modulating GSH metabolism and sustaining memory
            CD8+ T cell infiltration.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2283)
  AUTHORS   Luo,Z., Chen,Y., Chen,B., Zhao,Z., Wu,R. and Ren,J.
  TITLE     GGT5 facilitates migration and invasion through the induction of
            epithelial-mesenchymal transformation in gastric cancer
  JOURNAL   BMC Med Genomics 17 (1), 82 (2024)
   PUBMED   38581025
  REMARK    GeneRIF: GGT5 facilitates migration and invasion through the
            induction of epithelial-mesenchymal transformation in gastric
            cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2283)
  AUTHORS   Gallman,A.E., Wolfreys,F.D., Nguyen,D.N., Sandy,M., Xu,Y., An,J.,
            Li,Z., Marson,A., Lu,E. and Cyster,J.G.
  TITLE     Abcc1 and Ggt5 support lymphocyte guidance through export and
            catabolism of S-geranylgeranyl-l-glutathione
  JOURNAL   Sci Immunol 6 (60) (2021)
   PUBMED   34088745
  REMARK    GeneRIF: Abcc1 and Ggt5 support lymphocyte guidance through export
            and catabolism of S-geranylgeranyl-l-glutathione.
REFERENCE   4  (bases 1 to 2283)
  AUTHORS   Wei,J.R., Dong,J. and Li,L.
  TITLE     Cancer-associated fibroblasts-derived gamma-glutamyltransferase 5
            promotes tumor growth and drug resistance in lung adenocarcinoma
  JOURNAL   Aging (Albany NY) 12 (13), 13220-13233 (2020)
   PUBMED   32640421
  REMARK    GeneRIF: Cancer-associated fibroblasts-derived
            gamma-glutamyltransferase 5 promotes tumor growth and drug
            resistance in lung adenocarcinoma.
REFERENCE   5  (bases 1 to 2283)
  AUTHORS   Heisterkamp,N., Groffen,J., Warburton,D. and Sneddon,T.P.
  TITLE     The human gamma-glutamyltransferase gene family
  JOURNAL   Hum Genet 123 (4), 321-332 (2008)
   PUBMED   18357469
REFERENCE   6  (bases 1 to 2283)
  AUTHORS   Enoiu,M., Aberkane,H., Salazar,J.F., Leroy,P., Groffen,J., Siest,G.
            and Wellman,M.
  TITLE     Evidence for the pro-oxidant effect of
            gamma-glutamyltranspeptidase-related enzyme
  JOURNAL   Free Radic Biol Med 29 (9), 825-833 (2000)
   PUBMED   11063908
REFERENCE   7  (bases 1 to 2283)
  AUTHORS   Edelmann,L., Pandita,R.K. and Morrow,B.E.
  TITLE     Low-copy repeats mediate the common 3-Mb deletion in patients with
            velo-cardio-facial syndrome
  JOURNAL   Am J Hum Genet 64 (4), 1076-1086 (1999)
   PUBMED   10090893
REFERENCE   8  (bases 1 to 2283)
  AUTHORS   Potdar,P.D., Andrews,K.L., Nettesheim,P. and Ostrowski,L.E.
  TITLE     Expression and regulation of gamma-glutamyl transpeptidase-related
            enzyme in tracheal cells
  JOURNAL   Am J Physiol 273 (5), L1082-L1089 (1997)
   PUBMED   9374738
REFERENCE   9  (bases 1 to 2283)
  AUTHORS   Morris,C., Courtay,C., Geurts van Kessel,A., ten Hoeve,J.,
            Heisterkamp,N. and Groffen,J.
  TITLE     Localization of a gamma-glutamyl-transferase-related gene family on
            chromosome 22
  JOURNAL   Hum Genet 91 (1), 31-36 (1993)
   PUBMED   8095916
REFERENCE   10 (bases 1 to 2283)
  AUTHORS   Heisterkamp,N., Rajpert-De Meyts,E., Uribe,L., Forman,H.J. and
            Groffen,J.
  TITLE     Identification of a human gamma-glutamyl cleaving enzyme related
            to, but distinct from, gamma-glutamyl transpeptidase
  JOURNAL   Proc Natl Acad Sci U S A 88 (14), 6303-6307 (1991)
   PUBMED   1676842
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX403504.2, AK293683.1,
            BC073999.1 and BU728951.1.
            
            Summary: This gene is a member of the gamma-glutamyl transpeptidase
            gene family, and some reports indicate that it is capable of
            cleaving the gamma-glutamyl moiety of glutathione. The protein
            encoded by this gene is synthesized as a single,
            catalytically-inactive polypeptide, that is processed
            post-transcriptionally to form a heavy and light subunit, with the
            catalytic activity contained within the small subunit. The encoded
            enzyme is able to convert leukotriene C4 to leukotriene D4, but
            appears to have distinct substrate specificity compared to
            gamma-glutamyl transpeptidase. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, Oct 2014].
            
            Transcript Variant: This variant (5) lacks two alternate exons and
            uses an alternate splice site in the 5' coding region, compared to
            variant 1. The encoded isoform (5) is shorter and contains a
            distinct internal segment, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293683.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                BX403504.2         1-60
            61-1174             AK293683.1         1-1114
            1175-2260           BC073999.1         1323-2408
            2261-2283           BU728951.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..2283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q11.23"
     gene            1..2283
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /note="gamma-glutamyltransferase 5"
                     /db_xref="GeneID:2687"
                     /db_xref="HGNC:HGNC:4260"
                     /db_xref="MIM:137168"
     exon            1..590
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             418..1950
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /EC_number="2.3.2.2"
                     /EC_number="3.4.19.13"
                     /EC_number="3.4.19.14"
                     /note="isoform 5 is encoded by transcript variant 5;
                     gamma-glutamyltransferase-like activity 1; gamma-glutamyl
                     transpeptidase-related protein;
                     gamma-glutamyltranspeptidase 5; gamma-glutamyl cleaving
                     enzyme; gamma-glutamyl transpeptidase-related enzyme;
                     leukotriene-C4 hydrolase; glutathione hydrolase 5
                     proenzyme"
                     /codon_start=1
                     /product="glutathione hydrolase 5 proenzyme isoform 5"
                     /protein_id="NP_001289394.1"
                     /db_xref="GeneID:2687"
                     /db_xref="HGNC:HGNC:4260"
                     /db_xref="MIM:137168"
                     /translation="MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHA
                     AVAADSKVCSDIGRGPVDRGARGAPWLCRGPPPPWPPALGAAVPAHHRAAPRGACGGP
                     CPQPFPAQQHPAAFLAGVNPALFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYT
                     GRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFI
                     LNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLL
                     GETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPF
                     GAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPAVSGDRVGGAPGRCWPPVPGERSP
                     SSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNS
                     KGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEGACVYAVSDLRKSGEAA
                     GY"
     exon            591..786
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            787..940
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1087
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1224
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1415
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1522
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1692
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1803
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2266
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2242..2247
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /note="hexamer: ATTAAA"
     polyA_site      2260
                     /gene="GGT5"
                     /gene_synonym="GGL; GGT 5; GGT-REL; GGTLA1"
                     /note="major polyA site"
ORIGIN      
        1 tgcctggcct cctgccagca acaagcagga gctgaaaacc agaagttgag gcgtgagttt
       61 ggccactccg tagtgtgcac ttggtgaggg cagcagctcg ccacagctgc cagccatctg
      121 tccattcacc catctgtcca tctggcagcc cgctgttcag acctgtctgt ctgtccgccc
      181 atctgtaagc ccatctctgt cccattgtct atctgaccat ctttctctta ctgtcctctt
      241 tgtctagcta tctggcctat ctgtcgatcc atcttcgtgt ctgtcttcag cccccacctg
      301 tttgtccatc tgtccaatta cctgtgactc tgtgcatctt cttgtccatt catctgccca
      361 cccatccgtc cctccgtctg cccaccagcc gcccctctcc tcctgggctg cagagccatg
      421 gcccggggct acggggccac ggtcagccta gtcctgctgg gtctggggct ggcgctggct
      481 gtcattgtgc tggctgtggt cctctctcga caccaggccc catgtggccc ccaggccttt
      541 gcccacgctg ctgttgccgc cgactccaag gtctgctcgg atattggacg gggcccagtg
      601 gatcggggtg cccggggagc tccgtggcta tgccgaggcc caccgccgcc atggccgcct
      661 gccctgggcg cagctgttcc agcccaccat cgcgctgctc cgaggggggc atgtggtggc
      721 ccctgtcctc agccgtttcc tgcacaacag catcctgcgg ccttccttgc aggcgtcaac
      781 cctgcgctct tcttcaacgg gacagaaccc ctgaggcctc aggacccact cccatggcct
      841 gcactggcca ccaccctgga gaccgtggcc acagagggcg tggaggtctt ctacacgggg
      901 aggctgggcc agatgctggt ggaggacatt gccaaggaag ggagccagct gacgctgcag
      961 gacctggcca agttccagcc cgaggtggtg gatgccctgg aggtgcccct gggggactat
     1021 accctgtact caccaccgcc gcctgcaggg ggtgccattc tcagctttat cctcaacgtg
     1081 ctaagagggt tcaacttctc aacagagtct atggccaggc ctgaagggag ggtgaacgtg
     1141 taccaccacc ttgtagagac gctcaagttt gccaaggggc agaggtggag gctgggggac
     1201 cctcgaagcc acccgaagct ccagaatgcc tcccgggacc tgctggggga gaccctggcc
     1261 cagctcatcc gccaacagat cgatggccgg ggggaccacc agctcagcca ctacagcttg
     1321 gccgaggcct ggggccacgg gacaggcacg tcccatgtgt ctgtgctggg ggaggatggc
     1381 agcgccgtgg ctgccaccag caccatcaac acaccctttg gagcgatggt gtattcacca
     1441 cggacaggca tcatcctcaa caacgagctc ctggacttat gcgagcgatg cccccggggt
     1501 tccggcacca ccccctcacc tgcagtgagt ggagacaggg tgggtggagc tcccggaagg
     1561 tgctggcccc cagttccagg cgagcgttcc ccatcctcca tggtgccctc catcttgatc
     1621 aacaaagccc aggggtcgaa gctagtgatt ggcggggctg gcggggagct catcatctct
     1681 gctgtggccc aggccatcat gagcaagctg tggcttggct ttgacctgag agcggccatt
     1741 gcagccccca tcctgcatgt caacagcaag ggctgtgtgg agtacgagcc caacttcagc
     1801 caggaggtgc agaggggact ccaagaccgt ggccagaacc agacccagag gcccttcttc
     1861 ctgaacgtgg tccaggctgt gtcccaggag ggggcctgtg tgtacgccgt ctcggacctg
     1921 aggaagagtg gggaggccgc aggctactaa gacactgctc tgcccagagc tgaagtctgg
     1981 ccccaccatg agtcctgtgt ccaggccgga catggctggg ggaccaacta ctctggcagg
     2041 atctggaccc ctggcagggg agtccagctg agagtggaag aggtggcggg gaccagctgg
     2101 gcagatgaga ggctgagcct catccctaac cccctttccc agagcccctg gtggtcctga
     2161 accggcccct ctatccctcc gcaggcctct tgcctggggc cactctccca ccctctcgat
     2221 ctgtatatcc tccagtccaa gattaaagag gcggactgtg gcctgaaaaa aaaaaaaaaa
     2281 aaa
//
