LOCUS       NM_024835               2816 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens gametogenetin binding protein 2 (GGNBP2), mRNA.
ACCESSION   NM_024835
VERSION     NM_024835.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2816)
  AUTHORS   Xu,X., Zhu,Z., Xu,Y., Tian,S., Jiang,Y. and Zhao,H.
  TITLE     Effects of zinc finger protein 403 on the proliferation, migration
            and invasion abilities of prostate cancer cells
  JOURNAL   Oncol Rep 44 (6), 2455-2464 (2020)
   PUBMED   33125130
  REMARK    GeneRIF: Effects of zinc finger protein 403 on the proliferation,
            migration and invasion abilities of prostate cancer cells.
REFERENCE   2  (bases 1 to 2816)
  AUTHORS   Yang,Z., Wang,Y. and Ma,L.
  TITLE     Effects of gametogenetin-binding protein 2 on proliferation,
            invasion and migration of prostate cancer PC-3 cells
  JOURNAL   Andrologia 52 (2), e13488 (2020)
   PUBMED   31797427
  REMARK    GeneRIF: Effects of gametogenetin-binding protein 2 on
            proliferation, invasion and migration of prostate cancer PC-3
            cells.
REFERENCE   3  (bases 1 to 2816)
  AUTHORS   Liu,J., Liu,L., Yague,E., Yang,Q., Pan,T., Zhao,H., Hu,Y. and
            Zhang,J.
  TITLE     GGNBP2 suppresses triple-negative breast cancer aggressiveness
            through inhibition of IL-6/STAT3 signaling activation
  JOURNAL   Breast Cancer Res Treat 174 (1), 65-78 (2019)
   PUBMED   30450530
  REMARK    GeneRIF: Our data demonstrate that GGNBP2 suppresses cancer
            aggressiveness by inhibition of IL-6/STAT3 activation in
            triple-negative breast cancer
REFERENCE   4  (bases 1 to 2816)
  AUTHORS   Zhu,Z., Lou,C., Zheng,Z., Zhu,R., Tian,S., Xie,C. and Zhao,H.
  TITLE     ZFP403, a novel tumor suppressor, inhibits the proliferation and
            metastasis in ovarian cancer
  JOURNAL   Gynecol Oncol 147 (2), 418-425 (2017)
   PUBMED   28864131
  REMARK    GeneRIF: The effects of ZFP403 on cell proliferation and metastasis
            suggest that it may serve as a tumor suppressor in ovarian cancer.
REFERENCE   5  (bases 1 to 2816)
  AUTHORS   Lan,Z.J., Hu,Y., Zhang,S., Li,X., Zhou,H., Ding,J., Klinge,C.M.,
            Radde,B.N., Cooney,A.J., Zhang,J. and Lei,Z.
  TITLE     GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor
            alpha activity in breast cancer cells
  JOURNAL   Breast Cancer Res Treat 158 (2), 263-276 (2016)
   PUBMED   27357812
  REMARK    GeneRIF: Results identified GGNBP2 as a novel tumor suppressor
            which is downregulated in human breast tumors and cell lines and
            suggest that GGNBP2 may function as a corepressor to inhibit ERa's
            transcriptional activity and consequently inhibit tumorigenic
            potential of breast cancer cells.
REFERENCE   6  (bases 1 to 2816)
  AUTHORS   Yin,F., Liu,L., Liu,X., Li,G., Zheng,L., Li,D., Wang,Q., Zhang,W.
            and Li,L.
  TITLE     Downregulation of tumor suppressor gene ribonuclease T2 and
            gametogenetin binding protein 2 is associated with drug resistance
            in ovarian cancer
  JOURNAL   Oncol Rep 32 (1), 362-372 (2014)
   PUBMED   24842157
  REMARK    GeneRIF: Results show that downregulation of RNASET2 and GGNBP2 in
            drug-resistant ovarian cancer tissues/cells contributes to the
            regulation of drug resistance in ovarian cancer.
REFERENCE   7  (bases 1 to 2816)
  AUTHORS   Guan,R., Wen,X.Y., Wu,J., Duan,R., Cao,H., Lam,S., Hou,D., Wang,Y.,
            Hu,J. and Chen,Z.
  TITLE     Knockdown of ZNF403 inhibits cell proliferation and induces G2/M
            arrest by modulating cell-cycle mediators
  JOURNAL   Mol Cell Biochem 365 (1-2), 211-222 (2012)
   PUBMED   22350815
  REMARK    GeneRIF: There is an essential role for ZNF403 in cell
            proliferation and G2/M cell-cycle transition.
REFERENCE   8  (bases 1 to 2816)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
REFERENCE   9  (bases 1 to 2816)
  AUTHORS   Li,Y. and Chen,Z.
  TITLE     Molecular cloning and characterization of LCRG1 a novel gene
            localized to the tumor suppressor locus D17S800-D17S930
  JOURNAL   Cancer Lett 209 (1), 75-85 (2004)
   PUBMED   15145523
  REMARK    GeneRIF: LCRG1 is a novel gene localized to the tumor suppressor
            locus D17S800-D17S930 involved in laryngeal carcinoma.
REFERENCE   10 (bases 1 to 2816)
  AUTHORS   Ohbayashi,T., Oikawa,K., Iwata,R., Kameta,A., Evine,K., Isobe,T.,
            Matsuda,Y., Mimura,J., Fujii-Kuriyama,Y., Kuroda,M. and Mukai,K.
  TITLE     Dioxin induces a novel nuclear factor, DIF-3, that is implicated in
            spermatogenesis
  JOURNAL   FEBS Lett 508 (3), 341-344 (2001)
   PUBMED   11728448
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA494492.1, BC137491.1 and AF126964.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024835.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.3666.1,
                                           SRR1660805.73604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000613102.5/ ENSP00000478220.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               DA494492.1         32-134
            104-2525            BC137491.1         1-2422
            2526-2816           AF126964.1         2288-2578
FEATURES             Location/Qualifiers
     source          1..2816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..2816
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /note="gametogenetin binding protein 2"
                     /db_xref="GeneID:79893"
                     /db_xref="HGNC:HGNC:19357"
                     /db_xref="MIM:612275"
     exon            1..179
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            180..378
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     CDS             286..2379
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /note="C3HC4-type zinc finger protein; zinc finger protein
                     403; laryngeal carcinoma related gene 1; laryngeal
                     carcinoma-related protein 1"
                     /codon_start=1
                     /product="gametogenetin-binding protein 2"
                     /protein_id="NP_079111.1"
                     /db_xref="CCDS:CCDS11314.1"
                     /db_xref="GeneID:79893"
                     /db_xref="HGNC:HGNC:19357"
                     /db_xref="MIM:612275"
                     /translation="MARLVAVCRDGEEEFPFERRQIPLYIDDTLTMVMEFPDNVLNLD
                     GHQNNGAQLKQFIQRHGMLKQQDLSIAMVVTSREVLSALSQLVPCVGCRRSVERLFSQ
                     LVESGNPALEPLTVGPKGVLSVTRSCMTDAKKLYTLFYVHGSKLNDMIDAIPKSKKNK
                     RCQLHSLDTHKPKPLGGCWMDVWELMSQECRDEVVLIDSSCLLETLETYLRKHRFCTD
                     CKNKVLRAYNILIGELDCSKEKGYCAALYEGLRCCPHERHIHVCCETDFIAHLLGRAE
                     PEFAGGRRERHAKTIDIAQEEVLTCLGIHLYERLHRIWQKLRAEEQTWQMLFYLGVDA
                     LRKSFEMTVEKVQGISRLEQLCEEFSEEERVRELKQEKKRQKRKNRRKNKCVCDIPTP
                     LQTADEKEVSQEKETDFIENSSCKACGSTEDGNTCVEVIVTNENTSCTCPSSGNLLGS
                     PKIKKGLSPHCNGSDCGYSSSMEGSETGSREGSDVACTEGICNHDEHGDDSCVHHCED
                     KEDDGDSCVECWANSEENDTKGKNKKKKKKSKILKCDEHIQKLGSCITDPGNRETSGN
                     TMHTVFHRDKTKDTHPESCCSSEKGGQPLPWFEHRKNVPQFAEPTETLFGPDSGKGAK
                     SLVELLDESECTSDEEIFISQDEIQSFMANNQSFYSNREQYRQHLKEKFNKYCRLNDH
                     KRPICSGWLTTAGAN"
     exon            379..459
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            460..713
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            714..812
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            813..926
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1130
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1305
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1500
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            1501..1651
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1777
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1926
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..2175
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2816
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2383..2388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /note="hexamer: AATAAA"
     polyA_site      2416
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /note="major polyA site"
     regulatory      2784..2789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /note="hexamer: AATAAA"
     polyA_site      2816
                     /gene="GGNBP2"
                     /gene_synonym="DIF-3; DIF3; LCRG1; LZK1; ZFP403; ZNF403"
                     /note="major polyA site"
ORIGIN      
        1 cactccccgc ggcgcgagcg gctgactgcc cgtagaggaa acgacattcg gagctgcgct
       61 cccgcccacg ccggccctga cgcgggcctc gtcagccagt aacagggagc agaggtggga
      121 gttagcgagg cgaccacgaa aacggtgaag gtcggaaccg acagcctcct ccgagaaggg
      181 caggagctgg gaggaggcgg cagcggcggc ggcagaaaca gcagcggcgg cggcggcggc
      241 agctgggagg aggtggtgac ggtggcaacg gcagcgtcgg ggacgatggc gcgactcgtg
      301 gcagtgtgca gggacgggga ggaggagttc cccttcgaga ggaggcagat tcccctctac
      361 atagacgaca ccctgacgat ggtgatggaa tttcctgata atgtgttaaa tctcgatgga
      421 catcagaata atggtgcaca gctaaagcag ttcattcagc gacatggtat gcttaagcaa
      481 caggatctaa gtattgccat ggtggtgaca tcacgcgaag tcctgagtgc actttctcag
      541 cttgtcccat gtgttggttg tcgtcgcagt gtggagcgtc tcttttccca gcttgtagag
      601 tctggaaatc ctgctcttga acccctaaca gtagggccca agggagtcct gtctgtaact
      661 agaagctgca tgactgatgc aaagaagctt tatacattat tttatgtaca tgggtccaaa
      721 ctaaatgaca tgatagatgc tattccaaaa agtaagaaga ataagagatg tcagttgcac
      781 tccttagata cgcacaagcc aaaacctttg ggaggttgtt ggatggatgt atgggaacta
      841 atgtcgcagg aatgcaggga tgaagtagtt ttaattgact cgagttgtct tttagaaaca
      901 ctagaaacat atctgcgaaa acacaggttt tgcactgatt gcaaaaataa agtcctccga
      961 gcatacaata tccttattgg tgaacttgac tgcagcaaag aaaagggcta ctgtgctgca
     1021 ctttatgaag gcttgcggtg ctgtccacat gaacgacaca tacatgtttg ctgtgaaaca
     1081 gacttcattg cacatctttt gggtcgtgct gagccagagt tcgcaggagg gcgaagagaa
     1141 aggcatgcaa agacaataga tatagctcaa gaagaagttc tgacctgctt gggaattcat
     1201 ctttatgaaa gactgcatcg aatctggcag aagctacggg cagaagagca gacatggcag
     1261 atgcttttct atcttggtgt tgatgcttta cgcaagagtt ttgagatgac cgtggaaaaa
     1321 gtacagggta ttagcagatt ggaacaactt tgtgaggaat tttcagaaga ggaacgagta
     1381 agagaactca agcaagaaaa gaaacgccaa aaacggaaga atagacgaaa aaataagtgt
     1441 gtgtgtgata ttcctactcc cttacaaaca gcagatgaaa aggaagtaag ccaagagaag
     1501 gaaacagact tcatagaaaa tagcagctgc aaagcctgtg gcagcactga agatggtaat
     1561 acttgtgtag aagtaattgt taccaatgaa aatacatcat gtacctgtcc tagcagtggc
     1621 aatcttttgg ggtcccctaa aataaagaaa ggcttatctc cacactgtaa tggtagtgat
     1681 tgtggatatt catctagcat ggaagggagt gaaacaggtt ctcgggaggg ttcggatgtt
     1741 gcctgcactg aaggcatttg taatcatgat gaacacggtg atgactcttg tgttcatcac
     1801 tgtgaagaca aagaggatga tggtgatagt tgtgttgaat gttgggcaaa ttctgaagag
     1861 aacgacacaa aaggaaaaaa taaaaagaag aagaagaaaa gcaagatact gaaatgtgat
     1921 gaacatatcc agaagcttgg aagctgtatt acagatccag gtaatcgaga gacctcagga
     1981 aataccatgc acacagtgtt tcaccgtgac aagaccaaag atacacatcc tgaaagctgt
     2041 tgcagctctg aaaagggtgg gcagccattg ccttggtttg agcataggaa aaatgtacca
     2101 cagtttgcag aacctacaga aacgttgttt ggtcccgatt ccggaaaagg tgccaagagc
     2161 ttagttgaac tccttgatga gtctgaatgt acttcagatg aggaaatctt tatctcacaa
     2221 gatgaaatac agtcatttat ggctaataac cagtctttct acagcaatag agaacaatac
     2281 cgacagcatc tgaaggagaa atttaataaa tactgccggt taaatgatca caagaggccc
     2341 atttgtagtg gctggttgac aacggctgga gcaaattaaa taaataaaat agctctgtct
     2401 ttcaatgaaa cactcacgat gactactgcg ccttctcttt cgaaaaactc ttaatttagt
     2461 gacttatggc aaaattttat cttaaatcaa tgtgattctt tcttgttttg ggagacggtg
     2521 gaggtatcct cattagttct ttcttcaggc ttgtgtcttt agttgcgtgg ctgcgcaggc
     2581 ctgccatatg atttaagcca tctcttttca ttaaatgttt ctcttcctgt gagacttact
     2641 aaagcaactt agtggcaaaa agtaatgttg tacttataat tctgtacaga aatgacaatg
     2701 agctgaatat atggttttac aaagtagaca tccacttgca aaatgtttgg atgtaatgtt
     2761 aaagcgcaat gtgcaaaatt taaaataaag aatatttatt aatacgcaca gtaaaa
//
