LOCUS       NM_152657               2245 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens gametogenetin (GGN), mRNA.
ACCESSION   NM_152657
VERSION     NM_152657.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2245)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2245)
  AUTHORS   Wang,W., Li,C., Chen,Y., Teng,L., Cao,Y., Xu,Y., Pan,H. and An,R.
  TITLE     Increased expression of GGN promotes tumorigenesis in bladder
            cancer and is correlated with poor prognosis
  JOURNAL   Gene 652, 7-15 (2018)
   PUBMED   29412153
  REMARK    GeneRIF: GGN played a tumor-promoting role in bladder cancer
            through regulation of NFkappaB/caspase3-mediated apoptosis
            signaling.
REFERENCE   3  (bases 1 to 2245)
  AUTHORS   Jamsai,D., Sarraj,M.A., Merriner,D.J., Drummond,A.E., Jones,K.T.,
            McLachlan,R.I. and O'Bryan,M.K.
  TITLE     GGN1 in the testis and ovary and its variance within the Australian
            fertile and infertile male population
  JOURNAL   Int J Androl 34 (6 Pt 1), 624-632 (2011)
   PUBMED   21114676
  REMARK    GeneRIF: No significant associations with fertility status were
            observed, suggesting that variance in the GGN gene are not a common
            cause of oligospermic infertility in Australian men
REFERENCE   4  (bases 1 to 2245)
  AUTHORS   Zhang,J., Wang,Y., Zhou,Y., Cao,Z., Huang,P. and Lu,B.
  TITLE     Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are
            potential interaction partners of testicular germ cell-specific
            protein GGN1
  JOURNAL   FEBS Lett 579 (2), 559-566 (2005)
   PUBMED   15642376
REFERENCE   5  (bases 1 to 2245)
  AUTHORS   Lu,B. and Bishop,C.E.
  TITLE     Mouse GGN1 and GGN3, two germ cell-specific proteins from the
            single gene Ggn, interact with mouse POG and play a role in
            spermatogenesis
  JOURNAL   J Biol Chem 278 (18), 16289-16296 (2003)
   PUBMED   12574169
  REMARK    GeneRIF: GGN1 and GGN3, interacted with POG, regulated the
            localization of POG, and played a role in spermatogenesis.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005789.1.
            
            On May 17, 2019 this sequence version replaced NM_152657.3.
            
            Summary: This gene is a germ cell-specific gene that encodes
            proteins that interact with POG (proliferation of germ cells).
            Alternatively spliced transcript variants of a similar mouse gene
            encode at least three different proteins, namely gametogenetin
            protein 1a, gametogenetin protein 2, and gametogenetin protein 3,
            which show a perinuclear, cytoplasmic, and nucleolar localization,
            respectively. These proteins regulate the localization of POG and
            may play a role in spermatogenesis. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035008.2, AF538035.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334928.11/ ENSP00000334940.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC005789.1         22466-22525         c
            61-122              AC005789.1         22252-22313         c
            123-1982            AC005789.1         19912-21771         c
            1983-2245           AC005789.1         18758-19020         c
FEATURES             Location/Qualifiers
     source          1..2245
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2245
                     /gene="GGN"
                     /note="gametogenetin"
                     /db_xref="GeneID:199720"
                     /db_xref="HGNC:HGNC:18869"
                     /db_xref="MIM:609966"
     exon            1..60
                     /gene="GGN"
                     /inference="alignment:Splign:2.1.0"
     exon            61..122
                     /gene="GGN"
                     /inference="alignment:Splign:2.1.0"
     exon            123..1982
                     /gene="GGN"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..2100
                     /gene="GGN"
                     /codon_start=1
                     /product="gametogenetin"
                     /protein_id="NP_689870.3"
                     /db_xref="CCDS:CCDS12516.1"
                     /db_xref="GeneID:199720"
                     /db_xref="HGNC:HGNC:18869"
                     /db_xref="MIM:609966"
                     /translation="MGNLQSEPSAGGGSRKVQPSDRAPDSRRTSLVEPEMTSQAMRLT
                     RGLGVWFPGSATPPGLMVPREPQASPSTLPLTLERPSPVMPPPEEAAAVSAPPPAPAG
                     TLLPGPSKWQKPAGTPVPRIRRLLEASHRGQGDPPSLRPLKPPPPPRQLSVKDTVPRA
                     PSQFPPPLETWKPPPPLPSERQPADRRITPALATPASPPTESQAGPRNQGQTAGRARG
                     GAPPHAGEGEMAQPADSESGLSLLCKITFKSRPSLAPPAASSSLAAKASLGGGGGGGL
                     FAASGAISYAEVLKQGPLPPGAARPLGEVSRGAQEAEGGDGDGEGCSGPPSAPASQAR
                     ALPPPPYTTFPGSKPKFDWVSAPDGPERHFRFNGAGGGIGAPRRRAAALSGPWGSPPP
                     PPEQIHSAPGPRRPAPALLAPPTFIFPAPTNGEPMRPGPPGLQELPPLPPPTPPPTLQ
                     PPALQPTPLPVAPPLTPGLGHKESALAPTAAPALPPALAADQAPAPSPAPAPTVAEPS
                     PPVSAPAPAAAPIKTRTRRNKGSRAARGATRKDGLHGDGPRERATATVPDSSGGGGGG
                     SGASQTGAANTRAARHWLPFQVLNSCPCKCYCHHQPRHRRLPRNVSAWLSTSTNHLGE
                     PPWVATIKLSGSLVAKLEHYDLQATHSN"
     exon            1983..2245
                     /gene="GGN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2141..2146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGN"
                     /note="hexamer: AATAAA"
     polyA_site      2160
                     /gene="GGN"
                     /note="major polyA site"
     regulatory      2223..2228
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGN"
                     /note="hexamer: ATTAAA"
     polyA_site      2245
                     /gene="GGN"
ORIGIN      
        1 agaaccagaa ggcctggggg cgaggaacaa gacctcggag tatttcaagg ggagacctag
       61 ttccctgccc tgccccgggc ccagggcgcc gcggtctgaa ctctgctcgg ctggaggact
      121 cgtctccgag ctccgtcaga aatggggaac ttgcagtcgg agccatccgc gggcgggggc
      181 tcccgaaaag tgcagccctc ggaccgcgcc cccgactccc gccggacgtc cctggtggag
      241 cccgagatga cctcccaggc catgcgcctg actcgtgggc tgggtgtctg gttccctggc
      301 agcgccacac ccccgggact catggtaccc cgggagcccc aggcctcacc ctcgaccctg
      361 cccctcacct tagaacggcc ctctccagtg atgccccctc ctgaagaggc ggccgcggtc
      421 tctgcaccac ccccggcccc cgcggggact ctgctgcccg gcccgtctaa atggcaaaag
      481 cccgcgggca ctccagttcc ccggatccgc cgcctgctgg aggcgagcca tcgcggccag
      541 ggcgaccctc cgagcctccg cccgctgaag ccgccgccgc cgccccggca actatccgtg
      601 aaggacactg tcccgagggc cccatcccaa tttccgccgc ccctggagac ttggaagccg
      661 ccaccaccat taccttctga acggcagccg gcggaccgca gaatcactcc tgctctggcc
      721 acacccgcct cacccccgac agaaagccag gctgggcccc gcaaccaggg ccagacggcc
      781 ggcagggctc gcggaggggc gcctccccat gcgggcgaag gcgaaatggc ccagcctgcg
      841 gattccgagt ccggtctgag cctgctgtgt aaaatcacct tcaagtcgag gccctctttg
      901 gcccctccgg cagcctcgag ttccttagca gccaaagctt cgctgggggg cggcggaggc
      961 ggcggcctct ttgctgcctc aggtgccatc tcttacgccg aggtcctgaa gcaagggccc
     1021 ctgcctcctg gagccgctcg ccccttggga gaggtttctc gaggggcaca ggaagccgag
     1081 ggaggtgatg gagacggcga agggtgctct ggtcctccct cggcgcctgc gtcccaagcc
     1141 cgggccctac cgccgccacc ctacaccacc ttcccaggct cgaagcccaa attcgactgg
     1201 gttagcgctc ccgacggccc tgaacgccac ttccgcttca acggggctgg cggaggcatc
     1261 ggggcgccgc gacggcgtgc ggccgcactc tctgggcctt ggggctcccc tccgccacca
     1321 ccagagcaga tacactcagc tcccgggccc cggaggcccg cacctgccct gctggcgccg
     1381 cctacgttca tcttcccagc acccaccaat ggcgagccca tgcgcccggg gcctccaggc
     1441 ctgcaggagt taccaccgct gccaccgccc acaccgccgc ccacactgca gccaccagcg
     1501 ctccagccaa cgccgctgcc ggtggctccc ccgctcaccc cgggtctggg ccacaaggag
     1561 tcagccctgg ctcccaccgc agcccctgct ctgcccccag ccttagccgc cgaccaggcc
     1621 ccggccccat ccccggctcc agctcccacc gtggctgagc cctcgccgcc tgtgtccgcg
     1681 cccgcacccg cggctgcgcc catcaagacc cgcacgcgca ggaacaaggg ttcccgtgca
     1741 gcccggggcg cgacccgtaa ggatggcttg catggagatg gtcctcgcga acgagctaca
     1801 gctaccgtgc ctgacagcag tggtggaggg ggtggtggca gcggggcctc tcagactggg
     1861 gcagctaaca cccgcgctgc gcgccactgg ctgcccttcc aggtgcttaa ctcctgtccc
     1921 tgcaagtgtt actgccacca ccagccacgc catcgccgcc tgccacgcaa cgtctctgcc
     1981 tggctgagca catccaccaa ccacctgggc gagccaccct gggttgccac catcaagctg
     2041 tccggctctc tggtggccaa gctggagcac tacgacttgc aggccaccca ttccaactga
     2101 gtgtagtcgg ctcaacaccc tccaccttcc cctccatgcc aataaaataa ccaatccaga
     2161 tgccagcagc ctgtcaatca ctcgccaagg cagtgggtag ggtgcagcag ggcaggatcg
     2221 ccattaaagc acatcttgga aacaa
//
