LOCUS       NM_003878               1248 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens gamma-glutamyl hydrolase (GGH), transcript variant 1,
            mRNA.
ACCESSION   NM_003878
VERSION     NM_003878.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1248)
  AUTHORS   Chen,Y.J., Guo,X., Liu,M.L., Yu,Y.Y., Cui,Y.H., Shen,X.Z., Liu,T.S.
            and Liang,L.
  TITLE     Interaction between glycolysis-cholesterol synthesis axis and tumor
            microenvironment reveal that gamma-glutamyl hydrolase suppresses
            glycolysis in colon cancer
  JOURNAL   Front Immunol 13, 979521 (2022)
   PUBMED   36569910
  REMARK    GeneRIF: Interaction between glycolysischolesterol synthesis axis
            and tumor microenvironment reveal that gamma-glutamyl hydrolase
            suppresses glycolysis in colon cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1248)
  AUTHORS   Wang,S., Chen,Y., Fang,H., Xu,Y., Ding,M., Ma,C., Lin,Y., Cui,Z.,
            Sun,H., Niu,Q., Sun,S., Zhou,B.S., Xiao,N. and Li,H.
  TITLE     A gamma-glutamyl hydrolase lacking the signal peptide confers
            susceptibility to folates/antifolates in acute lymphoblastic
            leukemia cells
  JOURNAL   FEBS Lett 596 (4), 437-448 (2022)
   PUBMED   35040120
  REMARK    GeneRIF: A gamma-glutamyl hydrolase lacking the signal peptide
            confers susceptibility to folates/antifolates in acute
            lymphoblastic leukemia cells.
REFERENCE   3  (bases 1 to 1248)
  AUTHORS   Li,M., Wang,S.M., Wu,W.S., Yan,D., Zhang,L.P. and Zheng,H.Y.
  TITLE     Frequency distribution of five SNPs in human GGH gene and their
            effects on clinical outcomes of Chinese pediatric patients with
            acute lymphoblastic leukemia
  JOURNAL   Pharmazie 75 (4), 142-146 (2020)
   PUBMED   32295690
  REMARK    GeneRIF: Frequency distribution of five SNPs in human GGH gene and
            their effects on clinical outcomes of Chinese pediatric patients
            with acute lymphoblastic leukemia.
REFERENCE   4  (bases 1 to 1248)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1248)
  AUTHORS   Wang,S.M., Li,M., Wu,W.S., Sun,L.L. and Yan,D.
  TITLE     The role of transcription factor Sp1 in the regulation of
            gamma-glutamyl hydrolase gene expression by the rs3758149
            polymorphism in CEM/C1 cells
  JOURNAL   Pharmazie 74 (11), 671-674 (2019)
   PUBMED   31739835
  REMARK    GeneRIF: The role of transcription factor Sp1 in the regulation of
            gamma-glutamyl hydrolase gene expression by the rs3758149
            polymorphism in CEM/C1 cells.
REFERENCE   6  (bases 1 to 1248)
  AUTHORS   Yao,R., Schneider,E., Ryan,T.J. and Galivan,J.
  TITLE     Human gamma-glutamyl hydrolase: cloning and characterization of the
            enzyme expressed in vitro
  JOURNAL   Proc Natl Acad Sci U S A 93 (19), 10134-10138 (1996)
   PUBMED   8816764
REFERENCE   7  (bases 1 to 1248)
  AUTHORS   Yao,R., Nimec,Z., Ryan,T.J. and Galivan,J.
  TITLE     Identification, cloning, and sequencing of a cDNA coding for rat
            gamma-glutamyl hydrolase
  JOURNAL   J Biol Chem 271 (15), 8525-8528 (1996)
   PUBMED   8621474
REFERENCE   8  (bases 1 to 1248)
  AUTHORS   O'Connor,B.M., Rotundo,R.F., Nimec,Z., McGuire,J.J. and Galivan,J.
  TITLE     Secretion of gamma-glutamyl hydrolase in vitro
  JOURNAL   Cancer Res 51 (15), 3874-3881 (1991)
   PUBMED   1713122
REFERENCE   9  (bases 1 to 1248)
  AUTHORS   Wang,T.T., Chandler,C.J. and Halsted,C.H.
  TITLE     Intracellular pteroylpolyglutamate hydrolase from human jejunal
            mucosa. Isolation and characterization
  JOURNAL   J Biol Chem 261 (29), 13551-13555 (1986)
   PUBMED   3759978
REFERENCE   10 (bases 1 to 1248)
  AUTHORS   Chandler,C.J., Wang,T.T. and Halsted,C.H.
  TITLE     Pteroylpolyglutamate hydrolase from human jejunal brush borders.
            Purification and characterization
  JOURNAL   J Biol Chem 261 (2), 928-933 (1986)
   PUBMED   2867095
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC025025.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003878.2.
            
            Summary: This gene catalyzes the hydrolysis of
            folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by
            the removal of gamma-linked polyglutamates and glutamate. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025025.1, U55206.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000260118.7/ ENSP00000260118.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1248              BC025025.1         47-1294
FEATURES             Location/Qualifiers
     source          1..1248
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q12.3"
     gene            1..1248
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /note="gamma-glutamyl hydrolase"
                     /db_xref="GeneID:8836"
                     /db_xref="HGNC:HGNC:4248"
                     /db_xref="MIM:601509"
     exon            1..147
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..995
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /EC_number="3.4.19.9"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; gamma-Glu-X carboxypeptidase; gamma-glutamyl
                     hydrolase (conjugase, folylpolygammaglutamyl hydrolase)"
                     /codon_start=1
                     /product="gamma-glutamyl hydrolase isoform 1 precursor"
                     /protein_id="NP_003869.1"
                     /db_xref="CCDS:CCDS6177.1"
                     /db_xref="GeneID:8836"
                     /db_xref="HGNC:HGNC:4248"
                     /db_xref="MIM:601509"
                     /translation="MASPGCLLCVLGLLLCGAASLELSRPHGDTAKKPIIGILMQKCR
                     NKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDL
                     RRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAM
                     PLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLT
                     TNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFV
                     NEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD"
     exon            148..262
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     exon            263..313
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     exon            314..398
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     exon            399..537
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     exon            538..644
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     exon            645..735
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     exon            736..873
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1248
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1227..1232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /note="hexamer: AATAAA"
     polyA_site      1248
                     /gene="GGH"
                     /gene_synonym="GATD10; GH"
                     /note="major polyA site"
ORIGIN      
        1 gcagagcttt tgaaaggcgg cgggaggcgg cgagcgccat ggccagtccg ggctgcctgc
       61 tgtgcgtgct gggcctgcta ctctgcgggg cggcgagcct cgagctgtct agaccccacg
      121 gcgacaccgc caagaagccc atcatcggaa tattaatgca aaaatgccgt aataaagtca
      181 tgaaaaacta tggaagatac tatattgctg cgtcctatgt aaagtacttg gagtctgcag
      241 gtgcgagagt tgtaccagta aggctggatc ttacagagaa agactatgaa atacttttca
      301 aatctattaa tggaatcctt ttccctggag gaagtgttga cctcagacgc tcagattatg
      361 ctaaagtggc caaaatattt tataacttgt ccatacagag ttttgatgat ggagactatt
      421 ttcctgtgtg gggcacatgc cttggatttg aagagctttc actgctgatt agtggagagt
      481 gcttattaac tgccacagat actgttgacg tggcaatgcc gctgaacttc actggaggtc
      541 aattgcacag cagaatgttc cagaattttc ctactgagtt gttgctgtca ttagcagtag
      601 aacctctgac tgccaatttc cataagtgga gcctctccgt gaagaatttt acaatgaatg
      661 aaaagttaaa gaagtttttc aatgtcttaa ctacaaatac agatggcaag attgagttta
      721 tttcaacaat ggaaggatat aagtatccag tatatggtgt ccagtggcat ccagagaaag
      781 caccttatga gtggaagaat ttggatggca tttcccatgc acctaatgct gtgaaaaccg
      841 cattttattt agcagagttt tttgttaatg aagctcggaa aaacaaccat cattttaaat
      901 ctgaatctga agaggagaaa gcattgattt atcagttcag tccaatttat actggaaata
      961 tttcttcatt tcagcaatgt tacatatttg attgaaagtc ttcaatttgt taacagagca
     1021 aatttgaata attccatgat taaactgtta gaataacttg ctactcatgg caagattagg
     1081 aagtcacaga ttcttttcta taatgtgcct ggctctgatt cttcattctg tatgtgacta
     1141 tttatataac attagataat taaatagtga gacataaata gagtgttttt catggaaaag
     1201 ccttcttata tctgaagatt gaaaaaaata aatttactga aatacaaa
//
