LOCUS       NM_000821               7556 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens gamma-glutamyl carboxylase (GGCX), transcript variant
            1, mRNA.
ACCESSION   NM_000821
VERSION     NM_000821.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7556)
  AUTHORS   Ilut,S., Vesa,S.C., Vacaras,V., Sipos-Lascu,D., Barsan,C.,
            Pop,R.M., Crisan,S., Macarie,A.E., Coada,C.A., Perju-Dumbrava,L.,
            Muresanu,D.F. and Buzoianu,A.D.
  TITLE     Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX
            rs11676382 polymorphisms and acute ischemic stroke
  JOURNAL   Medicine (Baltimore) 102 (34), e34836 (2023)
   PUBMED   37653796
  REMARK    GeneRIF: Association among VKORC1 rs9923231, CYP4F2 rs2108622, GGCX
            rs11676382 polymorphisms and acute ischemic stroke.
REFERENCE   2  (bases 1 to 7556)
  AUTHORS   Shen,G., Liu,H., Shen,Y. and Xi,S.
  TITLE     [Partial research progress of GGCX pathogenic variation associated
            phenotypes]
  JOURNAL   Zhonghua Yi Xue Yi Chuan Xue Za Zhi 39 (6), 646-650 (2022)
   PUBMED   35773773
  REMARK    GeneRIF: [Partial research progress of GGCX pathogenic variation
            associated phenotypes].
REFERENCE   3  (bases 1 to 7556)
  AUTHORS   Ghosh,S., Kraus,K., Biswas,A., Muller,J., Forin,F., Singer,H.,
            Honing,K., Hornung,V., Watzka,M., Oldenburg,J. and
            Czogalla-Nitsche,K.J.
  TITLE     GGCX variants leading to biallelic deficiency to gamma-carboxylate
            GRP cause skin laxity in VKCFD1 patients
  JOURNAL   Hum Mutat 43 (1), 42-55 (2022)
   PUBMED   34816548
  REMARK    GeneRIF: GGCX variants leading to biallelic deficiency to
            gamma-carboxylate GRP cause skin laxity in VKCFD1 patients.
REFERENCE   4  (bases 1 to 7556)
  AUTHORS   Schmidt-Krey,I., Haase,W., Mutucumarana,V., Stafford,D.W. and
            Kuhlbrandt,W.
  TITLE     Two-dimensional crystallization of human vitamin K-dependent
            gamma-glutamyl carboxylase
  JOURNAL   J Struct Biol 157 (2), 437-442 (2007)
   PUBMED   16979907
  REMARK    GeneRIF: Crystallization of human GGCX.
REFERENCE   5  (bases 1 to 7556)
  AUTHORS   Wu,S.M., Stafford,D.W., Frazier,L.D., Fu,Y.Y., High,K.A., Chu,K.,
            Sanchez-Vega,B. and Solera,J.
  TITLE     Genomic sequence and transcription start site for the human
            gamma-glutamyl carboxylase
  JOURNAL   Blood 89 (11), 4058-4062 (1997)
   PUBMED   9166845
REFERENCE   6  (bases 1 to 7556)
  AUTHORS   Kuo,W.L., Stafford,D.W., Cruces,J., Gray,J. and Solera,J.
  TITLE     Chromosomal localization of the gamma-glutamyl carboxylase gene at
            2p12
  JOURNAL   Genomics 25 (3), 746-748 (1995)
   PUBMED   7759116
REFERENCE   7  (bases 1 to 7556)
  AUTHORS   Zhang,L., Jhingan,A. and Castellino,F.J.
  TITLE     Role of individual gamma-carboxyglutamic acid residues of activated
            human protein C in defining its in vitro anticoagulant activity
  JOURNAL   Blood 80 (4), 942-952 (1992)
   PUBMED   1498334
REFERENCE   8  (bases 1 to 7556)
  AUTHORS   Wu,S.M., Cheung,W.F., Frazier,D. and Stafford,D.W.
  TITLE     Cloning and expression of the cDNA for human gamma-glutamyl
            carboxylase
  JOURNAL   Science 254 (5038), 1634-1636 (1991)
   PUBMED   1749935
REFERENCE   9  (bases 1 to 7556)
  AUTHORS   Brenner,B., Tavori,S., Zivelin,A., Keller,C.B., Suttie,J.W.,
            Tatarsky,I. and Seligsohn,U.
  TITLE     Hereditary deficiency of all vitamin K-dependent procoagulants and
            anticoagulants
  JOURNAL   Br J Haematol 75 (4), 537-542 (1990)
   PUBMED   2145029
REFERENCE   10 (bases 1 to 7556)
  AUTHORS   Borowski,M., Furie,B.C. and Furie,B.
  TITLE     Distribution of gamma-carboxyglutamic acid residues in partially
            carboxylated human prothrombins
  JOURNAL   J Biol Chem 261 (4), 1624-1628 (1986)
   PUBMED   3944102
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC296316.1, BC013979.2,
            AC016753.9, BM974022.1 and BQ000150.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000821.6.
            
            Summary: This gene encodes an integral membrane protein of the
            rough endoplasmic reticulum that carboxylates glutamate residues of
            vitamin K-dependent proteins to gamma carboxyl glutamate, a
            modification that is required for their activity. The vitamin
            K-dependent protein substrates have a propeptide that binds the
            enzyme, with carbon dioxide, dioxide, and reduced vitamin K acting
            as co-substrates. Vitamin K-dependent proteins affect a number of
            physiologic processes including blood coagulation, prevention of
            vascular calcification, and inflammation. Allelic variants of this
            gene have been associated with pseudoxanthoma elasticum-like
            disorder with associated multiple coagulation factor deficiency.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225663.1, AK222827.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000233838.9/ ENSP00000233838.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                DC296316.1         42-78
            38-3196             BC013979.2         1-3159
            3197-7337           AC016753.9         111898-116038       c
            7338-7421           BM974022.1         14-97               c
            7422-7468           BQ000150.1         107-153             c
            7469-7469           AC016753.9         111766-111766       c
            7470-7556           BQ000150.1         19-105              c
FEATURES             Location/Qualifiers
     source          1..7556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..7556
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /note="gamma-glutamyl carboxylase"
                     /db_xref="GeneID:2677"
                     /db_xref="HGNC:HGNC:4247"
                     /db_xref="MIM:137167"
     exon            1..108
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2342
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /EC_number="4.1.1.90"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vitamin K-dependent gamma-carboxylase; peptidyl-glutamate
                     4-carboxylase"
                     /codon_start=1
                     /product="vitamin K-dependent gamma-carboxylase isoform 1"
                     /protein_id="NP_000812.2"
                     /db_xref="CCDS:CCDS1978.1"
                     /db_xref="GeneID:2677"
                     /db_xref="HGNC:HGNC:4247"
                     /db_xref="MIM:137167"
                     /translation="MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTD
                     LSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFP
                     LLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNH
                     SYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKK
                     LDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSR
                     SIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLK
                     AAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTN
                     GLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATC
                     LSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMD
                     LSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVA
                     EQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEK
                     VENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFF
                     RFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTD
                     SSHSNPPESNPDPVHSEF"
     exon            109..279
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..438
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            439..604
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            605..683
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            684..790
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..954
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1220
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1352
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1504
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1674
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1805
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1806..1953
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2149
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..7556
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2423
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /note="major polyA site"
     regulatory      3184..3189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /note="hexamer: ATTAAA"
     polyA_site      3206
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /note="major polyA site"
     regulatory      7536..7541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /note="hexamer: AATAAA"
     polyA_site      7556
                     /gene="GGCX"
                     /gene_synonym="VKCFD1"
                     /note="major polyA site"
ORIGIN      
        1 aaattctcct ggcggcctcc gttcagacgc ggcagctgtg acccacctgc ctcctccgca
       61 gagcaatggc ggtgtctgcc gggtccgcgc ggacctcgcc cagctcagat aaagtacaga
      121 aagacaaggc tgaactgatc tcagggccca ggcaggacag ccgaataggg aaactcttgg
      181 gttttgagtg gacagatttg tccagttggc ggaggctggt gaccctgctg aatcgaccaa
      241 cggaccctgc aagcttagct gtctttcgtt ttctttttgg gttcttgatg gtgctagaca
      301 ttccccagga gcgggggctc agctctctgg accggaaata ccttgatggg ctggatgtgt
      361 gccgcttccc cttgctggat gccctacgcc cactgccact tgactggatg tatcttgtct
      421 acaccatcat gtttctgggg gcactgggca tgatgctggg cctgtgctac cggataagct
      481 gtgtgttatt cctgctgcca tactggtatg tgtttctcct ggacaagaca tcatggaaca
      541 accactccta tctgtatggg ttgttggcct ttcagctaac attcatggat gcaaaccact
      601 actggtctgt ggacggtctg ctgaatgccc ataggaggaa tgcccacgtg cccctttgga
      661 actatgcagt gctccgtggc cagatcttca ttgtgtactt cattgcgggt gtgaaaaagc
      721 tggatgcaga ctgggttgaa ggctattcca tggaatattt gtcccggcac tggctcttca
      781 gtcccttcaa actgctgttg tctgaggagc tgactagcct gctggtcgtg cactggggtg
      841 ggctgctgct tgacctctca gctggtttcc tgctcttttt tgatgtctca agatccattg
      901 gcctgttctt tgtgtcctac ttccactgca tgaattccca gcttttcagc attggtatgt
      961 tctcctacgt catgctggcc agcagccctc tcttctgctc ccctgagtgg cctcggaagc
     1021 tggtgtccta ctgcccccga aggttgcaac aactgttgcc cctcaaggca gcccctcagc
     1081 ccagtgtttc ctgtgtgtat aagaggagcc ggggcaaaag tggccagaag ccagggctgc
     1141 gccatcagct gggagctgcc ttcaccctgc tctacctcct ggagcagcta ttcctgccct
     1201 attctcattt tctcacccag ggctataaca actggacaaa tgggctgtat ggctattcct
     1261 gggacatgat ggtgcactcc cgctcccacc agcacgtgaa gatcacctac cgtgatggcc
     1321 gcactggcga actgggctac cttaaccctg gggtatttac acagagtcgg cgatggaagg
     1381 atcatgcaga catgctgaag caatatgcca cttgcctgag ccgcctgctt cccaagtata
     1441 atgtcactga gccccagatc tactttgata tttgggtctc catcaatgac cgcttccagc
     1501 agaggatttt tgaccctcgt gtggacatcg tgcaggccgc ttggtcaccc tttcagcgca
     1561 catcctgggt gcaaccactc ttgatggacc tgtctccctg gagggccaag ttacaggaaa
     1621 tcaagagcag cctagacaac cacactgagg tggtcttcat tgcagatttc cctggactgc
     1681 acttggagaa ttttgtgagt gaagacctgg gcaacactag catccagctg ctgcaggggg
     1741 aagtgactgt ggagcttgtg gcagaacaga agaaccagac tcttcgagag ggagaaaaaa
     1801 tgcagttgcc tgctggtgag taccataagg tgtatacgac atcacctagc ccttcttgct
     1861 acatgtacgt ctatgtcaac actacagagc ttgcactgga gcaagacctg gcatatctgc
     1921 aagaattaaa ggaaaaggtg gagaatggaa gtgaaacagg gcctctaccc ccagagctgc
     1981 agcctctgtt ggaaggggaa gtaaaagggg gccctgagcc aacacctctg gttcagacct
     2041 ttcttagacg ccaacaaagg ctccaggaga ttgaacgccg gcgaaatact cctttccatg
     2101 agcgattctt ccgcttcttg ttgcgaaagc tctatgtctt tcgccgcagc ttcctgatga
     2161 cttgtatctc acttcgaaat ctgatattag gccgtccttc cctggagcag ctggcccagg
     2221 aggtgactta tgcaaacttg agaccctttg aggcagttgg agaactgaat ccctcaaaca
     2281 cggattcttc acattctaat cctcctgagt caaatcctga tcctgtccac tcagagttct
     2341 gaagggggcc agatgttggg tgcagatgta gaagcagcca gtcacagacc cattctatgc
     2401 aatggacatt tatttgaaaa aaattctcaa aagttttttt tttttttttg ggggggcggg
     2461 gttctaaagc tgtttttaac tccgagatta caacttagag gaaccaagga aataaagcaa
     2521 ataagattta acaacccaag attaagaggc caggaagagg ttagacgcaa tgtgaaactg
     2581 tcctcctagg ataaggttta aagtggcttt ttgggggctg ggtgccgtgg ctcacgcctg
     2641 taatcccagc attttgggag gctgaggtgg gcagatcact tgaggccagg agttcgagac
     2701 cagcctggcc aacatggcaa aaccccttct ctactaaaaa tacaaaaatt agccagacgt
     2761 ggtggtgggt gcctgtaatc caactaccca ggaggctgag gcatgagaat cgcttgggcc
     2821 caggaggtgg aggttgcagt gagccgagat cgagccactg cactcctggg caacagagca
     2881 agacttcgtc tcaaaataaa taaataaagt ggctcttggg gaaaagcaat ttaatgtacc
     2941 acgatgaata gctaactgtt cccaagtgtt tgctatgtgc aacacaccgc gtgagcagtg
     3001 ttacctgcat tattacatta ggctgagagg taaaataatt tgcccgaaga catacagcta
     3061 gtgacgaatg gactgatggt ttgaacttaa cgtctatttg acttaaggtc ctgcaccctg
     3121 ccacttgtaa ttttcagaat cactgataat ctgaaataat gcagcttaaa acatgttttc
     3181 ttaattaaaa gtataattgg atggtggtca ggttgtaaat gcacacaaag taatttatct
     3241 tcattgcaat tttggttcct tctttgttcc tattatctat atacacccag tgtttcacta
     3301 gcagttatga gagcagtcag aatagcagca tcaaagttaa ataaggaaat ctagatgatt
     3361 gctagatttt ctctaaaaat aagcttagta tttggtatta ttctagcctt tggtgagcag
     3421 aaggggaggt aaagtaagaa ttaactaaat ttagtaaggg attagggaat gcttagacat
     3481 tttgtaggtt ggggtataca agggtaactc aggaagctcc tcagttcagt gaaaattcaa
     3541 agggttggca ctgagctagg aagcgagaat gcagggttat gaaaaaggat ccctgctttg
     3601 ggagctcatg gacttgtagc agagaccggt agtaaattgg cagtctcagt aacttctgta
     3661 aatgattgca tctctttgca ggcttctctt cccatactct cccccactcc tccttggaca
     3721 gtgttccggg ggttctttcc taagcaactg ctttttcagt atacatactt cagatgattg
     3781 tgtctactcc aggatttcca acgatgctag gtttctttcc tgtgccctag acgtataggt
     3841 ctaagttcca cctggatatc ccacagggct atcaagctca gttcatccta aacagaactt
     3901 acattcatcc ccaactcaga cttccttatt ctttattatt gaatggcagc tctgtacctt
     3961 agccaagctg ttatctctag gtcatcagcc ttgactcttc ctttttcctt gcatttctta
     4021 aaattgccaa gtcccatcaa ttttacctcc tggatacctc ttgaatctat ttttttttaa
     4081 agacagggtt tcactctatc acccaggctg gagttcagtg gcacaatctt ggcttactgc
     4141 agccaccacc tcctgggttt aaacgattct tccacttcag cctcccatgt agctgggact
     4201 acaggtgccc accaccacgc ccaactaatt tttgtatttt tagtagagac atggtttccc
     4261 acattggcca ggctggtctc aaactcatga ccttaagtat ccacctgcct tggcctccca
     4321 aagggctggg attacaggtg tgagccaccg tgcccagcca aatctgtttt cattactacc
     4381 tatatctgta ttttcaacct ttgtattagc atctagttag ggatagacca ggacagggcc
     4441 gacatgttag ttgtcaagca gattgccacc ctcccccacc actgaggagg ccaaatggag
     4501 tttggtggaa aatctctaat tcattcaagg tattatatgg gcaagcaatg gctgtggcac
     4561 agggtcccct gattactttg taagaatggg tgggagggat gctgattttc aatccttttg
     4621 cagatcttct ctcatagtaa cacaatagaa gatactttgc cactatgttg tttgccaaac
     4681 tcactgtacc tacttgactg gtaacaaaag tcccaagagt tacttgggag aagacacttg
     4741 aaaaagtatt tttctaaata tgggcaagga tgctgccctt ccccaaactg ttagtatacc
     4801 acctctctga ccaattttcc caaggaagat attggggtag ggtgaggtgt aaagaaaaag
     4861 tggtcatgta aatactggta ataaaagctg ttcagtgggg tagagttggg ttgcaactgt
     4921 agccattcta aaaatgggct atcaatgtcc ttttagccaa aagactttag tatacatcct
     4981 cctcattcta ccctcaggat ttggatcttt gcccctgatg ggtatccatc ccctttgaaa
     5041 ctttagaaag gcaggttata tacagaatgt tcaacctaaa gacatttcct taagtcatac
     5101 tttcatgctt tctaaactat aatcaccctt atcatcccct gctgttatgc tttccctctg
     5161 ctccctgtgg cctaatgttc ctccaccacc ttattaacct tcaggatact tttcccctag
     5221 gctgggcagg acaacactat ccccttggtc cacaagctcc ctcaaggttg gggaatcttt
     5281 gtttacttag caaatactga acataacctt aaagcggtta cttttgaaaa cttctcatgc
     5341 tattctacca acttggaggc acctatccat gctcattccc ctaatgtagc caatatggtt
     5401 atctgcaatg tattggcatc taaaaactcc cttatgaaac tgccagactt gttctggaac
     5461 atttcaatta catgcaaaat tcaggttctc aagttggaac aagtctaatt gacacacctg
     5521 cataggtttt aaccttgccc tccccctact tcccaacaga tttccaagtt ttttgagaag
     5581 gaaccttgct ctggcccagg ctggagtgca atggcgccat ctcggctcac tgcaacctct
     5641 gcctcctggg ttcaagtgat tctccagcct cctgagtagc tgggattaca agcacctgcc
     5701 accacaccca gcttttttgt atttttggta gagacggggt ttcagtttgc caggctggta
     5761 tcaaaccgtg acctcaggtg atccacccgc attagcctcc caaagtgctg ggattacagg
     5821 tgtaagctac catacccaga tttccacggc ttttttttta agtctcactc tgttaccctg
     5881 gccggagtgt ggtggcacga tttcagctca ctgcaagctc cacctcccgg gttcacgcca
     5941 ttctcctgcc tcggcctcct gagtagctgg gactacaggt gcctggctaa cttttttata
     6001 tttttagtag agacagggtt tcactgtgtt agccaggatg gtctcgtgat ctgcatgcct
     6061 tggcctccca aagtgctagg attataggct cacgcctata ttactatata gtggcctata
     6121 ttacaggcca ctccgcctgg cctccaaatt tccaagtttt taagtctcca tgcaaacagg
     6181 cataagcaag cactccttgg ctctacattt gcaggacaag ctggaccacc attcagatgt
     6241 tggtagaaat gtaatccaag tggctattct ctatgcatgt agctcctagg ttcaagagca
     6301 gtgtggtctg cggattttct acacaacctg ccataaatga aatttaagcc tttggaaatt
     6361 tatagcattt tcagctaatt tgcattattt atctctgcaa gatattgact agaaatcacg
     6421 tttcagaact tctcagatga aaacatcata caacccttaa aactaagctc ataatttaaa
     6481 aatgtatgca gattaatagg cttaaattgc caggacttta gatagacatt accacttcca
     6541 ggttaatact tttagcggtt tttatgcctt caatggtttg aagccctcaa ccttagttga
     6601 aaacttaaaa atggcattga atggctgctg caataaggac acatgaattt tggcttaagt
     6661 ggactaggag gactaaatct tgcttaggct tttaaaaaat gcccacccac tgggtctagg
     6721 gattgaggtt attttcctga attatggcta attatggatt acaattcaag gttaaagata
     6781 cacatatagt attctcaggt tattcatatg atagcatttt ttaagagcca aagtctcagt
     6841 cacccaggct ggagtgcagt ggcttgataa tggttcgcta cagcctccaa cttctatgtt
     6901 aaagtgatcc tcctacctca gcctttcaaa gtgttgggat tataggcacg tacctatggc
     6961 cccaaagcac tttaacaaat gagtaacaga cacagttaag gtagaaccta gcattttatt
     7021 tagatcttca ttaaactgtt ggaattgaga accagacata cgtaataaac ctccaaaaat
     7081 agatcctgaa aggcactttc tgcttagggc aagcagtcat ggaataagca tgtaaacaag
     7141 ctggcttctc tgtaccacac cagccaagtc agctttctcc atggccagcc gcaccagctc
     7201 tgccctccct tctgttaaca ccagccagac cccctgtagg tctaacccaa ggtttttctg
     7261 taggacacct tggcctacct gggaatgctg gaaacatgtt gttaaaggaa tcatggtgtt
     7321 gagagaaaaa aaaaaaatct tttaaaagct gccatctgag gtgatggctt ctctgtactt
     7381 acgccatacc ccagaataca ataaataagc aattagaaaa cgttcaagta tgaagggatt
     7441 tcctcctccc cgccaaaagc actgctctct gaaggaagct ggtttctctg tagctacacc
     7501 agctgttcag aaagctcatt ggacctggtt ttgaaaataa aacaaagtta aaaccc
//
