LOCUS       NM_024051               1158 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens gamma-glutamylcyclotransferase (GGCT), transcript
            variant 1, mRNA.
ACCESSION   NM_024051
VERSION     NM_024051.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1158)
  AUTHORS   Zhang,H.M., Li,Z.Y., Dai,Z.T., Wang,J., Li,L.W., Zong,Q.B.,
            Li,J.P., Zhang,T.C. and Liao,X.H.
  TITLE     Interaction of MRPL9 and GGCT Promotes Cell Proliferation and
            Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid
            Cancer
  JOURNAL   Int J Mol Sci 23 (19), 11989 (2022)
   PUBMED   36233293
  REMARK    GeneRIF: Interaction of MRPL9 and GGCT Promotes Cell Proliferation
            and Migration by Activating the MAPK/ERK Pathway in Papillary
            Thyroid Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1158)
  AUTHORS   Li,H.N., Zhang,H.M., Li,X.R., Wang,J., Xu,T., Li,S.Y., Dong,M.L.,
            Wang,G., Cui,X.Q., Yang,X., Wu,Y.L., Liao,X.H. and Du,Y.Y.
  TITLE     MiR-205-5p/GGCT Attenuates Growth and Metastasis of Papillary
            Thyroid Cancer by Regulating CD44
  JOURNAL   Endocrinology 163 (4) (2022)
   PUBMED   35213720
  REMARK    GeneRIF: MiR-205-5p/GGCT Attenuates Growth and Metastasis of
            Papillary Thyroid Cancer by Regulating CD44.
REFERENCE   3  (bases 1 to 1158)
  AUTHORS   Guo,Y.S., Wu,Y.D., Ma,H., Qi,L., Zhang,S.D. and Zang,Y.J.
  TITLE     [The expression of GGCT in the bladder urothelial cell carcinoma
            and its clinical significance]
  JOURNAL   Zhonghua Zhong Liu Za Zhi 43 (11), 1183-1187 (2021)
   PUBMED   34794221
  REMARK    GeneRIF: [The expression of GGCT in the bladder urothelial cell
            carcinoma and its clinical significance].
REFERENCE   4  (bases 1 to 1158)
  AUTHORS   Jia,C., Gao,J., Wang,L., Li,Z., Dong,Z., Yao,L. and Yao,X.
  TITLE     miR-877 inhibits the proliferation, migration, and invasion of
            osteosarcoma cells by targeting gamma-glutamylcyclotransferase
  JOURNAL   Endocr J 68 (9), 1109-1116 (2021)
   PUBMED   34121038
  REMARK    GeneRIF: miR-877 inhibits the proliferation, migration, and
            invasion of osteosarcoma cells by targeting
            gamma-glutamylcyclotransferase.
REFERENCE   5  (bases 1 to 1158)
  AUTHORS   Oakley,A.J., Coggan,M. and Board,P.G.
  TITLE     Identification and characterization of gamma-glutamylamine
            cyclotransferase, an enzyme responsible for
            gamma-glutamyl-epsilon-lysine catabolism
  JOURNAL   J Biol Chem 285 (13), 9642-9648 (2010)
   PUBMED   20110353
REFERENCE   6  (bases 1 to 1158)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1158)
  AUTHORS   Oakley,A.J., Yamada,T., Liu,D., Coggan,M., Clark,A.G. and
            Board,P.G.
  TITLE     The identification and structural characterization of C7orf24 as
            gamma-glutamyl cyclotransferase. An essential enzyme in the
            gamma-glutamyl cycle
  JOURNAL   J Biol Chem 283 (32), 22031-22042 (2008)
   PUBMED   18515354
  REMARK    GeneRIF: The GGCT gene is located on chromosome 7p14-15 and
            consists of four exons that span 8 kb, the primary sequence is 188
            amino acids in length and is unlike any protein of known function
            Erratum:[J Biol Chem. 2008 Nov 14;283(46):32152]
REFERENCE   8  (bases 1 to 1158)
  AUTHORS   Bae,E., Bingman,C.A., Aceti,D.J. and Phillips,G.N. Jr.
  TITLE     Crystal structure of Homo sapiens protein LOC79017
  JOURNAL   Proteins 70 (2), 588-591 (2008)
   PUBMED   17932939
  REMARK    GeneRIF: presence of extra electron density/ligands and
            conservation at the sequence and structure levels, it is likely
            that the cavity has a crucial role in the function of LOC79017 and
            its structural neighbors possibly as an active site or
            ligand-binding site
REFERENCE   9  (bases 1 to 1158)
  AUTHORS   Kageyama,S., Iwaki,H., Inoue,H., Isono,T., Yuasa,T., Nogawa,M.,
            Maekawa,T., Ueda,M., Kajita,Y., Ogawa,O., Toguchida,J. and
            Yoshiki,T.
  TITLE     A novel tumor-related protein, C7orf24, identified by proteome
            differential display of bladder urothelial carcinoma
  JOURNAL   Proteomics Clin Appl 1 (2), 192-199 (2007)
   PUBMED   21136669
REFERENCE   10 (bases 1 to 1158)
  AUTHORS   Masuda,Y., Maeda,S., Watanabe,A., Sano,Y., Aiuchi,T., Nakajo,S.,
            Itabe,H. and Nakaya,K.
  TITLE     A novel 21-kDa cytochrome c-releasing factor is generated upon
            treatment of human leukemia U937 cells with geranylgeraniol
  JOURNAL   Biochem Biophys Res Commun 346 (2), 454-460 (2006)
   PUBMED   16765912
  REMARK    GeneRIF: CRF21 might play an important role in the induction of
            apoptosis by GGO in leukemia U937 cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005154.1, BC000625.2 and
            BC019243.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024051.3.
            
            Summary: The protein encoded by this gene catalyzes the formation
            of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate
            step in glutathione catabolism, and may play a critical role in
            glutathione homeostasis. The encoded protein may also play a role
            in cell proliferation, and the expression of this gene is a
            potential marker for cancer. Pseudogenes of this gene are located
            on the long arm of chromosome 5 and the short arm of chromosomes 2
            and 20. Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Dec
            2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000625.2, SRR5189658.184821.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000275428.9/ ENSP00000275428.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC005154.1         47343-47428         c
            87-783              BC000625.2         94-790
            784-1158            BC019243.1         788-1162
FEATURES             Location/Qualifiers
     source          1..1158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.3"
     gene            1..1158
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /note="gamma-glutamylcyclotransferase"
                     /db_xref="GeneID:79017"
                     /db_xref="HGNC:HGNC:21705"
                     /db_xref="MIM:137170"
     exon            1..261
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..687
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /EC_number="4.3.2.9"
                     /note="isoform 1 is encoded by transcript variant 1; gamma
                     -glutamyl cyclotransferase; cytochrome c-releasing factor
                     21"
                     /codon_start=1
                     /product="gamma-glutamylcyclotransferase isoform 1"
                     /protein_id="NP_076956.1"
                     /db_xref="CCDS:CCDS5428.1"
                     /db_xref="GeneID:79017"
                     /db_xref="HGNC:HGNC:21705"
                     /db_xref="MIM:137170"
                     /translation="MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVA
                     RLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKS
                     GMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKL
                     KAIEPNDYTGKVSEEIEDIIKKGETQTL"
     exon            262..407
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /inference="alignment:Splign:2.1.0"
     exon            408..543
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /inference="alignment:Splign:2.1.0"
     exon            544..1158
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /note="hexamer: AATAAA"
     polyA_site      1158
                     /gene="GGCT"
                     /gene_synonym="C7orf24; CRF21; GCTG; GGC"
                     /note="major polyA site"
ORIGIN      
        1 cccctaaccc tgaggctgcc gcgcggcggt cactgcgccg gggtagtggg ccccagtgtt
       61 gcgctctctg gccgttcctt acactctgct tcaggctcca gtgcaggggc gtagtgggat
      121 atggccaact cgggctgcaa ggacgtcacg ggtccagatg aggagagttt tctgtacttt
      181 gcctacggca gcaacctgct gacagagagg atccacctcc gaaacccctc ggcggcgttc
      241 ttctgtgtgg cccgcctgca ggattttaag cttgactttg gcaattccca aggcaaaaca
      301 agtcaaactt ggcatggagg gatagccacc atttttcaga gtcctggcga tgaagtgtgg
      361 ggagtagtat ggaaaatgaa caaaagcaat ttaaattctc tggatgagca agaaggggtt
      421 aaaagtggaa tgtatgttgt aatagaagtt aaagttgcaa ctcaagaagg aaaagaaata
      481 acctgtcgaa gttatctgat gacaaattac gaaagtgctc ccccatcccc acagtataaa
      541 aagattattt gcatgggtgc aaaagaaaat ggtttgccgc tggagtatca agagaagtta
      601 aaagcaatag aaccaaatga ctatacagga aaggtctcag aagaaattga agacatcatc
      661 aaaaaggggg aaacacaaac tctttagaac ataacagaat atatctaagg gtattctatg
      721 tgctaatata aaatattttt aacacttgag aacagggatc tgggggatct ccacgtttga
      781 tccattttca gcagtgctct gaaggagtat cttacttggg tgattccttg tttttagact
      841 ataaaaagaa actgggatag gagttagaca atttaaaagg ggtgtatgag ggcctgaaat
      901 atgtgacaaa tgaatgtgag taccccttct gtgaacactg aaagctattc tcttgaattg
      961 atcttaagtg tctccttgct ctggtaaaag atagatttgt agctcacttg atgatggtgc
     1021 tggtgaattg ctctgctctg tctgagattt ttaaaaatca gcttaatgag agtaatctgc
     1081 agacaattga taataacatt ttgaaaattg gaaagatggt atactgtttt tagaggaata
     1141 aacgtatttg tggtttaa
//
