LOCUS       NM_001195087            2644 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens gamma-glutamylamine cyclotransferase (GGACT),
            transcript variant 2, mRNA.
ACCESSION   NM_001195087
VERSION     NM_001195087.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Oakley,A.J., Coggan,M. and Board,P.G.
  TITLE     Identification and characterization of gamma-glutamylamine
            cyclotransferase, an enzyme responsible for
            gamma-glutamyl-epsilon-lysine catabolism
  JOURNAL   J Biol Chem 285 (13), 9642-9648 (2010)
   PUBMED   20110353
  REMARK    GeneRIF: gamma-glutamylamine cyclotransferase is an enzyme
            responsible for gamma-glutamyl-epsilon-lysine catabolism
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK095850.1 and AL136526.27.
            
            On Aug 13, 2020 this sequence version replaced NM_001195087.1.
            
            Summary: The protein encoded by this gene aids in the proteolytic
            degradation of crosslinked fibrin by breaking down isodipeptide
            L-gamma-glutamyl-L-epsilon-lysine, a byproduct of fibrin
            degradation. The reaction catalyzed by the encoded
            gamma-glutamylaminecyclotransferase produces 5-oxo-L-proline and a
            free alkylamine. Two transcript variants encoding the same protein
            have been found for this gene.[provided by RefSeq, Aug 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095850.1, SRR14038193.3417184.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683975.1/ ENSP00000508020.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-699               AK095850.1         4-702
            700-2644            AL136526.27        151430-153374       c
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.3"
     gene            1..2644
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /note="gamma-glutamylamine cyclotransferase"
                     /db_xref="GeneID:87769"
                     /db_xref="HGNC:HGNC:25100"
                     /db_xref="MIM:613378"
     exon            1..49
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /inference="alignment:Splign:2.1.0"
     exon            50..222
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /inference="alignment:Splign:2.1.0"
     exon            223..2644
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             233..694
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /EC_number="4.3.2.8"
                     /note="AIG2-like domain-containing protein 1; AIG2-like
                     domain 1"
                     /codon_start=1
                     /product="gamma-glutamylaminecyclotransferase"
                     /protein_id="NP_001182016.1"
                     /db_xref="CCDS:CCDS45066.1"
                     /db_xref="GeneID:87769"
                     /db_xref="HGNC:HGNC:25100"
                     /db_xref="MIM:613378"
                     /translation="MALVFVYGTLKRGQPNHRVLRDGAHGSAAFRARGRTLEPYPLVI
                     AGEHNIPWLLHLPGSGRLVEGEVYAVDERMLRFLDDFESCPALYQRTVLRVQLLEDRA
                     PGAEEPPAPTAVQCFVYSRATFPPEWAQLPHHDSYDSEGPHGLRYNPRENR"
     regulatory      2533..2538
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /note="hexamer: AATAAA"
     polyA_site      2554
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /note="major polyA site"
     regulatory      2622..2627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /note="hexamer: ATTAAA"
     polyA_site      2644
                     /gene="GGACT"
                     /gene_synonym="A2LD1"
                     /note="major polyA site"
ORIGIN      
        1 gcatttccgc cctggccctg ccctccccga cagccccggc tgccggcagg actgaaaact
       61 ggatatttgg tccccatgga ctttctggtc accctgtgaa gtggacttaa ctttttcttg
      121 aatcatgtgg aaggattctg aagtcaaaag tttttaagac tctcaggctt actgtggatc
      181 tggattctaa ggcaacactt ccttgaagaa acaagcttac agctctgccc ggatggccct
      241 agtcttcgtg tacggcaccc tgaagcgggg tcagcccaac cacagggtcc tgcgggacgg
      301 cgcccacggc tccgcagcct ttcgggcgcg cggccgcacg ctggagccct acccgttggt
      361 gatcgcgggg gagcacaaca tcccgtggct gctgcacctg cccggctcgg ggcgcctcgt
      421 ggagggcgag gtctacgcgg tagacgagcg gatgctgcgc tttctggatg acttcgagag
      481 ttgcccggcc ctgtaccagc gcacggtgct gcgggtacag ctgctggagg accgggcccc
      541 gggcgcagag gagccgccag cgcccaccgc ggtgcagtgc ttcgtgtaca gcagggccac
      601 cttcccgccg gagtgggccc agctcccgca ccatgacagc tacgactccg aggggccgca
      661 cgggctgcgc tacaaccccc gggagaacag ataaggggga cgggcagggt gggcctaggt
      721 ttgagagccc tggggctcca agatgcgccc agcccatgct gggtgaaggc ggaagccgaa
      781 cagggccctt tccaatgaat ctgccggaaa ggaaccaatc tttcagtggc agctgatttt
      841 acaaataatg ttgagatacg aatagcaagg tgcttccctc ccatctttct acctggtaag
      901 aaaaatttag gattttaact cccctaaatg acatttagag aactcgtgtt atgcctaatt
      961 cttcttcctc ctcgtgttgt ttctgctgtt ggctctgctt tgagctcaag ataataataa
     1021 atatttagga tcagtgtaaa gacttggtgt tgccgctaga ttttagcagc cctactatac
     1081 tgattctggc ctgtaacccc tgagaaagcc gattttacac ggctgggtag aatttgtaga
     1141 aaagatccac agggcaagca tgctgtatat cagagtgcgt atagcaccat tcttcctaat
     1201 tttcagatca agcttcacag caaatattaa agattattta aatttgaagt cgatgttttg
     1261 ggaaatcaga tataaaagtg ttggtactgt gtttgacccc cacgtttttt ggtatactta
     1321 tttggtagaa ggttctttac attctgatct agcaaaataa tgaacaccca cttgctggta
     1381 gacacagctg agcgcccgga cttcaagtgg aagtttatct gagcccagat ctcagtagcc
     1441 agaccccgtc cctgccccct gaagggagag catttggggg tgagtccttt caaagaagag
     1501 ccaatgcatt agtaatttgt tcttcaggcc tgacagaagc ttagcttcca aatacaaaca
     1561 gcacttaaaa taattttagc aaggcacgaa gtaccaatta ctacccacct ccatctgata
     1621 attgtcagca tcgattcaac tcggtgcacg gctcttgctt ctgcttccca gcaaagtctg
     1681 aaatgtattc caaggatttc agaaccaaat gaaaatgcag ctgctgtgat ctttagtaac
     1741 ctcattctct gttgggagag ctcacttact cttcaactta atggcagact gtgatcgcta
     1801 actgcatctg gcacaaaaac atgatcatta tttttagctt cttttgctta attggaaact
     1861 tgcttcacaa aaaacacaaa aaggctacgc tgggtctcag ctgatgagct cgtggcggcc
     1921 ctgtgcttga tgagggcggt gaggcagccc aagctccttg tgactgccct ggcttgtgca
     1981 atggggaagg gaccaggcag cgcgctcatc ctcaaaacaa acaaaaacag tggagacagc
     2041 acccccggcc aaccaggaag cttcagggtg acctccaggg gagtcagcca ccaacagtac
     2101 acccacatag agacacagca ggaaagggat tgccaaaatc tgcatttgca gtctctggtc
     2161 cttaggaagt tttgaaaatc agcaccagga gtgagggcct cacttctaga agtagtaagg
     2221 caatcagatg aaaaaatggc aagtgctaat ttaataaagc aaggcagaga actgactgac
     2281 atttatatca atctcttaaa aggatcacaa agaaatgctg gtagtctact ggcagagcct
     2341 gtcgcctatg tgtacattgt cttcattcaa agaaagggca aactaatatt tagacaaatg
     2401 ctcagtttta ttgatttaat tttgacacta gggaatctca cagcagaagt acaaatcata
     2461 tgtacaagta tttatatcaa tgaaaatttc cattggtgat tttttggcag aatattggtc
     2521 ttgactctgt ggaataaatg acgacgtaaa cgtagctgca caggggtgtt cctgtataat
     2581 gcttgaatca attgtgtgtg aaagcatcat gcaaatggct aattaaattg ggtgatgact
     2641 gaaa
//
