LOCUS       NM_138619               3871 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens golgi associated, gamma adaptin ear containing, ARF
            binding protein 3 (GGA3), transcript variant long, mRNA.
ACCESSION   NM_138619
VERSION     NM_138619.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3871)
  AUTHORS   Moller-Hansen,A., Hejla,D., Lee,H.K., Lyles,J.B., Yang,Y., Chen,K.,
            Li,W.L., Thomas,G. and Boerkoel,C.F.
  TITLE     Do PACS1 variants impeding adaptor protein binding predispose to
            syndromic intellectual disability?
  JOURNAL   Am J Med Genet A 191 (8), 2181-2187 (2023)
   PUBMED   37141437
  REMARK    GeneRIF: Do PACS1 variants impeding adaptor protein binding
            predispose to syndromic intellectual disability?
REFERENCE   2  (bases 1 to 3871)
  AUTHORS   Mihalic,F., Simonetti,L., Giudice,G., Sander,M.R., Lindqvist,R.,
            Peters,M.B.A., Benz,C., Kassa,E., Badgujar,D., Inturi,R., Ali,M.,
            Krystkowiak,I., Sayadi,A., Andersson,E., Aronsson,H., Soderberg,O.,
            Dobritzsch,D., Petsalaki,E., Overby,A.K., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Large-scale phage-based screening reveals extensive pan-viral
            mimicry of host short linear motifs
  JOURNAL   Nat Commun 14 (1), 2409 (2023)
   PUBMED   37100772
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3871)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   4  (bases 1 to 3871)
  AUTHORS   Doray,B., Liu,L., Lee,W.S., Jennings,B.C. and Kornfeld,S.
  TITLE     Inactivation of the three GGA genes in HeLa cells partially
            compromises lysosomal enzyme sorting
  JOURNAL   FEBS Open Bio 11 (2), 367-374 (2021)
   PUBMED   33206455
  REMARK    GeneRIF: Inactivation of the three GGA genes in HeLa cells
            partially compromises lysosomal enzyme sorting.
REFERENCE   5  (bases 1 to 3871)
  AUTHORS   Frechette,L., Binda,C., Genier,S., Degrandmaison,J., Boisvert,M.
            and Parent,J.L.
  TITLE     GGA3 interacts with L-type prostaglandin D synthase and regulates
            the recycling and signaling of the DP1 receptor for prostaglandin
            D2 in a Rab4-dependent mechanism
  JOURNAL   Cell Signal 72, 109641 (2020)
   PUBMED   32334026
  REMARK    GeneRIF: GGA3 interacts with L-type prostaglandin D synthase and
            regulates the recycling and signaling of the DP1 receptor for
            prostaglandin D2 in a Rab4-dependent mechanism.
REFERENCE   6  (bases 1 to 3871)
  AUTHORS   Puertollano,R., Randazzo,P.A., Presley,J.F., Hartnell,L.M. and
            Bonifacino,J.S.
  TITLE     The GGAs promote ARF-dependent recruitment of clathrin to the TGN
  JOURNAL   Cell 105 (1), 93-102 (2001)
   PUBMED   11301005
REFERENCE   7  (bases 1 to 3871)
  AUTHORS   Takatsu,H., Yoshino,K. and Nakayama,K.
  TITLE     Adaptor gamma ear homology domain conserved in gamma-adaptin and
            GGA proteins that interact with gamma-synergin
  JOURNAL   Biochem Biophys Res Commun 271 (3), 719-725 (2000)
   PUBMED   10814529
REFERENCE   8  (bases 1 to 3871)
  AUTHORS   Dell'Angelica,E.C., Puertollano,R., Mullins,C., Aguilar,R.C.,
            Vargas,J.D., Hartnell,L.M. and Bonifacino,J.S.
  TITLE     GGAs: a family of ADP ribosylation factor-binding proteins related
            to adaptors and associated with the Golgi complex
  JOURNAL   J Cell Biol 149 (1), 81-94 (2000)
   PUBMED   10747089
REFERENCE   9  (bases 1 to 3871)
  AUTHORS   Hirst,J., Lui,W.W., Bright,N.A., Totty,N., Seaman,M.N. and
            Robinson,M.S.
  TITLE     A family of proteins with gamma-adaptin and VHS domains that
            facilitate trafficking between the trans-Golgi network and the
            vacuole/lysosome
  JOURNAL   J Cell Biol 149 (1), 67-80 (2000)
   PUBMED   10747088
REFERENCE   10 (bases 1 to 3871)
  AUTHORS   Boman,A.L., Zhang,Cj., Zhu,X. and Kahn,R.A.
  TITLE     A family of ADP-ribosylation factor effectors that can alter
            membrane transport through the trans-Golgi
  JOURNAL   Mol Biol Cell 11 (4), 1241-1255 (2000)
   PUBMED   10749927
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA312660.1, AF219138.1,
            BC070044.1, AK291685.1, AF190864.1 and CB240770.1.
            
            On Jun 2, 2019 this sequence version replaced NM_138619.3.
            
            Summary: This gene encodes a member of the Golgi-localized, gamma
            adaptin ear-containing, ARF-binding (GGA) family. This family
            includes ubiquitous coat proteins that regulate the trafficking of
            proteins between the trans-Golgi network and the lysosome. These
            proteins share an amino-terminal VHS domain which mediates sorting
            of the mannose 6-phosphate receptors at the trans-Golgi network.
            They also contain a carboxy-terminal region with homology to the
            ear domain of gamma-adaptins. Multiple alternatively spliced
            transcript variants have been identified in this gene. [provided by
            RefSeq, Feb 2010].
            
            Transcript Variant: This variant (long) encodes the longest isoform
            (long).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.198908.1,
                                           SRR1660809.223015.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000537686.6/ ENSP00000438085.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DA312660.1         56-65
            11-1347             AF219138.1         1-1337
            1348-1360           BC070044.1         1243-1255
            1361-1984           AF219138.1         1351-1974
            1985-2492           AK291685.1         1872-2379
            2493-3870           AF190864.1         2383-3760
            3871-3871           CB240770.1         24-24               c
FEATURES             Location/Qualifiers
     source          1..3871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..3871
                     /gene="GGA3"
                     /note="golgi associated, gamma adaptin ear containing, ARF
                     binding protein 3"
                     /db_xref="GeneID:23163"
                     /db_xref="HGNC:HGNC:17079"
                     /db_xref="MIM:606006"
     exon            1..59
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..2191
                     /gene="GGA3"
                     /note="isoform long is encoded by transcript variant long;
                     Golgi-localized, gamma ear-containing, ARF-binding protein
                     3; ADP-ribosylation factor-binding protein GGA3"
                     /codon_start=1
                     /product="ADP-ribosylation factor-binding protein GGA3
                     isoform long"
                     /protein_id="NP_619525.1"
                     /db_xref="CCDS:CCDS11717.1"
                     /db_xref="GeneID:23163"
                     /db_xref="HGNC:HGNC:17079"
                     /db_xref="MIM:606006"
                     /translation="MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQ
                     IAVRLLAHKIQSPQEWEALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYL
                     GDRVSEKVKTKVIELLYSWTMALPEEAKIKDAYHMLKRQGIVQSDPPIPVDRTLIPSP
                     PPRPKNPVFDDEEKSKLLAKLLKSKNPDDLQEANKLIKSMVKEDEARIQKVTKRLHTL
                     EEVNNNVRLLSEMLLHYSQEDSSDGDRELMKELFDQCENKRRTLFKLASETEDNDNSL
                     GDILQASDNLSRVINSYKTIIEGQVINGEVATLTLPDSEGNSQCSNQGTLIDLAELDT
                     TNSLSSVLAPAPTPPSSGIPILPPPPQASGPPRSRSSSQAEATLGPSSTSNALSWLDE
                     ELLCLGLADPAPNVPPKESAGNSQWHLLQREQSDLDFFSPRPGTAACGASDAPLLQPS
                     APSSSSSQAPLPPPFPAPVVPASVPAPSAGSSLFSTGVAPALAPKVEPAVPGHHGLAL
                     GNSALHHLDALDQLLEEAKVTSGLVKPTTSPLIPTTTPARPLLPFSTGPGSPLFQPLS
                     FQSQGSPPKGPELSLASIHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDV
                     LVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLL
                     ANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFPPVEQWGNL"
     exon            60..144
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            145..220
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            221..319
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            320..443
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            444..547
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            548..628
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            629..766
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            767..848
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..965
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1211
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1282
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1602
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1799
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1969
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2080
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..3871
                     /gene="GGA3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3851..3856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGA3"
                     /note="hexamer: AATAAA"
     polyA_site      3871
                     /gene="GGA3"
                     /note="major polyA site"
ORIGIN      
        1 ggggccgggc ggctgcaata tggcggaggc ggaaggggaa agcctggagt cctggctcaa
       61 taaagccacc aatccttcca accgccagga ggactgggaa tacataattg gcttctgtga
      121 tcagatcaac aaggagctgg aagggccaca gatcgccgtc cgactgctgg cccacaagat
      181 ccagtcccca caggaatggg aggcgctcca ggccctgacg gtgctggagg catgcatgaa
      241 gaactgtggg aggagatttc ataacgaagt ggggaagttc cgctttttga atgagttaat
      301 caaagtcgtc tctccaaagt acctggggga cagggtgtct gagaaagtga agaccaaggt
      361 tattgagctg ctgtacagct ggaccatggc cctgccagaa gaagcaaaga tcaaagacgc
      421 ctaccacatg ctgaagagac agggcatagt gcagtctgac ccaccaattc ctgtggatag
      481 gacgctgatc ccctctccac cacctcgtcc caaaaaccct gtttttgatg atgaggagaa
      541 gtccaagctt ttagccaagc tgctgaaaag caaaaaccca gatgacctgc aggaggccaa
      601 caagctcatc aagtccatgg tgaaggaaga cgaggcacgg atccagaagg tgaccaagcg
      661 tctgcacacg ttagaggaag ttaacaacaa cgtgagactg ctcagtgaga tgctgcttca
      721 ttacagccag gaggactctt cggacgggga cagagagctg atgaaggagc tgtttgatca
      781 gtgtgagaac aagaggcgga ctttatttaa actcgccagt gagactgagg acaatgataa
      841 cagtttgggg gacatcctgc aagccagtga caacctctcc cgggtcatca actcttacaa
      901 aacaattatt gaagggcagg tcatcaatgg cgaggtggct accttaaccc tgcctgactc
      961 ggaaggaaac agtcagtgca gtaaccaagg cacgctcatc gaccttgcgg agctggacac
     1021 gaccaacagt ttgtcctccg tgttggcccc agcacctact ccaccctcct caggcatccc
     1081 aatcctccct ccaccacccc aggcctcagg acctccacgg agccgctcct ctagccaggc
     1141 cgaggccacc ctggggccca gcagcacaag caacgccctc tcctggctgg acgaggagct
     1201 actctgcttg ggcctcgccg acccagcccc taatgttcct cccaaagagt cagctgggaa
     1261 cagccagtgg cacctgctcc agagggaaca gtccgacctg gacttcttca gccccaggcc
     1321 ggggaccgct gcctgtggcg cctccgatgc tcctctgctc cagccctcag ccccctcctc
     1381 aagcagctcc caagctccac tgccgcctcc cttcccagct cctgtggtcc cagccagtgt
     1441 tcctgccccc agtgcgggct cctccttgtt ttctactgga gtggccccag ccttggcccc
     1501 aaaagttgag cccgcagtcc ctgggcacca tggcttggcg ttgggcaaca gcgcgctgca
     1561 ccacctggat gccctcgatc agcttctaga agaggccaaa gtgacctcgg gcttggtgaa
     1621 acccactacc tcccctctca tccccaccac caccccagcc aggcccctcc tgcccttctc
     1681 cacggggccc ggcagcccgc tcttccagcc actgagtttc cagtcccagg gcagcccccc
     1741 gaaggggcct gagctctccc tggccagcat ccacgtgccc ctggaatcga tcaagcctag
     1801 cagtgccctt cctgtgacag cctacgataa aaacggcttc cgcatcctct tccactttgc
     1861 caaggagtgt cccccaggac gacctgacgt gctggtggtg gtggtgtcca tgctgaacac
     1921 ggctccctta cctgtcaaga gcatcgtgct gcaggctgca gtgcccaagt caatgaaagt
     1981 gaagttgcag ccaccttctg ggacagaact ctctccattt agccccatcc agccacctgc
     2041 agccatcacc caggtcatgt tgctggccaa tccactgaag gagaaggtgc ggcttcggta
     2101 taagctgacc ttcgccctgg gggagcagct gagcacagag gtgggcgagg tggaccagtt
     2161 ccctcctgtg gaacagtggg ggaacctatg accccagagg acgctgtgat ctccaccttg
     2221 aagccaggca ggctgccctg agacgaggag ggctctggtc ccgtcactct ccatgccctg
     2281 acaacagtgc ttgtagcttt gatgtggaac aggggccctg ggcatttctg ctgagaacca
     2341 aactgctgct gtgataacct ctcctttggc ccctaaaagg acctgttttt atctacctgt
     2401 gtgacttgaa gtggccatat gctgtcaggg gtgcggagtg gcccctgact tcactgctgt
     2461 cccgggaaca tggaccccca ggcttggcgt aggtgtttgc ttccttctac tggcattcac
     2521 tgaagccact ggggtggggg gtggggggtg ggagtctcta aagagagact gtcatgggtc
     2581 attccccaca agagccacat cctcacacct gacagatgca cggcccaagg ggctgcagcc
     2641 ctgttgcaat tccatgcttc ccccgccaac cagctcctgc tgccatcccc agggaggtgg
     2701 cccaggaagg tgcctggccc agaataagga actggcatac tgcaaagtcc ccagccctgc
     2761 ctctggtgga cagcatcgtc ctggaatggc cacggagtga tgagttgtgt gcttgtccct
     2821 ggcagtggca ggctgtgtcc tatggacatc ttggcaggac atggaatttg gcctcatgac
     2881 aggcccaact agggatagga aggaaaatga agagagccag tatttcccct tctccagaag
     2941 caggtactca gctttctggg aaaagcgtgc ctccagccgt ggggacaggc catcctactg
     3001 actacctctt gcttggcatg aaataaactg ctatcctccc cttggaatct accgccactc
     3061 tacatcctac tgctttggcc tccctctcct ctcaccagat ggcatgtggt gtggcacctg
     3121 tggctggaca caggaggcct caggatcaca aatgttacac tagacatatg tcctaatgtg
     3181 ctgcccagaa acctcaactg ttccccagct actgaggggc actgtcagcg agatgttggg
     3241 tctggaggtg atgagatcgg gccacacttg agctgagtca ccagacccta ttgcttcaac
     3301 agtgcttggc ccccgccagc ttgtcccagc cactctagct gctggatgtg atcctgggac
     3361 atgtactcca agcctccgtc acaaaaaaaa aatcaccagc tgccatagac acgggggaag
     3421 cttgcggagc ccaggtgaac aagctcagca atcggacatc tctggggaaa ggaaggtggc
     3481 acagaccatg ttccctggtt cctccctgcc ccttgccagg cttccttatt ccttactatg
     3541 ggaagaggtc atatcccttc cctgcccctc gctgtcttta gcaagcaggt ttcactgctt
     3601 cattagaaga ggacaagtca aaagtgaatc atttttcact acttaaggaa taaatccaag
     3661 agctttccag agactggctg ctgcagccct gggaatgtct gtggaattac tatgtggaaa
     3721 tggaactttg tgttatgctc tagacattac agttatttga gtgttactcg ttactgttga
     3781 ggtcagtgct tcgtggcaaa tggctgtact ggatatccca gctctgctgc ccttgttttg
     3841 ctgcatgtta aataaaacca ttttcactgt a
//
