LOCUS       NM_015044               5973 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens golgi associated, gamma adaptin ear containing, ARF
            binding protein 2 (GGA2), mRNA.
ACCESSION   NM_015044
VERSION     NM_015044.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5973)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 5973)
  AUTHORS   Doray,B., Liu,L., Lee,W.S., Jennings,B.C. and Kornfeld,S.
  TITLE     Inactivation of the three GGA genes in HeLa cells partially
            compromises lysosomal enzyme sorting
  JOURNAL   FEBS Open Bio 11 (2), 367-374 (2021)
   PUBMED   33206455
  REMARK    GeneRIF: Inactivation of the three GGA genes in HeLa cells
            partially compromises lysosomal enzyme sorting.
REFERENCE   3  (bases 1 to 5973)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 5973)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5973)
  AUTHORS   Sahgal,P., Alanko,J., Icha,J., Paatero,I., Hamidi,H., Arjonen,A.,
            Pietila,M., Rokka,A. and Ivaska,J.
  TITLE     GGA2 and RAB13 promote activity-dependent beta1-integrin recycling
  JOURNAL   J Cell Sci 132 (11) (2019)
   PUBMED   31076515
  REMARK    GeneRIF: GGA2 and RAB13 are important specificity determinants for
            integrin activity-dependent traffic.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5973)
  AUTHORS   Takatsu,H., Yoshino,K. and Nakayama,K.
  TITLE     Adaptor gamma ear homology domain conserved in gamma-adaptin and
            GGA proteins that interact with gamma-synergin
  JOURNAL   Biochem Biophys Res Commun 271 (3), 719-725 (2000)
   PUBMED   10814529
REFERENCE   7  (bases 1 to 5973)
  AUTHORS   Dell'Angelica,E.C., Puertollano,R., Mullins,C., Aguilar,R.C.,
            Vargas,J.D., Hartnell,L.M. and Bonifacino,J.S.
  TITLE     GGAs: a family of ADP ribosylation factor-binding proteins related
            to adaptors and associated with the Golgi complex
  JOURNAL   J Cell Biol 149 (1), 81-94 (2000)
   PUBMED   10747089
REFERENCE   8  (bases 1 to 5973)
  AUTHORS   Hirst,J., Lui,W.W., Bright,N.A., Totty,N., Seaman,M.N. and
            Robinson,M.S.
  TITLE     A family of proteins with gamma-adaptin and VHS domains that
            facilitate trafficking between the trans-Golgi network and the
            vacuole/lysosome
  JOURNAL   J Cell Biol 149 (1), 67-80 (2000)
   PUBMED   10747088
REFERENCE   9  (bases 1 to 5973)
  AUTHORS   Boman,A.L., Zhang,Cj., Zhu,X. and Kahn,R.A.
  TITLE     A family of ADP-ribosylation factor effectors that can alter
            membrane transport through the trans-Golgi
  JOURNAL   Mol Biol Cell 11 (4), 1241-1255 (2000)
   PUBMED   10749927
REFERENCE   10 (bases 1 to 5973)
  AUTHORS   Poussu,A., Lohi,O. and Lehto,V.P.
  TITLE     Vear, a novel Golgi-associated protein with VHS and gamma-adaptin
            'ear' domains
  JOURNAL   J Biol Chem 275 (10), 7176-7183 (2000)
   PUBMED   10702286
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA439738.1, AF165531.1 and
            AC008915.11.
            
            On Feb 25, 2010 this sequence version replaced NM_015044.3.
            
            Summary: This gene encodes a member of the Golgi-localized, gamma
            adaptin ear-containing, ARF-binding (GGA) family. This family
            includes ubiquitous coat proteins that regulate the trafficking of
            proteins between the trans-Golgi network and the lysosome. These
            proteins share an amino-terminal VHS domain which mediates sorting
            of the mannose 6-phosphate receptors at the trans-Golgi network.
            They also contain a carboxy-terminal region with homology to the
            ear domain of gamma-adaptins. This family member may play a
            significant role in cargo molecules regulation and clathrin-coated
            vesicle assembly. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024619.1, SRR11853561.11051.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309859.8/ ENSP00000311962.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                DA439738.1         1-62
            63-2041             AF165531.1         1-1979
            2042-5973           AC008915.11        131853-135784       c
FEATURES             Location/Qualifiers
     source          1..5973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p12.2"
     gene            1..5973
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /note="golgi associated, gamma adaptin ear containing, ARF
                     binding protein 2"
                     /db_xref="GeneID:23062"
                     /db_xref="HGNC:HGNC:16064"
                     /db_xref="MIM:606005"
     exon            1..174
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1925
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /note="VHS domain and ear domain-containing protein;
                     gamma-adaptin-related protein 2; VHS domain and ear domain
                     of gamma-adaptin; golgi-localized, gamma ear-containing,
                     ARF-binding protein 2"
                     /codon_start=1
                     /product="ADP-ribosylation factor-binding protein GGA2"
                     /protein_id="NP_055859.1"
                     /db_xref="CCDS:CCDS10611.1"
                     /db_xref="GeneID:23062"
                     /db_xref="HGNC:HGNC:16064"
                     /db_xref="MIM:606005"
                     /translation="MAATAVAAAVAGTESAQGPPGPAASLELWLNKATDPSMSEQDWS
                     AIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMCMNHCGEKFHSEVA
                     KFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIKIRDAYQMLKKQGI
                     IKQDPKLPVDKILPPPSPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAANRLIKNLV
                     KEEQEKSEKVSKRVSAVEEVRSHVKVLQEMLSMYRRPGQAPPDQEALQVVYERCEKLR
                     PTLFRLASDTTDDDDALAEILQANDLLTQGVLLYKQVMEGRVTFGNRVTSSLGDIPVS
                     RVFQNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGISDAPVTGMVSGQNC
                     CEEKRNPSSSTLPGGGVQNPSADRNLLDLLSAQPAPCPLNYVSQKSVPKEVPPGTKSS
                     PGWSWEAGPLAPSPSSQNTPLAQVFVPLESVKPSSLPPLIVYDRNGFRILLHFSQTGA
                     PGHPEVQVLLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQPASSSKLPAFSPLMPPAVI
                     SQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEVKDFPDLAVLGAA"
     exon            175..259
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            260..335
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            336..434
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            435..558
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            559..662
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            663..743
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            744..881
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            882..963
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1089
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1212
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1241
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1375
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1533
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1703
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1814
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..5973
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3332..3337
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /note="hexamer: ATTACA"
     polyA_site      3355
                     /gene="GGA2"
                     /gene_synonym="VEAR"
     regulatory      5171..5176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /note="hexamer: AATAAA"
     polyA_site      5193
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /note="major polyA site"
     regulatory      5954..5959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGA2"
                     /gene_synonym="VEAR"
                     /note="hexamer: AATAAA"
     polyA_site      5973
                     /gene="GGA2"
                     /gene_synonym="VEAR"
ORIGIN      
        1 gcagtcagca gaggagagcg ccaggacgct acagcggctg aagaggcagt ggcgcccgcg
       61 gccgcagcgt cggggctgga gcgatggcgg cgaccgcggt ggcggcggct gtggcgggaa
      121 ccgagtcggc ccagggtccc ccgggcccgg cagcgtcgct ggagctgtgg ctcaacaaag
      181 ccacagaccc aagcatgtcg gaacaggatt ggtcagctat ccagaatttc tgtgagcagg
      241 tgaacactga ccccaatggc cccacacatg cgccctggct actggcccac aagatccagt
      301 ctccgcaaga gaaggaagct ctttatgcct taacggtgct ggagatgtgc atgaaccact
      361 gtggggagaa gttccacagc gaggtggcca aatttcgttt cctgaacgaa ctgatcaaag
      421 tgttgtcccc aaagtacctg gggtcctggg ccacaggaaa agttaaagga agagtcattg
      481 aaatactctt cagttggaca gtctggtttc cggaagacat caagattcga gacgcttatc
      541 agatgctgaa gaaacaagga attataaaac aagaccctaa actaccagtg gataaaatct
      601 tacccccacc atctccctgg cccaagagct ccatctttga tgctgatgaa gaaaagtcca
      661 agcttctgac aaggcttcta aagagcaacc accccgagga ccttcaggct gcaaaccggt
      721 taatcaagaa tttggtcaag gaggaacaag aaaaatcgga gaaggtgtcc aagagggtca
      781 gtgcggtgga ggaagtgcga agccatgtga aggtgctgca ggagatgctg agcatgtacc
      841 gcaggccagg gcaggccccg cccgaccagg aggccctgca ggtcgtgtat gagaggtgtg
      901 aaaagctgcg gcccacgctg ttccggttgg cgagtgacac cactgatgac gatgatgcac
      961 tcgcggaaat tctccaggca aatgacctcc tcacccaagg agttctgctg tacaaacagg
     1021 tgatggaggg ccgggtcacc tttggaaaca gagtgaccag ctcattggga gacatccctg
     1081 tctccagagt ctttcagaat ccagcaggct gcatgaagac ctgccccctg attgacttgg
     1141 aggtggacaa tggacctgcg cagatgggga ctgtggtgcc atctttgctt catcaggacc
     1201 tggcagcctt gggaatcagt gatgctcctg ttacaggcat ggtttctggt cagaattgct
     1261 gtgaggaaaa gaggaatccc tcctccagca cgctgccagg cggtggtgtt cagaaccctt
     1321 ctgcagacag gaatttgctg gacctcctct cagcacagcc agctccgtgc cctctgaatt
     1381 atgtttcgca gaaaagtgtc cccaaggaag tgccaccagg tactaagtcc tctccaggtt
     1441 ggtcctggga ggctggcccg ttggctcctt ccccatcttc acagaataca cctctggctc
     1501 aagtgtttgt ccctttggag tctgttaagc ccagcagcct gccgcctctc attgtgtatg
     1561 accggaatgg attcagaatt ctgctccact tctcccagac gggagcccct gggcacccag
     1621 aggtacaggt gctgctcttg accatgatga gcacggctcc ccagcctgtc tgggatatca
     1681 tgtttcaagt ggctgtgcca aagtcaatga gagtgaagct gcagccggca tccagctcca
     1741 agcttcctgc attcagtcct ttgatgcctc cagctgtgat atctcagatg ctgctgcttg
     1801 acaatccaca caaagaacct atccgcttac ggtacaagct gacattcaac caaggtggac
     1861 agcctttcag cgaagtagga gaagtgaaag acttcccaga cctggctgtc ttgggcgcag
     1921 cctaactttt cacaagatgg acccttcatt tcaagcttag gctggcgtta cttttgctgt
     1981 ctagtcagga ctaatcacgg tgtttcagtg cggagtgcca agagtcctat cctgacgtca
     2041 ggctctgggt gtcaacctct gacttattct gcagatgctc tgtgtgtgtg tgtgtgtgtg
     2101 tgtgtgtgtg tgtgtgtgtg tgtgtgttcg gggagagggt ggtagcacag ggcttgggat
     2161 atcggcagtg tgggaaatgc gaagcatttc tcatcatcat catctctgct acagtcatgt
     2221 ttctgcatgt cagcgagcga cactgtccct gcctcaggtt ggaggtttta tcagccaaag
     2281 tgtttttttc atgtatcgtt cgttccattc atccactctg tgccttgtca gcctttgaaa
     2341 ggcttggttg ctcccaggct gctgttctca gggaccttaa aagggacctg gttagtcttg
     2401 gggcagagag tatctacttg ggcactctct tccaagaaag accttgtctc cattttcatt
     2461 agacaatgct tcttgtgtgt gttctggaag atcttctaaa tggaatgctt gttgcactgt
     2521 tcccaggcga gtggctgcca tgagacctga ggaccacact tgggggacca atcatgtcct
     2581 tcaccactgt gccttagaat cgcccctgga cagagttcct gggcagaggg gaaagcagct
     2641 cccaggcctt actcaggcct caggtccatg ggttgggcag ccagtctggg cccttctcag
     2701 gatcctcatc tccatcctca tcctcttcct tcacagcatt tacttggagc tctttgtgac
     2761 acaccatgtc agtcatgatg aatcggccaa cagccagccc ttgccagctg acgtcacagt
     2821 ctaagatggg aaactgtggt acagatagac atgaagagag cttagcagtg attgaggtgg
     2881 tgactaaata tacagtcatt gaataaatac catgtagcaa gtgtactttg tggagtgttg
     2941 agtaagtgga aaatggaaag ccagttgcat ttagagatga taggcctaaa gggaactgtc
     3001 ttctgtcgag aagtaaagga aacttcatga aggatgtaga agcttagctg cctcagagaa
     3061 gagagaacct gaagatctga ggcaagctgg acaggagagg tggatatttg ttgatggaag
     3121 aattcaagtt tataatcaat tcccacttag cacctactgt gtgctaggaa cttgaatgtg
     3181 tatgtttgac aagtcctgct tggcctgatg ggtgggagaa ggaacctgag cctggctgag
     3241 atggctaggc ggagggcttt gaagtccaag cagctgaact ggctgggtgg gtttctacct
     3301 ttgaaactgc aagacttgtt tggagctctt aattacaata tctgatattt ttacagtctg
     3361 atcttttgac ttctacatat agtggaaatc tgccaatact aattggtgga gatgggaact
     3421 gtaaaagatc aagtatgcta attttaagca aatgtaaaaa ctcataaaac aggtaaacag
     3481 tggggtgatt tcatttgcca taattcacat aagacgaatt ttaatctaaa agtactttct
     3541 tgcttgtatt ctgtgtggct tttttttgtt ttttgaggcc atatctcact ctgtcactca
     3601 ggctggagtg cggtggtata atctcagctc actgcaatct ctgcctacca ggttcaagcg
     3661 attctcgtgc ctcagcctct cgagtagctg ggactacagg cgtgagccag cacgcccagc
     3721 taatttttgt atttttagta gagacaggat ttcaccatgt tggccaggct ggtctcgaac
     3781 tcctgacctc aggtgatccg cctgccttgg cctcccagag tgctgggatt acaggcgtga
     3841 gccaccgcac ccggcctctg tgtagctttt ataggctctg ttactgttgc gtagtcttga
     3901 agaggtaccc atcataatga cagcatctcc ctctgaaggg ttttggtcaa aatgggtgaa
     3961 tgagacttat acataaagac aggctttctc ccctatagtt aggaggtgaa ctcacacatg
     4021 tgtacctgaa cattcttgct tttgaggaga cagactccca gtggtactac tatgcttagg
     4081 tgttggacag gataggggta ggaggagagg aggcaggctg ctgtcctgaa agtggctgtg
     4141 gtttatggca tcactccctt ctaatcagca agtccagtgg ccacttagag cccagctcct
     4201 acctcttcat tcacttaaca agtagttatt ggctgtgcac agtggctcac gcctataatc
     4261 ccagcatttt gggaggctga gtgggatgac cgcttgagcc caggatttca agtccagcct
     4321 gggctacata gtgagaccgt gtctctgttt ttttaaaagc tagttgttga ccagctaccc
     4381 tgagccaggc accaccctga aggagcttct tttcctctgg ggagaagcaa attcatgatg
     4441 tgtgtgctgg agatctggca ctcatggcca gtgctttcca gtatcttgaa ctcttcgggg
     4501 gtcctgttga cccatttcgt gacctacctc cgtgactgct ctttttcctc tgtctcttaa
     4561 gtgtgatggt tttccagagt ccaatcctca ggactttccc gtccacacac aggcctggta
     4621 gtcaggtggc tctaaaccat taggtgggtt gtagacctct ctcaagctgc cacctccttg
     4681 ctgtcgccag atcgtatttc agtctgtcag gggttatctg tatctggagg ttccactgtt
     4741 gcttcagtct cagttactta gaatggaacc cagagtcctg cccctttcca cctacatgct
     4801 cttacttgaa agcacctgag acttattggg tccctgattc ctgcttcgtc tgtatccgca
     4861 gagtagttgc atgtcatttg gcctgttttc taaataatcc cacatcatgt cctccctgca
     4921 cttacattgc cactgctctg atttgggctt tttttttttt gggacaatgc ctctgtccca
     4981 attctgagta acagctctgg ttcttgccac taccagagtt ctctagcaaa tctgagcatc
     5041 tgacagggtg aaaaattctg aatggcttcc tgatgcctga ctttatggga tcaaattcaa
     5101 gttgcacgct ggcactcagt gcccttctgg tatcatctgc caagaccagg gcctgcttca
     5161 ccacagccac aataaagtcc tttcaagccc tgataatgcc atgttttgtc ctaacctttt
     5221 gctgcagtta attactcttc ctattatctt ccatgaactt aagactgggc aaaaatgttt
     5281 ccttatctgt gagccactct gaacacaaac aggtcatgaa gatagtgttg aaaacaataa
     5341 atgacaacca aaagaaaagt gaatattacc tagtacaaat agtgtaaatt gagacagaaa
     5401 atgttaaagc tagaaagcaa gggcaatatt ctagaataca aatagtgctt gcctactaca
     5461 atattaatcc caaatccttt aaatataccc attatagaag atgcttaccc agcgtcaaga
     5521 gtataaaagt gggtttgttt gttttcttga gacagggctt tgctctgttg cccaggctgg
     5581 agtgcagtgg cgtgattgta gctcaatgca gccttgaatt cctgtgttca ggcgatcctc
     5641 cggcttcagc ctctggagta gctgggacta caggtgcatg ctgccacgcc cagctaatgt
     5701 tgcagttttt cgtaaagact ggatctctgt gttacccagg ctggtctcct gggctcaagc
     5761 agtcctcctg ccttgacctc ccaaagtgct gggattacag gcatgagcca ccatgtcctg
     5821 accccagttt gttttaaagc caagcgatgc accaagatgt ttgtgtgcac atctgacagt
     5881 ggtaatcttt gggtcaggga attatagata aattttcttt aaattttttc tgagctttct
     5941 aaaatcagct gaaaataaaa ccttattttt tta
//
