LOCUS       NM_013365               2800 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens golgi associated, gamma adaptin ear containing, ARF
            binding protein 1 (GGA1), transcript variant 1, mRNA.
ACCESSION   NM_013365
VERSION     NM_013365.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2800)
  AUTHORS   Kliche,J., Simonetti,L., Krystkowiak,I., Kuss,H., Diallo,M.,
            Rask,E., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Proteome-scale characterisation of motif-based interactome rewiring
            by disease mutations
  JOURNAL   Mol Syst Biol 20 (9), 1025-1048 (2024)
   PUBMED   39009827
REFERENCE   2  (bases 1 to 2800)
  AUTHORS   Kliche,J., Garvanska,D.H., Simonetti,L., Badgujar,D.,
            Dobritzsch,D., Nilsson,J., Davey,N.E. and Ivarsson,Y.
  TITLE     Large-scale phosphomimetic screening identifies phospho-modulated
            motif-based protein interactions
  JOURNAL   Mol Syst Biol 19 (7), e11164 (2023)
   PUBMED   37219487
REFERENCE   3  (bases 1 to 2800)
  AUTHORS   Chevalier,B., Baatallah,N., Najm,M., Castanier,S., Jung,V.,
            Pranke,I., Golec,A., Stoven,V., Marullo,S., Antigny,F.,
            Guerrera,I.C., Sermet-Gaudelus,I., Edelman,A. and Hinzpeter,A.
  TITLE     Differential CFTR-Interactome Proximity Labeling Procedures
            Identify Enrichment in Multiple SLC Transporters
  JOURNAL   Int J Mol Sci 23 (16), 8937 (2022)
   PUBMED   36012204
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2800)
  AUTHORS   Lim,S.H., Snider,J., Birimberg-Schwartz,L., Ip,W., Serralha,J.C.,
            Botelho,H.M., Lopes-Pacheco,M., Pinto,M.C., Moutaoufik,M.T.,
            Zilocchi,M., Laselva,O., Esmaeili,M., Kotlyar,M., Lyakisheva,A.,
            Tang,P., Lopez Vazquez,L., Akula,I., Aboualizadeh,F., Wong,V.,
            Grozavu,I., Opacak-Bernardi,T., Yao,Z., Mendoza,M., Babu,M.,
            Jurisica,I., Gonska,T., Bear,C.E., Amaral,M.D. and Stagljar,I.
  TITLE     CFTR interactome mapping using the mammalian membrane two-hybrid
            high-throughput screening system
  JOURNAL   Mol Syst Biol 18 (2), e10629 (2022)
   PUBMED   35156780
REFERENCE   5  (bases 1 to 2800)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2800)
  AUTHORS   Takatsu,H., Yoshino,K. and Nakayama,K.
  TITLE     Adaptor gamma ear homology domain conserved in gamma-adaptin and
            GGA proteins that interact with gamma-synergin
  JOURNAL   Biochem Biophys Res Commun 271 (3), 719-725 (2000)
   PUBMED   10814529
REFERENCE   7  (bases 1 to 2800)
  AUTHORS   Dell'Angelica,E.C., Puertollano,R., Mullins,C., Aguilar,R.C.,
            Vargas,J.D., Hartnell,L.M. and Bonifacino,J.S.
  TITLE     GGAs: a family of ADP ribosylation factor-binding proteins related
            to adaptors and associated with the Golgi complex
  JOURNAL   J Cell Biol 149 (1), 81-94 (2000)
   PUBMED   10747089
REFERENCE   8  (bases 1 to 2800)
  AUTHORS   Hirst,J., Lui,W.W., Bright,N.A., Totty,N., Seaman,M.N. and
            Robinson,M.S.
  TITLE     A family of proteins with gamma-adaptin and VHS domains that
            facilitate trafficking between the trans-Golgi network and the
            vacuole/lysosome
  JOURNAL   J Cell Biol 149 (1), 67-80 (2000)
   PUBMED   10747088
REFERENCE   9  (bases 1 to 2800)
  AUTHORS   Boman,A.L., Zhang,Cj., Zhu,X. and Kahn,R.A.
  TITLE     A family of ADP-ribosylation factor effectors that can alter
            membrane transport through the trans-Golgi
  JOURNAL   Mol Biol Cell 11 (4), 1241-1255 (2000)
   PUBMED   10749927
REFERENCE   10 (bases 1 to 2800)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK075256.1 and AL110219.1.
            
            On Nov 23, 2018 this sequence version replaced NM_013365.4.
            
            Summary: This gene encodes a member of the Golgi-localized, gamma
            adaptin ear-containing, ARF-binding (GGA) protein family. Members
            of this family are ubiquitous coat proteins that regulate the
            trafficking of proteins between the trans-Golgi network and the
            lysosome. These proteins share an amino-terminal VHS domain which
            mediates sorting of the mannose 6-phosphate receptors at the
            trans-Golgi network. They also contain a carboxy-terminal region
            with homology to the ear domain of gamma-adaptins. Multiple
            alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.755601.1, AK075256.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343632.9/ ENSP00000341344.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2369              AK075256.1         339-2707
            2370-2800           AL110219.1         2254-2684
FEATURES             Location/Qualifiers
     source          1..2800
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2800
                     /gene="GGA1"
                     /note="golgi associated, gamma adaptin ear containing, ARF
                     binding protein 1"
                     /db_xref="GeneID:26088"
                     /db_xref="HGNC:HGNC:17842"
                     /db_xref="MIM:606004"
     exon            1..70
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1947
                     /gene="GGA1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosylation factor binding protein 1; gamma-adaptin
                     related protein 1; ADP-ribosylation factor-binding protein
                     GGA1; golgi-localized, gamma ear-containing, ARF-binding
                     protein 1"
                     /codon_start=1
                     /product="ADP-ribosylation factor-binding protein GGA1
                     isoform 1"
                     /protein_id="NP_037497.1"
                     /db_xref="CCDS:CCDS13951.1"
                     /db_xref="GeneID:26088"
                     /db_xref="HGNC:HGNC:17842"
                     /db_xref="MIM:606004"
                     /translation="MEPAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGP
                     PLATRLLAHKIQSPQEWEAIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKY
                     LGSRTSEKVKNKILELLYSWTVGLPEEVKIAEAYQMLKKQGIVKSDPKLPDDTTFPLP
                     PPRPKNVIFEDEEKSKMLARLLKSSHPEDLRAANKLIKEMVQEDQKRMEKISKRVNAI
                     EEVNNNVKLLTEMVMSHSQGGAAAGSSEDLMKELYQRCERMRPTLFRLASDTEDNDEA
                     LAEILQANDNLTQVINLYKQLVRGEEVNGDATAGSIPGSTSALLDLSGLDLPPAGTTY
                     PAMPTRPGEQASPEQPSASVSLLDDELMSLGLSDPTPPSGPSLDGTGWNSFQSSDATE
                     PPAPALAQAPSMESRPPAQTSLPASSGLDDLDLLGKTLLQQSLPPESQQVRWEKQQPT
                     PRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEPPRPPQQPVPTELSLASITVPLESIK
                     PSNILPVTVYDQHGFRILFHFARDPLPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPK
                     VMKVKLQPPSGTELPAFNPIVHPSAITQVLLLANPQKEKVRLRYKLTFTMGDQTYNEM
                     GDVDQFPPPETWGSL"
     exon            71..155
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            156..231
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            232..330
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..454
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..555
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..636
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..777
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            778..859
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..967
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1120
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1185
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1358
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1555
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1725
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1836
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1837..2800
                     /gene="GGA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2778..2783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GGA1"
                     /note="hexamer: AATAAA"
     polyA_site      2800
                     /gene="GGA1"
                     /note="major polyA site"
ORIGIN      
        1 ggtgccgagg ctgggggccg gtggcggatg gagcccgcga tggagccgga gactctggag
       61 gcgcgaatca atagagccac gaaccccctg aacaaggagc tcgactgggc cagcatcaac
      121 ggcttctgcg agcagctcaa cgaggacttt gaggggcctc cactcgccac ccggctgctg
      181 gcccacaaga tccagtcccc acaggagtgg gaggcgatcc aggccttgac ggtgctggaa
      241 acatgcatga agagctgcgg caagcggttc cacgacgaag tgggcaagtt ccgctttctc
      301 aacgagctca tcaaggtcgt gtctcccaag tatctgggct ctcggacatc ggagaaggtg
      361 aagaacaaga tcttggagct cctctacagc tggacagtgg gcctgcccga ggaggtgaaa
      421 atcgcagagg cctaccagat gctaaagaag caggggattg taaagtccga ccccaagctt
      481 ccagatgaca ctacctttcc ccttcctcct ccacggccga agaatgtgat ctttgaagat
      541 gaggagaaat ccaagatgct ggcccgcctg ctgaagagct cccatcccga agacctccgc
      601 gcagccaata agctcatcaa agagatggtg caggaggacc agaagcggat ggagaagatc
      661 tcgaagaggg tgaatgccat cgaggaggtg aacaacaatg tgaaactgct cacggagatg
      721 gtgatgagcc acagccaggg cggcgcagca gctggcagca gcgaggacct catgaaggaa
      781 ctgtaccagc gctgtgagcg gatgcggccc acgctcttcc gactggcgag tgacacagag
      841 gacaatgatg aggccttagc ggagatcctg caggccaatg acaacctcac ccaggtgatc
      901 aacctgtata agcagctggt gcggggtgag gaggtcaacg gtgatgccac agccggctcc
      961 atccctggga gcacctcggc cctgctggat ctctcaggcc tggatctccc gcctgcgggc
     1021 accacctacc cagctatgcc cacccgccct ggcgagcagg ccagccctga gcagcccagt
     1081 gcctcagttt ccctgcttga cgacgagctc atgtctctgg gcctcagtga ccccacaccc
     1141 ccttcaggcc caagcctgga tggtaccgga tggaacagct tccagtcgtc ggatgccact
     1201 gagcccccag cccctgctct ggcccaggcc cccagtatgg aaagccgacc cccagcgcag
     1261 acatccctgc cagcaagcag cggtctggac gacctagacc tcctggggaa gaccctcctg
     1321 cagcagtcgc tgcccccgga atcccagcaa gtgcggtggg agaagcagca gccaaccccc
     1381 cggctcacac tccgggacct gcagaataag agcagcagct gcagctcccc cagctccagc
     1441 gccaccagcc ttctccacac cgtgtcccca gagcccccca ggcctccgca gcagcccgta
     1501 ccaaccgagc tctcactggc cagcatcact gtgcccctgg agtccatcaa acccagcaac
     1561 atcctgcccg tgactgtgta tgaccagcac ggcttccgca tcctcttcca ttttgcccgg
     1621 gacccactgc cagggcgctc cgacgtgctg gtggtggtgg tttccatgct gagcaccgcc
     1681 ccccagccca tccgcaacat cgtgttccag tcagctgtcc ccaaggttat gaaggtgaag
     1741 ctgcagccac cctcgggcac ggagctgcca gcttttaacc ccatcgtcca cccctcagca
     1801 atcacccagg tcctgctgct tgccaacccc cagaaggaga aggttcgcct ccgctacaag
     1861 ctcaccttca ccatgggtga ccagacctac aacgagatgg gggatgtgga ccagttcccc
     1921 ccacctgaaa cctggggtag cctctagaac agaggggctg gggagaggaa ggggcagagg
     1981 gaccggtcac tgtccagcct ggagggaggc attggtggcc aaggacaccc tttgttgccc
     2041 atggccattc acccccaggc ctggtgcttc tccccacacc cctgtaggcc tcaagtgact
     2101 cttccccctc ctgctccggc cccgcccctg ctgagccaaa cccagtagga ggctgggcct
     2161 gggtttgtgc cgctggggtc tccatcaccg ggacctggag agggaggggc tgtgtagcct
     2221 tggaagaact tgggtcatgg ggaggaagca cagctgttgg ggaagggcca ggacctcagg
     2281 cccagcccca accccagctg gggtggggtc ttccccacct gtctcttatg ccttatggga
     2341 aggcccagcc ataactcggg ggccatgctg gagctgggga ccagcttagg cctcctccat
     2401 aggaacccag tgactggggg gtgacgccta cacccccagc tatttgcact ctggtgtgtg
     2461 gtttgactct gcttttcttc cggattggcc ctgtggtcac agcctcaggg ggccaggctg
     2521 ggggaacctc acctggcccg tactcctggg ggtttccctt tgccattggg ccccctgagg
     2581 gactgtgggg gctcaagggt aatgccagag gcccatggcc ccagcgaggg gctgtggggc
     2641 acctagagtt ctcggtgtgt ctccttcatt cattggcctc tgctggggcc tcctatgggt
     2701 gtcttacgtc tgtccatcca tctgtccgtg gtcagaagtg gggtcagtgt gtgagtgaga
     2761 gcaggagtat ttatgaaaat aaaacgtcgt ttttcctgga
//
