LOCUS       NM_207410               1911 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens GDNF family receptor alpha like (GFRAL), mRNA.
ACCESSION   NM_207410
VERSION     NM_207410.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1911)
  AUTHORS   Xie,B., Tang,W., Wen,S., Chen,F., Yang,C., Wang,M., Yang,Y. and
            Liang,W.
  TITLE     GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the
            GFRAL/RET Signaling Complex
  JOURNAL   Biomolecules 14 (1), 38 (2023)
   PUBMED   38254638
  REMARK    GeneRIF: GDF-15 Inhibits ADP-Induced Human Platelet Aggregation
            through the GFRAL/RET Signaling Complex.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1911)
  AUTHORS   Chow,C.F.W., Guo,X., Asthana,P., Zhang,S., Wong,S.K.K., Fallah,S.,
            Che,S., Gurung,S., Wang,Z., Lee,K.B., Ge,X., Yuan,S., Xu,H.,
            Ip,J.P.K., Jiang,Z., Zhai,L., Wu,J., Zhang,Y., Mahato,A.K.,
            Saarma,M., Lin,C.Y., Kwan,H.Y., Huang,T., Lyu,A., Zhou,Z.,
            Bian,Z.X. and Wong,H.L.X.
  TITLE     Body weight regulation via MT1-MMP-mediated cleavage of GFRAL
  JOURNAL   Nat Metab 4 (2), 203-212 (2022)
   PUBMED   35177851
REFERENCE   3  (bases 1 to 1911)
  AUTHORS   Wittekind,D.A., Scholz,M., Kratzsch,J., Loffler,M., Horn,K.,
            Kirsten,H., Witte,V., Villringer,A. and Kluge,M.
  TITLE     Genome-wide association and transcriptome analysis suggests total
            serum ghrelin to be linked with GFRAL
  JOURNAL   Eur J Endocrinol 184 (6), 847-856 (2021)
   PUBMED   33852427
  REMARK    GeneRIF: Genome-wide association and transcriptome analysis
            suggests total serum ghrelin to be linked with GFRAL.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1911)
  AUTHORS   Zhao,Z., Zhang,J., Yin,L., Yang,J., Zheng,Y., Zhang,M., Ni,B. and
            Wang,H.
  TITLE     Upregulated GDF-15 expression facilitates pancreatic ductal
            adenocarcinoma progression through orphan receptor GFRAL
  JOURNAL   Aging (Albany NY) 12 (22), 22564-22581 (2020)
   PUBMED   33201838
  REMARK    GeneRIF: Upregulated GDF-15 expression facilitates pancreatic
            ductal adenocarcinoma progression through orphan receptor GFRAL.
REFERENCE   5  (bases 1 to 1911)
  AUTHORS   Suriben,R., Chen,M., Higbee,J., Oeffinger,J., Ventura,R., Li,B.,
            Mondal,K., Gao,Z., Ayupova,D., Taskar,P., Li,D., Starck,S.R.,
            Chen,H.H., McEntee,M., Katewa,S.D., Phung,V., Wang,M.,
            Kekatpure,A., Lakshminarasimhan,D., White,A., Olland,A.,
            Haldankar,R., Solloway,M.J., Hsu,J.Y., Wang,Y., Tang,J.,
            Lindhout,D.A. and Allan,B.B.
  TITLE     Antibody-mediated inhibition of GDF15-GFRAL activity reverses
            cancer cachexia in mice
  JOURNAL   Nat Med 26 (8), 1264-1270 (2020)
   PUBMED   32661391
  REMARK    GeneRIF: Antibody-mediated inhibition of GDF15-GFRAL activity
            reverses cancer cachexia in mice.
REFERENCE   6  (bases 1 to 1911)
  AUTHORS   Emmerson,P.J., Wang,F., Du,Y., Liu,Q., Pickard,R.T., Gonciarz,M.D.,
            Coskun,T., Hamang,M.J., Sindelar,D.K., Ballman,K.K., Foltz,L.A.,
            Muppidi,A., Alsina-Fernandez,J., Barnard,G.C., Tang,J.X., Liu,X.,
            Mao,X., Siegel,R., Sloan,J.H., Mitchell,P.J., Zhang,B.B.,
            Gimeno,R.E., Shan,B. and Wu,X.
  TITLE     The metabolic effects of GDF15 are mediated by the orphan receptor
            GFRAL
  JOURNAL   Nat Med 23 (10), 1215-1219 (2017)
   PUBMED   28846098
REFERENCE   7  (bases 1 to 1911)
  AUTHORS   Mullican,S.E., Lin-Schmidt,X., Chin,C.N., Chavez,J.A., Furman,J.L.,
            Armstrong,A.A., Beck,S.C., South,V.J., Dinh,T.Q., Cash-Mason,T.D.,
            Cavanaugh,C.R., Nelson,S., Huang,C., Hunter,M.J. and Rangwala,S.M.
  TITLE     GFRAL is the receptor for GDF15 and the ligand promotes weight loss
            in mice and nonhuman primates
  JOURNAL   Nat Med 23 (10), 1150-1157 (2017)
   PUBMED   28846097
REFERENCE   8  (bases 1 to 1911)
  AUTHORS   Li,Z., Wang,B., Wu,X., Cheng,S.Y., Paraoan,L. and Zhou,J.
  TITLE     Identification, expression and functional characterization of the
            GRAL gene
  JOURNAL   J Neurochem 95 (2), 361-376 (2005)
   PUBMED   16086688
REFERENCE   9  (bases 1 to 1911)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   10 (bases 1 to 1911)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358198.1 and AL592426.9.
            
            On May 23, 2007 this sequence version replaced NM_207410.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358198.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142680 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340465.2/ ENSP00000343636.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AY358198.1         1-58
            59-1244             AY358198.1         60-1245
            1245-1857           AL592426.9         95358-95970
            1858-1911           AY358198.1         1857-1910
FEATURES             Location/Qualifiers
     source          1..1911
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..1911
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /note="GDNF family receptor alpha like"
                     /db_xref="GeneID:389400"
                     /db_xref="HGNC:HGNC:32789"
                     /db_xref="MIM:617837"
     exon            1..108
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1271
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /note="IVFI9356"
                     /codon_start=1
                     /product="GDNF family receptor alpha-like precursor"
                     /protein_id="NP_997293.2"
                     /db_xref="CCDS:CCDS4957.1"
                     /db_xref="GeneID:389400"
                     /db_xref="HGNC:HGNC:32789"
                     /db_xref="MIM:617837"
                     /translation="MIVFIFLAMGLSLENEYTSQTNNCTYLREQCLRDANGCKHAWRV
                     MEDACNDSDPGDPCKMRNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCI
                     NKSDNVKEDKFKWNLTTRSHHGFKGMWSCLEVAEACVGDVVCNAQLASYLKACSANGN
                     PCDLKQCQAAIRFFYQNIPFNIAQMLAFCDCAQSDIPCQQSKEALHSKTCAVNMVPPP
                     TCLSVIRSCQNDELCRRHYRTFQSKCWQRVTRKCHEDENCISTLSKQDLTCSGSDDCK
                     AAYIDILGTVLQVQCTCRTITQSEESLCKIFQHMLHRKSCFNYPTLSNVKGMALYTRK
                     HANKITLTGFHSPFNGEVIYAAMCMTVTCGILLLVMVKLRTSRISSKARDPSSIQIPG
                     EL"
     exon            109..243
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     exon            244..402
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     exon            403..456
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     exon            457..787
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1038
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1134
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1207
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1911
                     /gene="GFRAL"
                     /gene_synonym="bA360D14.1; C6orf144; GRAL; UNQ9356"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttattctgga cagttactct taagaaagtt gtcagaagaa acgcatctgc ctttttttcc
       61 aggtgaactg ccgtgagttg tccagcatga tagtgtttat tttcttggct atggggttaa
      121 gcttggaaaa tgaatacact tcccaaacca ataattgcac atatttaaga gagcaatgct
      181 tacgtgatgc aaatggatgt aaacatgctt ggagagtaat ggaagatgcc tgcaatgatt
      241 cagatccagg tgacccctgc aagatgagga attcatcata ctgtaacctg agtatccagt
      301 acttagtgga aagcaatttc caatttaaag agtgtctttg cactgatgac ttctattgta
      361 ctgtgaacaa actgcttgga aaaaaatgta tcaataaatc agataacgtg aaagaggata
      421 aattcaaatg gaatctaact acacgttccc atcatggatt caaagggatg tggtcctgtt
      481 tggaagtggc agaggcatgt gtaggggatg tggtctgtaa tgcacagttg gcctcttacc
      541 ttaaagcttg ctcagcaaat ggaaatccgt gtgatctgaa acagtgccaa gcagccatac
      601 ggttcttcta tcaaaatata ccttttaaca ttgcccagat gttggctttt tgtgactgtg
      661 ctcaatctga tataccttgt cagcagtcca aagaagctct tcacagcaag acatgtgcag
      721 tgaacatggt tccaccccct acttgcctca gtgtaattcg cagctgccaa aatgatgaat
      781 tatgcaggag gcactataga acatttcagt caaaatgctg gcagcgtgtg actagaaagt
      841 gccatgaaga tgagaattgc attagcacct taagcaaaca ggacctcact tgttcaggaa
      901 gtgatgactg caaagctgct tacatagata tccttgggac ggtccttcaa gtgcaatgta
      961 cctgtaggac cattacacaa agtgaggaat ctttgtgtaa gattttccag cacatgcttc
     1021 atagaaaatc atgtttcaat tatccaaccc tgtctaatgt caaaggcatg gcattgtata
     1081 caagaaaaca tgcaaacaaa atcactttaa ctggatttca ttcccccttc aatggagaag
     1141 taatctatgc tgccatgtgc atgacagtca cctgtggaat ccttctgttg gttatggtca
     1201 agcttagaac ttccagaata tcaagtaaag caagagatcc ttcatcgatc caaatacctg
     1261 gagaactctg attcattagg agtcatggac ctataacaat cactcttttc tctgcttttc
     1321 ttctttcctc ttttcttctc tcctctcctc tcctctcttc tcctctcctc ccctcccctc
     1381 tctgtttctt tttctttttc ttttcttttt tgtggcggag ttttgctctt gttgcccagg
     1441 ctgcagtaca atggctcaat ctcggttcac tgcaacctct gcctccaagg ttcaagtgat
     1501 tttcctgcct cagccttccc gagtagctgg gattacaggt acccgccacc acgcccagct
     1561 aatttttttg tatttttagt agagatgggg ttttgccaaa ttggccaggg tggtctcaaa
     1621 ctcctgacct caggtgatcc acccacctcg gcctcccaaa gtgctgggat tacaggcgtg
     1681 agcaaccacg tcaagacaac aatcactttc tttaaagcaa atcctacagc tggtcaacac
     1741 cctattccat ctgtcatcga gaaagaaaat gttaaaatag acttaaaaat attgctttgt
     1801 tacatataat aatatggcat gatgatgtta tttttttctt aatactcaag aaaaaatata
     1861 tggtggtatc ttttacaaca ctggaacaga aataaagttt cccttgaagg c
//
