LOCUS       NM_001496               1988 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens GDNF family receptor alpha 3 (GFRA3), mRNA.
ACCESSION   NM_001496
VERSION     NM_001496.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1988)
  AUTHORS   Li,J., Shang,G., Chen,Y.J., Brautigam,C.A., Liou,J., Zhang,X. and
            Bai,X.C.
  TITLE     Cryo-EM analyses reveal the common mechanism and diversification in
            the activation of RET by different ligands
  JOURNAL   Elife 8, e47650 (2019)
   PUBMED   31535977
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1988)
  AUTHORS   Yan,Y., Li,M.N., Yang,B., Geng,J., Zheng,J.H. and Yao,X.D.
  TITLE     Expression of GFRalpha3 correlates with tumor progression and
            promotes cell metastasis in urothelial carcinoma
  JOURNAL   Minerva Urol Nefrol 70 (1), 79-86 (2018)
   PUBMED   28651425
  REMARK    GeneRIF: increased GFRalpha3 expression is significantly correlated
            with poor prognosis of patients with urothelial carcinoma
REFERENCE   3  (bases 1 to 1988)
  AUTHORS   Ito,Y., Inoue,A., Seers,T., Hato,Y., Igarashi,A., Toyama,T.,
            Taganov,K.D., Boldin,M.P. and Asahara,H.
  TITLE     Identification of targets of tumor suppressor microRNA-34a using a
            reporter library system
  JOURNAL   Proc Natl Acad Sci U S A 114 (15), 3927-3932 (2017)
   PUBMED   28356515
  REMARK    GeneRIF: Mir-34a directly regulates GFRA3 via its coding
            region.GFRA3 is crucial for breast cancer growth.
REFERENCE   4  (bases 1 to 1988)
  AUTHORS   Eftang,L.L., Klajic,J., Kristensen,V.N., Tost,J., Esbensen,Q.Y.,
            Blom,G.P., Bukholm,I.R. and Bukholm,G.
  TITLE     GFRA3 promoter methylation may be associated with decreased
            postoperative survival in gastric cancer
  JOURNAL   BMC Cancer 16, 225 (2016)
   PUBMED   26984265
  REMARK    GeneRIF: The GFRA3 promoter region showed marked hypermethylation
            in almost all tumors, and its correlation with survival and other
            clinicopathological parameters may have important prognostic
            significance.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1988)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 1988)
  AUTHORS   Baloh,R.H., Tansey,M.G., Lampe,P.A., Fahrner,T.J., Enomoto,H.,
            Simburger,K.S., Leitner,M.L., Araki,T., Johnson,E.M. Jr. and
            Milbrandt,J.
  TITLE     Artemin, a novel member of the GDNF ligand family, supports
            peripheral and central neurons and signals through the
            GFRalpha3-RET receptor complex
  JOURNAL   Neuron 21 (6), 1291-1302 (1998)
   PUBMED   9883723
REFERENCE   7  (bases 1 to 1988)
  AUTHORS   Baloh,R.H., Gorodinsky,A., Golden,J.P., Tansey,M.G., Keck,C.L.,
            Popescu,N.C., Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     GFRalpha3 is an orphan member of the GDNF/neurturin/persephin
            receptor family
  JOURNAL   Proc Natl Acad Sci U S A 95 (10), 5801-5806 (1998)
   PUBMED   9576965
REFERENCE   8  (bases 1 to 1988)
  AUTHORS   Masure,S., Cik,M., Pangalos,M.N., Bonaventure,P., Verhasselt,P.,
            Lesage,A.S., Leysen,J.E. and Gordon,R.D.
  TITLE     Molecular cloning, expression and tissue distribution of
            glial-cell-line-derived neurotrophic factor family receptor alpha-3
            (GFRalpha-3)
  JOURNAL   Eur J Biochem 251 (3), 622-630 (1998)
   PUBMED   9490034
REFERENCE   9  (bases 1 to 1988)
  AUTHORS   Jing,S., Yu,Y., Fang,M., Hu,Z., Holst,P.L., Boone,T., Delaney,J.,
            Schultz,H., Zhou,R. and Fox,G.M.
  TITLE     GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the
            GDNF family
  JOURNAL   J Biol Chem 272 (52), 33111-33117 (1997)
   PUBMED   9407096
REFERENCE   10 (bases 1 to 1988)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104116.3, AC106752.3,
            AY359037.1, BC037951.1 and AW020606.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001496.3.
            
            Summary: The protein encoded by this gene is a
            glycosylphosphatidylinositol(GPI)-linked cell surface receptor and
            a member of the GDNF receptor family. It forms a signaling receptor
            complex with RET tyrosine kinase receptor and binds the ligand,
            artemin. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.770867.1,
                                           SRR3476690.74221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152474 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274721.8/ ENSP00000274721.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AC104116.3         2929-2952           c
            25-57               AC106752.3         95894-95926         c
            58-576              AY359037.1         2-520
            577-1716            BC037951.1         405-1544
            1717-1849           AW020606.2         191-323
            1850-1988           BC037951.1         1678-1816
FEATURES             Location/Qualifiers
     source          1..1988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.2"
     gene            1..1988
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /note="GDNF family receptor alpha 3"
                     /db_xref="GeneID:2676"
                     /db_xref="HGNC:HGNC:4245"
                     /db_xref="MIM:605710"
     exon            1..288
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            289..576
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            577..669
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            670..982
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1086
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1221
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1222..1310
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1988
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1971..1976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /note="hexamer: ATTAAA"
     polyA_site      1988
                     /gene="GFRA3"
                     /gene_synonym="GDNFR3"
                     /note="major polyA site"
ORIGIN      
        1 ggaccagcgc tggaggcgcg tggtgtggac gcgcgcttcg gagttggagg gcggcgccca
       61 ggaccctggt gggagagtgt gtgcgtcgcg ctggagggcg ggaggcgggg gcgggaggtg
      121 ccggtcgagg gagccccgct ctcagagctc caggggagga gcgaggggag cgcggagccc
      181 ggcgcctaca gctcgccatg gtgcgccccc tgaacccgcg accgctgccg cccgtagtcc
      241 tgatgttgct gctgctgctg ccgccgtcgc cgctgcctct cgcagccgga gacccccttc
      301 ccacagaaag ccgactcatg aacagctgtc tccaggccag gaggaagtgc caggctgatc
      361 ccacctgcag tgctgcctac caccacctgg attcctgcac ctctagcata agcaccccac
      421 tgccctcaga ggagccttcg gtccctgctg actgcctgga ggcagcacag caactcagga
      481 acagctctct gataggctgc atgtgccacc ggcgcatgaa gaaccaggtt gcctgcttgg
      541 acatctattg gaccgttcac cgtgcccgca gccttggtaa ctatgagctg gatgtctccc
      601 cctatgaaga cacagtgacc agcaaaccct ggaaaatgaa tctcagcaaa ctgaacatgc
      661 tcaaaccaga ctcagacctc tgcctcaagt ttgccatgct gtgtactctc aatgacaagt
      721 gtgaccggct gcgcaaggcc tacggggagg cgtgctccgg gccccactgc cagcgccacg
      781 tctgcctcag gcagctgctc actttcttcg agaaggccgc cgagccccac gcgcagggcc
      841 tgctactgtg cccatgtgcc cccaacgacc ggggctgcgg ggagcgccgg cgcaacacca
      901 tcgcccccaa ctgcgcgctg ccgcctgtgg cccccaactg cctggagctg cggcgcctct
      961 gcttctccga cccgctttgc agatcacgcc tggtggattt ccagacccac tgccatccca
     1021 tggacatcct aggaacttgt gcaacagagc agtccagatg tctacgagca tacctggggc
     1081 tgattgggac tgccatgacc cccaactttg tcagcaatgt caacaccagt gttgccttaa
     1141 gctgcacctg ccgaggcagt ggcaacctgc aggaggagtg tgaaatgctg gaagggttct
     1201 tctcccacaa cccctgcctc acggaggcca ttgcagctaa gatgcgtttt cacagccaac
     1261 tcttctccca ggactggcca caccctacct ttgctgtgat ggcacaccag aatgaaaacc
     1321 ctgctgtgag gccacagccc tgggtgccct ctcttttctc ctgcacgctt cccttgattc
     1381 tgctcctgag cctatggtag ctggacttcc ccagggccct cttcccctcc accacaccca
     1441 ggtggacttg cagcccacaa ggggtgagga aaggacagca gcaggaagga ggtgcagtgc
     1501 gcagatgagg gcacaggaga agctaagggt tatgacctcc agatccttac tggtccagtc
     1561 ctcattccct ccaccccatc tccacttctg attcatgctg cccctccttg gtggccacaa
     1621 tttagccatg tcatctggtg gtgaccagct ccaccaagcc cctttctgag cccttcctct
     1681 tgactaccag gatcaccaga atctaataag ttagccattc tctattgcat tccagattag
     1741 ggttagggta gggaggactg ggtgttctga ggcagcctag aaagtcattc tcctttgtga
     1801 agaaggctcc tgccccctcg tctcctcctc tgagtggagg atggaaaact actgcctgca
     1861 ctgccctgtc cccggatcct gccgaacatc tgggcatcag gagctggagc ctgtgggcct
     1921 tgctttattc ctattattgt cctaaagtct ctctgggctc ttggatcatg attaaacctt
     1981 tgacttaa
//
