LOCUS       NM_001495               4991 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens GDNF family receptor alpha 2 (GFRA2), transcript
            variant 1, mRNA.
ACCESSION   NM_001495 XM_001124622
VERSION     NM_001495.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4991)
  AUTHORS   Li,J., Shang,G., Chen,Y.J., Brautigam,C.A., Liou,J., Zhang,X. and
            Bai,X.C.
  TITLE     Cryo-EM analyses reveal the common mechanism and diversification in
            the activation of RET by different ligands
  JOURNAL   Elife 8, e47650 (2019)
   PUBMED   31535977
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4991)
  AUTHORS   Bigalke,J.M., Aibara,S., Roth,R., Dahl,G., Gordon,E., Dorbeus,S.,
            Amunts,A. and Sandmark,J.
  TITLE     Cryo-EM structure of the activated RET signaling complex reveals
            the importance of its cysteine-rich domain
  JOURNAL   Sci Adv 5 (7), eaau4202 (2019)
   PUBMED   31392261
  REMARK    GeneRIF: We have reconstituted the complete extracellular region of
            the RET signaling complex together with Neurturin (NRTN) and
            GFRalpha2 and determined its structure at 5.7-A resolution by
            cryo-EM. The proteins form an assembly through RET-GFRalpha2 and
            RET-NRTN interfaces.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4991)
  AUTHORS   Li,Z., Xie,J., Fei,Y., Gao,P., Xie,Q., Gao,W. and Xu,Z.
  TITLE     GDNF family receptor alpha 2 promotes neuroblastoma cell
            proliferation by interacting with PTEN
  JOURNAL   Biochem Biophys Res Commun 510 (3), 339-344 (2019)
   PUBMED   30722993
  REMARK    GeneRIF: GFRA2 was upregulated in human neuroblastoma cells and
            tissues, and promoted neuroblastoma cell proliferation through
            interacting with the tumor suppressor PTEN.
REFERENCE   4  (bases 1 to 4991)
  AUTHORS   Pottier,C., Zhou,X., Perkerson,R.B. 3rd, Baker,M., Jenkins,G.D.,
            Serie,D.J., Ghidoni,R., Benussi,L., Binetti,G., Lopez de Munain,A.,
            Zulaica,M., Moreno,F., Le Ber,I., Pasquier,F., Hannequin,D.,
            Sanchez-Valle,R., Antonell,A., Llado,A., Parsons,T.M., Finch,N.A.,
            Finger,E.C., Lippa,C.F., Huey,E.D., Neumann,M., Heutink,P.,
            Synofzik,M., Wilke,C., Rissman,R.A., Slawek,J., Sitek,E.,
            Johannsen,P., Nielsen,J.E., Ren,Y., van Blitterswijk,M.,
            DeJesus-Hernandez,M., Christopher,E., Murray,M.E., Bieniek,K.F.,
            Evers,B.M., Ferrari,C., Rollinson,S., Richardson,A., Scarpini,E.,
            Fumagalli,G.G., Padovani,A., Hardy,J., Momeni,P., Ferrari,R.,
            Frangipane,F., Maletta,R., Anfossi,M., Gallo,M., Petrucelli,L.,
            Suh,E., Lopez,O.L., Wong,T.H., van Rooij,J.G.J., Seelaar,H.,
            Mead,S., Caselli,R.J., Reiman,E.M., Noel Sabbagh,M., Kjolby,M.,
            Nykjaer,A., Karydas,A.M., Boxer,A.L., Grinberg,L.T., Grafman,J.,
            Spina,S., Oblak,A., Mesulam,M.M., Weintraub,S., Geula,C.,
            Hodges,J.R., Piguet,O., Brooks,W.S., Irwin,D.J., Trojanowski,J.Q.,
            Lee,E.B., Josephs,K.A., Parisi,J.E., Ertekin-Taner,N.,
            Knopman,D.S., Nacmias,B., Piaceri,I., Bagnoli,S., Sorbi,S.,
            Gearing,M., Glass,J., Beach,T.G., Black,S.E., Masellis,M.,
            Rogaeva,E., Vonsattel,J.P., Honig,L.S., Kofler,J., Bruni,A.C.,
            Snowden,J., Mann,D., Pickering-Brown,S., Diehl-Schmid,J.,
            Winkelmann,J., Galimberti,D., Graff,C., Oijerstedt,L., Troakes,C.,
            Al-Sarraj,S., Cruchaga,C., Cairns,N.J., Rohrer,J.D., Halliday,G.M.,
            Kwok,J.B., van Swieten,J.C., White,C.L. 3rd, Ghetti,B.,
            Murell,J.R., Mackenzie,I.R.A., Hsiung,G.R., Borroni,B., Rossi,G.,
            Tagliavini,F., Wszolek,Z.K., Petersen,R.C., Bigio,E.H.,
            Grossman,M., Van Deerlin,V.M., Seeley,W.W., Miller,B.L.,
            Graff-Radford,N.R., Boeve,B.F., Dickson,D.W., Biernacka,J.M. and
            Rademakers,R.
  TITLE     Potential genetic modifiers of disease risk and age at onset in
            patients with frontotemporal lobar degeneration and GRN mutations:
            a genome-wide association study
  JOURNAL   Lancet Neurol 17 (6), 548-558 (2018)
   PUBMED   29724592
  REMARK    GeneRIF: A novel genome-wide significant locus at GFRA2 on
            chromosome 8p21.3 was identified to be associated with disease
            risk, and expression analyses showed that the risk-associated
            allele at rs36196656 decreased GFRA2 mRNA concentrations in GFRA2
            tissue.
REFERENCE   5  (bases 1 to 4991)
  AUTHORS   Sandmark,J., Dahl,G., Oster,L., Xu,B., Johansson,P., Akerud,T.,
            Aagaard,A., Davidsson,P., Bigalke,J.M., Winzell,M.S., Rainey,G.J.
            and Roth,R.G.
  TITLE     Structure and biophysical characterization of the human full-length
            neurturin-GFRa2 complex: A role for heparan sulfate in signaling
  JOURNAL   J Biol Chem 293 (15), 5492-5508 (2018)
   PUBMED   29414779
  REMARK    GeneRIF: biophysical results show that the relative concentration
            of GFRa2 on cell surfaces can affect the functional affinity of
            NRTN through avidity effects.
REFERENCE   6  (bases 1 to 4991)
  AUTHORS   Yoong,L.F. and Too,H.P.
  TITLE     Glial cell line-derived neurotrophic factor and neurturin inhibit
            neurite outgrowth and activate RhoA through GFR alpha 2b, an
            alternatively spliced isoform of GFR alpha 2
  JOURNAL   J Neurosci 27 (21), 5603-5614 (2007)
   PUBMED   17522305
  REMARK    GeneRIF: Both GFR alpha2a and GFR alpha2c, but not GFR alpha2b,
            promote neurite outgrowth in transfected Neuro2A cells.
REFERENCE   7  (bases 1 to 4991)
  AUTHORS   Suvanto,P., Wartiovaara,K., Lindahl,M., Arumae,U., Moshnyakov,M.,
            Horelli-Kuitunen,N., Airaksinen,M.S., Palotie,A., Sariola,H. and
            Saarma,M.
  TITLE     Cloning, mRNA distribution and chromosomal localisation of the gene
            for glial cell line-derived neurotrophic factor receptor beta, a
            homologue to GDNFR-alpha
  JOURNAL   Hum Mol Genet 6 (8), 1267-1273 (1997)
   PUBMED   9259272
REFERENCE   8  (bases 1 to 4991)
  AUTHORS   Klein,R.D., Sherman,D., Ho,W.H., Stone,D., Bennett,G.L., Moffat,B.,
            Vandlen,R., Simmons,L., Gu,Q., Hongo,J.A., Devaux,B., Poulsen,K.,
            Armanini,M., Nozaki,C., Asai,N., Goddard,A., Phillips,H.,
            Henderson,C.E., Takahashi,M. and Rosenthal,A.
  TITLE     A GPI-linked protein that interacts with Ret to form a candidate
            neurturin receptor
  JOURNAL   Nature 387 (6634), 717-721 (1997)
   PUBMED   9192898
  REMARK    Erratum:[Nature 1998 Mar 12;392(6672):210]
REFERENCE   9  (bases 1 to 4991)
  AUTHORS   Sanicola,M., Hession,C., Worley,D., Carmillo,P., Ehrenfels,C.,
            Walus,L., Robinson,S., Jaworski,G., Wei,H., Tizard,R., Whitty,A.,
            Pepinsky,R.B. and Cate,R.L.
  TITLE     Glial cell line-derived neurotrophic factor-dependent RET
            activation can be mediated by two different cell-surface accessory
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (12), 6238-6243 (1997)
   PUBMED   9177201
REFERENCE   10 (bases 1 to 4991)
  AUTHORS   Baloh,R.H., Tansey,M.G., Golden,J.P., Creedon,D.J.,
            Heuckeroth,R.O., Keck,C.L., Zimonjic,D.B., Popescu,N.C.,
            Johnson,E.M. Jr. and Milbrandt,J.
  TITLE     TrnR2, a novel receptor that mediates neurturin and GDNF signaling
            through Ret
  JOURNAL   Neuron 18 (5), 793-802 (1997)
   PUBMED   9182803
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC129925.12, BC041688.1 and
            AC105186.14.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001495.4.
            
            Summary: Glial cell line-derived neurotrophic factor (GDNF) and
            neurturin (NTN) are two structurally related, potent neurotrophic
            factors that play key roles in the control of neuron survival and
            differentiation. The protein encoded by this gene is a member of
            the GDNF receptor family. It is a
            glycosylphosphatidylinositol(GPI)-linked cell surface receptor for
            both GDNF and NTN, and mediates activation of the RET tyrosine
            kinase receptor. This encoded protein acts preferentially as a
            receptor for NTN compared to its other family member, GDNF family
            receptor alpha 1. This gene is a candidate gene for RET-associated
            diseases. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Sep 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.150371.1,
                                           SRR1803617.65978.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000524240.6/ ENSP00000428518.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC129925.12        54145-54185
            42-2215             BC041688.1         1-2174
            2216-3371           BC041688.1         2176-3331
            3372-4991           AC105186.14        42627-44246         c
FEATURES             Location/Qualifiers
     source          1..4991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.3"
     gene            1..4991
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /note="GDNF family receptor alpha 2"
                     /db_xref="GeneID:2675"
                     /db_xref="HGNC:HGNC:4244"
                     /db_xref="MIM:601956"
     exon            1..756
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             717..2111
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /note="isoform a preproprotein is encoded by transcript
                     variant 1; RET ligand 2; PI-linked cell-surface accessory
                     protein; GFR-alpha 2; TRN receptor, GPI-anchored; glial
                     cell line derived neurotrophic factor receptor, beta;
                     neurturin receptor alpha; GDNFR-beta; NTNR-alpha;
                     GDNFR-alpha-2; GDNF receptor beta; TGF-beta-related
                     neurotrophic factor receptor 2"
                     /codon_start=1
                     /product="GDNF family receptor alpha-2 isoform a
                     preproprotein"
                     /protein_id="NP_001486.4"
                     /db_xref="CCDS:CCDS47816.1"
                     /db_xref="GeneID:2675"
                     /db_xref="HGNC:HGNC:4244"
                     /db_xref="MIM:601956"
                     /translation="MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRAN
                     ELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKE
                     LQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNH
                     CLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYR
                     MLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCR
                     ASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEE
                     CEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDST
                     SLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSA
                     ALTVLSVLMLKLAL"
     exon            757..1071
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1155
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1510
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1620
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1761
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1934
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1935..1988
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..4991
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3351..3356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /note="hexamer: AATAAA"
     polyA_site      3371
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /note="major polyA site"
     regulatory      4966..4971
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
                     /note="hexamer: AATAAA"
     polyA_site      4991
                     /gene="GFRA2"
                     /gene_synonym="GDNFRB; NRTNR-ALPHA; NTNRA; RETL2; TRNR2"
ORIGIN      
        1 gagagctgga gagagcgaga gcaaagagcg agcgagggag aggagagaga gagagaggag
       61 agagaaagac acacgcacgc agagacacac ggtcactgga attccattag aaaaaagtga
      121 gccgagcaag ggttagcggg agaagatttt tttgaatctt gtcttcgtct tggtgcgaaa
      181 gaagcgactc cagtctctcg tcctcgaagc tccgactgga ttgttcttgg gcgctgacac
      241 ccgtctgtgg atttcttttc tatttgcatt ttattccgac cccctccctc gccgcttcct
      301 tccagccctt cactcgcaaa tcgcctctct ccccacctcc ccaggcccct cctgggaagc
      361 gcaggggaat tggacccgcg gggactcacg ccttcccgga cgattggagg ggagggctga
      421 ccccaggact gggctgttgg cttagaaagc cgatacacag atacgcgtat atttgattgt
      481 agcgggcaag gggggcgtcg agaggcagca gcccatcgcc cgcctctcac cccaccccct
      541 ccagccagag gcgagaatcg caggactcgg gatcttcatc gggtggacta gctgggatct
      601 ccgcattgga tttggggctg attaccactg cttgcctatt attattgttg ttgttactac
      661 tattattttt ttttacccaa gggagaaaga caaaaaaacg gtgggattta tttaacatga
      721 tcttggcaaa cgtcttctgc ctcttcttct ttctagacga gaccctccgc tctttggcca
      781 gcccttcctc cctgcagggc cccgagctcc acggctggcg ccccccagtg gactgtgtcc
      841 gggccaatga gctgtgtgcc gccgaatcca actgcagctc tcgctaccgc actctgcggc
      901 agtgcctggc aggccgcgac cgcaacacca tgctggccaa caaggagtgc caggcggcct
      961 tggaggtctt gcaggagagc ccgctgtacg actgccgctg caagcggggc atgaagaagg
     1021 agctgcagtg tctgcagatc tactggagca tccacctggg gctgaccgag ggtgaggagt
     1081 tctacgaagc ctccccctat gagccggtga cctcccgcct ctcggacatc ttcaggcttg
     1141 cttcaatctt ctcagggaca ggggcagacc cggtggtcag cgccaagagc aaccattgcc
     1201 tggatgctgc caaggcctgc aacctgaatg acaactgcaa gaagctgcgc tcctcctaca
     1261 tctccatctg caaccgcgag atctcgccca ccgagcgctg caaccgccgc aagtgccaca
     1321 aggccctgcg ccagttcttc gaccgggtgc ccagcgagta cacctaccgc atgctcttct
     1381 gctcctgcca agaccaggcg tgcgctgagc gccgccggca aaccatcctg cccagctgct
     1441 cctatgagga caaggagaag cccaactgcc tggacctgcg tggcgtgtgc cggactgacc
     1501 acctgtgtcg gtcccggctg gccgacttcc atgccaattg tcgagcctcc taccagacgg
     1561 tcaccagctg ccctgcggac aattaccagg cgtgtctggg ctcttatgct ggcatgattg
     1621 ggtttgacat gacacctaac tatgtggact ccagccccac tggcatcgtg gtgtccccct
     1681 ggtgcagctg tcgtggcagc gggaacatgg aggaggagtg tgagaagttc ctcagggact
     1741 tcaccgagaa cccatgcctc cggaacgcca tccaggcctt tggcaacggc acggacgtga
     1801 acgtgtcccc aaaaggcccc tcgttccagg ccacccaggc ccctcgggtg gagaagacgc
     1861 cttctttgcc agatgacctc agtgacagta ccagcttggg gaccagtgtc atcaccacct
     1921 gcacgtctgt ccaggagcag gggctgaagg ccaacaactc caaagagtta agcatgtgct
     1981 tcacagagct cacgacaaat atcatcccag ggagtaacaa ggtgatcaaa cctaactcag
     2041 gccccagcag agccagaccg tcggctgcct tgaccgtgct gtctgtcctg atgctgaaac
     2101 tggccttgta ggctgtggga accgagtcag aatatttttg aaagctacgc agacaagaac
     2161 agccgcctga cgaaatggaa acacacacag acacacacac accttgcaaa aaaaaaattg
     2221 tttttcccac cttgtcgctg aacctgtctc ctcccaggtt tcttctctgg agaagttttt
     2281 gtaaaccaaa cagacaagca ggcaggcagc ctgagagctg gcccaggggt cccctggcag
     2341 gggaaactct ggtgccgggg agggcacgag gctctagaaa tgcccttcac tttctcctgg
     2401 tgtttttctc tctggaccct tctgaagcag agaccggaca agagcctgca gcggaaggga
     2461 ctctgggctg tgcctgaggc tggctggggg caggacaaca cagctgcttc cccaggctgc
     2521 ccactctggg gacccgctgg gggctggcag agggcatcgg tcagcggggc agcggggctg
     2581 gccatgaggg tccaccttca gccctttggc ttcaaggatg gagatggttt tgccctccct
     2641 ctctgccctc gggtggggct ggtgggtctg cagctggtgt gggaacttcc ccacggatgg
     2701 cggtggaggg ggttcgcacc gtgctgggct ccccctgact gtagcacgga gtgttggggc
     2761 tgggggccag ctccaggagg gcttgagagc tcagcctgcc tgggagagcc cttgtggcga
     2821 ggcattaaaa cttgggcacc agcttctttc tcggtggcag aaattttgaa gtcagagaga
     2881 aacggtcctt tgttggcttc tttgctttct cgtgggtcct ttggcaggcc tccctttggg
     2941 gagagggagg ggagagacca cagccgggtg tgtgtctgca gcaccgtggg ccctcaagct
     3001 ttcctgctgt cttctccctc ctcctccttt cccctttctc tttcctcatt tcctagacgt
     3061 acgtcaactg tatgtacata ccggggctcc tctcctaaca tatatgtata tacacatcca
     3121 tatacatata ttgtgtggtt tcccctttct ttcctttttt taagcaacaa aactatggaa
     3181 ataatacccc aacagatgag cgaaaatgta ttattgtaaa gtttattttt tttaatactg
     3241 ttgtctataa tggggaaaaa ggacattggc cccgcagtgc cctgccccag tcagcctggc
     3301 tgggctctgg tgggggctcc tgatccgcat ccaagcttaa ccaaggctcc aataaacgtg
     3361 ctaggaagca agctgcctct gcctcggtcc cgtggggttt tgcccccatt ttgttcttgg
     3421 tccagtgtta cctgcgtaag tggagctccc agtgggctgg ggaaatgtgt gtccgtgtgt
     3481 gtgcctgtgt gcatgtgtgt gcatccatgt gtctcaccca tgtgtccaca ttgtgtgtag
     3541 atggagctct cttaggagct ggtttgacac tgggggcggg atctgagggt ccacgctgtg
     3601 ctgagcctgg tgggctgttc tgttccctct ttgctcactt ctccagttgg cgcaaatgcc
     3661 tgtggctccc aggctggaag agaatgcagt ggacgtggac gtggtgggga gccacagctt
     3721 ggcatcacac gttgggaatg ttttattgtc aggctgtctg ggtggccctg ttagtcttac
     3781 atagagcaaa gtggtatgtc cctctgggac tcctggctta tttgagatgt gtgattgtga
     3841 gtgcagtgac ctggcctttt gggtcccacc agagaagaag gacatgactg tgcatgttct
     3901 ggggtcatgg tctgaaagca taagtatttt ttgggtctcc ctctattcct tcctttcctg
     3961 tttctccatt tgctacccag gccccacttg gacactaggc ctgccatagt ctccaagaga
     4021 gattctcccc agagaggacc aggagaatgc ctgctggcca agtgtgtgtg tgtccatgta
     4081 tgtgagcatg tgtacatgtg tgtgcggtcg tgtgcaggct cgcacatgtt cacgtgcacg
     4141 tgtgaatata tacccatggc aggagggaga atggaagact ggtaggcgag aagatgtttc
     4201 tactgtcagc ctggccttca gggctgcatg tgagcccatc ccatttcaac tggacaatag
     4261 gatgcagttt tcccatctcc caatcgcagg tcccctcaat ggcttttgct tctggttgta
     4321 tatgtgtgag cagcatccgt tcacagcgtt tatcactgtg gtgtattgcc ttccagcctc
     4381 tgcatggaag gggtacagtg agccagccag gtctctgtcc agccattgcg ggtagacgtg
     4441 gtcatggcat ccacttagga atccgtgttc tttgcaaaca gcaaagacca tttaacttaa
     4501 aaagtacttt actggaaggc tatgggagaa ggtggctcac ggaatttgtg ggaggtgggg
     4561 ggaccagggg aggcgagggc agggactgga gggcatctga ggggctggaa ggcaggatgt
     4621 acagggtcag cattctgctg ccaaccattg cccatctggc tgaactgggc cttgtgcctg
     4681 ccctctgcca tacttgagtg tgagagagag gatatatatg tcatgtctgg tatccctaat
     4741 aggaggtaag cccttaggct acatcatggg ggagagaaaa tttcccaaga ggaaactgag
     4801 gtgccattat gaaggaggag tggatactag ctagctttac tctgccctca aatgtctccc
     4861 tatccaagta tcacatggct gaaattttac cattaggtat tcattccttt ggttgagatg
     4921 attcctattt gtgattctct caaaatatgc aaatcgaact agaagaataa attgttgcta
     4981 tcttaatgtt a
//
