LOCUS       NM_030819               2018 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Gfo/Idh/MocA-like oxidoreductase domain containing 2
            (GFOD2), transcript variant 1, mRNA.
ACCESSION   NM_030819
VERSION     NM_030819.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2018)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Guevara-Cruz,M., Lai,C.Q., Richardson,K., Parnell,L.D., Lee,Y.C.,
            Tovar,A.R., Ordovas,J.M. and Torres,N.
  TITLE     Effect of a GFOD2 variant on responses in total and LDL cholesterol
            in Mexican subjects with hypercholesterolemia after soy protein and
            soluble fiber supplementation
  JOURNAL   Gene 532 (2), 211-215 (2013)
   PUBMED   24064143
  REMARK    GeneRIF: Variation in the GFOD2 gene contributes to the genetic
            basis for a differential response to a cholesterol- or
            lipid-lowering diet.
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK225997.1 and BC000757.2.
            
            On Nov 22, 2018 this sequence version replaced NM_030819.3.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074382.1, AK225997.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268797.12/ ENSP00000268797.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1423              AK225997.1         25-1447
            1424-2018           BC000757.2         1085-1679
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..2018
                     /gene="GFOD2"
                     /note="Gfo/Idh/MocA-like oxidoreductase domain containing
                     2"
                     /db_xref="GeneID:81577"
                     /db_xref="HGNC:HGNC:28159"
                     /db_xref="MIM:619933"
     exon            1..154
                     /gene="GFOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            155..500
                     /gene="GFOD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1399
                     /gene="GFOD2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; glucose-fructose oxidoreductase
                     domain-containing protein 2; glucose-fructose
                     oxidoreductase domain containing 2"
                     /codon_start=1
                     /product="glucose-fructose oxidoreductase
                     domain-containing protein 2 isoform 1 precursor"
                     /protein_id="NP_110446.3"
                     /db_xref="CCDS:CCDS10845.1"
                     /db_xref="GeneID:81577"
                     /db_xref="HGNC:HGNC:28159"
                     /db_xref="MIM:619933"
                     /translation="MKMLPGVGVFGTGSSARVLVPLLRAEGFTVEALWGKTEEEAKQL
                     AEEMNIAFYTSRTDDILLHQDVDLVCISIPPPLTRQISVKALGIGKNVVCEKAATSVD
                     AFRMVTASRYYPQLMSLVGNVLRFLPAFVRMKQLISEHYVGAVMICDARIYSGSLLSP
                     SYGWICDELMGGGGLHTMGTYIVDLLTHLTGRRAEKVHGLLKTFVRQNAAIRGIRHVT
                     SDDFCFFQMLMGGGVCSTVTLNFNMPGAFVHEVMVVGSAGRLVARGADLYGQKNSATQ
                     EELLLRDSLAVGAGLPEQGPQDVPLLYLKGMVYMVQALRQSFQGQGDRRTWDRTPVSM
                     AASFEDGLYMQSVVDAIKRSSRSGEWEAVEVLTEEPDTNQNLCEALQRNNL"
     exon            501..2018
                     /gene="GFOD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1999..2004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GFOD2"
                     /note="hexamer: AATAAA"
     polyA_site      2018
                     /gene="GFOD2"
                     /note="major polyA site"
ORIGIN      
        1 agaaaccagg cggcgcgttc ccggtggcgg cgccctggac tcccgggccc gcgcatcccc
       61 gccagccttc cttaaggcgg atgggtggcc cccgagaccc cgtcggaccc atggtttcca
      121 gtgcagcgcg gagtgggcga tgccagcgtg ccaggagcca tgtctgacca ggacgtttgg
      181 aagatcatat ccatgccaga ggctcttgtg aggagatgag ttggtaaaga gagaggctgg
      241 gatgaagatg ctgccaggag tgggcgtgtt tgggactggc agctccgccc gagttctggt
      301 cccactgctg agggcagaag ggttcactgt tgaggccctg tgggggaaga ctgaggagga
      361 ggcgaagcag cttgctgagg agatgaacat cgccttctac accagccgga ctgatgacat
      421 cttgctgcat caagatgtgg atctggtgtg catcagcatc ccccctccac tcacccggca
      481 gatatccgtg aaggctctag gtattgggaa gaatgtggtt tgcgagaagg cagcaacatc
      541 ggtggatgcc ttccggatgg tgacagcctc gcgctactac ccgcagctca tgagcctggt
      601 agggaacgtg ctgcgcttcc tgcctgcctt cgtgcgcatg aaacagctga tttcggaaca
      661 ctatgtggga gcggtgatga tctgtgatgc ccgcatctac tcaggcagcc tgctgagccc
      721 cagctatggc tggatctgtg atgagctcat gggcggcggg ggcttgcaca ccatggggac
      781 ctacattgtg gacctgctga cccacctgac cggccggaga gccgagaagg tgcacgggct
      841 gctcaagaca ttcgtgaggc agaacgctgc catccgtggc atccggcacg tcactagcga
      901 tgacttctgt ttcttccaga tgctcatggg tgggggtgtg tgtagcacag tgacactcaa
      961 cttcaacatg ccaggcgcct ttgtgcatga agtcatggtg gtaggctctg caggacgcct
     1021 cgtcgcccgg ggagccgacc tctatgggca gaagaactct gccacgcaag aggagctgct
     1081 cttgagggac tcgctggcag tgggcgcagg actgcctgag caggggcccc aggatgtccc
     1141 gctgctgtac ctgaagggca tggtctacat ggtgcaggcc ttgcgccagt ccttccaggg
     1201 gcagggcgac cgccgcacct gggaccgcac ccctgtctcc atggccgcct ccttcgagga
     1261 tgggctgtac atgcagagcg tggtggatgc catcaagagg tcgagccgat ccggggagtg
     1321 ggaggctgtg gaggtgctga cggaggagcc cgacaccaac cagaacctgt gtgaggcact
     1381 tcagcggaac aacctatgag cctgcacctg ggctccttgc cacagggcag agggaccagg
     1441 gaggggaaca ggagccagac atgacaggga cttggcccta gcagagacag tgtctttcat
     1501 ttaatgagtc tgggtgaagc cagaggtggc tctgggactt cgccccctcc agtggctcat
     1561 ctgctcctca gacttgcagg gtggcaaatg ttcctgttgc caggttacca cggtgtgcac
     1621 agggcagagc tgccgccagg cctcctcatg gtgatgccag tgagtcggac caggaaaggc
     1681 tcaccctggg gagcccttca gcctgatccg cagtcctaac agggtgagaa agcacaagag
     1741 gggccagctc ggctgaggcc tgaggagaaa tgatgagaag ttttgtttcg ttcttgggct
     1801 ggggcatctc aggaacagtg agggcaacaa gctgtccctc agggaccctc acctgccctc
     1861 ccatgtgacc aggcccttcc caggtgggga ctggggcttg ctttattaag tgagctcttg
     1921 ggcttttgaa gtaggacaga gggccctggt ttggcagaga ggaggcaagg gagggcttta
     1981 gaacatctga gaaatgttaa taaataattc agaaaata
//
