LOCUS       NM_005262               2365 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens growth factor, augmenter of liver regeneration (GFER),
            mRNA.
ACCESSION   NM_005262
VERSION     NM_005262.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2365)
  AUTHORS   Feng,S., Zhao,J., Yang,T. and Li,L.
  TITLE     TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment
  JOURNAL   Int Immunopharmacol 124 (Pt A), 110869 (2023)
   PUBMED   37666068
  REMARK    GeneRIF: TMPRSS11D/ALR-mediated ER stress regulates the function of
            myeloid-derived suppressor cells in the cervical cancer
            microenvironment.
REFERENCE   2  (bases 1 to 2365)
  AUTHORS   Guo,L., Dou,Y., Xiang,Y., Luo,L., Xu,X., Wang,Q., Zhang,Y. and
            Liang,T.
  TITLE     Systematic analysis of cancer-specific synthetic lethal
            interactions provides insight into personalized anticancer therapy
  JOURNAL   FEBS J 290 (6), 1531-1548 (2023)
   PUBMED   36181326
REFERENCE   3  (bases 1 to 2365)
  AUTHORS   Zhou,Y., Liu,Y., Gupta,S., Paramo,M.I., Hou,Y., Mao,C., Luo,Y.,
            Judd,J., Wierbowski,S., Bertolotti,M., Nerkar,M., Jehi,L.,
            Drayman,N., Nicolaescu,V., Gula,H., Tay,S., Randall,G., Wang,P.,
            Lis,J.T., Feschotte,C., Erzurum,S.C., Cheng,F. and Yu,H.
  TITLE     A comprehensive SARS-CoV-2-human protein-protein interactome
            reveals COVID-19 pathobiology and potential host therapeutic
            targets
  JOURNAL   Nat Biotechnol 41 (1), 128-139 (2023)
   PUBMED   36217030
REFERENCE   4  (bases 1 to 2365)
  AUTHORS   Klyosova,E.Y., Shkurat,E.A., Azarova,Y.E. and Polonikov,A.V.
  TITLE     Polymorphism rs1046495 of the GFER Gene as a New Genetic Marker of
            Preposition to Type 2 Diabetes Mellitus
  JOURNAL   Bull Exp Biol Med 172 (5), 587-591 (2022)
   PUBMED   35352250
  REMARK    GeneRIF: Polymorphism rs1046495 of the GFER Gene as a New Genetic
            Marker of Preposition to Type 2 Diabetes Mellitus.
REFERENCE   5  (bases 1 to 2365)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2365)
  AUTHORS   Lisowsky,T., Weinstat-Saslow,D.L., Barton,N., Reeders,S.T. and
            Schneider,M.C.
  TITLE     A new human gene located in the PKD1 region of chromosome 16 is a
            functional homologue to ERV1 of yeast
  JOURNAL   Genomics 29 (3), 690-697 (1995)
   PUBMED   8575761
REFERENCE   7  (bases 1 to 2365)
  AUTHORS   Francavilla,A., Hagiya,M., Porter,K.A., Polimeno,L., Ihara,I. and
            Starzl,T.E.
  TITLE     Augmenter of liver regeneration: its place in the universe of
            hepatic growth factors
  JOURNAL   Hepatology 20 (3), 747-757 (1994)
   PUBMED   8076931
  REMARK    Review article
REFERENCE   8  (bases 1 to 2365)
  AUTHORS   Lisowsky,T.
  TITLE     Dual function of a new nuclear gene for oxidative phosphorylation
            and vegetative growth in yeast
  JOURNAL   Mol Gen Genet 232 (1), 58-64 (1992)
   PUBMED   1552903
REFERENCE   9  (bases 1 to 2365)
  AUTHORS   Renan,M.J. and Reeves,B.R.
  TITLE     Chromosomal localization of human endogenous retroviral element
            ERV1 to 18q22----q23 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 44 (2-3), 167-170 (1987)
   PUBMED   3568764
REFERENCE   10 (bases 1 to 2365)
  AUTHORS   O'Brien,S.J., Bonner,T.I., Cohen,M., O'Connell,C. and Nash,W.G.
  TITLE     Mapping of an endogenous retroviral sequence to human chromosome 18
  JOURNAL   Nature 303 (5912), 74-77 (1983)
   PUBMED   6843662
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG705583.1, AF306863.1 and
            BC002429.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005262.2.
            
            Summary: The hepatotrophic factor designated augmenter of liver
            regeneration (ALR) is thought to be one of the factors responsible
            for the extraordinary regenerative capacity of mammalian liver. It
            has also been called hepatic regenerative stimulation substance
            (HSS). The gene resides on chromosome 16 in the interval containing
            the locus for polycystic kidney disease (PKD1). The putative gene
            product is 42% similar to the scERV1 protein of yeast. The yeast
            scERV1 gene had been found to be essential for oxidative
            phosphorylation, the maintenance of mitochondrial genomes, and the
            cell division cycle. The human gene is both the structural and
            functional homolog of the yeast scERV1 gene. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002429.1, SRR3476690.738756.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248114.7/ ENSP00000248114.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                BG705583.1         55-80
            27-301              AF306863.1         1-275
            302-2364            BC002429.1         282-2344
            2365-2365           BC002429.1         2346-2346
FEATURES             Location/Qualifiers
     source          1..2365
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2365
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /note="growth factor, augmenter of liver regeneration"
                     /db_xref="GeneID:2671"
                     /db_xref="HGNC:HGNC:4236"
                     /db_xref="MIM:600924"
     exon            1..284
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..644
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /EC_number="1.8.3.2"
                     /note="hepatic regenerative stimulation substance; ERV1
                     homolog; erv1-like growth factor; hepatopoietin protein"
                     /codon_start=1
                     /product="FAD-linked sulfhydryl oxidase ALR"
                     /protein_id="NP_005253.3"
                     /db_xref="CCDS:CCDS32368.1"
                     /db_xref="GeneID:2671"
                     /db_xref="HGNC:HGNC:4236"
                     /db_xref="MIM:600924"
                     /translation="MAAPGERGRFHGGNLFFLPGGARSEMMDDLATDARGRGAGRRDA
                     AASASTPAQAPTSDSPVAEDASRRRPCRACVDFKTWMRTQQKRDTKFREDCPPDREEL
                     GRHSWAVLHTLAAYYPDLPTPEQQQDMAQFIHLFSKFYPCEECAEDLRKRLCRNHPDT
                     RTRACFTQWLCHLHNEVNRKLGKPDFDCSKVDERWRDGWKDGSCD"
     exon            285..481
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /inference="alignment:Splign:2.1.0"
     exon            482..2365
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      709..714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /note="hexamer: ATTAAA"
     polyA_site      730
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /note="major polyA site"
     regulatory      1325..1330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /note="hexamer: AATAAA"
     polyA_site      1352
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
     regulatory      2341..2346
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /note="hexamer: AATAAA"
     polyA_site      2365
                     /gene="GFER"
                     /gene_synonym="ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS;
                     MMCHD; MPMCD"
                     /note="major polyA site"
ORIGIN      
        1 gacccggcag gccttgcgcg ggcaacatgg cggcgcccgg cgagcggggc cgcttccacg
       61 gcgggaacct cttcttcctg ccggggggcg cgcgctccga gatgatggac gacctggcga
      121 ccgacgcgcg gggccggggc gcggggcgga gagacgcggc cgcctcggcc tcgacgccag
      181 cccaggcgcc gacctccgat tctcctgtcg ccgaggacgc ctcccggagg cggccgtgcc
      241 gggcctgcgt cgacttcaag acgtggatgc ggacgcagca gaagcgggac accaagttta
      301 gggaggactg cccgccggat cgcgaggaac tgggccgcca cagctgggct gtcctccaca
      361 ccctggccgc ctactacccc gacctgccca ccccagaaca gcagcaagac atggcccagt
      421 tcatacattt attttctaag ttttacccct gtgaggagtg tgctgaagac ctaagaaaaa
      481 ggctgtgcag gaaccaccca gacacccgca cccgggcatg cttcacacag tggctgtgcc
      541 acctgcacaa tgaagtgaac cgcaagctgg gcaagcctga cttcgactgc tcaaaagtgg
      601 atgagcgctg gcgcgacggc tggaaggatg gctcctgtga ctagagggtg gtcagccaga
      661 gctcatggga cagctagcca ggcatggttg gataggggca gggcactcat taaagtgcat
      721 cacagccaga gcctgttgtg tctcagttgg gtggtcccca ggacactgcc tgtggggacc
      781 tgccctgccc ctcttaggtt tggagcagaa gtggaggtgc ccacagcagg tacccactgg
      841 ccccctcctc agtggagacc ccaaggagct gcagctgaac tgcaggggag ggaaggagga
      901 gcagcctggg ctgccccttg acattcagga tgtagcttcc tgcccaccgc ataccctggc
      961 gcctcactcc tcacacggga agacagcggg cctggctggg catccctgtg cctgtccctg
     1021 gcggccaggc cattgccttc ccactatgca gccagggatg cccctgcccc ccatggctct
     1081 gtgctgctca ctttaggggg ctcaattctc cactctgctc agtccctaca gggaaagctc
     1141 aggtcgggtc tttctgaggg tccaccagcc atcctaccct ctccctgcct ggcacatgcc
     1201 tgccagcgtt gtgtcatgcc tgtccacagg ggattcgtgg ggctcacttc atcagagttt
     1261 gaagcccaaa tgaaacgctg aagtgactga gaacctggct tcagtatatt ttctgctggg
     1321 gcttaataaa gcagtagaca gggcttgttc catccctctg tgctcagctg catttcctgc
     1381 tggggtcctg gttcctcagg agagagagac cacagggtga gagtgagcca ggaacagcaa
     1441 ggacgttgat tggttggggc aggggggcca gagtagctga tgtaggagta ctgggaggcc
     1501 agacggcacg aggtctccaa ggccccagca aagccatggc ttctacccct agttcccctg
     1561 acaggaagtt cttggcgggt ttggagccag gggatggcat ggagtgatgt ggctttgaag
     1621 ggtcctctgg ctgctgagct gggatgaggc aggtaagggt ggaacaggag gggtggggag
     1681 gaagccgggg cagtcaccga gtgaccacca agaggaagac ccaccccacg gcggggacag
     1741 atgcggggta cgttaaaggg agagccagag aactcatggg gtgaggatgg agtccgagga
     1801 gactgctggg agccgccgtg tgggtcagag atggagaagg ctgagtgcag caaggtgggg
     1861 ggtgactggg acccagcctt tgggcctccc cagccagagc agcccagcaa cagtgtgtcc
     1921 tgtggtcata aaactccagg gacctctatc ctccaggagt ctcagccttt ccctgggcgc
     1981 aggcccacct tggcatggcc gcctcaggcc tccatggagg gagctgctat gtccccacca
     2041 gattggcccc gtgcggctgc tggcttctgt agaggctgcc cagaggggcc aggtggcaca
     2101 aataagagag gggagatggg gggcagccag gagaggaggt gtcccttcct cgcccagaca
     2161 cagcgcgctt ctctctggcc tttcccgagg cctgtgagtg cctcaggaag cagctgggcc
     2221 ctctgggaag gctgtgttca gcttaggaac ataccgcctg tatctgctgt ccctcccctg
     2281 cccccctgcc ccccccaccg ccttcccttt ttccctgtct tccttaaagt ttcactcctg
     2341 aataaaactt cactttgcct tagaa
//
