LOCUS       NM_015949               2090 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens guided entry of tail-anchored proteins factor 4
            (GET4), mRNA.
ACCESSION   NM_015949 XM_942533 XM_946077 XM_946078 XM_946079 XM_946080
            XM_946081 XM_946082 XM_946083
VERSION     NM_015949.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2090)
  AUTHORS   Koike,K., Masuda,T., Sato,K., Fujii,A., Wakiyama,H., Tobo,T.,
            Takahashi,J., Motomura,Y., Nakano,T., Saito,H., Matsumoto,Y.,
            Otsu,H., Takeishi,K., Yonemura,Y., Mimori,K. and Nakagawa,T.
  TITLE     GET4 is a novel driver gene in colorectal cancer that regulates the
            localization of BAG6, a nucleocytoplasmic shuttling protein
  JOURNAL   Cancer Sci 113 (1), 156-169 (2022)
   PUBMED   34704338
  REMARK    GeneRIF: GET4 is a novel driver gene in colorectal cancer that
            regulates the localization of BAG6, a nucleocytoplasmic shuttling
            protein.
REFERENCE   2  (bases 1 to 2090)
  AUTHORS   Keszei,A.F.A., Yip,M.C.J., Hsieh,T.C. and Shao,S.
  TITLE     Structural insights into metazoan pretargeting GET complexes
  JOURNAL   Nat Struct Mol Biol 28 (12), 1029-1037 (2021)
   PUBMED   34887561
REFERENCE   3  (bases 1 to 2090)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2090)
  AUTHORS   Tambe,M.A., Ng,B.G., Shimada,S., Wolfe,L.A., Adams,D.R., Gahl,W.A.,
            Bamshad,M.J., Nickerson,D.A., Malicdan,M.C.V. and Freeze,H.H.
  CONSRTM   Undiagnosed Diseases Network
  TITLE     Mutations in GET4 disrupt the transmembrane domain recognition
            complex pathway
  JOURNAL   J Inherit Metab Dis 43 (5), 1037-1045 (2020)
   PUBMED   32395830
REFERENCE   5  (bases 1 to 2090)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2090)
  AUTHORS   Mariappan,M., Li,X., Stefanovic,S., Sharma,A., Mateja,A.,
            Keenan,R.J. and Hegde,R.S.
  TITLE     A ribosome-associating factor chaperones tail-anchored membrane
            proteins
  JOURNAL   Nature 466 (7310), 1120-1124 (2010)
   PUBMED   20676083
REFERENCE   7  (bases 1 to 2090)
  AUTHORS   Chang,Y.W., Chuang,Y.C., Ho,Y.C., Cheng,M.Y., Sun,Y.J., Hsiao,C.D.
            and Wang,C.
  TITLE     Crystal structure of Get4-Get5 complex and its interactions with
            Sgt2, Get3, and Ydj1
  JOURNAL   J Biol Chem 285 (13), 9962-9970 (2010)
   PUBMED   20106980
REFERENCE   8  (bases 1 to 2090)
  AUTHORS   Fernandes,J.M., Macqueen,D.J., Lee,H.T. and Johnston,I.A.
  TITLE     Genomic, evolutionary, and expression analyses of cee, an ancient
            gene involved in normal growth and development
  JOURNAL   Genomics 91 (4), 315-325 (2008)
   PUBMED   18249086
REFERENCE   9  (bases 1 to 2090)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   10 (bases 1 to 2090)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM843540.1, AL133014.1, BG109419.1, BM980767.1 and AC073957.7.
            
            On Nov 23, 2018 this sequence version replaced NM_015949.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.723831.1,
                                           SRR3476690.64852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265857.8/ ENSP00000265857.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               BM843540.1         1-558
            559-1415            AL133014.1         1349-2205
            1416-1814           BG109419.1         108-506
            1815-2088           BM980767.1         19-292              c
            2089-2090           AC073957.7         17496-17497
FEATURES             Location/Qualifiers
     source          1..2090
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p22.3"
     gene            1..2090
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /note="guided entry of tail-anchored proteins factor 4"
                     /db_xref="GeneID:51608"
                     /db_xref="HGNC:HGNC:21690"
                     /db_xref="MIM:612056"
     exon            1..247
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1076
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /note="conserved edge expressed protein; conserved edge
                     protein; H_NH1244M04.5; transmembrane domain recognition
                     complex, 35kDa; transmembrane domain recognition complex
                     35 kDa subunit; golgi to ER traffic protein 4"
                     /codon_start=1
                     /product="Golgi to ER traffic protein 4 homolog"
                     /protein_id="NP_057033.2"
                     /db_xref="CCDS:CCDS5317.1"
                     /db_xref="GeneID:51608"
                     /db_xref="HGNC:HGNC:21690"
                     /db_xref="MIM:612056"
                     /translation="MAAAAAMAEQESARNGGRNRGGVQRVEGKLRASVEKGDYYEAHQ
                     MYRTLFFRYMSQSKHTEARELMYSGALLFFSHGQQNSAADLSMLVLESLEKAEVEVAD
                     ELLENLAKVFSLMDPNSPERVTFVSRALKWSSGGSGKLGHPRLHQLLALTLWKEQNYC
                     ESRYHFLHSADGEGCANMLVEYSTSRGFRSEVDMFVAQAVLQFLCLKNKSSASVVFTT
                     YTQKHPSIEDGPPFVEPLLNFIWFLLLAVDGGKLTVFTVLCEQYQPSLRRDPMYNEYL
                     DRIGQLFFGVPPKQTSSYGGLLGNLLTSLMGSSEQEDGEESPSDGSPIELD"
     exon            248..326
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     exon            327..408
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     exon            409..558
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     exon            559..697
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     exon            698..838
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     exon            839..914
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     exon            915..987
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     exon            988..2090
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1320..1325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /note="hexamer: AATAAA"
     polyA_site      1343
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /note="major polyA site"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /note="hexamer: AATAAA"
     polyA_site      2090
                     /gene="GET4"
                     /gene_synonym="C7orf20; CDG2Y; CEE; CGI-20; TRC35"
                     /note="major polyA site"
ORIGIN      
        1 agaagggcgt cgggcggccg tcgggacgga agccgggagg cgctgccgac cgcgcctgcg
       61 acagcgtcag ccctgcgcgg agcgccggcc cgatggcggc ggcggcggcg atggccgagc
      121 aggagagcgc ccggaacggc ggccgcaacc gcggcggcgt ccagcgtgtg gagggcaagc
      181 tgcgcgccag cgtcgagaag ggcgactact acgaggcgca ccagatgtac cggaccctgt
      241 tcttcaggta catgtcccag agcaagcaca cggaggcccg ggagctcatg tactcgggag
      301 ccctgctctt cttcagccat ggccagcaaa acagtgcagc agacttgtcc atgctggtcc
      361 tggagtccct ggagaaggcg gaagtggagg tggctgacga gctgctggaa aatctggcta
      421 aagtgttcag cctgatggac cccaactctc ctgagcgcgt gacctttgtg tccagagccc
      481 tgaagtggtc cagtgggggc tccgggaagc tgggccaccc ccggctgcac cagctgctgg
      541 ccctcaccct gtggaaagaa caaaactatt gtgagtcgag gtatcatttt ctgcactcag
      601 cggacgggga gggctgtgcc aacatgctgg tggagtattc cacgtcccgc ggcttccgca
      661 gcgaggtgga catgttcgtg gcccaggccg tgctacagtt tctctgttta aaaaacaaaa
      721 gtagcgcatc ggtggtcttc acgacgtaca cccagaagca cccgtccatc gaggacgggc
      781 ctccgtttgt ggagccgctg cttaacttca tctggttcct gctgctggct gtggacggtg
      841 ggaagctgac ggtgttcact gtgctgtgtg agcagtacca gccatccctc cggcgggacc
      901 ccatgtacaa cgagtacctc gaccgcatag gacagctgtt cttcggcgtc ccgcccaagc
      961 agacgtcttc ctacgggggc ctgctcggga accttctgac cagcctcatg ggctcctcag
     1021 agcaggagga tggggaggag agccccagcg acggcagccc catcgagctg gactgaactg
     1081 gccaggccac gtggagacac cacggtcgac gacggctgga gggacgtttc agaggcgagt
     1141 cctgggtggc tcctcgcctt gggggctcct ggccctgagg ctggcggtgg ccgcatgccg
     1201 gcgcgtgtct gtttctgtgc ggcggctcag ggtggcgcgg ctgctgctca ctgtgctgct
     1261 gggacccaag agtggggcgt cgcccctgct ggccgccgcg tcccccgaga ttgacccaca
     1321 ataaagcaca ggccttaccg cggcgtcacc ctctcccact cctttgttct gggtcctttc
     1381 gggagggctg atgggcagca caggaggccc gtcctcgggg ggctgcgcac atcacgctcc
     1441 ttgccgggcg tccggcacag ctgcggtcac caaagcaggt gctggccctc ggacctgaga
     1501 gcccagccag ggcccatgtg gtctgcaaat gggagcggct gtttttgaac acggggtcat
     1561 tctgcagtca ggacgaaccg gtccccgtcg cagacggagt gcacgtgccc tgcgccacat
     1621 cctcacgctc ggtggaggga cgcgtgcggc gggacggtgc ctacgggtac ttgcagctgt
     1681 gtcccatgtg gcatcccaga gctgcgccct gctggtctct gtgagcgcca cgctgctgtg
     1741 ctggaaatgc cgctttaaaa agggataccg tgggactctg cccgtctctt tcataacgca
     1801 atatttattt gtattgggtg atgattgatt ctttcgacct aacattttgg gttttaacca
     1861 aataaccggt ccaggagtga gcagctccgt tctgtcagat gctactccaa atgttaccag
     1921 aacgatgaca aaaggggaga cgctctattt tttcacagtt aaatgacagt tgtagattga
     1981 tacgcagttg tgcatgggaa ggggaaacgc acagctttat ttactgtaaa gtggaatttc
     2041 aggaaggctt gtgtgaaccg ttgcgcataa ataaaccctt tctaccgggc
//
