LOCUS       NM_001317744            1332 bp    mRNA    linear   PRI 15-SEP-2020
DEFINITION  Homo sapiens GET1-SH3BGR readthrough (GET1-SH3BGR), transcript
            variant 1, mRNA.
ACCESSION   NM_001317744
VERSION     NM_001317744.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1332)
  AUTHORS   Pflueger D, Mittmann C, Dehler S, Rubin MA, Moch H and Schraml P.
  TITLE     Functional characterization of BC039389-GATM and KLK4-KRSP1
            chimeric read-through transcripts which are up-regulated in renal
            cell cancer
  JOURNAL   BMC Genomics 16, 247 (2015)
   PUBMED   25888189
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1332)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS ONE 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF064861.5, CD514470.1 and AF121897.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001317744.1.
            
            Summary: This locus represents naturally occurring readthrough
            transcription between the neighboring WRB (tryptophan rich basic
            protein) and SH3BGR (SH3 domain binding glutamate-rich protein)
            genes on chromosome 21. Readthrough transcripts may encode fusion
            proteins that shares sequence identity with each individual gene
            product. [provided by RefSeq, Apr 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.179936.1,
                                           SRR5189652.109522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 6450, 7485
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AF064861.5         106808-106930
            124-824             CD514470.1         21-721
            825-906             AF121897.4         18856-18937
            907-941             CD514470.1         812-846
            942-1332            AF121897.4         22251-22641
FEATURES             Location/Qualifiers
     source          1..1332
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.2"
     gene            1..1332
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /note="GET1-SH3BGR readthrough"
                     /db_xref="GeneID:106865373"
                     /db_xref="HGNC:HGNC:54635"
     exon            1..161
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..881
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     WRB-SH3BGR readthrough"
                     /codon_start=1
                     /product="WRB-SH3BGR readthrough isoform 1"
                     /protein_id="NP_001304673.1"
                     /db_xref="GeneID:106865373"
                     /db_xref="HGNC:HGNC:54635"
                     /translation="MSSAAADHWAWLLVLSFVFGCNVLRILLPSFSSFMSRVLQKDAE
                     QESQMRAEIQDMKQELSTVNMMDEFARYARLERKINKMTDKLKTHVKARTAQLAKIKW
                     VISVAFYVLQIRKKQQEVVGFLEANKIDFKELDIAGDEDNRRWMRENVPGEKKPQNGI
                     PLPPQIFNEEQYCGDFDSFFSAKEENIIYSFLGLAPPPDSKGSEKAEEGGETEAQKEG
                     SEDVGNLPEAQEKNEEEGETATEETEEIAMEGAEGEAEEEEETAEGEEPGEDEDS"
     exon            162..327
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            328..395
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            396..581
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            582..662
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            663..755
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            756..785
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            786..915
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1332
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1313..1318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /note="hexamer: AATAAA"
     polyA_site      1332
                     /gene="GET1-SH3BGR"
                     /gene_synonym="WRB-SH3BGR"
                     /note="major polyA site"
ORIGIN      
        1 gttgttgtgg tccccatgga gctgccgtag cggacccagc acagccagga gcgtccggga
       61 tgagctcagc cgcggccgac cactgggcgt ggttgctggt gctcagcttc gtgtttggat
      121 gcaatgttct taggatcctc ctcccgtcct tctcatcctt catgtccagg gtgctgcaga
      181 aggacgcgga gcaggagtca cagatgagag cggagatcca ggacatgaag caggagctct
      241 ccacagtcaa catgatggac gagtttgcca gatatgccag gctggaaaga aagatcaaca
      301 agatgacgga taagctcaaa acccatgtga aagctcggac agctcaatta gccaagataa
      361 aatgggtgat aagtgtcgct ttctacgtat tgcagattag gaagaaacag caagaagtag
      421 tgggtttttt ggaagcgaat aaaatcgact ttaaggaatt agatattgct ggagatgaag
      481 acaacaggag gtggatgaga gagaatgttc ctggagagaa aaaacctcaa aatgggattc
      541 ctttgcctcc ccagatcttc aatgaggagc agtactgtgg ggattttgac tctttcttct
      601 ctgcaaaaga agagaatatt atttattcct tccttggttt ggctcctcct ccagactcaa
      661 agggatcaga gaaggctgaa gaaggtggag aaactgaggc acaaaaagag ggcagtgaag
      721 atgtgggcaa cctccctgaa gcccaggaga agaatgaaga agaaggagag acagccacag
      781 aagagacgga agaaatagcc atggagggtg cggaagggga agccgaggag gaggaagaaa
      841 ctgcagaagg agaagagcct ggagaagacg aagattccta ggccttttca tgcttcattt
      901 cttccacttc tccagaaaat ggaagctatg aagcaacatt tcaaatgtct ctccacaaac
      961 caaactcaac agaatacttt ggcttgaagc cggcacaccc agggttactg aggacttatg
     1021 ctgcctgacc tggttagatg tacatggagg tatctcccga atcatacaaa attaaatgtg
     1081 aagaccgttt atgcatacct tcatgtgcct gacagtcttg gcttttgaag attttttttt
     1141 cttttttgct ctgcatagct agaccatctt attaataata ctctgaaaaa aatgatttca
     1201 aggcatggaa gttctctgtg atacaacaat agtatttctt caaatgcgcc ttatgctact
     1261 tatctcagaa acaggtttta aaatgaagtg ctttccagag aaccatcata taaataaaga
     1321 ttaatagaaa aa
//
