LOCUS       NM_024707               1653 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens gem nuclear organelle associated protein 7 (GEMIN7),
            transcript variant 1, mRNA.
ACCESSION   NM_024707
VERSION     NM_024707.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1653)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1653)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1653)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1653)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 1653)
  AUTHORS   Carissimi,C., Baccon,J., Straccia,M., Chiarella,P., Maiolica,A.,
            Sawyer,A., Rappsilber,J. and Pellizzoni,L.
  TITLE     Unrip is a component of SMN complexes active in snRNP assembly
  JOURNAL   FEBS Lett 579 (11), 2348-2354 (2005)
   PUBMED   15848170
REFERENCE   7  (bases 1 to 1653)
  AUTHORS   Yong,J., Wan,L. and Dreyfuss,G.
  TITLE     Why do cells need an assembly machine for RNA-protein complexes?
  JOURNAL   Trends Cell Biol 14 (5), 226-232 (2004)
   PUBMED   15130578
  REMARK    Review article
REFERENCE   8  (bases 1 to 1653)
  AUTHORS   Baccon,J., Pellizzoni,L., Rappsilber,J., Mann,M. and Dreyfuss,G.
  TITLE     Identification and characterization of Gemin7, a novel component of
            the survival of motor neuron complex
  JOURNAL   J Biol Chem 277 (35), 31957-31962 (2002)
   PUBMED   12065586
  REMARK    GeneRIF: Identification and characterization a novel protein
            component of the survival of motor neurons complex termed Gemin7
            using native purified SMN complexes and peptide sequencing by mass
            spectrometry
REFERENCE   9  (bases 1 to 1653)
  AUTHORS   Paushkin,S., Gubitz,A.K., Massenet,S. and Dreyfuss,G.
  TITLE     The SMN complex, an assemblyosome of ribonucleoproteins
  JOURNAL   Curr Opin Cell Biol 14 (3), 305-312 (2002)
   PUBMED   12067652
  REMARK    Review article
REFERENCE   10 (bases 1 to 1653)
  AUTHORS   Sleeman,J.E. and Lamond,A.I.
  TITLE     Newly assembled snRNPs associate with coiled bodies before
            speckles, suggesting a nuclear snRNP maturation pathway
  JOURNAL   Curr Biol 9 (19), 1065-1074 (1999)
   PUBMED   10531003
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011489.6, W35331.1 and
            BC007793.2.
            
            On May 17, 2019 this sequence version replaced NM_024707.2.
            
            Summary: The protein encoded by this gene is a component of the
            core SMN complex, which is required for pre-mRNA splicing in the
            nucleus. The encoded protein is found in the nucleoplasm, in
            nuclear 'gems' (Gemini of Cajal bodies), and in the cytoplasm.
            Three transcript variants encoding the same protein have been found
            for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All five variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024018.1, BC007793.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270257.9/ ENSP00000270257.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC011489.6         107763-107774
            13-22               W35331.1           4-13
            23-118              W35331.1           15-110
            119-1053            BC007793.2         79-1013
            1054-1653           AC011489.6         119422-120021
FEATURES             Location/Qualifiers
     source          1..1653
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1653
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
                     /note="gem nuclear organelle associated protein 7"
                     /db_xref="GeneID:79760"
                     /db_xref="HGNC:HGNC:20045"
                     /db_xref="MIM:607419"
     exon            1..118
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            119..241
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
                     /inference="alignment:Splign:2.1.0"
     exon            242..1653
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..645
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
                     /note="gemin-7"
                     /codon_start=1
                     /product="gem-associated protein 7"
                     /protein_id="NP_078983.1"
                     /db_xref="CCDS:CCDS12654.1"
                     /db_xref="GeneID:79760"
                     /db_xref="HGNC:HGNC:20045"
                     /db_xref="MIM:607419"
                     /translation="MQTPVNIPVPVLRLPRGPDGFSRGFAPDGRRAPLRPEVPEIQEC
                     PIAQESLESQEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANF
                     YVSQLQTPIGVQAEALLRCSDIISYTFKP"
     polyA_site      1053
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
                     /note="major polyA site"
     regulatory      1627..1632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
                     /note="hexamer: AGTAAA"
     polyA_site      1653
                     /gene="GEMIN7"
                     /gene_synonym="SIP3"
ORIGIN      
        1 accagtagcc gcggacctcg gtgagtacaa ggtggtgggg ggtcgccagc aggttccctc
       61 tccccggccc cagctctgga cgctcacccc agtgcaacgc cctgagtgac ggaaagaggt
      121 ctggcggctt ctctgttgac aactcagctg gttccacacc ctggcaattg tgaagagttg
      181 gccaaatgtt tgtccactga gctgatctcc tctctggagc accggggcca ccaggaggga
      241 gccaagacaa tgcaaactcc agtgaacatt cccgtgcctg tgctccggct gccccggggc
      301 cctgatggct tcagccgtgg ctttgcccct gatggacgca gagccccctt gaggccagag
      361 gttcctgaaa tccaggagtg tcccatagct caagaatccc tggaatccca ggagcagcgg
      421 gcacgagccg cccttcggga gcgttacctc cgcagcctgc tggccatggt gggtcatcag
      481 gtgagcttca cgttgcacga gggtgtgcgt gtggccgccc actttggagc caccgacctg
      541 gatgtggcca acttctacgt gtcacagctg cagactccca taggtgtgca agcagaggcg
      601 ctgctccgat gtagtgacat tatttcatat accttcaagc cataaagata ttgtgttcac
      661 ttttctgctt gaggctaagg cactgtatcc caggcctccc aatgttcccg agccaggaac
      721 tctgggcccc atggagttat gagctccctt ggaattttga gccaagcttt aagcaagtct
      781 ggactcctga gacctcctgg gtctagtcag taaaattctg caactctagg aattctaaga
      841 tcccattgga aggaatgctc tacctcacag aactctgaac cctacagaaa tatgggcctg
      901 ctgccatttc ctgaagaccg gggcatcggg gtggggtgat aaaggataca acctgcacag
      961 ggggaagtta ttaaagaggc tgcaaagtcc agccaccctg aagatactcc ccagtgctcc
     1021 cctcctgcta aagaaccagt taccccagga aaattcgact cctgtttttc tttaattaac
     1081 tataccgacg gggatggagt catctttagg ggctggtagg gtggttatcc aagggctgaa
     1141 tccagtggag ctgggccaag tacgacagga gtccagataa aggtgtaggg gctgcacggc
     1201 cgcaagtctc ctggaaaggc tggagtgacc ggcatgccgg gattgggaga ttaggatttg
     1261 atttcatttt ggggcgggcg gtggctcgtg ctgggtcacg tggtcgtgcc caagcgctcc
     1321 tcctgttgcc ccacctgtgg ttgctgtgga ctgcacacga cagcagattc gctgtcccct
     1381 cgttggaggc gaatggtcgg accccgagtg gcggcgcccc tgataaaagg ccgaggattc
     1441 gcgatcaggg tgcaacttca ctccctcctc ttttctctcc agccttgcag cgtggccgtt
     1501 cacatcacgc gcttcactaa gcctcctatc actagtaacc tttcagcgca ttgtttaaaa
     1561 agaaagcagt ttctgtccct ttctgtagtt cctttaagtt caggatgtaa gcgaagcctt
     1621 ccattaagta aaggtgagtg tcgtttcgtc tca
//
