LOCUS       NM_024775               3705 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens gem nuclear organelle associated protein 6 (GEMIN6),
            mRNA.
ACCESSION   NM_024775
VERSION     NM_024775.10
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3705)
  AUTHORS   Lin,J., Liu,B., Zhang,Y., Lv,L., Cheng,D., Zhang,W., Shi,Y.,
            Jiang,X., Tang,L., Yuan,Y., Zhai,H., Shen,Q., Xiong,Q., Jin,Z.,
            Chen,Y. and Yang,C.
  TITLE     Gemin6 promotes c-Myc stabilisation and non-small cell lung cancer
            progression via accelerating AURKB mRNA maturation
  JOURNAL   Clin Transl Med 12 (4), e811 (2022)
   PUBMED   35452176
  REMARK    GeneRIF: Gemin6 promotes c-Myc stabilisation and non-small cell
            lung cancer progression via accelerating AURKB mRNA maturation.
REFERENCE   2  (bases 1 to 3705)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 3705)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3705)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3705)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3705)
  AUTHORS   Yong,J., Wan,L. and Dreyfuss,G.
  TITLE     Why do cells need an assembly machine for RNA-protein complexes?
  JOURNAL   Trends Cell Biol 14 (5), 226-232 (2004)
   PUBMED   15130578
  REMARK    Review article
REFERENCE   7  (bases 1 to 3705)
  AUTHORS   Baccon,J., Pellizzoni,L., Rappsilber,J., Mann,M. and Dreyfuss,G.
  TITLE     Identification and characterization of Gemin7, a novel component of
            the survival of motor neuron complex
  JOURNAL   J Biol Chem 277 (35), 31957-31962 (2002)
   PUBMED   12065586
REFERENCE   8  (bases 1 to 3705)
  AUTHORS   Paushkin,S., Gubitz,A.K., Massenet,S. and Dreyfuss,G.
  TITLE     The SMN complex, an assemblyosome of ribonucleoproteins
  JOURNAL   Curr Opin Cell Biol 14 (3), 305-312 (2002)
   PUBMED   12067652
  REMARK    Review article
REFERENCE   9  (bases 1 to 3705)
  AUTHORS   Pellizzoni,L., Baccon,J., Rappsilber,J., Mann,M. and Dreyfuss,G.
  TITLE     Purification of native survival of motor neurons complexes and
            identification of Gemin6 as a novel component
  JOURNAL   J Biol Chem 277 (9), 7540-7545 (2002)
   PUBMED   11748230
  REMARK    GeneRIF: Gemin6 is a component of the SMN complex that localizes to
            gems and interacts with several Sm proteins of the spliceosomal
            snRNPs.
REFERENCE   10 (bases 1 to 3705)
  AUTHORS   Sleeman,J.E. and Lamond,A.I.
  TITLE     Newly assembled snRNPs associate with coiled bodies before
            speckles, suggesting a nuclear snRNP maturation pathway
  JOURNAL   Curr Biol 9 (19), 1065-1074 (1999)
   PUBMED   10531003
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC029584.1, BM471707.1 and AC018693.8.
            
            On Nov 22, 2018 this sequence version replaced NM_024775.9.
            
            Summary: GEMIN6 is part of a large macromolecular complex,
            localized to both the cytoplasm and the nucleus, that plays a role
            in the cytoplasmic assembly of small nuclear ribonucleoproteins
            (snRNPs). Other members of this complex include SMN (MIM 600354),
            GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM
            606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM782269.1, BX417513.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281950.8/ ENSP00000281950.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               BC029584.1         475-633
            160-667             BM471707.1         131-638
            668-668             BC029584.1         1210-1210
            669-3705            AC018693.8         17470-20506
FEATURES             Location/Qualifiers
     source          1..3705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..3705
                     /gene="GEMIN6"
                     /note="gem nuclear organelle associated protein 6"
                     /db_xref="GeneID:79833"
                     /db_xref="HGNC:HGNC:20044"
                     /db_xref="MIM:607006"
     exon            1..72
                     /gene="GEMIN6"
                     /inference="alignment:Splign:2.1.0"
     exon            73..219
                     /gene="GEMIN6"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..595
                     /gene="GEMIN6"
                     /note="SIP2; gemin-6"
                     /codon_start=1
                     /product="gem-associated protein 6"
                     /protein_id="NP_079051.9"
                     /db_xref="CCDS:CCDS1799.1"
                     /db_xref="GeneID:79833"
                     /db_xref="HGNC:HGNC:20044"
                     /db_xref="MIM:607006"
                     /translation="MSEWMKKGPLEWQDYIYKEVRVTASEKNEYKGWVLTTDPVSANI
                     VLVNFLEDGSMSVTGIMGHAVQTVETMNEGDHRVREKLMHLFTSGDCKAYSPEDLEER
                     KNSLKKWLEKNHIPITEQGDAPRTLCVAGVLTIDPPYGPENCSSSNEIILSRVQDLIE
                     GHLTASQ"
     exon            220..3705
                     /gene="GEMIN6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      647..652
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GEMIN6"
                     /note="hexamer: CATAAA"
     polyA_site      668
                     /gene="GEMIN6"
                     /note="major polyA site"
     regulatory      1137..1142
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GEMIN6"
                     /note="hexamer: TATAAA"
     polyA_site      1159
                     /gene="GEMIN6"
     regulatory      3682..3687
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GEMIN6"
                     /note="hexamer: AATAAA"
     polyA_site      3705
                     /gene="GEMIN6"
ORIGIN      
        1 ggtctccgct caacgatcct tcctcaaagc atggttgctg agtacccaga gttgcgagga
       61 gttttttaac tgatttagcc aggtggcaat catgagtgaa tggatgaaga aaggcccctt
      121 agaatggcaa gattacattt acaaagaggt ccgagtgaca gccagtgaga agaatgagta
      181 taaaggatgg gttttaacta cagacccagt ctctgccaat attgtccttg tgaacttcct
      241 tgaagatggc agcatgtctg tgaccggaat tatgggacat gctgtgcaga ctgttgaaac
      301 tatgaatgaa ggggaccata gagtgaggga gaagctgatg catttgttca cgtctggaga
      361 ctgcaaagca tacagcccag aggatctgga agagagaaag aacagcctaa agaaatggct
      421 tgagaagaac cacatcccca tcactgaaca gggagacgct ccaaggactc tctgtgtggc
      481 tggggtcctg actatagacc caccatatgg tccagaaaat tgcagcagct ctaatgagat
      541 tattctgtcg cgtgttcagg atcttattga aggacatctt acagcttccc aatgagaggc
      601 caggaagtgt gaacatactg atagaaaaag actatatttt atccctcata aaatgtttta
      661 aatgtaaatg tacatgactg tgtgtgtgta tgtgtgtgtg tgtataattc tttgttgttt
      721 tggtaaaatc agaggagtgg gttataagtg ctaatttcct tgggaaatta atgaactagg
      781 gcaagtatag catcccatgc ataaaattag cacagggaca tcagaattgt atgggtcttc
      841 ttttttcttt ttttcttttt tttttgagat ggagtctcgc tctgttgcca ggtttgagtg
      901 cagtggcgca atctcagctc agtgcaacct ccgcctccca ggttcaaccg attcccctgc
      961 ctcagcctct cgagtagctg ggactacagg tgcacgccac cactcccagc taattttttg
     1021 tattttagta gagatggggt ttcacctgta tgggtctttt cttgtgatgg ggttacaccc
     1081 ccatttttgt taggcaagaa aagcatttgg aaaaaaatgt aacatgttag attcaatata
     1141 aaatattatg gtaagatcat ggtcttgtta agtctcttca ctaactgtat gtgtctgttt
     1201 ttaaaagatg tgtcttggtg gggcgcggtg gctcacgcct gtaatcccag cactttggga
     1261 ggccgaggca ggtggatcat gaggtcagga gatcgagacc atcctggcta acacggtgaa
     1321 accccttctc tactaaaaat acaaaaaaaa ttagccgggc gtggtggcag gtgcctgtag
     1381 tcccagctac tcaggaggct gaggcaggag aatggcatga acccgggagg cagagcttgc
     1441 agtgagccga gatcgcgcca ctgcactcta gcctgggtga cagagcgaga ctccgtctca
     1501 aaaaaaaaaa aaaaaattat tggaacacag cattacctat tgaattacag ttttctggtt
     1561 tttttgtgga gtttttgttt tggtttttga gatggagttt cactcttgtt ccccaggctg
     1621 gagtgtaata gtgcaatctc ggcttaccac aacctctgcc tcccaggttc aagcaattct
     1681 cctgcctcag cctcctgagt agctggtatt acaggcatgc accatcacgc cccactaatt
     1741 ttgtattttt ttagtagaga cggggttttt ccatgttggt caggctggtc tcaaactccc
     1801 gacctcaggt gatccgcccg cctcggcctc ccaaagttct gggattacag gtgtgagcca
     1861 ccgtgcccgg ctgttttttg tgggtttttt gtttgtttgt ttgtttttga gacagagtct
     1921 tgctctgtca ctcaggctgg agtgcagtgg cacaatctcg gctcactgca acctctgcct
     1981 cctgagttca agccattctc ctgcctcagc cccctcagta gctgggatta ccaggcacat
     2041 agcaccatgc ccagctaatg tttgtatttt tagtagagac agggtttcac catgttgacc
     2101 aggctggtct tgaactcctg acctcatgat ctgcctgccg tggcctccca aagtgctggg
     2161 attataggca tgagagcctc cgtgcctggc tttttttttt tttttttttt tttaaaagag
     2221 ggtcttgata tgttgcccag gcttgtcttc aactcctggg ttcaagtgat ccttccacct
     2281 tggcctccca aagtgctggg aatataggtg tgagctgcca tgtccagctg taagaaatat
     2341 tttaaaatat ttaagcttca gggcctttga atacaggccc tgataacata gctattttcc
     2401 tgcatagttg tctaataaca agatggtata gcccagtgct tcttgcactt tagcaagcat
     2461 cagaatcagc aaatatttag gtttcagggc ctttgaatac agtctgataa cacagctatt
     2521 ttcctgcata gttgtctaat aacaagatgg tatagtccag tgcttcctgc atgttggcaa
     2581 gcatcagaat cagctgcagg gcttttcaaa acagattgct ggaccctcct cccaacagat
     2641 tctgattcag tagttctagt tgggacccag gaatttgcat ttccaacaga ctcccagata
     2701 atgatgttac cgttcccaga ccacacttgc agaagcagtt cagaaacttc aggggaacag
     2761 aaagttcctc cctcacggct tcaaagttcc atgatcctga aagcaaaatt tagcacacat
     2821 cacctttctc ctagtggcta agactctcct gttcaaaccc tggatgtctt cagaaagcaa
     2881 atagaagggg aatatgaaca gactgaagtc agcaaggaaa tgactgacaa gatgagggag
     2941 gcctttgaaa aggaagaagc cagctgggcg cggtggctca cgcctgtaat cccagcactt
     3001 tgggaggcct aggcgggccg atcacttgag gccaggattt gtgaccaacc tgggcaacat
     3061 ggtgaaaccc tgtctctact aaaaaaaaaa aaaatagctg ggtgtggtgg tgagcgccta
     3121 taatctcagc tactcaggag gctgaggcac tcgcttgaat ctgggaggtg gaggttgcag
     3181 tgagccgaga ttgtacgcat tccagcttgg gcagcagaac gagactctgt ctcaaaaaaa
     3241 aaaaaaaagc cacgtaggaa attatccaca gcatcaattg gacttgatct tggctcaggg
     3301 accaggcccg gtgccttgat attggtagat ttatttgcca tcagactaat gagctgggga
     3361 cattgactgt ttcctggcaa ctgagtcctc tgattgtgta aacaatttgc ctgcaaacaa
     3421 aacctgagtg cttgaaaggg taagtgatcc tgatctgcca tagaaacctt catgcttagg
     3481 gagtttccct agctaattcc tcagctaaga ttctccccag gagtttcact cacctgtttc
     3541 cagtgcctcc tttgggctgt cagcatctgt gattccacat tccccagagg gagattcctc
     3601 cccaaagctg gttgtattta ctgccagtcc tgggctgtag ccagggcagt ctttgaacac
     3661 attatcaaga atacttttta aaataaaagt ctgtttcgac ttcca
//
