LOCUS       NM_001013657            5128 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens GDP-D-glucose phosphorylase 1 (GDPGP1), transcript
            variant 1, mRNA.
ACCESSION   NM_001013657 XM_372589
VERSION     NM_001013657.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5128)
  AUTHORS   Adler,L.N., Gomez,T.A., Clarke,S.G. and Linster,C.L.
  TITLE     A novel GDP-D-glucose phosphorylase involved in quality control of
            the nucleoside diphosphate sugar pool in Caenorhabditis elegans and
            mammals
  JOURNAL   J Biol Chem 286 (24), 21511-21523 (2011)
   PUBMED   21507950
  REMARK    GeneRIF: C15orf58 in humans and C10F3.4 in C. elegans display
            GDP-hexose phosphorylase activity but the major reaction catalyzed
            by these enzymes is the phosphorolysis of GDP-D-glucose to GDP and
            D-glucose 1-phosphate
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091167.19 and BX440248.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001013657.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.47151.1,
                                           SRR1163657.253795.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329600.8/ ENSP00000368405.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AC091167.19        104419-104464       c
            47-146              BX440248.2         1-100
            147-147             AC091167.19        104089-104089       c
            148-291             BX440248.2         102-245
            292-1397            AC091167.19        96593-97698         c
            1398-5128           AC091167.19        92862-96592         c
FEATURES             Location/Qualifiers
     source          1..5128
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..5128
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /note="GDP-D-glucose phosphorylase 1"
                     /db_xref="GeneID:390637"
                     /db_xref="HGNC:HGNC:34360"
                     /db_xref="MIM:619240"
     exon            1..84
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..159
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            160..216
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..5128
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..1383
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /EC_number="2.7.7.78"
                     /note="GDP-D-glucose phosphorylase C15orf58"
                     /codon_start=1
                     /product="GDP-D-glucose phosphorylase 1"
                     /protein_id="NP_001013679.2"
                     /db_xref="CCDS:CCDS32327.1"
                     /db_xref="GeneID:390637"
                     /db_xref="HGNC:HGNC:34360"
                     /db_xref="MIM:619240"
                     /translation="MALPHDSNETSYLLPPNNEDWGRQTIPDFVYGQKDLMAEGIQWP
                     RNAPGIPDALPQSPFDAALCSAWKQRVELGLFRYRLRELQTQILPGAVGFVAQLNVER
                     GVQRRPPQTIKSVRQAFDPVQFNFNKIRPGEVLFRLHREPDLPGTLLQEDILVVINVS
                     PLEWGHVLLVPEPARQLPQRLLPGALRAGIEAVLLSLHPGFRVGFNSLGGLASVNHLH
                     LHGYYLAHRLPVEQAPSEPLDPGGHLHLLQDLPAPGFLFYTRGPGPDLESLISRVCRA
                     TDYLTDHEIAHNLFVTRGAPPGKTSPSSALTGVRVILWARKSSFGIKDGEAFNVALCE
                     LAGHLPVKTSQDFSSLTEAAAVALIQDCRLPPSQAEDVQAALVALMSQEEQ"
     polyA_site      2666
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /note="major polyA site"
     regulatory      5087..5092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /note="hexamer: TATAAA"
     regulatory      5101..5106
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
                     /note="hexamer: AGTAAA"
     polyA_site      5107
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
     polyA_site      5128
                     /gene="GDPGP1"
                     /gene_synonym="C15orf58; VTC2"
ORIGIN      
        1 gtatgcgtca cgggcgtcat gacctcgctg tggccccggc agcggctgcg gggaaagtcg
       61 cgaggtgcat ccgcttcggc tgcagctatt tactgaggac ccactggatg tcaagcattg
      121 tgcatagttt tcttcgattg ttgcaacatc ccttgcgagt ttctggagca gcagagctga
      181 aggaacccaa acttggactg aagtgactct actaaggtca gctctatggc tcttccacat
      241 gattcaaacg aaacttccta tttgctgcct cccaacaatg aggactgggg caggcaaacc
      301 attcctgact ttgtttatgg gcagaaggat ctcatggcag aagggattca gtggccaagg
      361 aatgcacctg gcatcccaga tgctctgcca caatctccct ttgatgctgc actctgctct
      421 gcctggaagc agcgggtgga gctggggctg tttcgctacc gtctacggga gctacagacc
      481 caaatcctcc ctggtgctgt gggtttcgtg gctcagctga atgtggagcg tggtgtgcag
      541 aggaggcccc cgcagaccat caagagtgtg aggcaggcat ttgaccctgt acagttcaac
      601 ttcaacaaga tccggcccgg agaagtcctc ttccgtttgc accgggagcc tgatctccct
      661 gggactctgc tgcaagaaga catcctggtg gtgatcaacg tcagccccct ggagtggggc
      721 cacgtgctgc tggtgcctga gcctgcccgc cagctccccc agcgcctgct gccgggtgca
      781 ctgagggcag ggattgaggc tgtgctgctg agcttacacc cgggcttccg tgtcggcttc
      841 aacagcctgg gaggcttggc ctcggtgaac cacctccacc tgcatggcta ttacctggcc
      901 cacagactgc ccgtggagca ggcgccaagc gagcccctgg accctggagg ccatttgcat
      961 ctgctccagg acctcccagc tcctggcttc ctcttttaca ctcgtgggcc agggcctgac
     1021 ttggagtcct tgataagcag ggtatgtcgg gccactgatt atctgactga ccatgagatt
     1081 gctcataact tgtttgtcac ccggggagct ccgccgggaa agacatcacc ttcctcagcc
     1141 ctcacagggg tccgagtaat tctgtgggcc cggaagtcca gctttgggat aaaggacggt
     1201 gaagctttca atgttgccct ctgtgagctg gctgggcacc tccctgtcaa aacatcccag
     1261 gacttcagca gcctgacaga ggcagctgct gtggccctca ttcaggactg tcggctgccc
     1321 ccatcccagg cagaagacgt acaggcagca ctggtggccc tgatgtccca ggaagagcaa
     1381 taatacttct ggatgtattt atgttctttt tttcttttct tttgagatag ggtctcactc
     1441 tgtccccagg ctagagtgta gtggtatgat cctggctcac tgtagcctcc acctctgggg
     1501 ctgaagtgat cctcccacct cagcctcttg agtagctgag actataggcg tgcaccacca
     1561 cacacctggc tttttttttt tttttttttt tttttaacga ttaggtgatt ttgtattttt
     1621 ttatatagac agcgtttcac catgttgccc aggctggtct tgaactcttg ggctgaagca
     1681 gtcctcccac ctcggcctcc caaagtactg agatgacagg agtgagcccc tggattcttt
     1741 tctgtttctt tttttttttt tttttttttt tttttttttg agatagtctc gctctgtcac
     1801 ctaggttggg gtgcactggt acaatctcgg ctcactgcaa cctccacctc tagggttcga
     1861 gtgatcctcc tggctcagcc tcccgagtag ctgggactat acaggctcct gccaccaaac
     1921 ccggctaatt tttttgtatt tttaaaagag aaggggtttc accacattgg ctaggctggt
     1981 cttgaactcc tgactttagg tgatccgccc gcctcggcct cccaaagtgc tgggattaca
     2041 ggcgtgagcc accacaccca gccaggatgt attcattttc tacctgatga gtccctttcc
     2101 agagcactgt ccatcatagt cctttggaca tttattttca tggctgcctt ctcacctgtc
     2161 tcagcctaag aagaaggatg aagaaagctg ataatgatct cttaaagggg agaaagataa
     2221 tggtctcttt aaaggggagc tgatagtggt ctctttaaag gggagaaaat ctggaataat
     2281 tctactgagt aagacatcat gaatgtatct gctacctctc cccgttcttg ttcaagcccc
     2341 aggggtgtta aaaaggagtg tgtgtgacag ttacacactc ctgactttac atttagattt
     2401 tgtcttcctt tgatatcaaa tgttagcacg gtaatagtgc ctgtgcctcc agtattgagc
     2461 tgccacttct gttctcagcc tgtttattcc cctttgctca ccacttattt ttattgcttt
     2521 gtcccttctt tccatttagc cctgctccac ccaaatgccc cactccttca ctttccctgc
     2581 caccttgagc tttcctctag cccccaacac caagttgaat gctcttcact gacatcatct
     2641 gatgtaaaaa cacagtgttg tcacaacttt ccgggtgcac gtcttttttt gttttgtttt
     2701 tttgtaaggc tggggtgcag tggtgcaatc acagctcact gcagacccaa actcttggtc
     2761 tcaagccacc ctcccacctc agccccctga gtagctggga cgataggtgt gcaccatcac
     2821 acctggctaa tttttaaatt ttttgtagag atagggtctt gctatgttgc ccgggttgct
     2881 gtcaaactcc tggccttaag aaatcctccc acctcggcct cccagagtgc taagatgcca
     2941 ccacaccttg gtgcaggttt tttttttttt tttttttttt tttttttgac acagggtcac
     3001 tgtcacccag gctggagtgc agtggtatga agacagctaa ctgcaagctt caacctcctg
     3061 ggctcaaaca atactcccat ctcagcctcc ctagtagctg ggaccacagg catgcgccac
     3121 cacacccggc tatttttttg gagagatagc atcttgccaa gttgcccagg ctggtctcga
     3181 actcctggcc tcaagatcct cccacctcag cctcccaaag tgctgagatt ataggcatga
     3241 gccactgcac ctggcctgag tttttttttt tttttcttga atcagagttt cactctgttg
     3301 cccaggctgg agtgcagtgg tgtgatctcg gctcactgcg tctctgcctc ctgggttcaa
     3361 gcaattcagc ctgagtcttc ttaatacccc cattcaaaac gggatggaga ctgacagttt
     3421 gtactttgtt caaggtcagg cagctggagt cgggactgca gcacaggcag gtaccagaag
     3481 atgagctggg acaatgtgtg cttgtgaccg cctctccagt cagtggttcc catggtgggt
     3541 agcactgtcc ttaacagttt gccctccctg agcctcagcc atccctcttg gggtctttcc
     3601 caagcacttt agaagctcct cttgatgtag acacaaaatc caaagctaag tcgttgttcc
     3661 tccgtctgca tctgagtcaa tgtgggaaat ttttttttat ctcattgctt tgttctgtcc
     3721 tgtttctcca gacatttcac actggttcca gaggaactag tcagtagaca ctattctaag
     3781 agagtatgtg ggtgtgaaat ctcattttcc ttttagctcc cttgaatgtt atacagcaaa
     3841 agtaaaagaa gtcttgggtt ggctgggcac gttggctcac acctttaatc ctagcacttt
     3901 gggaagccga ggcaggcaaa tcacttgtca ggagttcgag accagcctgg ccaacatggt
     3961 gaaaccccat ctctactaaa aatacaaaaa ttaggcgttg tggcggccac ctgtaatccc
     4021 atctacttgg gaggctgagg caggagaatc acttgaaccc aggaggcgga ggttgcagtg
     4081 agctgagatt gcacgactgt actccagcct gggcgatagt gcgagactca gtctcaaaat
     4141 aaataaatac ataaagtctt gggtccagct ctcaacagag attatcaccg ccaccactcc
     4201 ttcatcaaac atcctgaagg aatgagagtc cctgttcaca gcgtaagggt gaaagggggc
     4261 tcacacaggt gggttctggc tgctgtctga gtgggctcac ccaggagggg ttttgatttc
     4321 tctgcctccc aaactgtggg tcctagccct ggcttaggcc ttcaggtcgt tggctcccta
     4381 tacctaggcc tgtataaagc cttagtttcc agttttcatt agaggtttta catcccaaat
     4441 gatgttacaa agtctccctg tgataaagca gaatatgtgt ccatagccca ttttataaga
     4501 aaaacagttt aggccaggtg cggtggctca cgcctgtaat cccagcactt tgggaggctg
     4561 aagcaggcag atcacaaggt caggagttca agaccagcct ggccaacatg gtgaaacccc
     4621 gtctctacta aaaacacaaa aattagctgg gtgtgggtgc acatctatag tcccagctac
     4681 tcaggaggct gaggcaggag aatcgcttgg acctgggagg cggaggtggc agtgagccga
     4741 gatcgcgcca ctgcactcca gcctgggcgg cagagagaga ctttgtctca aaaaaaaaaa
     4801 aaaagaaaaa aacagtttac cattctatca gaaaatgttg accaccctca tatttttggt
     4861 aaactgcagt aatttttcct taatactttt tgcaagcttt tgcatgcata agctccagta
     4921 tcacacttaa ttttgcttgc ttgctctctg aagggagttc ggatgaccat tacagcaaag
     4981 tggattttgc gttcaaagtg ataagccaaa tatcaggatt ttcccagttt ctccgtagga
     5041 ctgatgttta gaggaaagcc ttccctgact caaatatgtt tctccatata aaaaggggaa
     5101 agtaaaatgg gttttctttc tggtggta
//
