LOCUS       NM_030792               3561 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens glycerophosphodiester phosphodiesterase domain
            containing 5 (GDPD5), transcript variant 1, mRNA.
ACCESSION   NM_030792
VERSION     NM_030792.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3561)
  AUTHORS   Shuler,K.T., Llamas-Rodriguez,J., Levy-Myers,R. and Sockanathan,S.
  TITLE     The Six-Transmembrane Enzyme GDE2 Is Required for the Release of
            Molecularly Distinct Small Extracellular Vesicles from Neurons
  JOURNAL   Cells 13 (17), 1414 (2024)
   PUBMED   39272985
  REMARK    GeneRIF: The Six-Transmembrane Enzyme GDE2 Is Required for the
            Release of Molecularly Distinct Small Extracellular Vesicles from
            Neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3561)
  AUTHORS   Daudelin,D., Westerhaus,A., Zhang,N., Leyder,E., Savonenko,A. and
            Sockanathan,S.
  TITLE     Loss of GDE2 leads to complex behavioral changes including memory
            impairment
  JOURNAL   Behav Brain Funct 20 (1), 7 (2024)
   PUBMED   38575965
  REMARK    GeneRIF: Loss of GDE2 leads to complex behavioral changes including
            memory impairment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3561)
  AUTHORS   Wang,Y., Chen,H. and Wei,X.
  TITLE     Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal
            cancer cells
  JOURNAL   Eur J Clin Invest 51 (7), e13541 (2021)
   PUBMED   33797091
  REMARK    GeneRIF: Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on
            colorectal cancer cells.
REFERENCE   4  (bases 1 to 3561)
  AUTHORS   Nakamura,M., Li,Y., Choi,B.R., Matas-Rico,E., Troncoso,J.,
            Takahashi,C. and Sockanathan,S.
  TITLE     GDE2-RECK controls ADAM10 alpha-secretase-mediated cleavage of
            amyloid precursor protein
  JOURNAL   Sci Transl Med 13 (585) (2021)
   PUBMED   33731436
  REMARK    GeneRIF: GDE2-RECK controls ADAM10 alpha-secretase-mediated
            cleavage of amyloid precursor protein.
REFERENCE   5  (bases 1 to 3561)
  AUTHORS   Feng,C., Zhang,L., Sun,Y., Li,X., Zhan,L., Lou,Y., Wang,Y., Liu,L.
            and Zhang,Y.
  TITLE     GDPD5, a target of miR-195-5p, is associated with metastasis and
            chemoresistance in colorectal cancer
  JOURNAL   Biomed Pharmacother 101, 945-952 (2018)
   PUBMED   29635904
  REMARK    GeneRIF: miR-195-5p is a potent suppressor of GDPD5 and that, as
            such, it significantly increases chemosensitivity and apoptosis in
            chemoresistant colorectal cells.
REFERENCE   6  (bases 1 to 3561)
  AUTHORS   Lang,Q., Zhang,H., Li,J., Yin,H., Zhang,Y., Tang,W., Wan,B. and
            Yu,L.
  TITLE     Cloning and characterization of a human GDPD domain-containing
            protein GDPD5
  JOURNAL   Mol Biol Rep 35 (3), 351-359 (2008)
   PUBMED   17578682
  REMARK    GeneRIF: GDPD5 was widely expressed in human tissues and the
            expression levels in kidney and prostate were relatively low
REFERENCE   7  (bases 1 to 3561)
  AUTHORS   Yanaka,N., Nogusa,Y., Fujioka,Y., Yamashita,Y. and Kato,N.
  TITLE     Involvement of membrane protein GDE2 in retinoic acid-induced
            neurite formation in Neuro2A cells
  JOURNAL   FEBS Lett 581 (4), 712-718 (2007)
   PUBMED   17275818
REFERENCE   8  (bases 1 to 3561)
  AUTHORS   Rao,M. and Sockanathan,S.
  TITLE     Transmembrane protein GDE2 induces motor neuron differentiation in
            vivo
  JOURNAL   Science 309 (5744), 2212-2215 (2005)
   PUBMED   16195461
REFERENCE   9  (bases 1 to 3561)
  AUTHORS   Wan,D., Gong,Y., Qin,W., Zhang,P., Li,J., Wei,L., Zhou,X., Li,H.,
            Qiu,X., Zhong,F., He,L., Yu,J., Yao,G., Jiang,H., Qian,L., Yu,Y.,
            Shu,H., Chen,X., Xu,H., Guo,M., Pan,Z., Chen,Y., Ge,C., Yang,S. and
            Gu,J.
  TITLE     Large-scale cDNA transfection screening for genes related to cancer
            development and progression
  JOURNAL   Proc Natl Acad Sci U S A 101 (44), 15724-15729 (2004)
   PUBMED   15498874
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2004 Dec 14:101(50):17565]
REFERENCE   10 (bases 1 to 3561)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP002815.3.
            
            On Nov 23, 2018 this sequence version replaced NM_030792.7.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF318351.1, AF318377.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000336898.8/ ENSP00000337972.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-732               AP002815.3         91380-92111         c
            733-816             AP002815.3         56407-56490         c
            817-993             AP002815.3         43789-43965         c
            994-1097            AP002815.3         28956-29059         c
            1098-1191           AP002815.3         23863-23956         c
            1192-1251           AP002815.3         22927-22986         c
            1252-1350           AP002815.3         16055-16153         c
            1351-1444           AP002815.3         15687-15780         c
            1445-1590           AP002815.3         15147-15292         c
            1591-1673           AP002815.3         10583-10665         c
            1674-1824           AP002815.3         9306-9456           c
            1825-2043           AP002815.3         8533-8751           c
            2044-2201           AP002815.3         7816-7973           c
            2202-2349           AP002815.3         7333-7480           c
            2350-2432           AP002815.3         6049-6131           c
            2433-2545           AP002815.3         3106-3218           c
            2546-3561           AP002815.3         810-1825            c
FEATURES             Location/Qualifiers
     source          1..3561
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4-q13.5"
     gene            1..3561
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /note="glycerophosphodiester phosphodiesterase domain
                     containing 5"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
     exon            1..732
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            733..816
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            817..993
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     CDS             877..2694
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /EC_number="3.1.4.11"
                     /EC_number="3.1.4.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycerophosphodiester phosphodiesterase domain-containing
                     protein 5; glycerophosphodiester phosphodiesterase 2;
                     phosphoinositide phospholipase C GDPD5;
                     glycerophosphocholine phosphodiesterase GDPD5"
                     /codon_start=1
                     /product="glycerophosphodiester phosphodiesterase
                     domain-containing protein 5 isoform 1"
                     /protein_id="NP_110419.5"
                     /db_xref="CCDS:CCDS8238.1"
                     /db_xref="GeneID:81544"
                     /db_xref="HGNC:HGNC:28804"
                     /db_xref="MIM:609632"
                     /translation="MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLW
                     FLLLTFTFGLTLTWLYFWWEVHNDYDEFNWYLYNRMGYWSDWPVPILVTTAAAFAYIA
                     GLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGT
                     APFLHVGAVAAVTMLSWIVAGQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCI
                     MEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQKLYGLQADITISLDGVPFLMHD
                     TTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREA
                     QNQSICSLAELLELAKGNATLLLNLRDPPREHPYRSSFINVTLEAVLHSGFPQHQVMW
                     LPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQVSRQELRDYASWNLS
                     VNLYTVNAPWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSF
                     TLIVGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISDGVEVSD
                     VLSVCSDNSYDTYANSTATPVGPRGGGSHTKTLIERSGR"
     exon            994..1097
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1191
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1251
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1252..1350
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1444
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1590
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1673
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1824
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..2043
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            2044..2201
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            2202..2349
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            2350..2432
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            2433..2545
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..3561
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3543..3548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /note="hexamer: ATTAAA"
     polyA_site      3561
                     /gene="GDPD5"
                     /gene_synonym="GDE2; PP1665"
                     /note="major polyA site"
ORIGIN      
        1 ggctgagctc gggctgcggc tccggtgggg gtgggtggcg gggatgacag cggaggtggc
       61 agcggcgcgg cgctgagcga gcggcgaggg agcaggggaa gaggaggaag tggagccgcg
      121 gccgggagct cgggagtcgg ccgccgcgcc gaggttcgcc ccgttttgca gagagagccg
      181 agtcgggacc tggaaagact tccccgcggg gctccggccg ccgcgcctcc ccgccggcgc
      241 ctgccctgcc ctgcccgtcc cagccccgcg gttcggggcg tgcggccggg acgcgcggag
      301 ccccggccct gacccgctgc gccgggacgg gacgctccta acgccgccgt accggtccgt
      361 ggttgcaggg tcgctccgcg cctttccgtc agtgagggtc ggaaccccag ctccagggct
      421 agcgcagtgt ggccccaggc cctcgcctcc ggtgcacggg accccggacc cccccagcct
      481 ctggcttcac gagaccccaa ccttcagttg gaacagcttg gaacagcgcg agcgcccggg
      541 aagccctggc cgggtcgtgc gctcggtgag gggtcctagg cgggcaggac agtcggaccg
      601 aaccgccggg ctggtgccgc gagcccaggc tgtcaccttc gtcccgcctc aggtgagggg
      661 ttcagcgcct gccccgaaga taacacaggg gtccccttct gtcccggcgg cctgcgagag
      721 ccaaggctgc agctctccca gtgaagtgat atcactgcct ctgtggacaa gacacctcca
      781 ggagcccagc tcacagccac cggtaccttc ttccaggaca agctgggggc ctccatgggc
      841 gcctgagggc caggcgccag ggccgtgggc acgagtatgg tgagacacca gcccctgcag
      901 tactacgagc cacagctgtg cctctcctgc ctcacgggca tctacggctg ccgttggaag
      961 cgctaccagc gctcccatga tgataccaca ccgtgggagc gcctctggtt cctgctcctc
     1021 accttcacct ttggcctcac gctcacctgg ctttacttct ggtgggaagt ccacaatgac
     1081 tatgatgaat tcaactggta cctctacaac cgcatgggct actggagcga ctggcccgta
     1141 cccatccttg tgaccacagc tgctgccttc gcatacatcg ctggcctcct ggtcctggca
     1201 ctatgtcaca ttgccgtggg gcagcagatg aacctgcact ggctgcacaa gatcgggctg
     1261 gtggtcatcc tggcttccac ggtggtggcc atgtcggccg tggcccagct gtgggaggac
     1321 gagtgggagg tgctgctgat ctccctgcag ggcacagcgc cattcctgca tgtgggggct
     1381 gtggcagcag tcaccatgct ctcctggatc gtggcaggac agttcgcccg cgcagagcgg
     1441 acctcctccc aggtgaccat tctctgtacc ttcttcaccg tggtgtttgc cctctacctg
     1501 gcccctctca ccatctcctc tccctgcatc atggagaaga aagacctcgg ccccaagcct
     1561 gctctcattg gccaccgcgg ggcccccatg ctggctccag agcacacgct catgtccttc
     1621 cggaaggccc tcgagcagaa gctgtacggg ctccaggctg acattaccat cagcctggac
     1681 ggcgtgccct tcctcatgca tgacaccacc ctgcggcgca ccaccaacgt ggaggaggag
     1741 ttcccggagc tggcccgcag gcctgcctcc atgcttaact ggaccaccct gcagagactc
     1801 aacgctggcc agtggttcct gaagactgac cccttctgga cagccagctc cctgtcaccc
     1861 tccgaccaca gagaggccca gaaccagtcc atctgcagcc tggcagagct cctggagctg
     1921 gccaagggca atgccacact gctgctcaac ctgcgtgacc cgccccggga gcacccctac
     1981 cgcagcagtt ttatcaacgt gactctggag gccgtgctgc actccggctt cccccagcac
     2041 caggtcatgt ggctgcctag caggcagagg cccctggtgc ggaaggtggc tcccggcttc
     2101 caacagacat caggctccaa ggaggcagtc gccagcctgc ggagaggcca catccagcgg
     2161 ctgaacctgc gctacactca ggtgtcccgc caggagctca gggactacgc gtcctggaac
     2221 ctgagtgtga acctctacac agtcaacgca ccgtggctct tctccctgct gtggtgtgcg
     2281 ggggtcccat ccgtcacctc tgacaactcc cacgccctgt cccaggtgcc ttcccccctc
     2341 tggatcatgc ccccggacga gtactgtctc atgtgggtca ctgccgacct ggtctccttc
     2401 accctcatcg tgggcatctt cgtgctccag aagtggcgcc tgggtggcat acggagctac
     2461 aaccctgagc agatcatgct gagtgctgcg gtgcgccgga ccagccggga cgtcagcatc
     2521 atgaaggaga agcttatttt ctcagagatc agcgatggtg tagaggtctc cgatgtgctc
     2581 tccgtatgtt cagacaacag ttatgacaca tatgccaaca gcaccgccac ccctgtgggc
     2641 ccccgagggg gtggcagcca caccaagacc ctcatagagc ggagtgggcg ttagctgaag
     2701 acatgtctgt cccacctgta cctgacacag aagctgggga gcctaggaga gctggtggaa
     2761 gtgtgtctga actcggagtg ctctgggagc gggctccaca gcctccttgt gggctccagc
     2821 cccttgtcag ccgcagcctc tcttgagggg gactccctgt ctcctgaggc ccagctgggc
     2881 caggactcca tcctttcaga tgcccctgca ggcctggggc tccttctggg aagtatgggg
     2941 cctagggctt ggtccccctc ttctgaggcc ctctcctgta tcccgacctg gaagctttga
     3001 tgggtcatgg gccatgccat accccctgtg gcaatggagt gtgtggatgc tcacctgtgc
     3061 catctgtcct cctgtctgtg ccaggaggca cctgagttct ctgctgttat cctgccccaa
     3121 gggcctgggc cgagcctcta cctgaagcaa ctctgctctt cctgtcagtc tcaaagcaca
     3181 aggaggttca gcccaggagg aagccagctg caatgtggag acacgtcctc ctccccaacc
     3241 cacctcatgc caccgccaac cccctgcccc aggagcgggc ctgagccacg tcctctagga
     3301 gcagctggag atggccaaaa gagtgagctc aggactactg gatcccatgc ccaggtgtcc
     3361 agcagacctc aaggcagaag ggtcacctaa cccaggagtc cacagactga tgtgacctca
     3421 ggttcccaca tcagtggcca cagggcaggg cccacctggt agaagtgttc tggatatggc
     3481 cagggtgggt gtgtggctaa gtgggcctga acagagggaa cctagggccc ttggccaatg
     3541 tgattaaagc tgccatcttg a
//
