LOCUS       NM_024307               1078 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens glycerophosphodiester phosphodiesterase domain
            containing 3 (GDPD3), mRNA.
ACCESSION   NM_024307 NM_001031718
VERSION     NM_024307.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1078)
  AUTHORS   Kitakaze,K., Ali,H., Kimoto,R., Takenouchi,Y., Ishimaru,H.,
            Yamashita,A., Ueda,N., Tanaka,T., Okamoto,Y. and Tsuboi,K.
  TITLE     GDE7 produces cyclic phosphatidic acid in the ER lumen functioning
            as a lysophospholipid mediator
  JOURNAL   Commun Biol 6 (1), 524 (2023)
   PUBMED   37193762
  REMARK    GeneRIF: GDE7 produces cyclic phosphatidic acid in the ER lumen
            functioning as a lysophospholipid mediator.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1078)
  AUTHORS   Kitakaze,K., Tsuboi,K., Tsuda,M., Takenouchi,Y., Ishimaru,H. and
            Okamoto,Y.
  TITLE     Development of a selective fluorescence-based enzyme assay for
            glycerophosphodiesterase family members GDE4 and GDE7
  JOURNAL   J Lipid Res 62, 100141 (2021)
   PUBMED   34673020
  REMARK    GeneRIF: Development of a selective fluorescence-based enzyme assay
            for glycerophosphodiesterase family members GDE4 and GDE7.
REFERENCE   3  (bases 1 to 1078)
  AUTHORS   Key,C.C., Bishop,A.C., Wang,X., Zhao,Q., Chen,G.Y., Quinn,M.A.,
            Zhu,X., Zhang,Q. and Parks,J.S.
  TITLE     Human GDPD3 overexpression promotes liver steatosis by increasing
            lysophosphatidic acid production and fatty acid uptake
  JOURNAL   J Lipid Res 61 (7), 1075-1086 (2020)
   PUBMED   32430316
  REMARK    GeneRIF: Human GDPD3 overexpression promotes liver steatosis by
            increasing lysophosphatidic acid production and fatty acid uptake.
REFERENCE   4  (bases 1 to 1078)
  AUTHORS   Rahman,I.A., Tsuboi,K., Hussain,Z., Yamashita,R., Okamoto,Y.,
            Uyama,T., Yamazaki,N., Tanaka,T., Tokumura,A. and Ueda,N.
  TITLE     Calcium-dependent generation of N-acylethanolamines and
            lysophosphatidic acids by glycerophosphodiesterase GDE7
  JOURNAL   Biochim Biophys Acta 1861 (12 Pt A), 1881-1892 (2016)
   PUBMED   27637550
REFERENCE   5  (bases 1 to 1078)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   6  (bases 1 to 1078)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   7  (bases 1 to 1078)
  AUTHORS   Gress,T.M., Muller-Pillasch,F., Geng,M., Zimmerhackl,F.,
            Zehetner,G., Friess,H., Buchler,M., Adler,G. and Lehrach,H.
  TITLE     A pancreatic cancer-specific expression profile
  JOURNAL   Oncogene 13 (8), 1819-1830 (1996)
   PUBMED   8895530
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC002714.2.
            
            On Nov 22, 2018 this sequence version replaced NM_024307.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002714.2, SRR5189658.212183.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406256.8/ ENSP00000384363.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1078              BC002714.2         21-1098
FEATURES             Location/Qualifiers
     source          1..1078
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1078
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /note="glycerophosphodiester phosphodiesterase domain
                     containing 3"
                     /db_xref="GeneID:79153"
                     /db_xref="HGNC:HGNC:28638"
                     /db_xref="MIM:616318"
     exon            1..198
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1016
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /note="glycerophosphodiester phosphodiesterase
                     domain-containing protein 3; glycerophosphodiester
                     phosphodiesterase 7"
                     /codon_start=1
                     /product="lysophospholipase D GDPD3"
                     /protein_id="NP_077283.2"
                     /db_xref="CCDS:CCDS10671.2"
                     /db_xref="GeneID:79153"
                     /db_xref="HGNC:HGNC:28638"
                     /db_xref="MIM:616318"
                     /translation="MSLLLYYALPALGSYAMLSIFFLRRPHLLHTPRAPTFRIRLGAH
                     RGGSGELLENTMEAMENSMAQRSDLLELDCQLTRDRVVVVSHDENLCRQSGLNRDVGS
                     LDFEDLPLYKEKLEVYFSPGHFAHGSDRRMVRLEDLFQRFPRTPMSVEIKGKNEELIR
                     EIAGLVRRYDRNEITIWASEKSSVMKKCKAANPEMPLSFTISRGFWVLLSYYLGLLPF
                     IPIPEKFFFCFLPNIINRTYFPFSCSCLNQLLAVVSKWLIMRKSLIRHLEERGVQVVF
                     WCLNEESDFEAAFSVGATGVITDYPTALRHYLDNHGPAARTS"
     exon            199..241
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            242..377
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            378..423
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            424..542
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            543..632
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            633..766
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            767..826
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            827..878
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1078
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /note="hexamer: AATAAA"
     polyA_site      1078
                     /gene="GDPD3"
                     /gene_synonym="GDE7"
                     /note="major polyA site"
ORIGIN      
        1 agcacagtcc cgcggacggc tgagcgtgtg gctgcaggag cttctgtggg agtacggtca
       61 tgagcctttt gctgtactat gccctccctg ccctgggcag ctatgccatg ctctccatct
      121 tcttcctgcg ccggcctcat ctgctgcaca cgcccagggc tcccaccttc cgcatccgcc
      181 tgggggccca ccgaggagga tctggagagc tgctggagaa caccatggag gccatggaga
      241 actccatggc ccagcgctcg gacctcctgg agctcgactg tcagctgaca cgggacagag
      301 tggtggtggt gtcacatgat gagaacctgt gccgccagtc gggcctaaac agggatgtgg
      361 gcagcctgga cttcgaggac ctgcccctct acaaggagaa gctggaggtt tacttctctc
      421 caggccactt tgctcacggg tcagaccggc gcatggttcg tctggaggac ctgttccaga
      481 ggtttccaag gacacccatg agcgtagaga tcaaagggaa gaacgaagag ctcatccgtg
      541 agatagcagg cttggtgaga cgctatgacc gtaatgaaat caccatctgg gcctcggaga
      601 agagctcggt catgaagaaa tgcaaggctg ccaaccccga gatgcccctg tccttcacaa
      661 taagccgagg attctgggtg ctgctttcct actacctggg gctgctgccc ttcatcccaa
      721 tccctgagaa gttcttcttc tgcttcctgc ccaacatcat caacaggacc tatttcccat
      781 tttcctgctc ttgcctgaac cagttattgg ctgtggtttc gaaatggctg atcatgagga
      841 agagtctgat ccgacacttg gaggagcgag gggtgcaggt ggtcttttgg tgccttaatg
      901 aagagtcgga ttttgaagca gccttcagcg tgggagccac tggcgtcata acggattatc
      961 ccacagccct gcggcactac ctggacaacc atggaccagc tgcccggacc tcctaagtcc
     1021 agaagcctcg aggtctcctg tttctcttcc tgaaaaataa atatttgcct ttcgatca
//
