LOCUS       NM_017711               1993 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens glycerophosphodiester phosphodiesterase domain
            containing 2 (GDPD2), transcript variant 2, mRNA.
ACCESSION   NM_017711
VERSION     NM_017711.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1993)
  AUTHORS   Briand-Mesange,F., Pons,V., Allart,S., Masquelier,J., Chicanne,G.,
            Beton,N., Payrastre,B., Muccioli,G.G., Ausseil,J., Davignon,J.L.,
            Salles,J.P. and Chap,H.
  TITLE     Glycerophosphodiesterase 3 (GDE3) is a
            lysophosphatidylinositol-specific ectophospholipase C acting as an
            endocannabinoid signaling switch
  JOURNAL   J Biol Chem 295 (46), 15767-15781 (2020)
   PUBMED   32917725
  REMARK    GeneRIF: Glycerophosphodiesterase 3 (GDE3) is a
            lysophosphatidylinositol-specific ectophospholipase C acting as an
            endocannabinoid signaling switch.
REFERENCE   2  (bases 1 to 1993)
  AUTHORS   van Veen,M., Matas-Rico,E., van de Wetering,K., Leyton-Puig,D.,
            Kedziora,K.M., De Lorenzi,V., Stijf-Bultsma,Y., van den Broek,B.,
            Jalink,K., Sidenius,N., Perrakis,A. and Moolenaar,W.H.
  TITLE     Negative regulation of urokinase receptor activity by a
            GPI-specific phospholipase C in breast cancer cells
  JOURNAL   Elife 6, e23649 (2017)
   PUBMED   28849762
  REMARK    GeneRIF: The results establish GDE3 as a negative regulator of the
            uPAR signaling network and, furthermore, highlight GPI-anchor
            hydrolysis as a cell-intrinsic mechanism to alter cell behavior.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1993)
  AUTHORS   Corda,D., Kudo,T., Zizza,P., Iurisci,C., Kawai,E., Kato,N.,
            Yanaka,N. and Mariggio,S.
  TITLE     The developmentally regulated osteoblast phosphodiesterase GDE3 is
            glycerophosphoinositol-specific and modulates cell growth
  JOURNAL   J Biol Chem 284 (37), 24848-24856 (2009)
   PUBMED   19596859
  REMARK    GeneRIF: GDE3 substrate GroPIns is a candidate mediator for
            osteoblast proliferation
REFERENCE   4  (bases 1 to 1993)
  AUTHORS   Yanaka,N., Imai,Y., Kawai,E., Akatsuka,H., Wakimoto,K., Nogusa,Y.,
            Kato,N., Chiba,H., Kotani,E., Omori,K. and Sakurai,N.
  TITLE     Novel membrane protein containing glycerophosphodiester
            phosphodiesterase motif is transiently expressed during osteoblast
            differentiation
  JOURNAL   J Biol Chem 278 (44), 43595-43602 (2003)
   PUBMED   12933806
  REMARK    GeneRIF: GDE3 is a novel seven-transmembrane protein with a
            GP-PDE-like extracellular motif expressed during osteoblast
            differentiation that accelerates the program of osteoblast
            differentiation and is involved in morphological change of cells
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB048363.1 and AL139398.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_017711.3.
            
            Summary: This gene encodes a member of the glycerophosphodiester
            phosphodiesterase enzyme family. The encoded protein hydrolyzes
            glycerophosphoinositol to produce inositol 1-phosphate and
            glycerol. This protein may have a role in osteoblast
            differentiation and growth. Alternate splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, which results in a frameshift, compared to variant
            1. The resulting protein (isoform 2) is shorter than isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB048363.1, BC032009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374382.4/ ENSP00000363503.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1616              AB048363.1         174-1789
            1617-1617           AL139398.20        55324-55324
            1618-1993           AB048363.1         1791-2166
FEATURES             Location/Qualifiers
     source          1..1993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1993
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /note="glycerophosphodiester phosphodiesterase domain
                     containing 2"
                     /db_xref="GeneID:54857"
                     /db_xref="HGNC:HGNC:25974"
                     /db_xref="MIM:300940"
     exon            1..69
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            70..183
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1698
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /EC_number="3.1.4.43"
                     /note="isoform 2 is encoded by transcript variant 2;
                     osteoblast differentiation promoting factor;
                     glycerophosphodiester phosphodiesterase 3;
                     glycerophosphoinositol inositolphosphodiesterase GDPD2;
                     glycerophosphodiester phosphodiesterase domain-containing
                     protein 2"
                     /codon_start=1
                     /product="glycerophosphoinositol inositolphosphodiesterase
                     GDPD2 isoform 2"
                     /protein_id="NP_060181.2"
                     /db_xref="CCDS:CCDS14402.1"
                     /db_xref="GeneID:54857"
                     /db_xref="HGNC:HGNC:25974"
                     /db_xref="MIM:300940"
                     /translation="MAESPGCCSVWARCLHCLYSCHWRKCPRERMQTSKCDCIWFGLL
                     FLTFLLSLSWLYIGLVLLNDLHNFNEFLFRRWGHWMDWSLAFLLVISLLVTYASLLLV
                     LALLLRLCRQPLHLHSLHKVLLLLIMLLVAAGLVGLDIQWQQEWHSLRVSLQATAPFL
                     HIGAAAGIALLAWPVADTFYRIHRRGPKILLLLLFFGVVLVIYLAPLCISSPCIMEPR
                     DLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGATVFETDVMVSSDGVPFLMHDEHLS
                     RTTNVASVFPTRITAHSSDFSWTELKRLNAGSWFLERRPFWGAKPLAGPDQKEAESQT
                     VPALEELLEEAAALNLSIMFDLRRPPQNHTYYDTFVIQTLETVLNARVPQAMVFWLPD
                     EDRANVQRRAPGMRQIYGRQGGNRTERPQFLNLPYQDLPLLDIKALHKDNVSVNLFVV
                     NKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPIWLITPQTYLIIWVITNCVSTMLLLWT
                     FLLQRRFVKKRGKTGLETAVLLTRINNFMME"
     exon            184..287
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            288..381
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            382..441
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            442..540
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            541..634
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            635..780
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            781..863
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            864..1014
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1236
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1385
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1533
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1616
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1645
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..1993
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1972..1977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /note="hexamer: AGTAAA"
     polyA_site      1993
                     /gene="GDPD2"
                     /gene_synonym="GDE3; OBDPF"
                     /note="major polyA site"
ORIGIN      
        1 agaccactcg gagaggagct gggaagcagt gcagagagga gagcggagcg gagctgccgc
       61 tgagcaaagg ccttcaccat ggccgagtcc cccggctgct gctccgtctg ggcccgctgc
      121 ctccactgcc tgtatagctg ccactggagg aaatgcccca gagagaggat gcaaaccagc
      181 aagtgcgact gtatctggtt tggcctgctc ttcctcacct tcctcctttc cctgagctgg
      241 ctgtacatcg ggctcgtcct tctcaatgac ctgcacaact tcaatgaatt cctcttccgc
      301 cgctggggac actggatgga ctggtccctg gcattcctgc tggtcatctc tctactggtc
      361 acatatgcat ccttgctatt ggtcctggcc ctgctcctgc ggctttgtag acagcccctg
      421 catctgcaca gcctccacaa ggtgctgctg ctcctcatta tgctgcttgt ggcggctggc
      481 cttgtgggac tggacatcca atggcagcag gagtggcata gcttgcgtgt gtcactgcag
      541 gccacagccc cattccttca tattggagca gccgctggaa ttgccctcct ggcctggcct
      601 gtggctgata ccttctaccg tatccaccga agaggtccca agattctgct actgctccta
      661 ttttttggag ttgtcctggt catctacttg gcccccctat gcatctcctc accctgcatc
      721 atggaaccca gagacttacc acccaagcct gggctggtgg gacaccgagg ggcccccatg
      781 ctggctcccg agaacaccct gatgtccttg cggaagacag ctgaatgcgg agctactgtg
      841 tttgagactg atgtgatggt cagctccgat ggggtcccct tcctcatgca tgatgagcac
      901 ctcagcagga ccacgaatgt agcctctgta ttcccaaccc gaatcacagc ccacagcagt
      961 gacttctcct ggactgaact gaagagactc aatgctggat cctggttcct agagaggcga
     1021 cccttctggg gggccaaacc gctggcaggc cctgatcaga aagaggctga gagtcagacg
     1081 gtaccagcat tagaagagct attggaggaa gctgcagccc tcaacctttc catcatgttc
     1141 gacttgcgcc gacccccaca gaaccacaca tactatgaca cttttgtgat ccagacattg
     1201 gagactgtgc tgaatgcaag ggtgccccaa gccatggtct tttggctacc agatgaagat
     1261 cgggctaatg tccaacgacg ggcacctgga atgcgccaga tatatggacg tcagggaggc
     1321 aacagaacgg agaggcccca gtttcttaac ctcccctatc aagatctgcc actattggat
     1381 atcaaggcat tgcataagga taatgtctcg gtgaacctat ttgtagtgaa caagccctgg
     1441 ctcttctctc tgctttggtg tgcaggggtg gattcggtca ccaccaacga ctgccagctg
     1501 ctgcagcaga tgcgttaccc tatctggctt attacccctc aaacctacct aatcatatgg
     1561 gtcattacca attgtgtttc caccatgctg cttttgtgga ccttcctcct ccaaagaaga
     1621 tttgttaaga agagagggaa aactggctta gaaacagcag tgctgctgac aaggatcaac
     1681 aatttcatga tggagtgaat gccctgccct gcttccccac ccaagccagt ctacattgcc
     1741 caaacagcaa gggttggaga gtggcttaag tggaatgctt caggggtggt gggttgcaag
     1801 tggggggagc tttgccaaca ggaggttttg aaccatgagg gccctctgcc caggtgatgg
     1861 gcattcccta agctgctatg gaatctgctc cctttggggt tttgacctga gatgtttggg
     1921 aagagagtga gtaatgagaa gtttctcctc aaatgaaact agaacagagg aagtaaaagg
     1981 gagattgctc gga
//
