LOCUS       NM_182569               3241 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens glycerophosphodiester phosphodiesterase domain
            containing 1 (GDPD1), transcript variant 1, mRNA.
ACCESSION   NM_182569
VERSION     NM_182569.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3241)
  AUTHORS   Kitakaze,K., Tsuboi,K., Tsuda,M., Takenouchi,Y., Ishimaru,H. and
            Okamoto,Y.
  TITLE     Development of a selective fluorescence-based enzyme assay for
            glycerophosphodiesterase family members GDE4 and GDE7
  JOURNAL   J Lipid Res 62, 100141 (2021)
   PUBMED   34673020
  REMARK    GeneRIF: Development of a selective fluorescence-based enzyme assay
            for glycerophosphodiesterase family members GDE4 and GDE7.
REFERENCE   2  (bases 1 to 3241)
  AUTHORS   de Bruijn,S.E., Fiorentino,A., Ottaviani,D., Fanucchi,S.,
            Melo,U.S., Corral-Serrano,J.C., Mulders,T., Georgiou,M.,
            Rivolta,C., Pontikos,N., Arno,G., Roberts,L., Greenberg,J.,
            Albert,S., Gilissen,C., Aben,M., Rebello,G., Mead,S., Raymond,F.L.,
            Corominas,J., Smith,C.E.L., Kremer,H., Downes,S., Black,G.C.,
            Webster,A.R., Inglehearn,C.F., van den Born,L.I., Koenekoop,R.K.,
            Michaelides,M., Ramesar,R.S., Hoyng,C.B., Mundlos,S., Mhlanga,M.M.,
            Cremers,F.P.M., Cheetham,M.E., Roosing,S. and Hardcastle,A.J.
  TITLE     Structural Variants Create New Topological-Associated Domains and
            Ectopic Retinal Enhancer-Gene Contact in Dominant Retinitis
            Pigmentosa
  JOURNAL   Am J Hum Genet 107 (5), 802-814 (2020)
   PUBMED   33022222
  REMARK    GeneRIF: Structural Variants Create New Topological-Associated
            Domains and Ectopic Retinal Enhancer-Gene Contact in Dominant
            Retinitis Pigmentosa.
REFERENCE   3  (bases 1 to 3241)
  AUTHORS   Rahman,I.A., Tsuboi,K., Hussain,Z., Yamashita,R., Okamoto,Y.,
            Uyama,T., Yamazaki,N., Tanaka,T., Tokumura,A. and Ueda,N.
  TITLE     Calcium-dependent generation of N-acylethanolamines and
            lysophosphatidic acids by glycerophosphodiesterase GDE7
  JOURNAL   Biochim Biophys Acta 1861 (12 Pt A), 1881-1892 (2016)
   PUBMED   27637550
REFERENCE   4  (bases 1 to 3241)
  AUTHORS   Tsuboi,K., Okamoto,Y., Rahman,I.A., Uyama,T., Inoue,T., Tokumura,A.
            and Ueda,N.
  TITLE     Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a
            possible involvement in bioactive N-acylethanolamine biosynthesis
  JOURNAL   Biochim Biophys Acta 1851 (5), 537-548 (2015)
   PUBMED   25596343
REFERENCE   5  (bases 1 to 3241)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3241)
  AUTHORS   Chang,P.A., Shao,H.B., Long,D.X., Sun,Q. and Wu,Y.J.
  TITLE     Isolation, characterization and molecular 3D model of human GDE4, a
            novel membrane protein containing glycerophosphodiester
            phosphodiesterase domain
  JOURNAL   Mol Membr Biol 25 (6-7), 557-566 (2008)
   PUBMED   18991142
  REMARK    GeneRIF: 3-D model provides the structural information; subcellular
            localization is in the cytoplasm; over-expression of GDE4 did not
            induce neurite formation or change cell morphology
REFERENCE   7  (bases 1 to 3241)
  AUTHORS   Yanaka,N.
  TITLE     Mammalian glycerophosphodiester phosphodiesterases
  JOURNAL   Biosci Biotechnol Biochem 71 (8), 1811-1818 (2007)
   PUBMED   17690467
  REMARK    Review article
REFERENCE   8  (bases 1 to 3241)
  AUTHORS   Wu,M., Ji,C., Xu,J., Zou,X., Wang,L., Zheng,H., Jin,F., Wang,Y.,
            Gu,S., Ying,K., Xie,Y. and Mao,Y.
  TITLE     A novel splice variant of human gene GDPD1 is mainly expressed in
            human ovary and small intestine
  JOURNAL   Int J Mol Med 12 (6), 1003-1007 (2003)
   PUBMED   14612981
  REMARK    GeneRIF: A novel splice variant of the gene is mainly expressed in
            human ovary and small intestine.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK094770.1, AC099850.7,
            AC091059.12 and AI478202.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182569.3.
            
            Summary: This gene encodes a member of the glycerophosphodiester
            phosphodiesterase family of enzymes that catalyze the hydrolysis of
            deacylated glycerophospholipids to glycerol phosphate and alcohol.
            The encoded protein is localized to the cytoplasm and concentrates
            near the perinuclear region. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.434620.1, AK094770.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284116.9/ ENSP00000284116.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AK094770.1         40-346
            308-308             AC099850.7         18789-18789         c
            309-1365            AK094770.1         348-1404
            1366-2776           AC091059.12        165287-166697       c
            2777-3241           AI478202.1         12-476              c
FEATURES             Location/Qualifiers
     source          1..3241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..3241
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /note="glycerophosphodiester phosphodiesterase domain
                     containing 1"
                     /db_xref="GeneID:284161"
                     /db_xref="HGNC:HGNC:20883"
                     /db_xref="MIM:616317"
     exon            1..241
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1044
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /EC_number="3.1.4.39"
                     /note="isoform 1 is encoded by transcript variant 1;
                     glycerophosphodiester phosphodiesterase domain-containing
                     protein 1; glycerophosphodiester phosphodiesterase 4;
                     lysophospholipase D GDPD1"
                     /codon_start=1
                     /product="lysophospholipase D GDPD1 isoform 1"
                     /protein_id="NP_872375.2"
                     /db_xref="CCDS:CCDS11616.1"
                     /db_xref="GeneID:284161"
                     /db_xref="HGNC:HGNC:20883"
                     /db_xref="MIM:616317"
                     /translation="MSSTAAFYLLSTLGGYLVTSFLLLKYPTLLHQRKKQRFLSKHIS
                     HRGGAGENLENTMAAFQHAVKIGTDMLELDCHITKDEQVVVSHDENLKRATGVNVNIS
                     DLKYCELPPYLGKLDVSFQRACQCEGKDNRIPLLKEVFEAFPNTPINIDIKVNNNVLI
                     KKVSELVKRYNREHLTVWGNANYEIVEKCYKENSDIPILFSLQRVLLILGLFFTGLLP
                     FVPIREQFFEIPMPSIILKLKEPHTMSRSQKFLIWLSDLLLMRKALFDHLTARGIQVY
                     IWVLNEEQEYKRAFDLGATGVMTDYPTKLRDFLHNFSA"
     exon            242..284
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            285..420
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            421..466
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            467..585
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            586..675
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            676..809
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            810..869
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            870..921
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     exon            922..3241
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /note="hexamer: AATAAA"
     polyA_site      3241
                     /gene="GDPD1"
                     /gene_synonym="GDE4"
                     /note="major polyA site"
ORIGIN      
        1 gagccgacct cgagcagccg ccgccgccgc cgtcgttgct actgccgcag cggagttcag
       61 agggcccgga ggtgggagac ttcccacacg gtgactgaga tgtcgtccac tgcggctttt
      121 taccttctct ctacgctagg aggatacttg gtgacctcat tcttgttgct taaatacccg
      181 accttgctgc accagagaaa gaagcagcga ttcctcagta aacacatctc tcaccgcgga
      241 ggtgctggag aaaatttgga gaatacaatg gcagcctttc agcatgcggt taaaatcgga
      301 actgatatgc tagaattgga ctgccatatc acaaaagatg aacaagttgt agtgtcacat
      361 gatgagaatc taaagagagc aactggggtc aatgtaaaca tctctgatct caaatactgt
      421 gagctcccac cttaccttgg caaactggat gtctcatttc aaagagcatg ccagtgtgaa
      481 ggaaaagata accgaattcc attactgaag gaagtttttg aggcctttcc taacactccc
      541 attaacatcg atatcaaagt caacaacaat gtgctgatta agaaggtttc agagttggtg
      601 aagcggtata atcgagaaca cttaacagtg tggggtaatg ccaattatga aattgtagaa
      661 aagtgctaca aagagaattc agatattcct atactcttca gtctacaacg tgtcctgctc
      721 attcttggcc ttttcttcac tggcctcttg ccctttgtgc ccattcgaga acagtttttt
      781 gaaatcccaa tgccttctat tatactgaag ctaaaagaac cacacaccat gtccagaagt
      841 caaaagtttc tcatctggct ttctgatctc ttactaatga ggaaagcttt gtttgaccac
      901 ctaactgctc gaggcattca agtgtatatt tgggtattaa atgaagaaca agaatacaaa
      961 agagcttttg atttgggagc aactggggtg atgacagact atccaacaaa gcttagggat
     1021 tttttacata acttttcagc atagaaaaag aggtacttag aagtattgaa ggaaaaaatg
     1081 aagacctaag aaaaaaatat ttcatgatca tttccctaag ccatttccag aatggtaaaa
     1141 ggtttaatca gtttttatta cctcattttt aagcctgtat gagaatgtag aaactatata
     1201 ttatatgtat atttatttta aataatattg tatattttat gtttgtaaat tgtttagaaa
     1261 gataattggt tatgagatgt aagttttaat ttcttaatgt gcatttttgt ttctagatct
     1321 tatacagaaa tcttgattaa taacatacac agaaatgtac atactacatc atctacagaa
     1381 atcttgatca ataacctaga aactaggtta tctaggttat tgatcaagat ttctgtagat
     1441 gatgcagtgt tctatcataa gtaattctgg aatcaaagac tattggatac atttggcatt
     1501 gggctgagtg tggtggctca tgcctgtaat cccagcactt tgggaggctg agacaggcgg
     1561 atcatctgaa gtcaggagtt aaagaccagc ctggccaaca tggcaaaacc ccatctctac
     1621 caaaaataca aaaattaacc atgcgtggtg gtacacgtct gtcatcccag cagctcttaa
     1681 ggctgaggca caagaattgc ttgaacccgg gaggcagagg ctgtagtgag ccaagatagc
     1741 accactgcac tccagcctgg gagacagagt gagactccgt ctcaaaaaaa aaaaaaaaaa
     1801 aaaaaaatgg gaggccgagg cgggcggatc acgaggtcag gagatcgaga ccatcctggc
     1861 taacatggtg aaaccccgtc tctactaaaa atacaaaaaa ttagctgggc gtggtggtgg
     1921 gcaccttagt cccagctact cgggaggctg agtcaggaga atggcgtgaa cccgggaggc
     1981 ggagcttgca gtgagccgag atcgcgccac tgcactccag cctgggctac agagcaagac
     2041 tccgtctcaa aaaaagaaaa aaagaaaaaa aattggcaat agtcttcact ggaatacaat
     2101 caattagtaa aagatttttt tttttttttt gacatgtagt cttgctctgt cgccgaggcc
     2161 ggagtgcagt ggtgcgatct tggctcactg caacctctgc ctcccaggtt ccagcaattc
     2221 tcctgcctct gcctcccgag tacctgggat tacaggtgcc tgctaccatg cccagctaat
     2281 ttttgtattt ttagtagaga cagggttttg ccacgttggc cagactggtc tcgaactcct
     2341 gacctcaggt gatccaccca cctcggcctc tcaaagtgct gggattacag gtttgaacca
     2401 ctgcacccgg ccagtaaaag aaattttgaa ggccattgca gctatttggt agtgtcttgt
     2461 tatttctagg tgtaccttag ttaaagagga aaaataaaac ggaaaaaagc ttggaaatca
     2521 gtgatgtgta gttatttggc aagttataca taatcagcag cagccaggct caagaaaata
     2581 aaagttgatt agttgatcag aaataaaatc tgtagagtga attagatttc tgagttgttg
     2641 ttgttaatgg aacattctat ttgagacctt tttcaggtgt gtagcaattc taccatgtcc
     2701 atttttttaa gcattaaaaa ggaacttacc agttgtaaat taagacaaga tccaaatagt
     2761 catatttttg tgtttcctct aaaaaaatgt aagatttcca tttttggcac tgactaactg
     2821 agcctacatc tagattttaa ataccatctt gaatcctaat aattaaactg atgaaagtgc
     2881 atatcattgt tcctaacatt tatgaacccc cataaagatg ttcctgatct ttaaaactca
     2941 ttaatctgag tattaagtag aaacagaatt ttccaaagca ttagacatca ctttctcagt
     3001 ttatctgagg tgacttcgtg tacatctgtt tctaatatat ttgactaatt ttcatgatct
     3061 cagattgtga ggtaaatgta atctggaata ataagtgtct tttacctaga ttacatctct
     3121 catttggagt ttggcaatga aactgctatg aagaatgact gtactctcct atctgtccct
     3181 ggatgacata aatatcattt gctttgttgt ttaaactgaa ataaagtttt ccaagaacaa
     3241 a
//
