LOCUS       NM_001494               2297 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens GDP dissociation inhibitor 2 (GDI2), transcript
            variant 1, mRNA.
ACCESSION   NM_001494
VERSION     NM_001494.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2297)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 2297)
  AUTHORS   Zhang,W., Liu,Z., Xia,S., Yao,L., Li,L., Gan,Z., Tang,H., Guo,Q.,
            Yan,X. and Sun,Z.
  TITLE     GDI2 is a novel diagnostic and prognostic biomarker in
            hepatocellular carcinoma
  JOURNAL   Aging (Albany NY) 13 (23), 25304-25324 (2021)
   PUBMED   34894398
  REMARK    GeneRIF: GDI2 is a novel diagnostic and prognostic biomarker in
            hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2297)
  AUTHORS   Bolado-Carrancio,A., Lee,M., Ewing,A., Muir,M., Macleod,K.G.,
            Gallagher,W.M., Nguyen,L.K., Carragher,N.O., Semple,C.A.,
            Brunton,V.G., Caswell,P.T. and von Kriegsheim,A.
  TITLE     ISGylation drives basal breast tumour progression by promoting EGFR
            recycling and Akt signalling
  JOURNAL   Oncogene 40 (44), 6235-6247 (2021)
   PUBMED   34556814
  REMARK    GeneRIF: ISGylation drives basal breast tumour progression by
            promoting EGFR recycling and Akt signalling.
REFERENCE   4  (bases 1 to 2297)
  AUTHORS   Liu,C., Wang,W., Lin,P., Xie,H., Jiang,S., Jia,H., Li,R., Wang,N.
            and Yu,X.
  TITLE     GDI2 is a target of paclitaxel that affects tumorigenesis of
            prostate cancer via the p75NTR signaling pathway
  JOURNAL   Biochem Biophys Res Commun 562, 119-126 (2021)
   PUBMED   34051575
  REMARK    GeneRIF: GDI2 is a target of paclitaxel that affects tumorigenesis
            of prostate cancer via the p75NTR signaling pathway.
REFERENCE   5  (bases 1 to 2297)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2297)
  AUTHORS   Nishimura,N., Goji,J., Nakamura,H., Orita,S., Takai,Y. and Sano,K.
  TITLE     Cloning of a brain-type isoform of human Rab GDI and its expression
            in human neuroblastoma cell lines and tumor specimens
  JOURNAL   Cancer Res 55 (22), 5445-5450 (1995)
   PUBMED   7585614
REFERENCE   7  (bases 1 to 2297)
  AUTHORS   Shisheva,A., Doxsey,S.J., Buxton,J.M. and Czech,M.P.
  TITLE     Pericentriolar targeting of GDP-dissociation inhibitor isoform 2
  JOURNAL   Eur J Cell Biol 68 (2), 143-158 (1995)
   PUBMED   8575461
REFERENCE   8  (bases 1 to 2297)
  AUTHORS   Bachner,D., Sedlacek,Z., Korn,B., Hameister,H. and Poustka,A.
  TITLE     Expression patterns of two human genes coding for different rab
            GDP-dissociation inhibitors (GDIs), extremely conserved proteins
            involved in cellular transport
  JOURNAL   Hum Mol Genet 4 (4), 701-708 (1995)
   PUBMED   7543319
REFERENCE   9  (bases 1 to 2297)
  AUTHORS   Shisheva,A., Buxton,J. and Czech,M.P.
  TITLE     Differential intracellular localizations of GDP dissociation
            inhibitor isoforms. Insulin-dependent redistribution of GDP
            dissociation inhibitor-2 in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 269 (39), 23865-23868 (1994)
   PUBMED   7929030
REFERENCE   10 (bases 1 to 2297)
  AUTHORS   Shisheva,A., Sudhof,T.C. and Czech,M.P.
  TITLE     Cloning, characterization, and expression of a novel GDP
            dissociation inhibitor isoform from skeletal muscle
  JOURNAL   Mol Cell Biol 14 (5), 3459-3468 (1994)
   PUBMED   7513052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK312485.1 and BC005145.2.
            
            On Nov 22, 2018 this sequence version replaced NM_001494.3.
            
            Summary: GDP dissociation inhibitors are proteins that regulate the
            GDP-GTP exchange reaction of members of the rab family, small
            GTP-binding proteins of the ras superfamily, that are involved in
            vesicular trafficking of molecules between cellular organelles.
            GDIs slow the rate of dissociation of GDP from rab proteins and
            release GDP from membrane-bound rabs. GDI2 is ubiquitously
            expressed. The GDI2 gene contains many repetitive elements
            indicating that it may be prone to inversion/deletion
            rearrangements. Alternative splicing results in multiple transcript
            variants encoding distinct isoforms. [provided by RefSeq, Jul
            2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.99195.1,
                                           SRR5189667.140127.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380191.9/ ENSP00000369538.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1514              AK312485.1         1-1514
            1515-1751           BC005145.2         1423-1659
            1752-2297           BC005145.2         1661-2206
FEATURES             Location/Qualifiers
     source          1..2297
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.1"
     gene            1..2297
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /note="GDP dissociation inhibitor 2"
                     /db_xref="GeneID:2665"
                     /db_xref="HGNC:HGNC:4227"
                     /db_xref="MIM:600767"
     exon            1..221
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1514
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /note="isoform 1 is encoded by transcript variant 1; rab
                     GDP-dissociation inhibitor, beta; GDI-2; rab GDI beta;
                     guanosine diphosphate dissociation inhibitor 2; epididymis
                     secretory sperm binding protein Li 46e"
                     /codon_start=1
                     /product="rab GDP dissociation inhibitor beta isoform 1"
                     /protein_id="NP_001485.2"
                     /db_xref="CCDS:CCDS7071.1"
                     /db_xref="GeneID:2665"
                     /db_xref="HGNC:HGNC:4227"
                     /db_xref="MIM:600767"
                     /translation="MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESA
                     SITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIPKFLMANGQLVKMLLYTEVTRYLDF
                     KVTEGSFVYKGGKIYKVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPRTFEG
                     IDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTDDYLDQPCYETINRIKLYSESLAR
                     YGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGEIAR
                     CKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQNQVNRKSDIYV
                     CMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPKDL
                     GTESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEFDFEEMKRKKNDIYGED"
     exon            222..329
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            330..429
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            430..564
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            565..763
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            764..895
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            896..995
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1167
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1312
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1367
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..2297
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /note="hexamer: AATAAA"
     polyA_site      2297
                     /gene="GDI2"
                     /gene_synonym="HEL-S-46e; RABGDIB"
                     /note="major polyA site"
ORIGIN      
        1 agttcttctc ttcccgtctg aggtggcggt cggtctcgcc ttgtcgccag ctccattttc
       61 ctctctttct cttccccttt ccttcgcgcc caagagcgcc tcccagcctc gtagggtggt
      121 cacggagccc ctgcgccttt tccttgctcg ggtcctgcgt ccgcgcctgc cccgccatga
      181 atgaggagta cgacgtgatc gtgctgggca ccggcctgac ggaatgtatc ctgtcaggta
      241 taatgtcagt gaatggcaag aaagttcttc atatggatcg aaacccttac tacggaggag
      301 agagtgcatc tataacacca ttggaagatt tatacaaaag atttaaaata ccaggatcac
      361 cacccgagtc aatggggaga ggaagagact ggaatgttga cttgattccc aagttcctta
      421 tggctaatgg tcagctggtt aagatgctgc tttatacaga ggtaactcgc tatctggatt
      481 ttaaagtgac tgaagggagc tttgtctata agggtggaaa aatctacaag gttccttcca
      541 ctgaagcaga agccctggca tctagcctaa tgggattgtt tgaaaaacgt cgcttcagga
      601 aattcctagt gtatgttgcc aacttcgatg aaaaagatcc aagaactttt gaaggcattg
      661 atcctaagaa gaccacaatg cgagatgtgt ataagaaatt tgatttgggt caagacgtta
      721 tagattttac tggtcatgct cttgcacttt acagaactga tgattactta gatcaaccgt
      781 gttatgaaac cattaataga attaaacttt acagtgaatc tttggcaaga tatggcaaaa
      841 gcccatacct ttatccactc tatggccttg gagaactgcc ccaaggattt gcaaggctaa
      901 gtgctattta tggaggtacc tatatgctga ataaacccat tgaagaaatc attgtacaga
      961 atggaaaagt aattggtgta aaatctgaag gagaaattgc tcgctgtaag cagctcatct
     1021 gtgaccccag ctacgtaaaa gatcgggtag aaaaagtggg ccaggtgatc agagttattt
     1081 gcatcctcag ccaccccatc aagaacacca atgatgccaa ctcctgccag atcattattc
     1141 cacagaacca agtcaatcga aagtcagata tctacgtctg catgatctcc tttgcgcaca
     1201 atgtagcagc acaagggaag tacattgcta tagttagtac aactgtggaa accaaggagc
     1261 ctgagaagga aatcagacca gctttggagc tcttggaacc aattgaacag aaatttgtta
     1321 gcatcagtga cctcctggta ccaaaagact tgggaacaga aagccagatc tttatttccc
     1381 gcacatatga tgccaccact cattttgaga caacgtgtga tgacattaaa aacatctata
     1441 agaggatgac aggatcagag tttgactttg aggaaatgaa gcgcaagaag aatgacatct
     1501 atggggaaga ctaacagcag tacatgttat tatgtaatta ggacacattt aaaatttggc
     1561 aaataatgca tataatgaaa tcaatattgt aaggcctgct tttgtaatga aaatggagag
     1621 aatgaagagc gctgtgccag taaatactcc ccttcacctt tctaattatt aacttgtttt
     1681 catggagtgg ctattcagca ttggcagtta ccacattctg ttcaatttaa ccaaactggc
     1741 tttttttttt tctagtgaag ttaaacaaac attgggatac cgacacagac aacttgagac
     1801 agttttttta atcttttaat cagtgtagct atgtgctgct gctgctcaag agctggatcc
     1861 atacaggttg tgtgtcatct gtcctcttga ggttcaggag attctaaatt gaatattcca
     1921 cggtttggga cagcatccgg aagttttccc tatgacttta tattttgtat tatgtcaaat
     1981 gttatggcag ggcccaaata gcatagccac aagtttggtt tatgtgggca taaaattcta
     2041 accaaacccc agacataggg agtcatttgg agaaagcctg tatgtggtgt tttaacctaa
     2101 taaagttgat gagagagaag gggagaggaa gcgaacataa agcgggtcaa gtgtagtgca
     2161 tcttttgtat ctcaggcgtg gcttcttcag tggaccaagc tgcaatgcag tattgacttg
     2221 acagagcctc tacttctgtc tcaaaatggc tccaaatgat ttctgtactg caaaataaag
     2281 ccaaattctg gaaacta
//
