LOCUS       NM_182828               9267 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens growth differentiation factor 7 (GDF7), mRNA.
ACCESSION   NM_182828 XM_087210
VERSION     NM_182828.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9267)
  AUTHORS   Kong,D., Mourtzinos,A., Heegsma,J., Blokzijl,H., de Meijer,V.E. and
            Faber,K.N.
  TITLE     Growth differentiation factor 7 autocrine signaling promotes
            hepatic progenitor cell expansion in liver fibrosis
  JOURNAL   Stem Cell Res Ther 14 (1), 288 (2023)
   PUBMED   37798809
  REMARK    GeneRIF: Growth differentiation factor 7 autocrine signaling
            promotes hepatic progenitor cell expansion in liver fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9267)
  AUTHORS   Ding,M., Malhotra,R., Ottosson,T., Lundqvist,M., Mebrahtu,A.,
            Brengdahl,J., Gehrmann,U., Back,E., Ross-Thriepland,D.,
            Isaksson,I., Magnusson,B., Sachsenmeier,K.F., Tegel,H., Hober,S.,
            Uhlen,M., Mayr,L.M., Davies,R., Rockberg,J. and Schiavone,L.H.
  TITLE     Secretome screening reveals immunomodulating functions of
            IFNalpha-7, PAP and GDF-7 on regulatory T-cells
  JOURNAL   Sci Rep 11 (1), 16767 (2021)
   PUBMED   34408239
  REMARK    GeneRIF: Secretome screening reveals immunomodulating functions of
            IFNalpha-7, PAP and GDF-7 on regulatory T-cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9267)
  AUTHORS   Wan,P., Long,E., Li,Z., Zhu,Y., Su,W. and Zhuo,Y.
  TITLE     TET-dependent GDF7 hypomethylation impairs aqueous humor outflow
            and serves as a potential therapeutic target in glaucoma
  JOURNAL   Mol Ther 29 (4), 1639-1657 (2021)
   PUBMED   33388417
  REMARK    GeneRIF: TET-dependent GDF7 hypomethylation impairs aqueous humor
            outflow and serves as a potential therapeutic target in glaucoma.
REFERENCE   4  (bases 1 to 9267)
  AUTHORS   Zarychta-Wisniewska,W., Burdzinska,A., Kulesza,A., Gala,K.,
            Kaleta,B., Zielniok,K., Siennicka,K., Sabat,M. and Paczek,L.
  TITLE     Bmp-12 activates tenogenic pathway in human adipose stem cells and
            affects their immunomodulatory and secretory properties
  JOURNAL   BMC Cell Biol 18 (1), 13 (2017)
   PUBMED   28214472
  REMARK    GeneRIF: BMP-12 activates tenogenic pathway in human adipose stem
            cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9267)
  AUTHORS   Becker,J., May,A., Gerges,C., Anders,M., Schmidt,C., Veits,L.,
            Noder,T., Mayershofer,R., Kreuser,N., Manner,H., Venerito,M.,
            Hofer,J.H., Lyros,O., Ahlbrand,C.J., Arras,M., Hofer,S.,
            Heinrichs,S.K., Weise,K., Hess,T., Bohmer,A.C., Kosiol,N.,
            Kiesslich,R., Izbicki,J.R., Holscher,A.H., Bollschweiler,E.,
            Malfertheiner,P., Lang,H., Moehler,M., Lorenz,D., Ott,K.,
            Schmidt,T., Nothen,M.M., Hackelsberger,A., Schumacher,B., Pech,O.,
            Vashist,Y., Vieth,M., Weismuller,J., Knapp,M., Neuhaus,H.,
            Rosch,T., Ell,C., Gockel,I. and Schumacher,J.
  TITLE     The Barrett-associated variants at GDF7 and TBX5 also increase
            esophageal adenocarcinoma risk
  JOURNAL   Cancer Med 5 (5), 888-891 (2016)
   PUBMED   26783083
  REMARK    GeneRIF: The Barrett-associated variants at GDF7 and TBX5 also
            increase esophageal adenocarcinoma risk.
REFERENCE   6  (bases 1 to 9267)
  AUTHORS   Yeh,L.C. and Lee,J.C.
  TITLE     Effects of cartilage-derived morphogenetic protein-3 on the
            expression of chondrogenic and osteoblastic markers in the
            pluripotent mesenchymal C3H10T1/2 cell line
  JOURNAL   Growth Factors 28 (2), 117-128 (2010)
   PUBMED   20102312
  REMARK    GeneRIF: stimulates expression of both chondrogenic and osteoblstic
            markers in pluripotent mesenchymal C3H10T1/2 cells.
REFERENCE   7  (bases 1 to 9267)
  AUTHORS   Mazerbourg,S., Sangkuhl,K., Luo,C.W., Sudo,S., Klein,C. and
            Hsueh,A.J.
  TITLE     Identification of receptors and signaling pathways for orphan bone
            morphogenetic protein/growth differentiation factor ligands based
            on genomic analyses
  JOURNAL   J Biol Chem 280 (37), 32122-32132 (2005)
   PUBMED   16049014
REFERENCE   8  (bases 1 to 9267)
  AUTHORS   Butler,S.J. and Dodd,J.
  TITLE     A role for BMP heterodimers in roof plate-mediated repulsion of
            commissural axons
  JOURNAL   Neuron 38 (3), 389-401 (2003)
   PUBMED   12741987
  REMARK    GeneRIF: In mouse, the expression of Gdf7 in roof plate cells is
            required for the fidelity of commissural axon growth.
REFERENCE   9  (bases 1 to 9267)
  AUTHORS   Davidson,A.J., Postlethwait,J.H., Yan,Y.L., Beier,D.R., van
            Doren,C., Foernzler,D., Celeste,A.J., Crosier,K.E. and Crosier,P.S.
  TITLE     Isolation of zebrafish gdf7 and comparative genetic mapping of
            genes belonging to the growth/differentiation factor 5, 6, 7
            subgroup of the TGF-beta superfamily
  JOURNAL   Genome Res 9 (2), 121-129 (1999)
   PUBMED   10022976
REFERENCE   10 (bases 1 to 9267)
  AUTHORS   Lee,K.J., Mendelsohn,M. and Jessell,T.M.
  TITLE     Neuronal patterning by BMPs: a requirement for GDF7 in the
            generation of a discrete class of commissural interneurons in the
            mouse spinal cord
  JOURNAL   Genes Dev 12 (21), 3394-3407 (1998)
   PUBMED   9808626
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF522369.1, AB158468.1,
            AC012065.8 and BQ182131.1.
            
            On Nov 23, 2018 this sequence version replaced NM_182828.3.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein may play a role in the
            differentiation of tendon cells and spinal cord interneurons. A
            mutation in this gene may be associated with increased risk for
            Barrett's esophagus and esophageal adenocarcinoma. [provided by
            RefSeq, Sep 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF522369.1, AB158468.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272224.5/ ENSP00000272224.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1083              AF522369.1         481-1563
            1084-1085           AB158468.1         1046-1047
            1086-1514           AF522369.1         1566-1994
            1515-8664           AC012065.8         189178-196327
            8665-9267           BQ182131.1         13-615              c
FEATURES             Location/Qualifiers
     source          1..9267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..9267
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /note="growth differentiation factor 7"
                     /db_xref="GeneID:151449"
                     /db_xref="HGNC:HGNC:4222"
                     /db_xref="MIM:604651"
     exon            1..487
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1449
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /note="GDF-7"
                     /codon_start=1
                     /product="growth/differentiation factor 7 preproprotein"
                     /protein_id="NP_878248.2"
                     /db_xref="CCDS:CCDS1701.1"
                     /db_xref="GeneID:151449"
                     /db_xref="HGNC:HGNC:4222"
                     /db_xref="MIM:604651"
                     /translation="MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPVRSPGGGG
                     GGGGGGRTLAQAAGAAAVPAAAVPRARAARRAAGSGFRNGSVVPHHFMMSLYRSLAGR
                     APAGAAAVSASGHGRADTITGFTDQATQDESAAETGQSFLFDVSSLNDADEVVGAELR
                     VLRRGSPESGPGSWTSPPLLLLSTCPGAARAPRLLYSRAAEPLVGQRWEAFDVADAMR
                     RHRREPRPPRAFCLLLRAVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRTQR
                     KESLFREIRAQARALGAALASEPLPDPGTGTASPRAVIGGRRRRRTALAGTRTAQGSG
                     GGAGRGHGRRGRSRCSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEP
                     TNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR
                     "
     exon            488..9267
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3661..3666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /note="hexamer: AGTAAA"
     polyA_site      3686
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /note="major polyA site"
     polyA_site      4991
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /note="major polyA site"
     regulatory      9246..9251
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /note="hexamer: ATTAAA"
     polyA_site      9267
                     /gene="GDF7"
                     /gene_synonym="BMP12"
                     /note="major polyA site"
ORIGIN      
        1 acttccccca ttattaaaca ctatgttcaa aaggcgccgg gggacttccc ggagccacgg
       61 agcccgcgcc gcccgcccgc ccggcccacg gagcccatgg acctgagcgc cgccgccgcg
      121 ctgtgccttt ggctgctgag cgcctgccgc ccccgcgacg ggctggaagc ggccgccgtg
      181 ctgcgagcgg cgggggctgg gccggtccgg agcccagggg gcggcggcgg cggcggcggc
      241 ggcgggcgga ctcttgccca ggctgcgggc gccgcggctg tcccggccgc cgcggttccc
      301 cgggcccgcg ccgcgcgccg cgccgcgggc tccggcttca ggaacggctc ggtggtgccg
      361 caccacttca tgatgtcgct ttaccggagc ctggccggga gggctccggc cggggcagcc
      421 gctgtctccg cctcgggcca tggtcgcgcg gacacgatca ccggcttcac agaccaggcg
      481 acccaagacg aatcggcagc cgaaacaggc cagagcttcc tgttcgacgt gtccagcctt
      541 aacgacgcag acgaggtggt gggtgccgag ctgcgcgtgc tgcgccgggg atctccagag
      601 tcgggcccag gcagctggac ttctccgccg ttgctgctgc tgtccacgtg cccgggcgcc
      661 gcccgagcgc cacgcctgct gtactcgcgg gcagctgagc ccctagtcgg tcagcgctgg
      721 gaggcgttcg acgtggcgga cgccatgagg cgccaccgtc gtgaaccgcg ccccccccgc
      781 gcgttctgcc tcttgctgcg cgcagtggca ggcccggtgc cgagcccgtt ggcactgcgg
      841 cggctgggct tcggctggcc gggcggaggg ggctctgcgg cagaggagcg cgcggtgcta
      901 gtcgtctcct cccgcacgca gaggaaagag agcttattcc gggagatccg cgcccaggcc
      961 cgcgcgctcg gggccgctct ggcctcagag ccgctgcccg acccaggaac cggcaccgcg
     1021 tcgccaaggg cagtcattgg cggccgcaga cggaggagga cggcgttggc cgggacgcgg
     1081 acagcgcagg gcagcggcgg gggcgcgggc cggggccacg ggcgcagggg ccggagccgc
     1141 tgcagccgca agccgttgca cgtggacttc aaggagctcg gctgggacga ctggatcatc
     1201 gcgccgctgg actacgaggc gtaccactgc gagggccttt gcgacttccc tttgcgttcg
     1261 cacctcgagc ccaccaacca tgccatcatt cagacgctgc tcaactccat ggcaccagac
     1321 gcggcgccgg cctcctgctg tgtgccagcg cgcctcagcc ccatcagcat cctctacatc
     1381 gacgccgcca acaacgttgt ctacaagcaa tacgaggaca tggtggtgga ggcctgcggc
     1441 tgcaggtagc gcgagggccg gggagggggc agccacgcgg ccgaggatcc ccagctgatg
     1501 agcagcagcg ggccaccctg tcaccgagcg tgggtgcatg tccgatgtga cccagcaccc
     1561 tctcagagga gggagagcac acgttcacac tcacacacac tcgtgcagtc acgcacacat
     1621 ttaccgggga cagcatgtga aagccttggg aagagatgac ctgccggtac cgaatgtcaa
     1681 agccctgtgt attttgcaaa cagataacca tggcgcccac tgcccccatt tagggagagg
     1741 aaggtgtttg tgctgatgtt gcagttagag gcacgaaaat caggtagcaa caacgggtta
     1801 ggaaattcga agttccagaa tgggagaacc aaaggggtac tcgagcatgc tttatctcac
     1861 ccccttttgt ttctggcccg atgtggggca tcgcttccct ggggggctga gcgccgcgtg
     1921 gtgcactccg tgacccactg caaggctgta atgcccttcc cgagggtttg tgttgcatgg
     1981 ggccgtttac cctggaactg ctgcaaaaag catctttctt tttttaactt ttaaaattta
     2041 acgtgcccct gcttcatttt tgaaagggaa gttttgtctg aaagtagctg ttgtggagct
     2101 tcccagattt ctgcaaaggt cggtaccgcc accccccccc ccccccccgc cttttttttt
     2161 ttttttttta atcaattcca ataggaaatg ttatggaaag tggaaaggat atttttcttt
     2221 taaacggctg agtctgatct aacaggatat tggggtggga taggatctgc caggttcgga
     2281 agctccccag ttggtcaggg ggaggtggga gccatgcctc gggtggctca ggaggaagtt
     2341 agtgcaatgg cccggaatgg ggaaggtggg gctgggggag gggagctact gcttttccta
     2401 gagacctgcc aggaggtttt cctaagaagc cagggaagag gctctcaggg cttgaaaggc
     2461 aaggaggtgt cctggggccc actccagccg aggactccgg cttgccggcc aggtaggcgg
     2521 aagctcccgg ggccgactcg ggcttgtgct agttatcaag taagtcggcc tccgcttttt
     2581 acctgctttc gctgtgttgt tgctgtagtt gttggcagtg tgatagtaac gggaagtgaa
     2641 gccactcaaa aatgcttttg tcagacttca actcacaacc cagaccttta gagcaggggg
     2701 aaggtctgcc ccttcccctc atcggctccc tggcttggct gctgtgccct tggaagggca
     2761 gggccttggt gtgggggagc agaggtggaa tatcccccag ttcccttatt tggccccaaa
     2821 gggtcttatt gatgggagga ttttctaggc atgtaaaagt gagttcgaac attcagactt
     2881 cactgtttga tttgatttgt ttatgcctgg gaatcctttg tggctttttg tcaataggct
     2941 gggagaggga acctagttgg actccagctg tccggggtgg gggcttctta gaacagcccc
     3001 gcagccctct cggtgcatct gtgtgatgtt gtgtaggact ttccccttca gagtcctggg
     3061 gagcattatt tccaccctgt gttggatgca ggacaattca tacacatttt gattctcagt
     3121 gattacactc ttgagagaga gaagacagac ttacgattta gatacagcta atttacttag
     3181 gggccctacc tgaatcggtt ttcatcctgt aaaattctcc caaaagaaaa aaaaatacac
     3241 gtgtaaatta ctcttaaaat taagattccc cccttcctcc tattatgtga atttatattc
     3301 tgtggctgta tgagtagcta taaataacca gaacatgaac agtctcttca ggttaaaaat
     3361 tttaaaaata tccaaaagtg gctgctctgg tacaattcca tcttatttta gtgactgggc
     3421 aaagatggtc cctaaatttg tggattttgc cagagatgcc tcactctcgt ttttaaaatg
     3481 aagcttgtca taatgaagaa ttatatatta aaaaaagcac tgaagtgttg aaagttgtag
     3541 tattagaagg tttagaaagg aagttaatga caaagtgcag ttaaatgtta ttttgaggaa
     3601 ggtctggggt atttaatatc tttggataaa agcaaacatt ttgatacttt tttagtgact
     3661 agtaaaaaca attttttggg cagaaatgtc ttgatttagc ctggcctttt tatagtaggg
     3721 aaaaaaactg tcaatttccc ctctttcctt ctgatgacct ccttctaacg agatgtgttg
     3781 tgagtggtgt gggaagtagg taccttcctg catcttgagt tcaggtggca cccggtggga
     3841 ggggtgttgt ccttggacag tgactgttcc ttccatggcc ccataccctc agtgtgctct
     3901 ttgtttactg gataaaagga atgcttccca gatttcctct ggagcaggtg aagcccccag
     3961 gggccactct gcccagccct ctggcatctc agtccattca ctaggtgaat gcagaggatc
     4021 catttcactt gtaaaaatga caacaaaggg ccaacacatg tggggcagac ggctttttgc
     4081 tgctaagatg tggtttaact agcattgcca aggtgtggag aaaagcgttc tgccagcaca
     4141 gttggtagta gcaccctgag ctctctgtct tctaggtagc gggggacagg cctgggtgac
     4201 tggcatgaac ccagcttctc tgttgcaacc cccagctgga atctccagtc accatggatg
     4261 ggagaactga caggcaggga gaaagcatgt caagactgtg aggaaaggct gtcccctcaa
     4321 ccccaacctg aggtcaccaa agtctccctc ctaaagtaaa cagaattttc cattttgtag
     4381 ggagaattgt gcactactag ttgacatcac ttgaaccagg atttcctgct agtgagtagg
     4441 atttggcatc cctacttagg gagctcggga caggccagct ggggcccaac gggggctggt
     4501 gctgggtctg tcaaacacaa tgatagcctg gtcactgctg cttgaaacca gggctttcgt
     4561 attaaggagg atcacccaca ctggcaggcg ggcatttcca ctgattccca aacacacttg
     4621 ccttgttgaa ttctgacttt ccaaacagcc gcactgggtc ttccagagaa ggtggcaggc
     4681 tttgctgtgt tagcttgggg aagccaggct tgagctgtgc tcagtcattg tatccatgct
     4741 ccccttcacc ataccctcct ggcaacgata tgaggtgtgg attgtgtgat agaagaatcc
     4801 agactccacg aagccaagga cagtcacttc tccctggcag ctctcatggt gtcggcagga
     4861 gtgggcgcct caccttgggt actgaagaga gtaccgataa tcccgtggat ggaacaggag
     4921 ggagtgtaat tcaatcccta cacattgtat atgctgttgg caatttcatt taaactcaca
     4981 gcagaaaaca accaggattt gtagactgat tttcttctta gagcagggag aaaaattacg
     5041 ttctttccaa gagcagctcg tgcacagata aggtcagact tttcctgtgc ttgaatctgg
     5101 tctccaggaa atccagtggc aggaagagag tgtcctgagg ctgcctctgg gggcacagaa
     5161 tcactgggcc tcgctgattc tcatgagaac ctgtcatctc agtgagacag gcctcccact
     5221 ggccctcagt gggccatagg ccaagaggtc tgagtcagat cgcgcagtga gctggaggga
     5281 gcgaggctct gaaagcagca gtctagcaga gggagtttgg gcctgcgctt acccctcaga
     5341 aagtgtctgg attgggaagg gaagagagga agctgccgag cgaacccagc agccaaactt
     5401 tgggtgagtg gaaagtaact agatccctct ggtggatggt atatttgagc tgcaccagag
     5461 tcagagccca ctgtgggctt ccgagtgccc agaggcagct gctcccacag cacggactgc
     5521 gcccgccagg ggaggccgct caggggccag ggcaccacaa ggcgtctcct gagagacgtc
     5581 tgaggcaagt tatgggcagt cacctccctg ctggagcttc atcttctgcc ctgtaaaatg
     5641 atgccctttc cagttccaag gttctaggat tttaccttgc ctcaaaaccc actcagatag
     5701 cttgaaggca gagcaaatgt gatggctcct ggagaaggtc ctctcccaat cccagtccca
     5761 gagcctcatc ttaccggttt cgcagctctt gcctgtgcat gtgcatgtgt gtgcgtgtgt
     5821 ccattttact cctatcctta ataggtgcct catggatgtg ctttgaattc ccctgggctg
     5881 aggtaggtgt ggggagggcc cgcaccttga gggtggggtt cagctcccca gagccaggag
     5941 ctggctgagg gcactgccca tccagctgca gttcctcctg tgctcagtgg ggtgggcgga
     6001 gccacactca agctgagact gtctgagaga cctagtgctg ggaagggctc tacctgctgc
     6061 tggggcctct gcaggcagaa gggtaaaggc aaggctgtgc ctggttggtc acccaaacgg
     6121 gggcctggga ctgtcccaga agccctggat gaggcaggca ggactgtccc agaatggact
     6181 ccttgggtcc tcaccccctc ctcaccacca tgcccatgtc tggctctgag gtccccttgc
     6241 agcttcccag gggagtgacc ctggggtagc atcagaagag cttgtctctc tcttcctttt
     6301 tgtggtctgg agaagttaac ataaagaagc accagaaggg aggacccaaa aagatgttta
     6361 tttctaagtt ttcagacagc ttggcatctt gtacctggaa cctcctgacc atgtaggctg
     6421 cagcacagct gtcttcctcc ctctgtgctg ttctggactt taatctgtgt gcacagctta
     6481 gtgcgtcaca aatagtaact gagtgaggct gttgtgaaag aagcctgttt ttttcaggag
     6541 ggccaccgtc ctagcctgag gagacacctg gtggacacag actgcaggga gagggctgaa
     6601 agttggccta gtgaatcaga ggggtgactg agggcctaga agttgccgcg tgagctctga
     6661 tcatcattag gggtgctgtc tgcccatgac ctgcaggtac ccaccttaac cagagcttgg
     6721 cttgtggcct gcaacttggc gacaggcctt tggctgggca aagtttgggc tggtgcttca
     6781 tggcggcagg accaattaca gcagagcaac ccaggatggg tggtcattga aaaatgggtg
     6841 tgaagtcact gaaaaatcag actgagtttc aagttatgct cacagttgct gaaaaagcaa
     6901 aaatatgccc ttagagcagc agagcagcgt gcgatggtcc acttcctcct gcctctgcag
     6961 agcttgcagg cctcttctag catctgtgca tggtgcgcat gtgtctgtga caacagaaag
     7021 ggtgggtttc tctcacacgt ttccctgaca gtggcaaggg ggctgcagcg gtcacagaaa
     7081 cttccggaga gaggtgtttc tgtgcagtca ggtgaatttg ttggcaggac agcttggtgt
     7141 gatgatacaa gaagtacagt ttcactcttt ttttgtcaga tgaacttcct tctgctagtt
     7201 tagaaatgct tcactccaga gagggccacc tgatagaagc tgtattacag aaacttttaa
     7261 tctcttttct atgtcagtaa ggggatgctg aaataaactg tctagaaaaa caagaagctt
     7321 ctgtcacacc caggccactt tcggcagagt ggtccagagc ggccagggca cggccagctg
     7381 ctttgcatct gcattcccgt ttcattacct tttgtgttgt gggccaacag gagtgctacg
     7441 tagtgggggc tggagatttg tccaggcagg aggtgggcaa gtggctgtct tctctgcaga
     7501 atacctgcac tgctccatct gaccagcagt ggcaacagcc acaaccagtt ctgcatctag
     7561 ctcctgccca gacctttggc tgccagaatc tagaaccatg gctgaccaaa gcgagacttc
     7621 cgagtaaggt tcgttaacag gcatcctgct gaattagaag gaaacaggaa cgaatccaaa
     7681 gcaaacgggg ctaaacttcc ctcgaggaca tttcctgagc tgcaacatgg gaagcgacag
     7741 caccgaagct ggtgagctgg tgcaactgca cacacctttt ctctggtttt tagtactcac
     7801 aggtcatcct ggggagaccg ctcatgggct atgggcagcc catgcctgga ttttttggtg
     7861 aatgagtctg aaaagcagtg accaggtgtg ttgagggcct ccccttgcct gcaccttttt
     7921 atctctgagt gactgagggc tgccaaggcc agacaacgca catgtgtcct ggatcctccc
     7981 ctggcctggg gcagcagcag cagcagcagc tgggcttggg gtgagtaggc tggcttgagg
     8041 aaggggctgc ccacaagcag ggctcatttc ctgggtcagg gcctgtcaga ctcaaagtca
     8101 gctcttcagc attctgttta gaaaatgatg atgcagttca gtgagaaaga aagctcagga
     8161 taaaatatgt tttctggagg ggaaatactc aagtgttcta agccaggaac agagactctc
     8221 aagagaggaa ttctctggca ttctctgcct tggataaatc atggattaaa catgagcatc
     8281 cttagaataa ttttattttt gtatttcact ttacactgta atgcaaacag cttttatgtt
     8341 ttctttgacg aagaatcata attgagtcac tttaggtctt ttagctggaa gcatttcacc
     8401 ctaaatgaaa agttaatgca ttttttacaa ggattaacat gctaactaca acttgccctt
     8461 tcagcagatg acaataaggg attctgaaaa gtttggactg tctttttctt tttgtataca
     8521 aataaagcag cagatccttt ctctgtgaag gttgttgcag agctcccgta ccagcttata
     8581 aaatgcggct gtttaagcag gacttgggtg ggcagcagaa ttctgcacat gacgagtggc
     8641 tgcagcttag aaagcaaatt tcatctgatt ccagtactgt gattttaagg aaacggtaaa
     8701 actcaaagtg ccagtaatgc catcaaggct cagtaacatg ccatttcctc agcagctaaa
     8761 gacaaaaaga attattttgg tgaggggata gaaatccttt cgctttgcag tgacacccac
     8821 tttttcttag cttggcttgg gagtaaggag attggagtgt ggggggacat tagaaactca
     8881 tttaaggcaa actgaaatct ccttcatcag cagtcttcct gctggtgtag ccacagcaga
     8941 actccgaggc ttgcaggctg ggctgtctcc ttgctgcctg gcttgggtgt ttatttgggc
     9001 aatgcaagct gacattgtga ggtgttgccg atgcccaggc cagctagcag ggagccctcc
     9061 cagggctggt agaaacctat gtgtatatat attctcaaat ttaaatagat tgtacatagt
     9121 gaaatgtaaa tgacatgtaa aacagcaatc tctatttttc ttaactatta tatagcagta
     9181 tatatttgtt gaacatgctt gtatactctt cattaaccat tttaatattt tgtacagata
     9241 agttgattaa atattttatt cataaaa
//
