LOCUS       NM_005811               8801 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens growth differentiation factor 11 (GDF11), mRNA.
ACCESSION   NM_005811
VERSION     NM_005811.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8801)
  AUTHORS   Strosahl,J., Ye,K. and Pazdro,R.
  TITLE     Novel insights into the pleiotropic health effects of growth
            differentiation factor 11 gained from genome-wide association
            studies in population biobanks
  JOURNAL   BMC Genomics 25 (1), 837 (2024)
   PUBMED   39237910
  REMARK    GeneRIF: Novel insights into the pleiotropic health effects of
            growth differentiation factor 11 gained from genome-wide
            association studies in population biobanks.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8801)
  AUTHORS   Wu,Z., Zhang,Q., Wang,H., Zhou,S., Fu,B., Fang,L., Cheng,J.C. and
            Sun,Y.P.
  TITLE     Growth differentiation factor-11 upregulates matrix
            metalloproteinase 2 expression by inducing Snail in human
            extravillous trophoblast cells
  JOURNAL   Mol Cell Endocrinol 585, 112190 (2024)
   PUBMED   38369181
  REMARK    GeneRIF: Growth differentiation factor-11 upregulates matrix
            metalloproteinase 2 expression by inducing Snail in human
            extravillous trophoblast cells.
REFERENCE   3  (bases 1 to 8801)
  AUTHORS   Zhou,Q. and Hu,Q.
  TITLE     Oncogenic miR-106b-5p promotes cisplatin resistance in
            triple-negative breast cancer by targeting GDF11
  JOURNAL   Histol Histopathol 39 (4), 533-541 (2024)
   PUBMED   37905957
  REMARK    GeneRIF: Oncogenic miR-106b-5p promotes cisplatin resistance in
            triple-negative breast cancer by targeting GDF11.
REFERENCE   4  (bases 1 to 8801)
  AUTHORS   Shao,Y., Liu,T., Wen,X., Zhang,R., Liu,X. and Xing,D.
  TITLE     The regulatory effect of growth differentiation factor 11 on
            different cells
  JOURNAL   Front Immunol 14, 1323670 (2023)
   PUBMED   38143761
  REMARK    GeneRIF: The regulatory effect of growth differentiation factor 11
            on different cells.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8801)
  AUTHORS   Gao,J., Wang,H., Shen,J., Liu,X., Zhu,X., Huang,C., Li,G., Sun,Y.,
            Liu,Z., Sun,Y.E. and Liu,H.
  TITLE     Mutual regulation between GDF11 and TET2 prevents senescence of
            mesenchymal stem cells
  JOURNAL   J Cell Physiol 238 (12), 2827-2840 (2023)
   PUBMED   37801347
  REMARK    GeneRIF: Mutual regulation between GDF11 and TET2 prevents
            senescence of mesenchymal stem cells.
REFERENCE   6  (bases 1 to 8801)
  AUTHORS   Yokoe,T., Ohmachi,T., Inoue,H., Mimori,K., Tanaka,F., Kusunoki,M.
            and Mori,M.
  TITLE     Clinical significance of growth differentiation factor 11 in
            colorectal cancer
  JOURNAL   Int J Oncol 31 (5), 1097-1101 (2007)
   PUBMED   17912435
  REMARK    GeneRIF: Quantitative real-time reverse transcription-PCR in
            colorectal cancer specimens obtained from 130 patients showed that
            GDF11 mRNA expression in cancer tissue was significantly higher
            than in normal tissue
REFERENCE   7  (bases 1 to 8801)
  AUTHORS   Ge,G., Hopkins,D.R., Ho,W.B. and Greenspan,D.S.
  TITLE     GDF11 forms a bone morphogenetic protein 1-activated latent complex
            that can modulate nerve growth factor-induced differentiation of
            PC12 cells
  JOURNAL   Mol Cell Biol 25 (14), 5846-5858 (2005)
   PUBMED   15988002
REFERENCE   8  (bases 1 to 8801)
  AUTHORS   Lee,S.J. and McPherron,A.C.
  TITLE     Myostatin and the control of skeletal muscle mass
  JOURNAL   Curr Opin Genet Dev 9 (5), 604-607 (1999)
   PUBMED   10508689
  REMARK    Review article
REFERENCE   9  (bases 1 to 8801)
  AUTHORS   McPherron,A.C., Lawler,A.M. and Lee,S.J.
  TITLE     Regulation of anterior/posterior patterning of the axial skeleton
            by growth/differentiation factor 11
  JOURNAL   Nat Genet 22 (3), 260-264 (1999)
   PUBMED   10391213
REFERENCE   10 (bases 1 to 8801)
  AUTHORS   Gamer,L.W., Wolfman,N.M., Celeste,A.J., Hattersley,G., Hewick,R.
            and Rosen,V.
  TITLE     A novel BMP expressed in developing mouse limb, spinal cord, and
            tail bud is a potent mesoderm inducer in Xenopus embryos
  JOURNAL   Dev Biol 208 (1), 222-232 (1999)
   PUBMED   10075854
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073487.34, AF100907.1 and
            BU620213.1.
            
            On May 17, 2019 this sequence version replaced NM_005811.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This protein plays a role in the
            development of the nervous and other organ systems, and may
            regulate aging. [provided by RefSeq, Aug 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF100907.1, SRR1163657.417516.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000257868.10/ ENSP00000257868.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AC073487.34        7933-8106
            175-1600            AF100907.1         18-1443
            1601-4379           AC073487.34        14875-17653
            4380-4907           BU620213.1         19-546              c
            4908-8801           AC073487.34        18182-22075
FEATURES             Location/Qualifiers
     source          1..8801
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.2"
     gene            1..8801
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /note="growth differentiation factor 11"
                     /db_xref="GeneID:10220"
                     /db_xref="HGNC:HGNC:4216"
                     /db_xref="MIM:603936"
     exon            1..640
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..1419
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /note="bone morphogenetic protein 11; GDF-11"
                     /codon_start=1
                     /product="growth/differentiation factor 11 preproprotein"
                     /protein_id="NP_005802.1"
                     /db_xref="CCDS:CCDS8891.1"
                     /db_xref="GeneID:10220"
                     /db_xref="HGNC:HGNC:4216"
                     /db_xref="MIM:603936"
                     /translation="MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVG
                     GERSSRPAPSVAPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQ
                     LLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPL
                     CCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRH
                     IRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGP
                     GAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPK
                     RYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQII
                     YGKIPGMVVDRCGCS"
     exon            641..1038
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..8801
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3367..3372
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /note="hexamer: AGTAAA"
     polyA_site      3392
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /note="major polyA site"
     regulatory      8645..8650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /note="hexamer: AATAAA"
     polyA_site      8667
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /note="major polyA site"
     regulatory      8773..8778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
                     /note="hexamer: AATAAA"
     polyA_site      8801
                     /gene="GDF11"
                     /gene_synonym="BMP-11; BMP11; VHO"
ORIGIN      
        1 agccgcccgc cccggccgcc cgcccgcccc gcccgcgcgc ccgccgcccc cggccccccg
       61 ggtcccccct cggccgggca gcccccaatc ccgcgccgcc cggaccccct cctcctccct
      121 ccctcctccc tccgccccct ccccgcggga ctccggcgtc cccgcccccc agtcctccct
      181 cccctcccct ccagcatggt gctcgcggcc ccgctgctgc tgggcttcct gctcctcgcc
      241 ctggagctgc ggccccgggg ggaggcggcc gagggccccg cggcggcggc ggcggcggcg
      301 gcggcggcgg cagcggcggg ggtcgggggg gagcgctcca gccggccagc cccgtccgtg
      361 gcgcccgagc cggacggctg ccccgtgtgc gtttggcggc agcacagccg cgagctgcgc
      421 ctagagagca tcaagtcgca gatcttgagc aaactgcggc tcaaggaggc gcccaacatc
      481 agccgcgagg tggtgaagca gctgctgccc aaggcgccgc cgctgcagca gatcctggac
      541 ctacacgact tccagggcga cgcgctgcag cccgaggact tcctggagga ggacgagtac
      601 cacgccacca ccgagaccgt cattagcatg gcccaggaga cggacccagc agtacagaca
      661 gatggcagcc ctctctgctg ccattttcac ttcagcccca aggtgatgtt cacaaaggta
      721 ctgaaggccc agctgtgggt gtacctacgg cctgtacccc gcccagccac agtctacctg
      781 cagatcttgc gactaaaacc cctaactggg gaagggaccg cagggggagg gggcggaggc
      841 cggcgtcaca tccgtatccg ctcactgaag attgagctgc actcacgctc aggccattgg
      901 cagagcatcg acttcaagca agtgctacac agctggttcc gccagccaca gagcaactgg
      961 ggcatcgaga tcaacgcctt tgatcccagt ggcacagacc tggctgtcac ctccctgggg
     1021 ccgggagccg aggggctgca tccattcatg gagcttcgag tcctagagaa cacaaaacgt
     1081 tcccggcgga acctgggtct ggactgcgac gagcactcaa gcgagtcccg ctgctgccga
     1141 tatcccctca cagtggactt tgaggctttc ggctgggact ggatcatcgc acctaagcgc
     1201 tacaaggcca actactgctc cggccagtgc gagtacatgt tcatgcaaaa atatccgcat
     1261 acccatttgg tgcagcaggc caatccaaga ggctctgctg ggccctgttg tacccccacc
     1321 aagatgtccc caatcaacat gctctacttc aatgacaagc agcagattat ctacggcaag
     1381 atccctggca tggtggtgga tcgctgtggc tgctcttaag gtgggggata gaggatgcct
     1441 cccccacaga ccctacccca agacccctag ccctgccccc atccccccaa gccctagagc
     1501 tccctccact cttcccgcga acatcacacc gttccccgac caagccgtgt gcaatacaac
     1561 agagggaggc aggtgggaat tgagggtgag gggtttgggg gaaaggggaa gcaggggcat
     1621 agtcagggtg gggagtgttt gaagtttgca gatgagaagg tttgacaaaa agacagagag
     1681 atgtagagac agtgatagag acagaggaac aaaaagagca gcagtgagaa ggcaaagaga
     1741 gaggcagaag agacagacga ggcagagaca aaacactgag aaagagactg aaatggagta
     1801 ataaatgaaa gccccacacc aagcctcctt tcttccactg gcaaggtgag gggcttggta
     1861 tagtttgggg agatcccctg actattcagt aggagaagaa atcaaaaatc cattcttttc
     1921 tccttctctc cctccaacag tggccagggg aaggggaagt gagggcaggg gcaaaaagat
     1981 ttgggaattt ttatttattt atttattgtg acttttcatt tttttggtat ttggctttac
     2041 tggaatagga gggcccctgc ccactgtgcc ccgtttatcc cttattcccc aaaccctgct
     2101 ctccccaaca cctactcact taagcacttg tataaagcct ccagggttgg gaatgggagt
     2161 aaagggcaag agggcggaca catgaagttt agtttctaac ccatcatcac cctaactcaa
     2221 ccttttctga gccaaatggc ttgaattgaa gccagttgtc atggaaatag taagaggtta
     2281 gggtttaaga gctggggatg cgggggtggg agagagaacc ctcaacatcc aggatctata
     2341 taatgagagc tactttaaac cctcaggtcc accctcatga tgctgagtta tttagccaga
     2401 gggtgcagcc tgcttatgcc caaattccct cagccaagag agagaccaaa gagcctctgg
     2461 aatggccctg ctcccagcct ctatcttcag gtcaattaga gagagtatag agaccccaga
     2521 gtcccctggg tctggaaagc gttaggagag gtcaagaaag gagcagtaag gaggctgaag
     2581 gttacagggc atttgaatcc aaatcactgc tctgggctag ggaatagagc cagcagacca
     2641 aggtgggaag gattctggaa gggggacatt ttagtctcct aaccccaaag ctcagggtgg
     2701 aagaggggag aacaaggaag cagagtgtat aattattttt tccttttatt tttggaatct
     2761 aacagtacct ggcagcaggg aggggaaagt acagtgggga aaagcatctg acaaggccag
     2821 ttagaacaga ggatgggaag gatggagact cccgggcttg gaaggctagg aagcaggcag
     2881 agactggttg ccatttcaag tcactagcta ggcccattca ttcctcccac aaccctgacc
     2941 cattctcctc tggactcact gtgcctcagt ttcttcccct caatggaatg agaaatgaca
     3001 gcacccgcca cagccaagag atgaattctg agcacttacc acgggcactt tatggacata
     3061 aaatacctct cgctgtggga cagataacca gggcaccaga gtagtggtga agagatgtga
     3121 ggcttaagag gagtcacagg cttcagagta caagttcccc tctgcctccc agctggacag
     3181 tgcctagaag ccaaggagtt gagaatctcc tgatccacac cctatcctta cttcaccacc
     3241 aggcctcttg gctccaggca agagcttaga ggatgtcagg agaggtgggg gtaagaatct
     3301 tcagcaaaac tgtcactcta agtagagcca gcagttacgg gtctgataaa aacagtactg
     3361 aactaaagta aagcccaagc tggtgagcaa aactggatgg ctcattcttc ccaagagcat
     3421 gactctcccc cttggccagt tggtggaagg ggcaaaggta tgtgaccacc cttgagaagg
     3481 tgatgttggt gagctttaac atcttattcc tattcttata gtgagaaagt gaaacaagat
     3541 ctttcagtag aggaatgggc agggctgtta ggctcttcag cttgccttca cccatatagc
     3601 agctatgcta accccaagcc tctctggccc tgttcttcat ccttccttct gccccaatcc
     3661 tgaaggacaa gacacacccg gccatcaaca ccactcacat ttccttggtg gaaggaaagg
     3721 aacagagaag tgaagaacag atacctccct ccaaggtcaa atgcctcgtg atcttggcag
     3781 agtagggatt gggcaataag catcaggtat cttccctcta cagattctag agagctgggg
     3841 cattaaatat gggggacact tagaatacag ctccttaaat accaccaaat aaagaccttt
     3901 gtgtgtgtgt ggtgggtggg gggggggcag gggtctttct cttatgaaca taaatctgtg
     3961 agctgaagtc tcattcccct gttcctccct acccccaaag aggcacagag tgaagggact
     4021 tggggggcac agctcagcaa cccagtggga gttagcaccc cctcccacct tatgatgtgt
     4081 gtggacctgg ccagtgcccc tctgaacata tcattattag tgtaattatc atttattttg
     4141 tgtatttgtc acattgtgtg catgacagcc tttgttaagg gtgtctgagg agtatggagc
     4201 tgacaggggc attggaatgc caggaaagaa cttcttcaac tgagatcaag gcttcctgga
     4261 gggaaccact gcaaaaaggc catcaggcag ttttcaagtt atgtgacaga gggcaaagac
     4321 ggccataggg tgctctgagt tttgggatgg tcacatgaca caatccagca cttgaacctg
     4381 aaaaaaaaaa taaaagcggt caaagagttt agaattcagt gctgagctct tctccctaat
     4441 caagtgccac atttacacct tggagaaccg gaggtgaaga ggatctgaga caggaaacct
     4501 cgtgttcaat gactaagaag atggggtcct ggagcaagac agaaaacact aagggcatgg
     4561 tggtataagg tttgggacat gcaggccaag gaaggatgga aagaggacag gaaactgggg
     4621 gtacctagaa caacccctct ctgaaaagct tgagccaaaa cagtcccaaa gacaacaaga
     4681 cccctctccc agcctccaca gaatggaaga tctaaaggtt ctcttgagat gatccagcta
     4741 gtatggaaga tctaaaggtt ctcttgagat gatccagcta gtgtcctatt ctcctgcagt
     4801 ccctgttcct aggtttcctc aacgaagttt gacaaaaatc taaaccaaca tagccaacga
     4861 acttgccttg ttacacaaga gtggctaaaa tagcatctca aatattcttt cagttcactg
     4921 taaaaatttt tcccatgtac ctagagcaca attccccagg aatatgagtt gggaatggca
     4981 aaagaatatt gcctgactca catttttcaa aaataaggaa agctggctgg gcgcagtggc
     5041 ttacatctgt aatcccagca ctttgggggg ccgaggcggg cggatcatgc aaggtccgga
     5101 gttcgagacc atgctggcca acattgtgaa acctcatctc tactaaaata cccaaaatta
     5161 gccgggcgtg gtggcgtgcg cctgtaatcc cagctacatg gaaggctgag gcagaagaat
     5221 cgcttgaacc caggtggcgg aggttgcagt gagctgagat cgcaccactg cactctagca
     5281 tggtgacaga gtgagactcc catctccaaa aaaaaaaaaa aaaaaaaaaa aaggaaagca
     5341 ggacccagtg gtgtgctcct gtagttccag ctattcagga ggctgtggca ggaggaccac
     5401 ttgaggccag agggtcaagg ctgcagtgtg ctataattgg gcctgtaaat agccactgta
     5461 ctccaagctg agcaacacag taagacactg tctctaaaaa taattaaagt aaaataaaaa
     5521 taaggaaagc tcctgtgaca tcaacctgat ccagaattgg ggacagcgct actgcgggtt
     5581 caatgtactg ccatgttttc cctgtcttat cagttctatc agcacactga ccccactcga
     5641 gaccaactac aagactaagg ctggaagtgg ttgagtagca gaagtgttat gtattctatc
     5701 ttcccaaggg aaccatatcc acatctaccc ctaactttgg cctgagctga aaatgggttt
     5761 tctctccctg tggctcattt gtttcctata ttgagagaac acccaaaaaa agactactca
     5821 agatgacttt ttacaagtct tttctttatc ctaaaacatc ctccaaccga aggcatggga
     5881 agctatccta tactctgacc ttgcctatat tttaaatggc aggggcccca agctaagaat
     5941 cagcaggcag tggcatctac agcttctggt ctgtagtggc gtagaagcag gaaaatcaat
     6001 gctccaaagc aacaatgtcc agctttcctg ccagtgagct gggcttgagg gagtgaatgg
     6061 gactctttct gccttttctt tttctcaaaa tacgactgca ttaactgggt gtatgcacac
     6121 acaaacatgt tcaaactagg gcactcatac ctagctagaa cctactcagg gaaagaaata
     6181 tgtatttcca cagtaccctg atcacccagt aaaagctaat atttattgaa taattactat
     6241 gcaaattatg gtaagcaaat tgtagtgtga atacatgata tgagaatatc acttaattca
     6301 cacagcaacc ttcacaatgg ggttcctttt ggtacagtct gaaaagagaa tgattatctg
     6361 cgcagggtct cagagctagt gtggtagaat aagaaattaa acctaagtag ttgctaaaca
     6421 atattacatt ctaatctatc ctattgaaag tgatccggga ggtagaaacc taaatacagg
     6481 aataacataa gggaaagaga taacaagaaa gttagggaca ccttggactc aaagaatctg
     6541 gaaagatgtg aaacctgtaa ttttaaatcc ctttggaagg gaaaaacaag aaaagtctag
     6601 atatggcaag agaaggggag gttaaatttt ggggggattc caataatcag aaataagtgg
     6661 cattgccaga ggccctcata taagagaaca gcaaaaaagt tatcctccct taagttcctc
     6721 cctcactcct catatcagac acagcaagag aactcagctc aacaccaaga agtcctgccc
     6781 ttattcacac cttccttcct atagccctca tcctcacaga agcttctagc ctctatcttc
     6841 agcagttctt aagaggtggg gtggggggct gggcagttta gagtgagagt ggaaaaaaag
     6901 aataatccta gagaaccata aaaaagtaca gatttacagc tgaggaagct agttctcccc
     6961 acagctttta tagactccct cattaagagc ttccaggtat gcagagaatg tcacagcttc
     7021 aggaattgga atcagttaac cacatctgga tgctggatca actatagtag ggaaacgggg
     7081 agaggaagga agggtactaa gatctcaggt aaacaattac aagcctcaat gtctgttcca
     7141 tctccaaacg gaattactat tttaaaactg aattgggaaa aaggcatcct gaactattca
     7201 tgctcaaaga gtatgtggag aatgactata atgagatagg aaggggagga cttcatctgg
     7261 cttggaggtt agagacttct gaccaacata ggaacagctg ctgaaatggg atgaaagagg
     7321 ttaataagaa aaaaaaaaaa atcctcacaa attggaaaac actgttcaaa gatctagggg
     7381 aagtaagatg agtgaggaga ataattaggc ttcaagaaga gaatcctggc aagtaaggct
     7441 gaatatcttt ctggaaggtt atagaggata aagagacgaa gaaaacttcc aaaagatcca
     7501 ctgttccact tcataatcag catctgctct attccctcat gtatttttct ctttttaaaa
     7561 ccatattcag gaagaaacca ttagtgaatc tataatctct caagttacaa atcagatcta
     7621 ttctgttttc agatgaaggc agagtagaga gaggaaaagc tagccccaag atcagagcct
     7681 gaggtaaaga aaaggaaggc agacagaaaa gagggaaaag ggaaggtcat tccaatttta
     7741 aggtttattt ggttgaagag gtgtcaaaaa tttaaccagc attccctttt gttcacttct
     7801 ccaaagtctc agaatggggc aaacttcaca acaaatgggc agcagttttt ggatctgctc
     7861 tccaaggcac aatttttcta aattatctaa actttaggtc cctgctttcc tcaccaacca
     7921 gagactttgg agaaataaag agatatcttg acattagaaa ggtgatcaaa ctattaccat
     7981 ttcattaagc acaaaaccag gcaggtttta gtagaaataa ggataaagga ttacaccaca
     8041 gcaacatggg acctgatcat agtaccaaag tcttcaggta aggtgtcagg ctcctaagtc
     8101 ttattaccaa aaatagctca aacaaaaacc gagcttatat aaagattaag aggagaaatt
     8161 ctgcaataac atatccaaaa agattaagca ggtttcagat ctacatgaac ttgaagcctc
     8221 cagttccact gcttatgttc ccaatgattt agctaacaat gcgtaacagc tctgacatcc
     8281 tctgtcatgc tttgattctg catacaaaat ttcttctgtc tctgagggat atccagccca
     8341 tctcccttcc tgaactgact gaccaacata gtatcgtatc acatcaccct tgaaatcagg
     8401 gcccttttcc tttaatgtgg gaccctggac tccattttat ccaagaaaaa gtctgcatta
     8461 ttagctaata acagaaggct actaatcact gcccttgtat ttatatcctt tgcaacacct
     8521 aaaacctccc atgttctgtt ttatttcagt gggtcactac aagctgctgg agcaaagact
     8581 tggtgggtgg gtaacttaac ctcttcacag aggataaaaa atgcttgtga gtatgacaga
     8641 agggaataaa caggcttaaa gggtaaactc agtccttttc cttgtcttct cttctaaggg
     8701 ataaaggtat tatggccaat tctctataat atttgcccct gaagctcccc ttatctggtc
     8761 taatctagct ccaataaatc aaaggagcac ctaataaaac a
//
