LOCUS       NM_004962               2677 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens growth differentiation factor 10 (GDF10), mRNA.
ACCESSION   NM_004962
VERSION     NM_004962.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2677)
  AUTHORS   Yousof,T.R., Mejia-Benitez,A., Morrison,K.M. and Austin,R.C.
  TITLE     Reduced plasma GDF10 levels are positively associated with
            cholesterol impairment and childhood obesity
  JOURNAL   Sci Rep 14 (1), 1805 (2024)
   PUBMED   38245533
  REMARK    GeneRIF: Reduced plasma GDF10 levels are positively associated with
            cholesterol impairment and childhood obesity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2677)
  AUTHORS   He,F., Feng,G., Ma,N., Midorikawa,K., Oikawa,S., Kobayashi,H.,
            Zhang,Z., Huang,G., Takeuchi,K. and Murata,M.
  TITLE     GDF10 inhibits cell proliferation and epithelial-mesenchymal
            transition in nasopharyngeal carcinoma by the transforming growth
            factor-beta/Smad and NF-kappaB pathways
  JOURNAL   Carcinogenesis 43 (2), 94-103 (2022)
   PUBMED   34922336
  REMARK    GeneRIF: GDF10 inhibits cell proliferation and
            epithelial-mesenchymal transition in nasopharyngeal carcinoma by
            the transforming growth factor-beta/Smad and NF-kappaB pathways.
REFERENCE   3  (bases 1 to 2677)
  AUTHORS   Brandt,K.J., Burger,F., Baptista,D., Roth,A., Fernandes da
            Silva,R., Montecucco,F., Mach,F. and Miteva,K.
  TITLE     Single-Cell Analysis Uncovers Osteoblast Factor Growth
            Differentiation Factor 10 as Mediator of Vascular Smooth Muscle
            Cell Phenotypic Modulation Associated with Plaque Rupture in Human
            Carotid Artery Disease
  JOURNAL   Int J Mol Sci 23 (3), 1796 (2022)
   PUBMED   35163719
  REMARK    GeneRIF: Single-Cell Analysis Uncovers Osteoblast Factor Growth
            Differentiation Factor 10 as Mediator of Vascular Smooth Muscle
            Cell Phenotypic Modulation Associated with Plaque Rupture in Human
            Carotid Artery Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2677)
  AUTHORS   Zhang,D., Song,Y., Li,D., Liu,X., Pan,Y., Ding,L., Shi,G., Wang,Y.,
            Ni,Y. and Hou,Y.
  TITLE     Cancer-associated fibroblasts promote tumor progression by
            lncRNA-mediated RUNX2/GDF10 signaling in oral squamous cell
            carcinoma
  JOURNAL   Mol Oncol 16 (3), 780-794 (2022)
   PUBMED   33657265
  REMARK    GeneRIF: Cancer-associated fibroblasts promote tumor progression by
            lncRNA-mediated RUNX2/GDF10 signaling in oral squamous cell
            carcinoma.
REFERENCE   5  (bases 1 to 2677)
  AUTHORS   Uezumi,A., Ikemoto-Uezumi,M., Zhou,H., Kurosawa,T., Yoshimoto,Y.,
            Nakatani,M., Hitachi,K., Yamaguchi,H., Wakatsuki,S., Araki,T.,
            Morita,M., Yamada,H., Toyoda,M., Kanazawa,N., Nakazawa,T., Hino,J.,
            Fukada,S.I. and Tsuchida,K.
  TITLE     Mesenchymal Bmp3b expression maintains skeletal muscle integrity
            and decreases in age-related sarcopenia
  JOURNAL   J Clin Invest 131 (1) (2021)
   PUBMED   33170806
  REMARK    GeneRIF: Mesenchymal Bmp3b expression maintains skeletal muscle
            integrity and decreases in age-related sarcopenia.
REFERENCE   6  (bases 1 to 2677)
  AUTHORS   Lafont,J.E., Talma,S., Hopfgarten,C. and Murphy,C.L.
  TITLE     Hypoxia promotes the differentiated human articular chondrocyte
            phenotype through SOX9-dependent and -independent pathways
  JOURNAL   J Biol Chem 283 (8), 4778-4786 (2008)
   PUBMED   18077449
  REMARK    GeneRIF: new hypoxia-inducible and SOX9-regulated genes, Gdf10 and
            Chm-I. In addition, Mig6 and InhbA were induced by hypoxia,
            predominantly via HIF-2alpha
REFERENCE   7  (bases 1 to 2677)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2677)
  AUTHORS   Ducy,P. and Karsenty,G.
  TITLE     The family of bone morphogenetic proteins
  JOURNAL   Kidney Int 57 (6), 2207-2214 (2000)
   PUBMED   10844590
  REMARK    Review article
REFERENCE   9  (bases 1 to 2677)
  AUTHORS   Hino,J., Takao,M., Takeshita,N., Konno,Y., Nishizawa,T., Matsuo,H.
            and Kangawa,K.
  TITLE     cDNA cloning and genomic structure of human bone morphogenetic
            protein-3B (BMP-3b)
  JOURNAL   Biochem Biophys Res Commun 223 (2), 304-310 (1996)
   PUBMED   8670277
REFERENCE   10 (bases 1 to 2677)
  AUTHORS   Cunningham,N.S., Jenkins,N.A., Gilbert,D.J., Copeland,N.G.,
            Reddi,A.H. and Lee,S.J.
  TITLE     Growth/differentiation factor-10: a new member of the transforming
            growth factor-beta superfamily related to bone morphogenetic
            protein-3
  JOURNAL   Growth Factors 12 (2), 99-109 (1995)
   PUBMED   8679252
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL731561.12, DA165700.1,
            D49492.1 and BU678075.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004962.4.
            
            Summary: This gene encodes a secreted ligand of the TGF-beta
            (transforming growth factor-beta) superfamily of proteins. Ligands
            of this family bind various TGF-beta receptors leading to
            recruitment and activation of SMAD family transcription factors
            that regulate gene expression. The encoded preproprotein is
            proteolytically processed to generate each subunit of the
            disulfide-linked homodimer. This promotes neural repair after
            stroke. Additionally, this protein may act as a tumor suppressor
            and reduced expression of this gene is associated with oral cancer.
            [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1017024.1, D49492.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000580279.2/ ENSP00000464145.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AL731561.12        161732-161758       c
            28-189              DA165700.1         66-227
            190-2647            D49492.1           1-2458
            2648-2677           BU678075.1         22-51               c
FEATURES             Location/Qualifiers
     source          1..2677
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..2677
                     /gene="GDF10"
                     /gene_synonym="BIP; BMP-3b; BMP3B"
                     /note="growth differentiation factor 10"
                     /db_xref="GeneID:2662"
                     /db_xref="HGNC:HGNC:4215"
                     /db_xref="MIM:601361"
     exon            1..774
                     /gene="GDF10"
                     /gene_synonym="BIP; BMP-3b; BMP3B"
                     /inference="alignment:Splign:2.1.0"
     CDS             456..1892
                     /gene="GDF10"
                     /gene_synonym="BIP; BMP-3b; BMP3B"
                     /note="bone morphogenetic protein 3B; bone-inducing
                     protein"
                     /codon_start=1
                     /product="growth/differentiation factor 10 preproprotein"
                     /protein_id="NP_004953.1"
                     /db_xref="CCDS:CCDS73117.1"
                     /db_xref="GeneID:2662"
                     /db_xref="HGNC:HGNC:4215"
                     /db_xref="MIM:601361"
                     /translation="MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALP
                     AAADGLQGDRDLQRHPGDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSF
                     RARLEVVDQKAVYFFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGR
                     PLPLGPPTRQHLLFRSLSQNTATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGE
                     LLLSAQLDSEERDPGVPRPSPYAPYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEP
                     RAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPFRALKPR
                     PGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNE
                     WIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNS
                     LGVLFLDENRNVVLKVYPNMSVDTCACR"
     exon            775..1700
                     /gene="GDF10"
                     /gene_synonym="BIP; BMP-3b; BMP3B"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..2677
                     /gene="GDF10"
                     /gene_synonym="BIP; BMP-3b; BMP3B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2650..2655
                     /regulatory_class="polyA_signal_sequence"
                     /gene="GDF10"
                     /gene_synonym="BIP; BMP-3b; BMP3B"
                     /note="hexamer: ATTAAA"
     polyA_site      2677
                     /gene="GDF10"
                     /gene_synonym="BIP; BMP-3b; BMP3B"
                     /note="major polyA site"
ORIGIN      
        1 acacacgggc gcacgcacac ggcagccggg ccagggacga ccctgtcagc tgcagcccca
       61 gaggtccggg gcgcgcagcc gggtcccctc gagggcgcag ccggccgccc cgccccgccc
      121 ctcgaagcag ccgggccggg cgcgcagtgg gctacaaact ttcgcggcgc gagtccgcca
      181 aggcagcgcg ccgactcggg ctcggctcgg ctctgcgctg ctccggacgg ctgtgaccgc
      241 tggccggggg ctcgggccgc cggtacccac ggaccgcgcg cccgggtgcc tgctccgcta
      301 agcccctcgc cccgcgcgga cctcggtatc cagcgccctg ctgcccgggc tctccccgcg
      361 cgccctactg ccgcgaggtc agtccgcagc ctccggtgcg ccagcgctcg ccttcctcct
      421 cctggacttc ggccctttgc cgccctcacc acgccatggc tcatgtcccc gctcggacca
      481 gcccgggacc cgggccccag ctgctgctgc tgctgctgcc gttgtttctg ctgttgctcc
      541 gggatgtggc cggcagccac agggcccccg cctggtccgc actgcccgcg gccgccgacg
      601 gcctgcaggg ggacagggat ctccagcggc accctgggga cgcggccgcc acgttgggcc
      661 ccagcgccca ggacatggtc gctgtccaca tgcacaggct ctatgagaag tacagccggc
      721 agggcgcgcg gccgggaggg ggcaacacgg tccgcagctt cagggccagg ctggaagtgg
      781 tcgaccagaa ggccgtgtat ttcttcaacc tgacttccat gcaagactcg gaaatgatcc
      841 ttacggccac tttccacttc tactcagagc cgcctcggtg gcctcgagcg ctcgaggtgc
      901 tatgcaagcc gcgggccaag aacgcttcag gccgcccgct gcccctgggc ccgcccacac
      961 gccagcacct gctcttccgc agcctctcgc agaacacggc cacacagggg ctactccgcg
     1021 gggccatggc cctggcgccc ccaccgcgcg gcctgtggca ggccaaggac atctccccca
     1081 tcgtcaaggc ggcccgccgg gatggcgagc tgctcctctc cgcccagctg gattctgagg
     1141 agagggaccc gggggtgccc cggcccagcc cctatgcgcc ctacatccta gtctatgcca
     1201 acgatctggc catctcggag cccaacagcg tggcagtgac gctgcagaga tacgacccct
     1261 tccctgccgg agaccccgag ccccgcgcag cccccaacaa ctcagcggac ccccgcgtgc
     1321 gccgagccgc gcaggccact gggcccctcc aggacaacga gctgccgggg ctggatgaga
     1381 ggccgccgcg cgcccacgca cagcacttcc acaagcacca gctgtggccc agccccttcc
     1441 gggcgctgaa accccggcca gggcgcaaag accgcaggaa gaagggccag gaggtgttca
     1501 tggccgcctc gcaggtgctg gactttgacg agaagacgat gcagaaagcc cggaggaagc
     1561 agtgggatga gccgagggtg tgctcccgga ggtacctgaa ggtggacttc gcagacatcg
     1621 gctggaatga atggataatc tcaccgaaat cttttgatgc ctactactgc gcgggagcat
     1681 gtgagttccc catgcctaag atcgttcgtc catccaacca tgccaccatc cagagcattg
     1741 tcagggctgt gggcatcatc cctggcatcc cagagccctg ctgtgttccc gataagatga
     1801 actcccttgg ggtcctcttc ctggatgaga atcggaatgt ggttctgaag gtgtacccca
     1861 acatgtccgt ggacacctgt gcctgccggt gagaccactc cagggtggaa agaagccacg
     1921 cccagcagag ctgccttctc ggagccttct gcaaccagga cttgtggtgc agctgcagac
     1981 acagagcaca gctcatgggc aacatcactg gggcccagag agagctgtcc gccagtgcat
     2041 cattaggggg tctttcattg ctagtgacta gccccttaaa tgccagcctg agtacctgaa
     2101 ggaatctggg aattagccct ggcctgaaag tggcccatca ttcataccca ctgttctgaa
     2161 ggcttgaaaa caaaacatat ccacaacatt ggcttgatgt gatcatcatc tcataactga
     2221 gcaagaagac tatgcaaatc ttagggcgct cgctccctgc acacggaaag aactctgttt
     2281 aaatgctcag ttcagaacac tttgggccac atagtgattt tggaaaacag gataatcgtg
     2341 gtgtaaatga gtgtttcctt tcaaagtcca ctgcagagct tttatccata tggtatgcac
     2401 atgtagccaa tattggtttc tttttcttaa tatatatatt ttattttaaa acaacaaaaa
     2461 gggagggcgt tgacaccatt ccccacagag atagtcatgc tgagtgtggg ttgtttaaac
     2521 atgcatattg aaataacaca tatagtaacg tgggaatact aaaaaataac caagatttta
     2581 tatttttgta aattatactt tctatactgt agattgtgta tgttatgtgt ttttatggaa
     2641 agctaataaa ttaaaggtac agtggtatct tgaaaaa
//
